{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:02:11Z","timestamp":1792000931635,"version":"4.4.0"},"reference-count":50,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad Bernardo O\u2019Higgins","award":["UBO\/VRIP 1803-ID12009"],"award-info":[{"award-number":["UBO\/VRIP 1803-ID12009"]}]},{"name":"Universidad Bernardo O\u2019Higgins","award":["UBO\/VVCMEI-T3"],"award-info":[{"award-number":["UBO\/VVCMEI-T3"]}]},{"award":["UBO\/VRIP 1803-ID12009"],"award-info":[{"award-number":["UBO\/VRIP 1803-ID12009"]}],"id":[{"id":"https:\/\/ror.org\/00x0xhn70","id-type":"ROR","asserted-by":"publisher"}]},{"award":["UBO\/VVCMEI-T3"],"award-info":[{"award-number":["UBO\/VVCMEI-T3"]}],"id":[{"id":"https:\/\/ror.org\/00x0xhn70","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Background:\u00a0Buddleja globosa Hope (matico) is a Chilean medicinal plant traditionally used in Mapuche and Aymara ethnomedicine. However, no systematic synthesis of its phytochemical composition and pharmacological evidence has been previously reported. Methods: A PRISMA 2020-compliant systematic review was conducted using Google Scholar, PubMed, EBSCOhost, and Springer Nature databases from inception to March 2026. Studies reporting phytochemical characterization and\/or biological activities of B. globosa were included. Methodological quality was assessed using an adapted five-criterion tool for non-clinical studies. The protocol was registered in OSF. Results: Fourteen studies (1989\u20132026), mainly from Chilean research groups, identified 27 bioactive compounds across leaves, roots, and flowers. These included phenylethanoid glycosides (e.g., verbascoside\/acteoside, echinacoside, forsitoside B, and linarin), flavonoids (luteolin 7-O-glucoside, apigenin 7-O-glucoside, myricetin, catechin, and epicatechin), pentacyclic triterpenes (\u03b1\/\u03b2-amyrins and \u03b2-sitosterol), iridoid glycosides, and clerodane diterpenoids (buddledines A\u2013C), as well as four newly reported phenylethanoids. Antioxidant activity was the most frequently evaluated endpoint (11\/14 studies), mainly mediated through hydrogen atom transfer and single-electron transfer mechanisms linked to caffeoyl and flavonoid structures. Anti-inflammatory effects (five studies) involved COX and 5-LOX inhibition and reduced PGE2 production in LPS-stimulated macrophages. Additional reported activities included antihepatotoxic, antiplatelet, wound-healing, antibacterial, and antifungal effects. Conclusions:B. globosa exhibits a coherent phytochemical profile supporting strong preclinical antioxidant and anti-inflammatory activities. The main limitation for clinical translation is the low oral bioavailability of phenylethanoid glycosides. Nanoformulation strategies, investigation of colonic metabolites, and topical delivery systems represent promising approaches to bridge the preclinical-to-clinical gap.<\/jats:p>","DOI":"10.3390\/antiox15070790","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:52:11Z","timestamp":1782453131000},"page":"790","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antioxidant and Anti-Inflammatory Properties of Buddleja globosa Hope (Matico): A Systematic Review of Phytochemical Composition, Molecular Mechanisms, and Translational Evidence"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8182-6135","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Becerra","sequence":"first","affiliation":[{"name":"Escuela de Fonoaudiolog\u00eda & Departamento de Ciencias Qu\u00edmicas y Biol\u00f3gicas, Facultad de Ciencias de la Salud, Universidad Bernardo O\u2019Higgins, Santiago 8370854, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4058-8504","authenticated-orcid":false,"given":"Felipe","family":"Soto","sequence":"additional","affiliation":[{"name":"Escuela de Fonoaudiolog\u00eda & Departamento de Ciencias Qu\u00edmicas y Biol\u00f3gicas, Facultad de Ciencias de la Salud, Universidad Bernardo O\u2019Higgins, Santiago 8370854, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4264-7967","authenticated-orcid":false,"given":"Daniela","family":"Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Escuela de Nutrici\u00f3n y Diet\u00e9tica & Centro Integrativo de Biolog\u00eda y Qu\u00edmica Aplicada (CIBQA), Facultad de Ciencias de la Salud, Universidad Bernardo O\u2019Higgins, Santiago 8370854, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"Valenzuela-Fuenzalida","sequence":"additional","affiliation":[{"name":"Departamento de Morfolog\u00eda, Facultad de Medicina, Universidad Andr\u00e9s Bello, Santiago 8370146, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria P.","family":"Moya","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Santiago 7500912, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8130-6460","authenticated-orcid":false,"given":"Jos\u00e9 E.","family":"Le\u00f3n-Rojas","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n Bienestar, Salud y Sociedad, Escuela de Psicolog\u00eda y Educaci\u00f3n, Universidad de Las Am\u00e9ricas, Quito 170124, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel E.","family":"Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Investigaci\u00f3n, Vicerrector\u00eda Acad\u00e9mica, Universidad Bernardo O\u2019Higgins, Santiago 8370854, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"M\u00e1th\u00e9, \u00c1. 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