{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:10:44Z","timestamp":1785172244735,"version":"3.55.0"},"reference-count":76,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Blueberry pomace is a polyphenol-rich by-product of fruit processing. A face-centered central composite design (FCCCD) optimized hydroethanolic extraction across time (20\u201360 min), temperature (20\u201360 \u00b0C) and ethanol (20\u201380%), evaluating total phenolic content (TPC), yield and selectivity. The selected condition (40 min, 60 \u00b0C, 50% ethanol) reached 20.0 mg GAE\/g dry biomass, a yield of 27% and a selectivity of 75.2 mg GAE\/g dry extract. Peleg\u2019s model adequately described the kinetics at 20 and 60 \u00b0C; pseudo-equilibrium was reached within 5 min, with equilibrium concentration rising from 9.9 to 20.8 mg GAE\/g DW, and initial rate tripling. Based on the kinetic analysis (t99 \u2248 2.5 min), 5 min was adopted as the operational reference for phytochemical characterization; extracts were characterized by FRAP, DPPH, total anthocyanin content (TAC), and HPLC-DAD anthocyanin profiling. Increasing the temperature from 20 to 60 \u00b0C raised FRAP 3.4-fold and TAC 1.9-fold while reducing DPPH by 14%, decoupling bulk phenolic recovery from antioxidant capacity. HPLC-DAD identified five glycosylated anthocyanins, with petunidin-3-glucoside as the dominant constituent. Antimicrobial screening confirmed activity against Staphylococcus aureus. These results provide foundational process and compositional data to guide GRAS-compatible valorization of Chilean blueberry pomace and caution against bulk phenolic indicators as the sole quality criteria.<\/jats:p>","DOI":"10.3390\/antiox15070883","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:32:17Z","timestamp":1784266337000},"page":"883","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential Temperature Effects on Phenolic Recovery and Antioxidant Capacity During the Hydroethanolic Extraction of Chilean Blueberry Pomace"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8125-6671","authenticated-orcid":false,"given":"Franco","family":"Espinoza-Cartagena","sequence":"first","affiliation":[{"name":"Center for Systems Biotechnology (CSB), Universidad Andr\u00e9s Bello, Fern\u00e1ndez Concha 700, Santiago 7591538, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Ben\u00edtez-Fajardo","sequence":"additional","affiliation":[{"name":"Department of Chemical and Environmental Engineering, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Av. Vicu\u00f1a Mackenna 3939, Santiago 8940897, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7179-490X","authenticated-orcid":false,"given":"Sebasti\u00e1n","family":"Ormaz\u00e1bal-Latorre","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica y Bioprocesos, Escuela de Ingenier\u00eda, Pontificia Universidad Cat\u00f3lica de Chile, Avenida Vicu\u00f1a Mackenna 4860, Santiago 7820436, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8479-0932","authenticated-orcid":false,"given":"Laura M.","family":"Cuellar","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica y Bioprocesos, Escuela de Ingenier\u00eda, Pontificia Universidad Cat\u00f3lica de Chile, Avenida Vicu\u00f1a Mackenna 4860, Santiago 7820436, Chile"},{"name":"Centro Interdisciplinario de Investigaci\u00f3n Biom\u00e9dica e Ingenier\u00eda para la Salud (MEDING), Universidad de Valpara\u00edso, General Cruz 222, Valpara\u00edso 2340003, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7244-4227","authenticated-orcid":false,"given":"Camilo","family":"S\u00e1nchez-Baeza","sequence":"additional","affiliation":[{"name":"Center for Systems Biotechnology (CSB), Universidad Andr\u00e9s Bello, Fern\u00e1ndez Concha 700, Santiago 7591538, Chile"},{"name":"Doctorado en Biotecnolog\u00eda, Facultad de Ciencias de la Vida, Universidad Andr\u00e9s Bello, Avenida Rep\u00fablica 440, Santiago 8370186, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0678-6879","authenticated-orcid":false,"given":"Gonzalo A.","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Chemical and Environmental Engineering, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Av. Vicu\u00f1a Mackenna 3939, Santiago 8940897, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8908-6227","authenticated-orcid":false,"given":"Andr\u00e9s F.","family":"Arroyo-Avirama","sequence":"additional","affiliation":[{"name":"Escuela de Ingenier\u00eda Bioqu\u00edmica, Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Av. Brasil 2085, Valpara\u00edso 2340025, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"ref_1","unstructured":"Food and Agriculture Organization of the United Nations (FAO) (2026, June 06). Crops and Livestock Products\u2014Global Blueberry Production. Available online: https:\/\/www.fao.org\/faostat\/."},{"key":"ref_2","unstructured":"Comit\u00e9 de Ar\u00e1ndanos de Chile\u2014ASOEX (2024). 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