{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T18:37:19Z","timestamp":1786387039672,"version":"build-2736575974"},"reference-count":67,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The valorization of agri-food by-products generated during juice extraction represents a key strategy within circular economy frameworks, as it reduces the environmental impact of waste disposal while creating added value and improving the food supply chain. In this work, five betaine-based natural deep eutectic solvents (NaDES) differing in their hydrogen-bond donors, namely citric acid, lactic acid, acetic acid, glycerol, and ethylene glycol, were used for the green extraction of blueberry pomace, a largely underutilized by-product that is nevertheless rich in bioactive compounds. The extracts were characterized by liquid chromatography coupled with diode-array and tandem mass spectrometric detection, allowing targeted profiling of anthocyanins and non-anthocyanin phenolics, including phenolic acids, flavonoids, and phenolic aldehydes. The extraction performance of NaDES was benchmarked against conventional solvents (water and ethanol) to evaluate differences in selectivity and efficiency toward distinct phenolic classes. Antioxidant capacity was determined using DPPH and ABTS radical scavenging assays. Among the NaDES systems, the betaine\u2013citric acid NaDES extract exhibited notable phenolic recovery together with marked radical scavenging activity. After evaluating its inhibitory activity against elastase and tyrosinase, enzymes involved in the skin aging process, the selected NaDES extract was incorporated into a natural-based antiaging cosmetic formulation, and its main physicochemical properties were assessed to verify suitability for topical application. This study demonstrated that the use of NaDES represents an environmentally friendly and sustainable approach to transform blueberry by-products into high-value, safe, and ready-to-use cosmetic functional ingredients without the need for solvent removal.<\/jats:p>","DOI":"10.3390\/antiox15060744","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:22:56Z","timestamp":1781684576000},"page":"744","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Green Extraction of Phenolic Compounds from Blueberry (Vaccinium corymbosum L.) By-Products Using Natural Deep Eutectic Solvents for Cosmetic Applications"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5686-7993","authenticated-orcid":false,"given":"Yassine","family":"Jaouhari","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze del Farmaco, Universit\u00e0 Degli Studi del Piemonte Orientale \u201cA. Avogadro\u201d, Largo Donegani 2, 28100 Novara, Italy"},{"name":"nutractiva S.r.l., Largo Donegani 2, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9950-813X","authenticated-orcid":false,"given":"Giuseppe","family":"Morreale","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco, Universit\u00e0 Degli Studi del Piemonte Orientale \u201cA. Avogadro\u201d, Largo Donegani 2, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6422-341X","authenticated-orcid":false,"given":"Lorella","family":"Giovannelli","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco, Universit\u00e0 Degli Studi del Piemonte Orientale \u201cA. Avogadro\u201d, Largo Donegani 2, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0241-0620","authenticated-orcid":false,"given":"Elia","family":"Bari","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco, Universit\u00e0 Degli Studi del Piemonte Orientale \u201cA. Avogadro\u201d, Largo Donegani 2, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8256-2968","authenticated-orcid":false,"given":"H\u00e9lder","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9318-9732","authenticated-orcid":false,"given":"Nuno","family":"Mateus","sequence":"additional","affiliation":[{"name":"Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2853-0949","authenticated-orcid":false,"given":"Alessandro","family":"Candiani","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco, Universit\u00e0 Degli Studi del Piemonte Orientale \u201cA. Avogadro\u201d, Largo Donegani 2, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Gull\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Science, University of Vigo (Campus Ourense), As Lagoas, 32004 Ourense, Spain"},{"name":"IAA\u2014Instituto de Agroecolox\u00eda e Alimentaci\u00f3n, University of Vigo (Campus Auga), As Lagoas, 32004 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6587-9843","authenticated-orcid":false,"given":"Matteo","family":"Bordiga","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco, Universit\u00e0 Degli Studi del Piemonte Orientale \u201cA. Avogadro\u201d, Largo Donegani 2, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5456-0711","authenticated-orcid":false,"given":"Jean Daniel","family":"Co\u00efsson","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco, Universit\u00e0 Degli Studi del Piemonte Orientale \u201cA. Avogadro\u201d, Largo Donegani 2, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9427-4605","authenticated-orcid":false,"given":"Pedro","family":"Ferreira-Santos","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Science, University of Vigo (Campus Ourense), As Lagoas, 32004 Ourense, Spain"},{"name":"IAA\u2014Instituto de Agroecolox\u00eda e Alimentaci\u00f3n, University of Vigo (Campus Auga), As Lagoas, 32004 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"ref_1","unstructured":"(2023, April 04). SDGs. Available online: https:\/\/sdgs.un.org\/goals."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Jaouhari, Y., Travaglia, F., Giovannelli, L., Picco, A., Oz, E., Oz, F., and Bordiga, M. (2023). From Industrial Food Waste to Bioactive Ingredients: A Review on the Sustainable Management and Transformation of Plant-Derived Food Waste. Foods, 12.","DOI":"10.3390\/foods12112183"},{"key":"ref_3","first-page":"1","article-title":"Comparative Study of Red Berry Pomaces (Blueberry, Red Raspberry, Red Currant and Blackberry) as Source of Antioxidants and Pigments","volume":"245","author":"Santisteban","year":"2019","journal-title":"Eur. Food Res. Technol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1111\/ijfs.13112","article-title":"Berry Pomace\u2014A Review of Processing and Chemical Analysis of Its Polyphenols","volume":"51","author":"Struck","year":"2016","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"119729","DOI":"10.1016\/j.indcrop.2024.119729","article-title":"Isolation of Valuable Substances from Berry Seeds and Pomace by the Green High-Pressure Methods, Their Evaluation and Application in Cosmetic Creams","volume":"222","author":"Venskutonis","year":"2024","journal-title":"Ind. Crops Prod."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Popovi\u0107, T., \u0160ari\u0107, B., Marta\u010di\u0107, J.D., Arsi\u0107, A., Jovanov, P., Stoki\u0107, E., Mi\u0161an, A., and Mandi\u0107, A. (2022). Potential Health Benefits of Blueberry and Raspberry Pomace as Functional Food Ingredients: Dietetic Intervention Study on Healthy Women Volunteers. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.969996"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/jtxs.12374","article-title":"Fiber Concentrates from Raspberry and Blueberry Pomace in Gluten-Free Cookie Formulation: Effect on Dough Rheology and Cookie Baking Properties","volume":"50","year":"2019","journal-title":"J. Texture Stud."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/jocd.13093","article-title":"Polyphenols as Natural Antioxidants in Cosmetics Applications","volume":"19","year":"2020","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Liberti, D., Alfieri, M.L., Monti, D.M., Panzella, L., and Napolitano, A. (2020). A Melanin-Related Phenolic Polymer with Potent Photoprotective and Antioxidant Activities for Dermo-Cosmetic Applications. Antioxidants, 9.","DOI":"10.3390\/antiox9040270"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00011-022-01598-8","article-title":"Photoaging: UV Radiation-Induced Inflammation and Immunosuppression Accelerate the Aging Process in the Skin","volume":"71","author":"Salminen","year":"2022","journal-title":"Inflamm. Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Chaiprasongsuk, A., and Panich, U. (2022). Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.823881"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/php.12938","article-title":"Ribes nigrum L. Prevents UVB-Mediated Photoaging in Human Dermal Fibroblasts: Potential Antioxidant and Antiinflammatory Activity","volume":"94","author":"Li","year":"2018","journal-title":"Photochem. Photobiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6815","DOI":"10.1039\/C9FO00706G","article-title":"Anthocyanins from Black Peanut Skin Protect against UV-B Induced Keratinocyte Cell and Skin Oxidative Damage through Activating Nrf 2 Signaling","volume":"10","author":"Li","year":"2019","journal-title":"Food Funct."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Hering, A., Stefanowicz-Hajduk, J., Gucwa, M., Wielgomas, B., and Ochocka, J.R. (2023). Photoprotection and Antiaging Activity of Extracts from Honeybush (Cyclopia sp.)\u2014In Vitro Wound Healing and Inhibition of the Skin Extracellular Matrix Enzymes: Tyrosinase, Collagenase, Elastase and Hyaluronidase. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15051542"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.fitote.2015.01.005","article-title":"Inhibitory Effects of Polyphenols from Grape Pomace Extract on Collagenase and Elastase Activity","volume":"101","author":"Wittenauer","year":"2015","journal-title":"Fitoterapia"},{"key":"ref_16","first-page":"e01585","article-title":"A Review of Modern and Conventional Extraction Techniques and Their Applications for Extracting Phytochemicals from Plants","volume":"19","author":"Bitwell","year":"2023","journal-title":"Sci. Afr."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kumar, A., P, N., Kumar, M., Jose, A., Tomer, V., Oz, E., Proestos, C., Zeng, M., Elobeid, T., and K, S. (2023). Major Phytochemicals: Recent Advances in Health Benefits and Extraction Method. Molecules, 28.","DOI":"10.3390\/molecules28020887"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.trac.2017.03.006","article-title":"Extraction with Environmentally Friendly Solvents","volume":"91","author":"Rutkowska","year":"2017","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Cannavacciuolo, C., Pagliari, S., Frigerio, J., Giustra, C.M., Labra, M., and Campone, L. (2023). Natural Deep Eutectic Solvents (NADESs) Combined with Sustainable Extraction Techniques: A Review of the Green Chemistry Approach in Food Analysis. Foods, 12.","DOI":"10.3390\/foods12010056"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6660","DOI":"10.1111\/ijfs.16641","article-title":"Natural Deep Eutectic Solvents (NaDES) as an Emerging Technology for the Valorisation of Natural Products and Agro-Food Residues: A Review","volume":"58","year":"2023","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Villa, C., Caviglia, D., Robustelli della Cuna, F.S., Zuccari, G., and Russo, E. (2024). NaDES Application in Cosmetic and Pharmaceutical Fields: An Overview. Gels, 10.","DOI":"10.3390\/gels10020107"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Allahyari, A., Borji, M., Jahanban-Esfahlan, A., Khanalipour, A., Tabibiazar, M., and Ahmadi, P. (2025). Current Status and Future Perspectives of Betaine and Betaine-Based Natural Deep Eutectic Solvents: A Review. Foods, 14.","DOI":"10.3390\/foods14234122"},{"key":"ref_23","unstructured":"European Union (2009). Regulation (EC) No 1223\/2009 of the European Parliament and of the Council of 30 November 2009 on Cosmetic Products (Recast) (Text with EEA Relevance), Publications Office of the European Union."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Ouyang, L., Liang, W., Bian, C., Shan, Y., and Wang, S. (2025). Ultrasound-Assisted Green Natural Deep Eutectic Solvent Extraction of Flavonoids from Wild Blueberry: Process Optimization, Composition Identification, and Antioxidant Activity. Foods, 14.","DOI":"10.3390\/foods14193325"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"111220","DOI":"10.1016\/j.lwt.2021.111220","article-title":"Natural Deep Eutectic Solvent Enhanced Pulse-Ultrasonication Assisted Extraction as a Multi-Stability Protective and Efficient Green Strategy to Extract Anthocyanin from Blueberry Pomace","volume":"144","author":"Fu","year":"2021","journal-title":"LWT"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"115642","DOI":"10.1016\/j.lwt.2023.115642","article-title":"Microwave-Assisted Extraction (MAE) of Bioactive Compounds from Blueberry by-Products Using a Sugar-Based NADES: A Novelty in Green Chemistry","volume":"192","author":"Alchera","year":"2024","journal-title":"LWT"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Mart\u00ednez, B., Ferreira-Santos, P., Alfonso, I.M., Mart\u00ednez, S., Genisheva, Z., and Gull\u00f3n, B. (2022). Deep Eutectic Solvents as a Green Tool for the Extraction of Bioactive Phenolic Compounds from Avocado Peels. Molecules, 27.","DOI":"10.3390\/molecules27196646"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"115313","DOI":"10.1016\/j.indcrop.2022.115313","article-title":"Manufacturing of Hemicellulosic Oligosaccharides from Fast-Growing Paulownia Wood via Autohydrolysis: Microwave versus Conventional Heating","volume":"187","author":"Garrote","year":"2022","journal-title":"Ind. Crops Prod."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"6762","DOI":"10.1039\/D2FO00335J","article-title":"Sambucus Nigra Flower and Berry Extracts for Food and Therapeutic Applications: Effect of Gastrointestinal Digestion on in Vitro and in Vivo Bioactivity and Toxicity","volume":"13","author":"Nogueira","year":"2022","journal-title":"Food Funct."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"101004","DOI":"10.1016\/j.foohum.2026.101004","article-title":"In-Depth Study of the Chemical Composition and Volatile Profile of Oils Extracted from Blueberry and Raspberry Pomace","volume":"6","author":"Jaouhari","year":"2026","journal-title":"Food Humanit."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.indcrop.2017.05.034","article-title":"Antioxidant and Antimicrobial Activities of Extracts Obtained from the Refining of Autohydrolysis Liquors of Vine Shoots","volume":"107","author":"Eibes","year":"2017","journal-title":"Ind. Crops Prod."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Bari, E., Perteghella, S., Rassu, G., Gavini, E., Petretto, G.L., Bonferoni, M.C., Giunchedi, P., and Torre, M.L. (2023). Sericin\/Crocetin Micro\/Nanoparticles for Nucleus Pulposus Cells Regeneration: An \u201cActive\u201d Drug Delivery System. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1129882"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Picco, A., Segale, L., Miletto, I., Pollastro, F., Aprile, S., Locatelli, M., Bari, E., Torre, M.L., and Giovannelli, L. (2023). Spray-Dried Powder Containing Cannabigerol: A New Extemporaneous Emulgel for Topical Administration. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15122747"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.foodchem.2016.02.094","article-title":"Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds and Anthocyanins from Blueberry (Vaccinium ashei) Wine Pomace","volume":"204","author":"He","year":"2016","journal-title":"Food Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1111\/1750-3841.16315","article-title":"A Dark Purple Multifunctional Ingredient from Blueberry Pomace Enhanced with Lactic Acid Bacteria for Various Applications","volume":"87","author":"Dermengiu","year":"2022","journal-title":"J. Food Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1007\/s11947-012-0997-0","article-title":"The Influence of Selected Osmotic Dehydration and Pretreatment Parameters on Dry Matter and Polyphenol Content in Highbush Blueberry (Vaccinium corymbosum L.) Fruits","volume":"6","author":"Kucner","year":"2013","journal-title":"Food Bioprocess Technol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1541-4337.2011.00164.x","article-title":"Blueberries and Their Anthocyanins: Factors Affecting Biosynthesis and Properties","volume":"10","author":"Routray","year":"2011","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"127958","DOI":"10.1016\/j.foodchem.2020.127958","article-title":"Phenolics Profiling by HPLC-DAD-ESI-MSn Aided by Principal Component Analysis to Classify Rabbiteye and Highbush Blueberries","volume":"340","year":"2021","journal-title":"Food Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jff.2016.07.026","article-title":"Antimicrobial Activity and Differentiation of Anthocyanin Profiles of Rabbiteye and Highbush Blueberries Using HPLC\u2013DAD\u2013ESI-MSn and Multivariate Analysis","volume":"26","author":"Pertuzatti","year":"2016","journal-title":"J. Funct. Foods"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"102512","DOI":"10.1016\/j.ifset.2020.102512","article-title":"Highly Efficient Extraction of Mulberry Anthocyanins in Deep Eutectic Solvents: Insights of Degradation Kinetics and Stability Evaluation","volume":"66","author":"Bi","year":"2020","journal-title":"Innov. Food Sci. Emerg. Technol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.fbp.2016.12.005","article-title":"Natural Deep Eutectic Solvents and Ultrasound-Assisted Extraction: Green Approaches for Extraction of Wine Lees Anthocyanins","volume":"102","author":"Bosiljkov","year":"2017","journal-title":"Food Bioprod. Process."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"113184","DOI":"10.1016\/j.lwt.2022.113184","article-title":"Greener Extraction of Anthocyanins and Antioxidant Activity from Blackberry (Rubus Spp) Using Natural Deep Eutectic Solvents","volume":"158","author":"Zannou","year":"2022","journal-title":"LWT"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"134816","DOI":"10.1016\/j.foodchem.2022.134816","article-title":"Natural Deep Eutectic Solvents Combined with Cyclodextrins: A Novel Strategy for Chokeberry Anthocyanins Extraction","volume":"405","author":"Radan","year":"2023","journal-title":"Food Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s43014-023-00150-3","article-title":"Effects of Four Drying Methods on the Quality, Antioxidant Activity and Anthocyanin Components of Blueberry Pomace","volume":"5","author":"Zhang","year":"2023","journal-title":"Food Prod. Process. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"100476","DOI":"10.1016\/j.fochx.2022.100476","article-title":"Recovering High Value-Added Anthocyanins from Blueberry Pomace with Ultrasound-Assisted Extraction","volume":"16","author":"Zhang","year":"2022","journal-title":"Food Chem. X"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"116573","DOI":"10.1016\/j.lwt.2024.116573","article-title":"Carbohydrases Treatment on Blueberry Pomace: Influence on Chemical Composition and Bioactive Potential","volume":"206","author":"Jaouhari","year":"2024","journal-title":"LWT"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jfca.2017.03.006","article-title":"Polyphenols, Anthocyanins, and Flavonoids Contents and the Antioxidant Capacity of Various Cultivars of Highbush and Half-High Blueberries","volume":"62","author":"Li","year":"2017","journal-title":"J. Food Compos. Anal."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Lon\u010dari\u0107, A., Celeiro, M., Jozinovi\u0107, A., Jelini\u0107, J., Kova\u010d, T., Joki\u0107, S., Babi\u0107, J., Moslavac, T., Zavadlav, S., and Lores, M. (2020). Green Extraction Methods for Extraction of Polyphenolic Compounds from Blueberry Pomace. Foods, 9.","DOI":"10.3390\/foods9111521"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"138778","DOI":"10.1016\/j.foodchem.2024.138778","article-title":"A New UHPLC-HRMS Metabolomics Approach for the Rapid and Comprehensive Analysis of Phenolic Compounds in Blueberry, Raspberry, Blackberry, Cranberry and Cherry Fruits","volume":"445","author":"Kodikara","year":"2024","journal-title":"Food Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"130743","DOI":"10.1016\/j.foodchem.2021.130743","article-title":"A New HPLC-MS\/MS Method for the Simultaneous Determination of 36 Polyphenols in Blueberry, Strawberry and Their Commercial Products and Determination of Antioxidant Activity","volume":"367","author":"Mustafa","year":"2022","journal-title":"Food Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"462315","DOI":"10.1016\/j.chroma.2021.462315","article-title":"Targeted and Semi-Untargeted Determination of Phenolic Compounds in Plant Matrices by High Performance Liquid Chromatography-Tandem Mass Spectrometry","volume":"1651","author":"Oliva","year":"2021","journal-title":"J. Chromatogr. A"},{"key":"ref_52","unstructured":"Watson, R.R., Preedy, V.R., and Zibadi, S. (2018). Chapter 34\u2014Galangin as a Plant Phenolic and Usage in Health and Disease. Polyphenols: Prevention and Treatment of Human Disease, Academic Press. [2nd ed.]."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.foodchem.2005.12.036","article-title":"Determination of Red Wine Flavonoids by HPLC and Effect of Aging","volume":"101","author":"Fang","year":"2007","journal-title":"Food Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00217-013-2020-z","article-title":"Changes of Flavonol Synthase and Flavonol Contents during Grape Berry Development","volume":"237","author":"Fang","year":"2013","journal-title":"Eur. Food Res. Technol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"110482","DOI":"10.1016\/j.cbi.2023.110482","article-title":"Galangin as an Inflammatory Response Modulator: An Updated Overview and Therapeutic Potential","volume":"378","author":"Thapa","year":"2023","journal-title":"Chem.-Biol. Interact."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"103897","DOI":"10.1016\/j.mex.2026.103897","article-title":"Measuring Antioxidant Capacity Directly in Emulsions: A New Paper-Based FRAP Assay and Comparison with Its DPPH Counterpart","volume":"16","author":"Tsotsou","year":"2026","journal-title":"MethodsX"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Bamba, B.S.B., Shi, J., Tranchant, C.C., Xue, S.J., Forney, C.F., and Lim, L.-T. (2018). Influence of Extraction Conditions on Ultrasound-Assisted Recovery of Bioactive Phenolics from Blueberry Pomace and Their Antioxidant Activity. Molecules, 23.","DOI":"10.3390\/molecules23071685"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.3390\/ijms10094066","article-title":"Mechanisms Regulating Skin Pigmentation: The Rise and Fall of Complexion Coloration","volume":"10","author":"Ebanks","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Vinardell, M.P., Maddaleno, A.S., and Mitjans, M. (2024). Harmonizing In Vitro Techniques for Anti-Aging Cosmetic Ingredient Assessment: A Comprehensive Review. Cosmetics, 11.","DOI":"10.3390\/cosmetics11050170"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Lee, A.-Y. (2021). Skin Pigmentation Abnormalities and Their Possible Relationship with Skin Aging. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073727"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1467-2494.2004.00241.x","article-title":"Ultraviolet Radiation and Skin Aging: Roles of Reactive Oxygen Species, Inflammation and Protease Activation, and Strategies for Prevention of Inflammation-Induced Matrix Degradation\u2014A Review","volume":"27","author":"Pillai","year":"2005","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1002\/jctb.5459","article-title":"Polyphenols Extracted from Red Grape Pomace by a Surfactant Based Method Show Enhanced Collagenase and Elastase Inhibitory Activity","volume":"93","author":"Michael","year":"2018","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Martinovi\u0107, M., Ne\u0161i\u0107, I., \u017dugi\u0107, A., and Tadi\u0107, V.M. (2025). Preliminary Analysis of Bilberry NaDES Extracts as Versatile Active Ingredients of Natural Dermocosmetic Products: In Vitro Evaluation of Anti-Tyrosinase, Anti-Hyaluronidase, Anti-Collagenase, and UV Protective Properties. Plants, 14.","DOI":"10.3390\/plants14152374"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Kulawik-Pi\u00f3ro, A., and Miastkowska, M. (2021). Polymeric Gels and Their Application in the Treatment of Psoriasis Vulgaris: A Review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22105124"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Li, Q., Li, S., Wang, Z., Yang, S., Xie, Y., Yang, D., Zhang, L., and Lu, Y. (2024). New Co-Crystals of Betaine: Significant Improvements in Hygroscopicity. Crystals, 14.","DOI":"10.3390\/cryst14110917"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Chen, A., An, Y., Huang, W., Xuan, T., Zhang, Q., Ye, M., Luo, S., Xuan, X., He, H., and Zheng, J. (2020). Highly Water-Preserving Zwitterionic Betaine-Incorporated Collagen Sponges With Anti-Oxidation and Anti-Inflammation for Wound Regeneration. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.00491"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"109510","DOI":"10.1016\/j.foodhyd.2023.109510","article-title":"Vanillin-Assisted Preparation of Chitosan-Betaine Stabilized Corn Starch Gel: Gel Properties and Microstructure Characteristics","volume":"148","author":"Liu","year":"2024","journal-title":"Food Hydrocoll."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/6\/744\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T09:06:58Z","timestamp":1781687218000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/6\/744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":67,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["antiox15060744"],"URL":"https:\/\/doi.org\/10.3390\/antiox15060744","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,11]]}}}