{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:10:56Z","timestamp":1785172256774,"version":"3.55.0"},"reference-count":50,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008990","name":"Zhejiang Province Key R&D Program","doi-asserted-by":"publisher","award":["2026C02A1021"],"award-info":[{"award-number":["2026C02A1021"]}],"id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008990","name":"Zhejiang Province Key R&D Program","doi-asserted-by":"publisher","award":["2024C02004"],"award-info":[{"award-number":["2024C02004"]}],"id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National R&D Program of China","doi-asserted-by":"publisher","award":["2022YFD1300504"],"award-info":[{"award-number":["2022YFD1300504"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Ulcerative colitis (UC) is a chronic inflammatory disease characterized by persistent colonic inflammation, excessive oxidative stress, and impaired barrier function. Transition metal-based nanoparticles offer promising antioxidant platforms to address oxidative stress-related pathologies. To overcome the poor gastrointestinal stability of the potent dietary antioxidant epigallocatechin gallate (EGCG), we utilized zinc-coordinated EGCG (EGCG-Zn) nanoparticles (NPs), which function as a transition metal\u2013phenolic network, to achieve sustained colonic release and overcome the poor gastrointestinal stability of free EGCG. The therapeutic efficacy and underlying mechanisms were evaluated in dextran sulfate sodium (DSS)-induced colitis in mice. Oral administration of EGCG-Zn NPs effectively reduced oxidative stress, suppressed pro-inflammatory cytokine production, alleviated colitis symptoms, and repaired the intestinal mucus and mechanical barriers. Mechanistically, transcriptomic analysis revealed that EGCG-Zn NPs pretreatment markedly reversed DSS-induced transcriptional alterations. Integrated K-means clustering and KEGG enrichment analyses further demonstrated that these protective effects were mediated by down-regulating inflammation-associated genes and up-regulating tight junction proteins, primarily involving the modulation of calcium signaling, T-cell differentiation, and the PI3K-Akt, Wnt, NF-\u03baB, and TNF pathways. Collectively, these findings suggest that EGCG-Zn NPs alleviate DSS-induced colitis by mitigating inflammation, suppressing oxidative stress, and promoting epithelial barrier repair, supporting their potential as a functional nutraceutical for UC management.<\/jats:p>","DOI":"10.3390\/antiox15080924","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:11:56Z","timestamp":1785168716000},"page":"924","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcriptomic Analysis Reveals the Antioxidant and Anti-Inflammatory Mechanisms of EGCG-Zn Nanoparticles in Dextran Sulfate Sodium-Induced Colitis in Mice"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5763-1173","authenticated-orcid":false,"given":"Tingting","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Animal Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"},{"name":"Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Animal Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"},{"name":"Key Laboratory of Animal Molecular Nutrition, Ministry of Education, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Animal Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"},{"name":"Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5091-6429","authenticated-orcid":false,"given":"Feifei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Animal Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"},{"name":"Key Laboratory of Animal Molecular Nutrition, Ministry of Education, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2690-429X","authenticated-orcid":false,"given":"Jie","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Animal Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"},{"name":"Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Hangzhou 310058, China"},{"name":"Key Laboratory of Animal Molecular Nutrition, Ministry of Education, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s43556-025-00395-z","article-title":"Inflammatory Bowel Diseases: Pathological Mechanisms and Therapeutic Perspectives","volume":"7","author":"Yang","year":"2026","journal-title":"Mol. 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