{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:47:29Z","timestamp":1782539249314,"version":"3.54.5"},"reference-count":71,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Social Development Project of Jiangsu Province","award":["BE2023757"],"award-info":[{"award-number":["BE2023757"]}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"crossref","award":["BK20231251"],"award-info":[{"award-number":["BK20231251"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"crossref"}]},{"name":"sixth phase 333 s level talent training project of Jiangsu Province","award":["BRA2022008"],"award-info":[{"award-number":["BRA2022008"]}]},{"name":"Scientific Research Project of Jiangsu Provincial Health Commission","award":["K2024069"],"award-info":[{"award-number":["K2024069"]}]},{"name":"Traditional Chinese Medicine Science and Technology Development Plan Project of Jiangsu Province","award":["MS2024142"],"award-info":[{"award-number":["MS2024142"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Metabolic and cardiometabolic diseases are closely associated with mitochondrial dysfunction and redox imbalance. Ubiquinol\u2013cytochrome c reductase core protein 2 (UQCRC2), a non-catalytic structural core subunit of mitochondrial respiratory chain Complex III, is increasingly recognized as a regulator of Complex III integrity, electron transfer, oxidative phosphorylation, and mitochondrial redox homeostasis. Under metabolic stress, reduced expression or functional impairment of UQCRC2 may promote electron leakage, mitochondrial reactive oxygen species (mtROS) generation, lipid peroxidation, impaired antioxidant defense, and disrupted glucose\u2013lipid metabolism. These alterations may contribute to insulin resistance (IR), metabolic dysfunction-associated steatotic liver disease (MASLD), obesity, and cardiovascular disease (CVD). This review summarizes current evidence linking UQCRC2 dysfunction to mitochondrial bioenergetic failure, oxidative stress, inflammatory signaling, and cardiometabolic injury. We further discuss redox-regulatory pathways, including Nrf2, AMPK\u2013SIRT1\u2013PGC-1\u03b1, glutathione metabolism, and mitophagy, as well as pharmacological agents and natural compounds that may modulate UQCRC2-related mitochondrial responses. Collectively, these findings highlight UQCRC2 as a redox-sensitive mitochondrial node linking Complex III dysfunction to cardiometabolic injury and targeted redox-based interventions.<\/jats:p>","DOI":"10.3390\/antiox15070794","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:52:11Z","timestamp":1782453131000},"page":"794","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial UQCRC2 as a Redox-Regulatory Node in Metabolic and Cardiometabolic Diseases"],"prefix":"10.3390","volume":"15","author":[{"given":"Shiyi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China"},{"name":"Institute of Endocrine and Metabolic Diseases, Jiangsu University, Zhenjiang 212001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China"},{"name":"Institute of Endocrine and Metabolic Diseases, Jiangsu University, Zhenjiang 212001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6495-122X","authenticated-orcid":false,"given":"Wen","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China"},{"name":"Institute of Endocrine and Metabolic Diseases, Jiangsu University, Zhenjiang 212001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingru","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China"},{"name":"Institute of Endocrine and Metabolic Diseases, Jiangsu University, Zhenjiang 212001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyue","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China"},{"name":"Institute of Endocrine and Metabolic Diseases, Jiangsu University, Zhenjiang 212001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1871-5015","authenticated-orcid":false,"given":"Jue","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China"},{"name":"Institute of Endocrine and Metabolic Diseases, Jiangsu University, Zhenjiang 212001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cmet.2023.02.003","article-title":"The global burden of metabolic disease: Data from 2000 to 2019","volume":"35","author":"Chew","year":"2023","journal-title":"Cell Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/dom.14322","article-title":"Nonalcoholic fatty liver disease as a metabolic disease in humans: A literature review","volume":"23","author":"Cariou","year":"2021","journal-title":"Diabetes Obes. 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