{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:53:41Z","timestamp":1785405221946,"version":"3.56.0"},"reference-count":28,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"INAIL (National Institute for Industrial Accidents and Workers\u2019 Compensation) Research","award":["BRIC 2022 ID 52"],"award-info":[{"award-number":["BRIC 2022 ID 52"]}]},{"name":"University of Rome Tor Vergata","award":["E83C25000500005"],"award-info":[{"award-number":["E83C25000500005"]}]},{"award":["E83C25000500005"],"award-info":[{"award-number":["E83C25000500005"]}],"id":[{"id":"https:\/\/ror.org\/02p77k626","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Erythrocyte glutathione transferase (e-GST) and oxidized human serum albumin (HSAox) were used as biomarkers to assess the environmental health of a foundry and a ceramics factory located in the Umbria region (Italy). While HSAox level indicates that no relevant oxidative stress is present in workers of either company, a distinct overexpression of e-GST, also present in non-workers residents, suggests exposure to broad environmental stressors that may be attributed to common sources. A more careful analysis of different job sectors and the effect of filtering facepieces indicates that the workers exposed to solvents show the highest e-GST expression, while different pollutants (possibly dust and\/or metal fumes) seem to be present in other areas of the foundry as well as in external areas. In the ceramic company, the high e-GST activity reveals the presence of other contaminants which can be efficiently blocked by filtering facepieces and gloves together. Intriguingly, a cohort of monks (n = 14) residing in a monastery adjacent to the foundry exhibited e-GST activities significantly lower than those observed in non-worker residents, suggesting that specific lifestyle or localized environmental factors may influence exposure levels, a finding that warrants further targeted research.<\/jats:p>","DOI":"10.3390\/antiox15060741","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T05:56:31Z","timestamp":1781675791000},"page":"741","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glutathione Transferase as a Potential First-Tier Biomarker of Environmental Pollution in Workers and Residents of Umbria Region, Italy"],"prefix":"10.3390","volume":"15","author":[{"given":"Sara","family":"Notari","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences and Technologies, University of Rome \u2018Tor Vergata\u2019, Via della Ricerca Scientifica 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6148-0333","authenticated-orcid":false,"given":"Fiorella","family":"Faienza","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences and Technologies, University of Rome \u2018Tor Vergata\u2019, Via della Ricerca Scientifica 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8973-6046","authenticated-orcid":false,"given":"Giovanna","family":"Tranfo","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, Epidemiology, Occupational and Environmental Hygiene, INAIL Research, Via Fontana Candida 1, Monte Porzio Catone, 00078 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3756-4163","authenticated-orcid":false,"given":"Anna Maria","family":"Caccuri","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences and Technologies, University of Rome \u2018Tor Vergata\u2019, Via della Ricerca Scientifica 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences and Technologies, University of Rome \u2018Tor Vergata\u2019, Via della Ricerca Scientifica 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Gambardella","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences and Technologies, University of Rome \u2018Tor Vergata\u2019, Via della Ricerca Scientifica 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"109786","DOI":"10.1016\/j.abb.2023.109786","article-title":"Erythrocyte glutathione transferase. 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