{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:12:58Z","timestamp":1785413578496,"version":"3.56.0"},"reference-count":92,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004442","name":"National Science Centre NCN Poland","doi-asserted-by":"publisher","award":["2020\/39\/D\/NZ9\/02023"],"award-info":[{"award-number":["2020\/39\/D\/NZ9\/02023"]}],"id":[{"id":"10.13039\/501100004442","id-type":"DOI","asserted-by":"publisher"}]},{"award":["2020\/39\/D\/NZ9\/02023"],"award-info":[{"award-number":["2020\/39\/D\/NZ9\/02023"]}],"id":[{"id":"https:\/\/ror.org\/03ha2q922","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012190","name":"Minister of Science of the Republic of Poland","doi-asserted-by":"publisher","award":["RID\/SP\/0010\/2024\/1"],"award-info":[{"award-number":["RID\/SP\/0010\/2024\/1"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Methoxyflavones, along with chalcones and phenolic acids, belong to natural polyphenols. Apart from their antioxidant function, in plants, they act as pigments and are a part of plant chemical defense system. A member of this group is pedalitin, which expresses a range of interesting biological properties. The compound acts as an anticancer agent, strengthens the immune system, improves insulin sensitivity, protects internal organs, and also shows anti-inflammatory and neuroprotective activity. Due to the constant need for alternative therapies for treatment and prevention of lifestyle diseases, O-methylated flavonoids, including pedalitin, may serve as natural lead molecules in designing new structures with significant pharmacological potential. This review summarizes the literature reports on obtaining pedalitin and assessing its biological activity, also in the context of further functionalization of this compound and potential new applications.<\/jats:p>","DOI":"10.3390\/antiox15070792","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:52:11Z","timestamp":1782453131000},"page":"792","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pedalitin as an Interesting Phytocompound with a High Potential for Further Functionalization and Application in the Prevention and Treatment of Lifestyle Diseases\u2014The First Narrative Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5618-8899","authenticated-orcid":false,"given":"Monika","family":"Stompor-Gor\u0105cy","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Medicine, Collegium Medicum, University of Rzesz\u00f3w, Rejtana 16C, 35-959 Rzesz\u00f3w, Poland"},{"name":"Department of Pathophysiology, Faculty of Medicine, Collegium Medicum, University of Rzesz\u00f3w, Rejtana 16C, 35-959 Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Ostatek","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Rzesz\u00f3w University of Technology, 35-959 Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2525-8051","authenticated-orcid":false,"given":"Agata","family":"Bajek-Bil","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Rzesz\u00f3w University of Technology, 35-959 Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2564-6820","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Kus-Li\u015bkiewicz","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology, Collegium Medicum, University of Rzeszow, Pigonia 1, 35-310 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Gala-B\u0142\u0105dzi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Endocrinology, Faculty of Medicine, University of Rzesz\u00f3w, al. Tadeusza Rejtana 16C, 35-959 Rzesz\u00f3w, Poland"},{"name":"Clinic of Nephrology and Dialysis Unit, Fryderyk Chopin University Clinical Hospital, ul. Fryderyka Szopena 2, 35-055 Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7711-4127","authenticated-orcid":false,"given":"Maciej","family":"Machaczka","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Faculty of Medicine, Collegium Medicum, University of Rzesz\u00f3w, Rejtana 16C, 35-959 Rzesz\u00f3w, Poland"},{"name":"Department of Clinical Science and Education, Division of Internal Medicine, Karolinska Institutet S\u00f6dersjukhuset, 11883 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Stompor, M., and \u017barowska, B. (2016). 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