{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T11:04:45Z","timestamp":1779966285821,"version":"3.53.1"},"reference-count":77,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Chronic non-communicable diseases are closely linked to low-grade inflammation and oxidative stress. Native Brazilian fruits, rich in bioactive compounds such as polyphenols and carotenoids, have recognized antioxidant, anti-inflammatory, and neuroprotective properties. Mechanisms of action included inhibition of NF-\u03baB signaling, downregulation of pro-inflammatory cytokines, modulation of oxidative biomarkers, and improvement of metabolic parameters. Several studies demonstrate protective effects against insulin resistance, hepatic steatosis, cardiovascular alterations, and neuroinflammation, alongside modulation of gut microbiota. Most evidence is from animal or cell models, with scarce clinical trials, limiting translational applicability. Overall, native Brazilian fruits represent promising dietary sources of bioactive compounds that may contribute to the modulation of oxidative stress and chronic inflammation. Challenges include variability in phytochemical content due to species, maturity, processing, a lack of standardized extraction and dosage protocols, and limited bioavailability data. Although preclinical findings are robust, further controlled human trials are necessary to confirm their efficacy and clarify their role in the clinical management of inflammatory and neurodegenerative diseases.<\/jats:p>","DOI":"10.3390\/antiox15060677","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T09:57:43Z","timestamp":1779962263000},"page":"677","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential of Native Brazilian Fruits in Modulating Oxidative Stress and Inflammation: A Focused Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3780-8672","authenticated-orcid":false,"given":"Maria Carolina Zsigovics","family":"Alfino","sequence":"first","affiliation":[{"name":"Department of Nutrition, School of Public Health, University of Sao Paulo, 715 Doutor Arnaldo Ave, Sao Paulo 01246-904, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7763-4664","authenticated-orcid":false,"given":"Geni Rodrigues","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health, University of Sao Paulo, 715 Doutor Arnaldo Ave, Sao Paulo 01246-904, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9404-1193","authenticated-orcid":false,"given":"Adriano Costa","family":"de Camargo","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias Aplicadas, Universidad Aut\u00f3noma de Chile, Santiago 7500910, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1012-1418","authenticated-orcid":false,"given":"Elizabeth Aparecida Ferraz da Silva","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health, University of Sao Paulo, 715 Doutor Arnaldo Ave, Sao Paulo 01246-904, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature21363","article-title":"Inflammation, metaflammation and immunometabolic disorders","volume":"542","author":"Hotamisligil","year":"2017","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.cell.2010.02.016","article-title":"Mechanisms Underlying Inflammation in Neurodegeneration","volume":"140","author":"Glass","year":"2010","journal-title":"Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Sugden, S.G., and Merlo, G. 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