{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:22:14Z","timestamp":1790223734265,"version":"4.1.0"},"reference-count":135,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto Polit\u00e9cnico Nacional, IPN","award":["SIP 20253875"],"award-info":[{"award-number":["SIP 20253875"]}]},{"name":"Instituto Polit\u00e9cnico Nacional, IPN","award":["SIP 20230870"],"award-info":[{"award-number":["SIP 20230870"]}]},{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico, UNAM","award":["DGAPA-PAPIIT IT201724"],"award-info":[{"award-number":["DGAPA-PAPIIT IT201724"]}]},{"award":["DGAPA-PAPIIT IT201724"],"award-info":[{"award-number":["DGAPA-PAPIIT IT201724"]}],"id":[{"id":"https:\/\/ror.org\/01tmp8f25","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Plants long employed in traditional medicine remain promising yet underexplored sources of antioxidant compounds. Montanoa bipinnatifida C. Koch, native to southern Mexico, is one such species with a largely uncharacterized chemical profile. In this study, a hydroethanolic of Montanoa bipinnatifida C. Koch leaf extract (MB-LE) was prepared via maceration with 70% ethanol, yielding 18% (w\/w), and subsequently analyzed using spectroscopic and metabolomic approaches. UV\u2013Vis and FTIR spectra revealed a chemically diverse matrix enriched in phenolic and nitrogen-containing constituents. High-resolution ESI-FT-ICR-MS profiling enabled the tentative identification of structurally varied metabolites, including alkaloids, saponins, glycosides, coumarins, and small peptides, while GC\u2013MS analysis further indicated the presence of terpenoids and lipid-related compounds. These findings highlight a previously unrecognized chemical complexity in these species. Functionally, MB-LE exhibited moderate antioxidant activity in the DPPH, ABTS, and FRAP assays (IC50 = 56.21 \u00b1 0.67 \u00b5g\/mL, 724.82 \u00b1 27.49 \u00b5mol TE\/g extract, and 614.90 \u00b1 42.63 \u00b5mol TE\/g extract, respectively), while the extract\u2019s high phenolic content (333.31 \u00b1 11.93 mg GAE\/g extract) suggests a central role of these compounds in its observed activity. Overall, this work positions M. bipinnatifida as a novel source of bioactive metabolites and establishes a foundation for future studies focused on its structural elucidation and biological validation.<\/jats:p>","DOI":"10.3390\/antiox15050598","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:11:13Z","timestamp":1778271073000},"page":"598","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phytochemical Profile and Antioxidant Potential of Montanoa bipinnatifida C. Koch Leaf Extract: Promising Bioactives for Pharmaceutical Applications"],"prefix":"10.3390","volume":"15","author":[{"given":"Ver\u00f3nica Edith","family":"Gallegos-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n en Ciencia Aplicada y Tecnolog\u00eda Avanzada (CICATA), Unidad Legaria, Instituto Polit\u00e9cnico Nacional, Av. Legaria 694, Irrigaci\u00f3n, Miguel Hidalgo, Mexico City 11500, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehekatzin","family":"Garc\u00eda-Vald\u00e9s","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Ciencia Aplicada y Tecnolog\u00eda Avanzada (CICATA), Unidad Legaria, Instituto Polit\u00e9cnico Nacional, Av. Legaria 694, Irrigaci\u00f3n, Miguel Hidalgo, Mexico City 11500, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fernanda","family":"Vargas-Torrico","sequence":"additional","affiliation":[{"name":"Laboratorio de Procesos de Transformaci\u00f3n y Tecnolog\u00edas Emergentes de Alimentos, Facultad de Estudios Superiores Cuautitl\u00e1n, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Km 2.5 Carretera Cuautitl\u00e1n\u2013Teoloyucan, San Sebasti\u00e1n Xhala, Cuautitl\u00e1n Izcalli 54714, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo G.","family":"Medina-Mendoza","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnolog\u00eda y Bioingenier\u00eda, Centro de Investigaci\u00f3n y de Estudios Avanzados (CINVESTAV), Instituto Polit\u00e9cnico Nacional, Av. Instituto Polit\u00e9cnico Nacional 2508, San Pedro Zacatenco, Gustavo A. Madero, Mexico City 07360, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Vergara-Arag\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. Universidad 3000, Coyoac\u00e1n, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4754-0920","authenticated-orcid":false,"given":"M\u00f3nica Rosal\u00eda","family":"Jaime-Fonseca","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Ciencia Aplicada y Tecnolog\u00eda Avanzada (CICATA), Unidad Legaria, Instituto Polit\u00e9cnico Nacional, Av. Legaria 694, Irrigaci\u00f3n, Miguel Hidalgo, Mexico City 11500, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1080\/0972060X.2024.2411398","article-title":"Chemical Composition and Antimicrobial Investigation of the Essential Oil Isolated from Montanoa bipinnatifida (Kunth) K. Koch Leaves","volume":"27","author":"Abbas","year":"2024","journal-title":"J. Essent. Oil Bear. Plants"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.ympev.2003.10.021","article-title":"A Phylogeny of the ITS and ETS for Montanoa (Asteraceae: Heliantheae)","volume":"31","author":"Plovanich","year":"2004","journal-title":"Mol. Phylogenet. 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