{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:33:15Z","timestamp":1787027595735,"version":"build-2736575974"},"reference-count":88,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015377","name":"Shanghai Key Laboratory of Molecular Imaging","doi-asserted-by":"crossref","award":["18DZ2260400"],"award-info":[{"award-number":["18DZ2260400"]}],"id":[{"id":"10.13039\/501100015377","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Ulomoides dermestoides (Yangchong) is a tenebrionid beetle used in traditional medicine across Asia and Latin America. While crude extracts show effects on inflammation, oxidative stress, and other conditions, systematic integration of its bioactive substances, mechanisms, and translational potential is lacking. This review consolidates its chemical basis, comprising volatile benzoquinones, terpenes, and alkenes, alongside non-volatile fatty acids, proteins (antioxidant enzymes, glycoproteins), and phenolics. Pharmacological evidence indicates multi-target modulation of reactive oxygen species (ROS), cytokines, leukocyte recruitment, endothelial activation, and thromboinflammation. Recent advances include proteomic identification of antioxidant protein complexes, neuroprotection in a Parkinson\u2019s disease model, chromosome-level genome assembly, and isolation of the UDP-glucose pyrophosphorylase 2a (UGP2A) glycoprotein, which alleviates thrombosis partly via toll-like receptor 4\/myeloid differentiation primary response 88 (TLR4\/MyD88)-mediated endothelial anti-inflammatory effects. However, most evidence remains preclinical, relying on non-standardized crude extracts, and benzoquinone-containing fractions display potential cytotoxicity and genotoxicity. Future research should integrate bioassay-guided isolation, structural characterization, multi-omics, pharmacokinetic\/pharmacodynamic (PK\/PD) analysis, standardized quality markers, and rigorous safety evaluation to transform U. dermestoides from an empirical insect-derived medicinal resource into a scientifically validated source of preclinical antioxidant and anti-inflammatory candidate substances.<\/jats:p>","DOI":"10.3390\/antiox15070849","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:56:42Z","timestamp":1783349802000},"page":"849","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ulomoides dermestoides as an Insect Pharmacological Resource of Antioxidant and Anti-Inflammatory Bioactive Substances: Chemical Basis, Mechanisms of Action, Pharmacological Evidence, and Translational Challenges"],"prefix":"10.3390","volume":"15","author":[{"given":"Tianzi","family":"Wang","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China"},{"name":"Digital and Intelligent Empowerment Biomedical Innovation Center, School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenling","family":"Shi","sequence":"additional","affiliation":[{"name":"Digital and Intelligent Empowerment Biomedical Innovation Center, School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyue","family":"Song","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China"},{"name":"Digital and Intelligent Empowerment Biomedical Innovation Center, School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglei","family":"Huang","sequence":"additional","affiliation":[{"name":"Digital and Intelligent Empowerment Biomedical Innovation Center, School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youqing","family":"Cheng","sequence":"additional","affiliation":[{"name":"Digital and Intelligent Empowerment Biomedical Innovation Center, School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3975-1018","authenticated-orcid":false,"given":"Xiaofan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China"},{"name":"Digital and Intelligent Empowerment Biomedical Innovation Center, School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6288-3046","authenticated-orcid":false,"given":"Wei","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China"},{"name":"Digital and Intelligent Empowerment Biomedical Innovation Center, School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China"},{"name":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7457-4154","authenticated-orcid":false,"given":"Guoqing","family":"Wan","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China"},{"name":"Digital and Intelligent Empowerment Biomedical Innovation Center, School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China"},{"name":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: Advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. 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