{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:58:29Z","timestamp":1785232709445,"version":"3.55.0"},"reference-count":52,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Introduction. Oxidative stress plays a critical role in the pathogenesis of idiopathic pulmonary fibrosis (IPF), yet its prognostic significance remains unclear. This study investigated the association between plasma sulfhydryl (SH) group concentrations and thiobarbituric acid reactive substances (TBARS), systemic markers of oxidative stress, and mortality in patients with IPF. Materials and methods. Eighty-eight patients with newly diagnosed IPF were recruited between 2016 and 2023 for the purposes of the study. Plasma SH and TBARS were measured at baseline under standardized conditions and normalized to plasma protein content. Survival analyses were performed using Kaplan\u2013Meier curves and Cox regression models, adjusting for lung function parameters and IPF stage. Results. Patients with lower SH concentrations had significantly higher mortality (log-rank p = 0.012). SH group concentrations, but not TBARS, were independently and negatively associated with survival in multivariate models adjusting for %TLC, %FVC, %DLCO, and IPF stage (HR: 0.606, 95% CI: 0.443\u20130.830, p = 0.0018). Conclusions. Low plasma SH concentrations, reflecting systemic redox imbalance, are independently associated with increased mortality in newly diagnosed IPF. SH quantification represents a promising prognostic biomarker in IPF.<\/jats:p>","DOI":"10.3390\/antiox15080923","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:11:56Z","timestamp":1785168716000},"page":"923","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma SH Concentrations and Mortality in Patients with Newly Diagnosed Idiopathic Pulmonary Fibrosis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5485-6056","authenticated-orcid":false,"given":"Panagiotis","family":"Paliogiannis","sequence":"first","affiliation":[{"name":"Department of Medicine, Surgery and Pharmacy, University of Sassari, Viale San Pietro 43, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Zoroddu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Fois","sequence":"additional","affiliation":[{"name":"Unit of Pulmonology and Respiratory Diseases, University Hospital (AOU) of Sassari, Viale San Pietro 43, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Scala","sequence":"additional","affiliation":[{"name":"Unit of Pulmonology and Respiratory Diseases, University Hospital (AOU) of Sassari, Viale San Pietro 43, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Zinellu","sequence":"additional","affiliation":[{"name":"Unit of Pulmonology and Respiratory Diseases, University Hospital (AOU) of Sassari, Viale San Pietro 43, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8699-1412","authenticated-orcid":false,"given":"Arduino A.","family":"Mangoni","sequence":"additional","affiliation":[{"name":"Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Sturt Road, Bedford Park, Adelaide, SA 5042, Australia"},{"name":"Department of Clinical Pharmacology, Flinders Medical Centre, Southern Adelaide Local Health Network, Flinders Drive, Bedford Park, Adelaide, SA 5042, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6985-4907","authenticated-orcid":false,"given":"Ciriaco","family":"Carru","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1457-8025","authenticated-orcid":false,"given":"Pietro","family":"Pirina","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Pharmacy, University of Sassari, Viale San Pietro 43, 07100 Sassari, Italy"},{"name":"Unit of Pulmonology and Respiratory Diseases, University Hospital (AOU) of Sassari, Viale San Pietro 43, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8396-0968","authenticated-orcid":false,"given":"Angelo","family":"Zinellu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5330-572X","authenticated-orcid":false,"given":"Alessandro G.","family":"Fois","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Pharmacy, University of Sassari, Viale San Pietro 43, 07100 Sassari, Italy"},{"name":"Unit of Pulmonology and Respiratory Diseases, University Hospital (AOU) of Sassari, Viale San Pietro 43, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1136\/thorax-2024-221581","article-title":"Epidemiology of idiopathic pulmonary fibrosis: Opportunities and hurdles for population-level studies of rare disease","volume":"79","author":"Marinescu","year":"2024","journal-title":"Thorax"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Zinellu, A., Paliogiannis, P., and Mangoni, A.A. 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