{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:42:24Z","timestamp":1785404544044,"version":"3.56.0"},"reference-count":56,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scripps Korea Antibody Institute","award":["SKAI-23PS11"],"award-info":[{"award-number":["SKAI-23PS11"]}]},{"award":["SKAI-23PS11"],"award-info":[{"award-number":["SKAI-23PS11"]}],"id":[{"id":"https:\/\/ror.org\/007f41232","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Ministry of Health & Welfare, Republic of Koreae","award":["RS-2025-24535069"],"award-info":[{"award-number":["RS-2025-24535069"]}]},{"award":["RS-2025-24535069"],"award-info":[{"award-number":["RS-2025-24535069"]}],"id":[{"id":"https:\/\/ror.org\/00vxgjw72","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Pectolinarigenin (PEC), a naturally occurring flavonoid, exhibits anti-inflammatory and antioxidant activities in various experimental models. However, its protective effects against lipopolysaccharide (LPS)-induced lung inflammation and the underlying molecular mechanisms remain unclear. This study investigated the protective effects of PEC using LPS-treated MLE12 cells and RAW264.7 macrophages, as well as a prophylactic mouse model in which PEC was administered before LPS exposure. In LPS-treated MLE12 cells and RAW264.7 macrophages, PEC reduced inflammatory responses and cellular injury, accompanied by decreased reactive oxygen species production and modulation of the histone deacetylase 3 (HDAC3)\/nuclear factor \u03baB (NF-\u03baB)\/NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) signaling. Consistent with these findings, PEC pretreatment attenuated pulmonary edema, inflammatory cell infiltration, pro-inflammatory cytokine production, oxidative stress, pyroptosis-associated signaling, and histopathological lung injury in LPS-exposed mice. These protective effects were accompanied by reduced HDAC3 expression and nuclear localization, together with reduced NF-kB\/NLRP3 signaling in lung tissues. Overall, PEC attenuated LPS-induced lung inflammation and injury, accompanied by reduced oxidative stress and modulation of HDAC3\/NF-\u03baB\/NLRP3 signaling. These findings support the potential of PEC as a preventive agent against excessive pulmonary inflammation.<\/jats:p>","DOI":"10.3390\/antiox15070898","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:00:17Z","timestamp":1784548817000},"page":"898","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pectolinarigenin Attenuates LPS-Induced Lung Inflammation and Injury with Reduced HDAC3\/NF-\u03baB\/NLRP3 Signaling"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3149-5045","authenticated-orcid":false,"given":"Danbee","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Research Program, Scripps Korea Antibody Institute, Chuncheon 24341, Gangwon-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Keon","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Research Program, Scripps Korea Antibody Institute, Chuncheon 24341, Gangwon-do, Republic of Korea"},{"name":"Department of Biochemistry, School of Medicine, Wonkwang University, Iksan-Daero 460, Iksan-Si 54538, Jeonbuk-Do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5254-4665","authenticated-orcid":false,"given":"Jeong-Ran","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Research Program, Scripps Korea Antibody Institute, Chuncheon 24341, Gangwon-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"21804","DOI":"10.1038\/s41598-023-49165-3","article-title":"Exploration of the role of oxidative stress-related genes in LPS-induced acute lung injury via bioinformatics and experimental studies","volume":"13","author":"Liu","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Wang, F., Ge, R., Cai, Y., Zhao, M., Fang, Z., Li, J., Xie, C., Wang, M., Li, W., and Wang, X. (2025). Oxidative stress in ARDS: Mechanisms and therapeutic potential. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1603287"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1186\/s12967-025-06994-2","article-title":"Acute lung injury: Pathogenesis and treatment","volume":"23","author":"Liu","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"116773","DOI":"10.1016\/j.biopha.2024.116773","article-title":"Exploring immune-related pathogenesis in lung injury: Providing new insights Into ALI\/ARDS","volume":"175","author":"Zheng","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s42003-025-08010-1","article-title":"Targeting alveolar epithelial cells with lipid micelle-encapsulated necroptosis inhibitors to alleviate acute lung injury","volume":"8","author":"Kang","year":"2025","journal-title":"Commun. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Sanches Santos Rizzo Zuttion, M., Moore, S.K.L., Chen, P., Beppu, A.K., and Hook, J.L. (2022). New Insights into the Alveolar Epithelium as a Driver of Acute Respiratory Distress Syndrome. Biomolecules, 12.","DOI":"10.3390\/biom12091273"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1007\/s00011-022-01645-4","article-title":"The role of lung macrophages in acute respiratory distress syndrome","volume":"71","author":"Dang","year":"2022","journal-title":"Inflamm. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10753-022-01726-w","article-title":"The Role of Macrophages and Alveolar Epithelial Cells in the Development of ARDS","volume":"46","author":"Tao","year":"2023","journal-title":"Inflammation"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41423-025-01284-9","article-title":"Updated insights into the molecular networks for NLRP3 inflammasome activation","volume":"22","author":"Paik","year":"2025","journal-title":"Cell Mol. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s13105-022-00909-1","article-title":"Pyroptosis in inflammation-related respiratory disease","volume":"78","author":"Feng","year":"2022","journal-title":"J. Physiol. Biochem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5974","DOI":"10.4049\/jimmunol.1400368","article-title":"Critical role for the NLRP3 inflammasome during acute lung injury","volume":"192","author":"Grailer","year":"2014","journal-title":"J. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"112628","DOI":"10.1016\/j.biopha.2022.112628","article-title":"The dynamic interplay between AMPK\/NFkappaB signaling and NLRP3 is a new therapeutic target in inflammation: Emerging role of dapagliflozin in overcoming lipopolysaccharide-mediated lung injury","volume":"147","author":"Saber","year":"2022","journal-title":"BioMed. Pharmacother."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Chen, X., He, Y., Fu, W., Sahebkar, A., Tan, Y., Xu, S., and Li, H. (2020). Histone Deacetylases (HDACs) and Atherosclerosis: A Mechanistic and Pharmacological Review. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.581015"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"107158","DOI":"10.1016\/j.isci.2023.107158","article-title":"HDAC3 promotes macrophage pyroptosis via regulating histone deacetylation in acute lung injury","volume":"26","author":"Li","year":"2023","journal-title":"iScience"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Al-Khayri, J.M., Sahana, G.R., Nagella, P., Joseph, B.V., Alessa, F.M., and Al-Mssallem, M.Q. (2022). Flavonoids as Potential Anti-Inflammatory Molecules: A Review. Molecules, 27.","DOI":"10.3390\/molecules27092901"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ullah, A., Munir, S., Badshah, S.L., Khan, N., Ghani, L., Poulson, B.G., Emwas, A.H., and Jaremko, M. (2020). Important Flavonoids and Their Role as a Therapeutic Agent. Molecules, 25.","DOI":"10.3390\/molecules25225243"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1248\/bpb.31.2063","article-title":"Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum","volume":"31","author":"Lim","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"112538","DOI":"10.1016\/j.fct.2021.112538","article-title":"Neuroprotective and anti-inflammatory effect of pectolinarigenin, a flavonoid from Amazonian Aegiphila integrifolia (Jacq.), against lipopolysaccharide-induced inflammation in astrocytes via NFkappaB and MAPK pathways","volume":"157","author":"Heimfarth","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3724\/abbs.2024161","article-title":"Phillyrin prevents sepsis-induced acute lung injury through inhibiting the NLRP3\/caspase-1\/GSDMD-dependent pyroptosis signaling pathway","volume":"57","author":"Ji","year":"2024","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e832","DOI":"10.1002\/iid3.832","article-title":"Citrulline inhibits LPS-induced pyroptosis of RAW264.7 macrophages through NF-kappaB signaling pathway","volume":"11","author":"Yin","year":"2023","journal-title":"Immun. Inflamm. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lee, M., Ham, H., Lee, J., Lee, E.S., Chung, C.H., Kong, D.H., Park, J.R., and Lee, D.K. (2024). TGF-beta-Induced PAUF Plays a Pivotal Role in the Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cell Line Panc-1. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252111420"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s42826-025-00245-7","article-title":"Fludarabine attenuates inflammation and dysregulated autophagy in alveolar macrophages via inhibition of STAT1\/IRF1 pathway","volume":"41","author":"Lee","year":"2025","journal-title":"Lab. Anim. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"117361","DOI":"10.1016\/j.jep.2023.117361","article-title":"Bletilla striata polysaccharides protect against ARDS by modulating the NLRP3\/caspase1\/GSDMD and HMGB1\/TLR4 signaling pathways to improve pulmonary alveolar macrophage pyroptosis","volume":"319","author":"Wu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"154726","DOI":"10.1016\/j.phymed.2023.154726","article-title":"Pectolinarigenin ameliorates acetaminophen-induced acute liver injury via attenuating oxidative stress and inflammatory response in Nrf2 and PPARa dependent manners","volume":"113","author":"Li","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"115089","DOI":"10.1016\/j.bmc.2019.115089","article-title":"Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo","volume":"27","author":"Gan","year":"2019","journal-title":"Bioorg. Med. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Ren, Q., Wang, B., Guo, F., Huang, R., Tan, Z., Ma, L., and Fu, P. (2021). Natural Flavonoid Pectolinarigenin Alleviated Hyperuricemic Nephropathy via Suppressing TGFbeta\/SMAD3 and JAK2\/STAT3 Signaling Pathways. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.792139"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Kim, D., Go, S.H., Song, Y., Lee, D.K., and Park, J.R. (2024). Decursin Induces G1 Cell Cycle Arrest and Apoptosis through Reactive Oxygen Species-Mediated Endoplasmic Reticulum Stress in Human Colorectal Cancer Cells in In Vitro and Xenograft Models. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25189939"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","article-title":"An official American Thoracic Society workshop report: Features and measurements of experimental acute lung injury in animals","volume":"44","author":"Downey","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/978-1-0716-1001-5_15","article-title":"Cellular and Biochemical Analysis of Bronchoalveolar Lavage Fluid from Murine Lungs","volume":"2223","author":"Kalidhindi","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1016\/S0002-9440(10)63588-2","article-title":"Regulatory effects of iNOS on acute lung inflammatory responses in mice","volume":"163","author":"Speyer","year":"2003","journal-title":"Am. J. Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1186\/s12951-024-03015-0","article-title":"ROS-responsive nanoparticles for bioimaging and treating acute lung injury by releasing dexamethasone and improving alveolar macrophage homeostasis","volume":"22","author":"Fan","year":"2024","journal-title":"J. Nanobiotechnology"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Liu, Q.H., Zhang, K., Feng, S.S., Zhang, L.J., Li, S.Y., Wang, H.Y., and Wang, J.H. (2024). Rosavin Alleviates LPS-Induced Acute Lung Injure by Modulating the TLR-4\/NF-kappaB\/MAPK Singnaling Pathways. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25031875"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Cheriet, T., Ben-Bachir, B., Thamri, O., Seghiri, R., and Mancini, I. (2020). Isolation and Biological Properties of the Natural Flavonoids Pectolinarin and Pectolinarigenin-A Review. Antibiotics, 9.","DOI":"10.3390\/antibiotics9070417"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41586-020-2576-2","article-title":"Dichotomous engagement of HDAC3 activity governs inflammatory responses","volume":"584","author":"Nguyen","year":"2020","journal-title":"Nature"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Yu, H., Liu, S., Wang, S., and Gu, X. (2024). The involvement of HDAC3 in the pathogenesis of lung injury and pulmonary fibrosis. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1392145"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"tkae033","DOI":"10.1093\/burnst\/tkae033","article-title":"BRD3308 suppresses macrophage oxidative stress and pyroptosis via upregulating acetylation of H3K27 in sepsis-induced acute lung injury","volume":"12","author":"Liu","year":"2024","journal-title":"Burn. Trauma"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/s41420-023-01508-9","article-title":"Pectolinarigenin inhibits bladder urothelial carcinoma cell proliferation by regulating DNA damage\/autophagy pathways","volume":"9","author":"Deng","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1007\/s10753-022-01710-4","article-title":"Pectolinarigenin Suppresses LPS-Induced Inflammatory Response in Macrophages and Attenuates DSS-Induced Colitis by Modulating the NF-kappaB\/Nrf2 Signaling Pathway","volume":"45","author":"Feng","year":"2022","journal-title":"Inflammation"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"112741","DOI":"10.1016\/j.intimp.2024.112741","article-title":"Pectolinarigenin targeting FGFR3 alleviates osteoarthritis progression by regulating the NF-kappaB\/NLRP3 inflammasome pyroptotic pathway","volume":"140","author":"Jiang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1042\/CS20210879","article-title":"Pathogenesis of pneumonia and acute lung injury","volume":"136","author":"Long","year":"2022","journal-title":"Clin. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"10245","DOI":"10.1038\/s41598-022-14618-8","article-title":"Lipopolysaccharide-induced murine lung injury results in long-term pulmonary changes and downregulation of angiogenic pathways","volume":"12","author":"Tsikis","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Wang, G., Huang, X., Li, Y., Guo, K., Ning, P., and Zhang, Y. (2013). PARP-1 inhibitor, DPQ, attenuates LPS-induced acute lung injury through inhibiting NF-kappaB-mediated inflammatory response. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079757"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1017\/jns.2016.41","article-title":"Flavonoids: An overview","volume":"5","author":"Panche","year":"2016","journal-title":"J. Nutr. Sci."},{"key":"ref_44","first-page":"331","article-title":"Anti-inflammatory activities of flavonoid derivates","volume":"11","author":"Ysrafil","year":"2023","journal-title":"ADMET DMPK"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Shiraiwa, M., Kitakaze, T., Yamashita, Y., Ukawa, Y., Mukai, K., and Ashida, H. (2022). Pectolinarigenin Induces Antioxidant Enzymes through Nrf2\/ARE Pathway in HepG2 Cells. Antioxidants, 11.","DOI":"10.3390\/antiox11040675"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e8092","DOI":"10.1590\/1414-431x20198092","article-title":"Epigallocatechin-3-gallate ameliorates lipopolysaccharide-induced acute lung injury by suppression of TLR4\/NF-kappaB signaling activation","volume":"52","author":"Wang","year":"2019","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Millar, M.W., Fazal, F., and Rahman, A. (2022). Therapeutic Targeting of NF-kappaB in Acute Lung Injury: A Double-Edged Sword. Cells, 11.","DOI":"10.3390\/cells11203317"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Kelley, N., Jeltema, D., Duan, Y., and He, Y. (2019). The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133328"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"105886","DOI":"10.1016\/j.intimp.2019.105886","article-title":"Suppression of NLRP3 and NF-kappaB signaling pathways by alpha-Cyperone via activating SIRT1 contributes to attenuation of LPS-induced acute lung injury in mice","volume":"76","author":"Liu","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3892\/ijmm.2017.2935","article-title":"Silybin attenuates LPS-induced lung injury in mice by inhibiting NF-kappaB signaling and NLRP3 activation","volume":"39","author":"Zhang","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1186\/s40001-024-02169-9","article-title":"SS31 alleviates LPS-induced acute lung injury by inhibiting inflammatory responses through the S100A8\/NLRP3\/GSDMD signaling pathway","volume":"29","author":"Luo","year":"2024","journal-title":"Eur. J. Med. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"115954","DOI":"10.1016\/j.bmc.2020.115954","article-title":"MCC950, a NLRP3 inhibitor, ameliorates lipopolysaccharide-induced lung inflammation in mice","volume":"30","author":"Wang","year":"2021","journal-title":"Bioorg Med. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"E2865\u201374","DOI":"10.1073\/pnas.1121131109","article-title":"Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages","volume":"109","author":"Chen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cbpa.2016.06.019","article-title":"Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-kappaB-mediated inflammation","volume":"33","author":"Leus","year":"2016","journal-title":"Curr. Opin. Chem. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41420-023-01399-w","article-title":"The role of HDAC3 and its inhibitors in regulation of oxidative stress and chronic diseases","volume":"9","author":"He","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.bcp.2016.03.010","article-title":"HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-kappaB p65 transcriptional activity","volume":"108","author":"Leus","year":"2016","journal-title":"Biochem. Pharmacol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/7\/898\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:22:41Z","timestamp":1784550161000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/7\/898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,20]]},"references-count":56,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["antiox15070898"],"URL":"https:\/\/doi.org\/10.3390\/antiox15070898","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,20]]}}}