{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T03:04:28Z","timestamp":1779678268193,"version":"3.53.1"},"reference-count":48,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFF1106000"],"award-info":[{"award-number":["2024YFF1106000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Guangdong Natural Science Foundation","doi-asserted-by":"publisher","award":["2025A1515010320"],"award-info":[{"award-number":["2025A1515010320"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017687","name":"Guangdong Academy of Agricultural Sciences Talent Development Young Researcher Program","doi-asserted-by":"publisher","award":["R2023PY-QY011"],"award-info":[{"award-number":["R2023PY-QY011"]}],"id":[{"id":"10.13039\/501100017687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017687","name":"Jinying Zhiguang Project of GDAAS","doi-asserted-by":"publisher","award":["R2023PY-JG016"],"award-info":[{"award-number":["R2023PY-JG016"]}],"id":[{"id":"10.13039\/501100017687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Cyclophosphamide (CTX)-induced premature ovarian failure (POF) is characterized by disruption of the follicular microenvironment, granulosa-cell loss, endocrine imbalance, and oxidative-inflammatory injury. Here, we evaluated two multi-bioactive formulations developed to enhance ovarian stress resilience: a base formulation containing coenzyme Q10, calcium L-5-methyltetrahydrofolate, and Vitex agnus-castus extract (Base), and a urolithin A-enriched formulation (Base + U). Using a CTX-induced female C57BL\/6 mouse model, we integrated phenotypic, histological, endocrine, oxidative-inflammatory, and transcriptional readouts to assess efficacy and mechanistic consistency. CTX markedly reduced ovarian index, disrupted estrous cyclicity, shifted follicle development toward atresia, increased granulosa-cell apoptosis, and caused endocrine dysregulation, including decreased anti-M\u00fcllerian hormone and estradiol and increased GnRH, FSH, and LH. CoQ10, Base, and Base + U each partially alleviated these abnormalities, improving ovarian index and coat condition, showing a trend toward improved follicular distribution, and normalizing hormone profiles. CTX also induced an ovarian oxidative-inflammatory shift, as reflected by decreased GSH-Px, increased MDA, and elevated IL-1\u03b2, IL-6, and TNF-\u03b1, all of which were attenuated by the interventions. Notably, Base + U more effectively reduced lipid peroxidation and TNF-\u03b1 than Base alone. Consistently, ovarian transcripts related to follicle responsiveness and steroid regulation, including Fshr, Esr1, and Hsd17b2, were restored, whereas hypothalamic qRT-PCR analysis did not reveal robust transcriptional alterations within the intervention window. These findings suggest that the urolithin A-enhanced formulation partially alleviates CTX-induced ovarian dysfunction by suppressing oxidative-inflammatory stress and preserving granulosa-cell and follicle fate.<\/jats:p>","DOI":"10.3390\/antiox15060662","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T02:32:28Z","timestamp":1779676348000},"page":"662","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Urolithin A-Enhanced Multi-Bioactive Formulation Mitigates Cyclophosphamide-Induced Premature Ovarian Failure Through Suppression of Oxidative-Inflammatory Stress and Preservation of Follicle Fate"],"prefix":"10.3390","volume":"15","author":[{"given":"Yangyan","family":"Dai","sequence":"first","affiliation":[{"name":"WONDERLAB Institute of Microecology and Nutrition, Shenzhen Porshealth Bioengineering Co., Ltd., Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7385-272X","authenticated-orcid":false,"given":"Silu","family":"Zhang","sequence":"additional","affiliation":[{"name":"WONDERLAB Institute of Microecology and Nutrition, Shenzhen Porshealth Bioengineering Co., Ltd., Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijia","family":"Yang","sequence":"additional","affiliation":[{"name":"Sericulture & Agri-food Research Institute Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penglong","family":"Liu","sequence":"additional","affiliation":[{"name":"Sericulture & Agri-food Research Institute Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sericulture & Agri-food Research Institute Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Li","sequence":"additional","affiliation":[{"name":"WONDERLAB Institute of Microecology and Nutrition, Shenzhen Porshealth Bioengineering Co., Ltd., Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Pang","sequence":"additional","affiliation":[{"name":"WONDERLAB Institute of Microecology and Nutrition, Shenzhen Porshealth Bioengineering Co., Ltd., Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijing","family":"Ma","sequence":"additional","affiliation":[{"name":"WONDERLAB Institute of Microecology and Nutrition, Shenzhen Porshealth Bioengineering Co., Ltd., Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sericulture & Agri-food Research Institute Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4092-1261","authenticated-orcid":false,"given":"Tiantian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Sericulture & Agri-food Research Institute Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mikhael, S., Punjala-Patel, A., and Gavrilova-Jordan, L. (2019). Hypothalamic-Pituitary-Ovarian Axis Disorders Impacting Female Fertility. Biomedicines, 7.","DOI":"10.3390\/biomedicines7010005"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Eshre Guideline Group on POI, Webber, L., Davies, M., Anderson, R., Bartlett, J., Braat, D., Cartwright, B., Cifkova, R., de Muinck Keizer-Schrama, S., and Hogervorst, E. (2016). ESHRE Guideline: Management of Women with Premature Ovarian Insufficiency. Hum. Reprod., 31, 926\u2013937.","DOI":"10.1093\/humrep\/dew027"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13048-022-01032-x","article-title":"The Role of Oxidative Stress in Ovarian Aging: A Review","volume":"15","author":"Yan","year":"2022","journal-title":"J. Ovarian Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0039-128X(89)90084-6","article-title":"Chemotherapy-Induced Premature Ovarian Failure: Mechanisms and Prevention","volume":"54","author":"Ataya","year":"1989","journal-title":"Steroids"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/ame2.12477","article-title":"An Overview of Different Methods to Establish a Murine Premature Ovarian Failure Model","volume":"7","author":"Pouladvand","year":"2024","journal-title":"Anim. Model. Exp. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1093\/biolre\/ioae181","article-title":"Granulosa Cell Death Is a Significant Contributor to DNA-Damaging Chemotherapy-Induced Ovarian Insufficiency","volume":"112","author":"Kawano","year":"2025","journal-title":"Biol. Reprod."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1477-7827-4-16","article-title":"The Role of Steroids in Follicular Growth","volume":"4","author":"Drummond","year":"2006","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13048-024-01369-5","article-title":"Efficacy of Natural Products on Premature Ovarian Failure: A Systematic Review and Meta-Analysis of Preclinical Studies","volume":"17","author":"Hu","year":"2024","journal-title":"J. Ovarian Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1007\/s43032-022-01136-1","article-title":"Association of Coenzyme Q10 with Premature Ovarian Insufficiency","volume":"30","author":"Ma","year":"2023","journal-title":"Reprod. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Barbarska, O., Zaryczny-Trojan, L., and Minkiewicz-Zochniak, A. (2025). Folate Supplementation Awareness Among Women of Reproductive Age in Poland: Focus on Active Forms and Updated National Recommendations. Nutrients, 17.","DOI":"10.3390\/nu17243881"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1002\/ptr.8438","article-title":"V Effects, Mechanisms of Action and Application of Vitex agnus-castus for Improvement of Health and Female Reproduction","volume":"39","author":"Sirotkin","year":"2025","journal-title":"Phyther. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1002\/ptr.70237","article-title":"Vitex agnus-castus in Menopause: Phytochemistry, Mechanistic Insights, Clinical Applications, and Safety Perspectives","volume":"40","author":"Sopjani","year":"2026","journal-title":"Phytother. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"102190","DOI":"10.1016\/j.ctim.2019.08.024","article-title":"Vitex agnus-castus in Premenstrual Syndrome: A Meta-Analysis of Double-Blind Randomised Controlled Trials","volume":"47","author":"Csupor","year":"2019","journal-title":"Complement. Ther. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"6900","DOI":"10.1080\/10408398.2022.2036693","article-title":"Ellagic Acid and Intestinal Microflora Metabolite Urolithin A: A Review on Its Sources, Metabolic Distribution, Health Benefits, and Biotransformation","volume":"63","author":"Zhang","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/s41467-025-56266-2","article-title":"Diet-Derived Urolithin A Is Produced by a Dehydroxylase Encoded by Human Gut Enterocloster Species","volume":"16","author":"Pidgeon","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/s42255-019-0073-4","article-title":"The Mitophagy Activator Urolithin A Is Safe and Induces a Molecular Signature of Improved Mitochondrial and Cellular Health in Humans","volume":"1","author":"Andreux","year":"2019","journal-title":"Nat. Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1095\/biolreprod19.3.597","article-title":"Morphometric Analysis of Foilicular Development in the Rat","volume":"19","author":"Hirshfield","year":"1978","journal-title":"Biol. Reprod."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/humupd\/dmz027","article-title":"Ovarian Damage from Chemotherapy and Current Approaches to Its Protection","volume":"25","author":"Spears","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kim, J., and You, S. (2021). Extended Adverse Effects of Cyclophosphamide on Mouse Ovarian Function. BMC Pharmacol. Toxicol., 22.","DOI":"10.1186\/s40360-020-00468-5"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0890-6238(93)90229-Z","article-title":"Reproductive Performance of Female Rats Treated with Cyclophosphamide and\/or LHRH Agonist","volume":"7","author":"Ataya","year":"1993","journal-title":"Reprod. Toxicol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1210\/jcem-49-5-687","article-title":"The Production of Progesterone, Androgens, and Estrogens by Granulosa Cells, Thecal Tissue, and Stromal Tissue from Human Ovaries in Vitro","volume":"49","author":"McNatty","year":"1979","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1111\/jog.16004","article-title":"Role of DNA Damage Response in Cyclophosphamide-induced Premature Ovarian Failure in Mice","volume":"50","author":"Song","year":"2024","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13048-023-01117-1","article-title":"Effect of Hysterectomy on Ovarian Function: A Systematic Review and Meta-Analysis","volume":"16","author":"Huang","year":"2023","journal-title":"J. Ovarian Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1210\/clinem\/dgac039","article-title":"Evaluation of Female Fertility\u2014AMH and Ovarian Reserve Testing","volume":"107","author":"Cedars","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12958-023-01159-6","article-title":"A Review of Nitric Oxide and Oxidative Stress in Typical Ovulatory Women and in the Pathogenesis of Ovulatory Dysfunction in PCOS","volume":"21","author":"Awonuga","year":"2023","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"113859","DOI":"10.1016\/j.ecoenv.2022.113859","article-title":"Carbon Tetrachloride Exposure Induces Ovarian Damage through Oxidative Stress and Inflammatory Mediated Ovarian Fibrosis","volume":"242","author":"Xue","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s13048-024-01551-9","article-title":"Unraveling the Complexity of Follicular Fluid: Insights into Its Composition, Function, and Clinical Implications","volume":"17","author":"Pan","year":"2024","journal-title":"J. Ovarian Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"39451","DOI":"10.31083\/JIN39451","article-title":"Acupuncture and the HPO Axis: A Review of Neuroendocrine Mechanisms with Implications for Ovarian Function","volume":"24","author":"Bu","year":"2025","journal-title":"J. Integr. Neurosci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13287-023-03333-4","article-title":"Comparison of the Different Animal Modeling and Therapy Methods of Premature Ovarian Failure in Animal Model","volume":"14","author":"Dai","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1200\/JCO.22.01885","article-title":"Cancer Treatment-Related Ovarian Dysfunction in Women of Childbearing Potential: Management and Fertility Preservation Options","volume":"41","author":"Reynolds","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/bio.2021.0159","article-title":"Protective Effects of Antioxidants on Cyclophosphamide-Induced Ovarian Toxicity","volume":"21","author":"Barberino","year":"2023","journal-title":"Biopreserv. Biobank."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"106","DOI":"10.14218\/JERP.2023.00025S","article-title":"Cytotoxic Properties of Cyclophosphamide: A Focus on Its Mechanistic Impacts on Male Gonadal Functions","volume":"9","author":"Olowe","year":"2024","journal-title":"J. Explor. Res. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13048-024-01434-z","article-title":"Cyclophosphamide Induces Ovarian Granulosa Cell Ferroptosis via a Mechanism Associated with HO-1 and ROS-Mediated Mitochondrial Dysfunction","volume":"17","author":"Chen","year":"2024","journal-title":"J. Ovarian Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/humupd\/dmae020","article-title":"Ovarian Microenvironment: Challenges and Opportunities in Protecting against Chemotherapy-Associated Ovarian Damage","volume":"30","author":"Guo","year":"2024","journal-title":"Hum. Reprod. Update"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00418-025-02399-w","article-title":"The Protective Role of Vitamin E against the Effects of Hyperthyroidism on the Rat Pituitary\u2013Ovary Axis","volume":"163","author":"Kaplan","year":"2025","journal-title":"Histochem. Cell Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1080\/10253890.2017.1369523","article-title":"Hypothalamic\u2013Pituitary\u2013Adrenal and Hypothalamic\u2013Pituitary\u2013Gonadal Axes: Sex Differences in Regulation of Stress Responsivity","volume":"20","author":"Oyola","year":"2017","journal-title":"Stress"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.fertnstert.2009.04.040","article-title":"The Antral Follicle Count: Practical Recommendations for Better Standardization","volume":"94","author":"Broekmans","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1210\/endo-108-3-772","article-title":"Ovarian Feedback Control of Follicle-Stimulating Hormone in the Ewe: Evidence for Selective Suppression","volume":"108","author":"GOODMAN","year":"1981","journal-title":"Endocrinology"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Homburg, R. (2014). Ovulation Induction and Controlled Ovarian Stimulation: A Practical Guide, Springer. [2nd ed.].","DOI":"10.1007\/978-3-319-05612-8"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3892\/ijmm.2021.4906","article-title":"Estrogen Disorders: Interpreting the Abnormal Regulation of Aromatase in Granulosa Cells","volume":"47","author":"Liu","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Chauvin, S., Cohen-Tannoudji, J., and Guigon, C.J. (2022). Estradiol Signaling at the Heart of Folliculogenesis: Its Potential Deregulation in Human Ovarian Pathologies. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010512"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"bqaf006","DOI":"10.1210\/endocr\/bqaf006","article-title":"A Dynamic Shift in Estrogen Receptor Expression during Granulosa Cell Differentiation in the Ovary","volume":"166","author":"Park","year":"2025","journal-title":"Endocrinology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.str.2013.02.024","article-title":"Apoptosome Structure, Assembly, and Procaspase Activation","volume":"21","author":"Yuan","year":"2013","journal-title":"Structure"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1262\/jrd.2011-012","article-title":"Follicular Growth and Atresia in Mammalian Ovaries: Regulation by Survival and Death of Granulosa Cells","volume":"58","author":"Matsuda","year":"2012","journal-title":"J. Reprod. Dev."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Wang, S. (2023). The Systemic Effects of Ovarian Aging. Ovarian Aging, Springer.","DOI":"10.1007\/978-981-19-8848-6"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3109\/09513590.2012.651929","article-title":"Neuroendocrine Control of Ovulation","volume":"28","author":"Berga","year":"2012","journal-title":"Gynecol. Endocrinol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12958-018-0343-0","article-title":"Pretreatment with Coenzyme Q10 Improves Ovarian Response and Embryo Quality in Low-Prognosis Young Women with Decreased Ovarian Reserve: A Randomized Controlled Trial","volume":"16","author":"Xu","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Wang, W., Zhou, R., Ruan, Y., and Fan, S. (2025). Urolithin A Protects Ovarian Reserve Via Inhibiting PI3K\/Akt Signaling and Preventing Chemotherapy-Induced Follicle Apoptosis. Biology, 14.","DOI":"10.3390\/biology14070829"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/6\/662\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T02:59:35Z","timestamp":1779677975000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/6\/662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,24]]},"references-count":48,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["antiox15060662"],"URL":"https:\/\/doi.org\/10.3390\/antiox15060662","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,24]]}}}