{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:46:20Z","timestamp":1777866380708,"version":"3.51.4"},"reference-count":51,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The valorization of agri-food by-products aligns with circular economy principles and offers sustainable sources of bioactive compounds. This study investigated the peels of the purple-fleshed Solanum tuberosum L. cv. Vitelotte Noire (VN), cultivated in Sardinia, as a potential resource for nutraceutical antioxidants. Extracts were obtained using solvents of different polarities (water, 80% and 96% ethanol) and characterized. Phytochemical screening revealed high concentrations of total phenolics, flavonoids, and anthocyanins, with the 96% ethanolic extract showing superior anthocyanin content. Antioxidant capacity, assessed via ORAC-PYR, TEAC-ABTS, and DPPH assays, was highest in the alcoholic extracts. Furthermore, all extracts showed protective effects in an in vitro model of AAPH-induced oxidative DNA damage, as indicated by the preservation of plasmid supercoiling. Untargeted LC-QTOF-MS analysis detailed a rich metabolomic profile, including organic acids, amino acids, and vitamins. The findings confirm VN peel as a potent, sustainable source of antioxidants, supporting its valorization for developing high-added-value nutraceutical and functional food ingredients, while reducing waste disposal costs and environmental impact.<\/jats:p>","DOI":"10.3390\/antiox15050568","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:03:47Z","timestamp":1777536227000},"page":"568","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploiting Solanum tuberosum L. (Vitelotte Noire Cultivar) Peel as a Sustainable Antioxidant Source for Nutraceutical Applications"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2202-0980","authenticated-orcid":false,"given":"Stefania","family":"Peddio","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences (DiSB), University Campus, University of Cagliari, 09042 Monserrato, Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Lorrai","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences (DiSB), University Campus, University of Cagliari, 09042 Monserrato, Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0540-3082","authenticated-orcid":false,"given":"Alessandra","family":"Padiglia","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences (DiSVA), University Campus, University of Cagliari, 09042 Monserrato, Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2448-3767","authenticated-orcid":false,"given":"Pierluigi","family":"Caboni","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences (DiSVA), University Campus, University of Cagliari, 09042 Monserrato, Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8091-7908","authenticated-orcid":false,"given":"Cristina","family":"Manis","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences (DiSVA), University Campus, University of Cagliari, 09042 Monserrato, Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2855-8378","authenticated-orcid":false,"given":"Antonio","family":"Rescigno","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences (DiSB), University Campus, University of Cagliari, 09042 Monserrato, Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3548-7635","authenticated-orcid":false,"given":"Paolo","family":"Zucca","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences (DiSB), University Campus, University of Cagliari, 09042 Monserrato, Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/bs.afnr.2019.07.001","article-title":"Chapter Five\u2014Bioactive Potential of Fruit and Vegetable Wastes","volume":"Volume 91","year":"2020","journal-title":"Advances in Food and Nutrition Research"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"124684","DOI":"10.1016\/j.biortech.2021.124684","article-title":"Sustainable Processing of Food Waste for Production of Bio-Based Products for Circular Bioeconomy","volume":"325","author":"Sharma","year":"2021","journal-title":"Bioresour. 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