{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:02:44Z","timestamp":1791147764509,"version":"4.1.0"},"reference-count":239,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Coronary artery bypass grafting (CABG) remains one of the most effective treatments for advanced coronary artery disease; however, substantial variability persists in both perioperative and long-term outcomes despite advances in surgical technique, myocardial protection, and risk stratification. Oxidative stress is a central mediator of tissue injury during cardiac surgery, contributing to ischemia\u2013reperfusion injury, endothelial dysfunction, systemic inflammation, and postoperative organ complications. At the same time, chronic exposure to ambient air pollution has emerged as an important environmental determinant of cardiovascular disease through mechanisms that converge on many of the same redox-sensitive pathways. We propose the concept of environmental oxidative priming, whereby long-term exposure to particulate matter, nitrogen oxides, ozone, and other pollutants establishes a persistent state of endothelial dysfunction, mitochondrial impairment, chronic inflammation, nitric oxide depletion, and reduced antioxidant reserve before surgery. Within this framework, CABG represents a second oxidative challenge superimposed on a pre-existing environmentally conditioned phenotype. We discuss the mechanistic overlap between air pollution-induced cardiovascular injury and cardiac surgical stress and examine how this interaction may contribute to postoperative complications, graft adaptation, major adverse cardiovascular events, and long-term survival. Recognition of air pollution as a modifier of biological resilience provides a novel framework for understanding outcome heterogeneity after CABG and may support future precision-based risk stratification and preventive strategies.<\/jats:p>","DOI":"10.3390\/antiox15080930","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:11:56Z","timestamp":1785168716000},"page":"930","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["From Exposure to Outcome: Air Pollution-Induced Oxidative Stress as a Determinant of Early and Late Outcomes After Coronary Artery Bypass Grafting"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8080-2764","authenticated-orcid":false,"given":"Tomasz","family":"Urbanowicz","sequence":"first","affiliation":[{"name":"Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6563-0877","authenticated-orcid":false,"given":"Krzysztof J.","family":"Filipiak","sequence":"additional","affiliation":[{"name":"The Center of Postgraduate Medical Education, 99\/103 Marymoncka Street, 01-813 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"ref_1","first-page":"e45511","article-title":"Recent Advances in Coronary Artery Bypass Grafting Techniques and Outcomes: A Narrative Review","volume":"15","author":"Thakare","year":"2023","journal-title":"Cureus"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1161\/CIRCULATIONAHA.124.068312","article-title":"Coronary Artery Bypass Grafting: Past and Future","volume":"150","author":"Ruel","year":"2024","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.5090\/jcs.24.122","article-title":"The Past, Present, and Future of Off-Pump Coronary Artery Bypass Grafting","volume":"58","author":"Yoo","year":"2025","journal-title":"J. Chest Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"eRW1353","DOI":"10.31744\/einstein_journal\/2025RW1353","article-title":"Perioperative management of adult patients undergoing coronary artery bypass grafting and valve surgery: A literature review","volume":"23","author":"Vasconcelos","year":"2025","journal-title":"Einstein"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s11886-024-02090-x","article-title":"The Current State of Coronary Revascularization: Coronary Artery Bypass Graft Surgery Versus Percutaneous Coronary Interventions","volume":"26","author":"Krittanawong","year":"2024","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_6","first-page":"100636","article-title":"Long-term Incidence of Myocardial Infarction and Death After CABG and PCI for Isolated Left Anterior Descending Artery Disease: A Meta-analysis of Randomized Controlled Trials","volume":"2","author":"Prasad","year":"2023","journal-title":"J. Soc. Cardiovasc. Angiogr. Interv."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1097\/SLA.0000000000003908","article-title":"Single Versus Multiple Arterial Revascularization in Patients with Reduced Renal Function: Long-term Outcome Comparisons in 23,406 CABG Patients From Ontario, Canada","volume":"275","author":"Hayatsu","year":"2022","journal-title":"Ann. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/ejcts\/ezs043","article-title":"EuroSCORE II","volume":"41","author":"Nashef","year":"2012","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1113\/EP092900","article-title":"EuroSCORE II: Current limitations and physiological gaps in risk stratification","volume":"111","author":"Ng","year":"2026","journal-title":"Exp. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"411","DOI":"10.25122\/jml-2025-0018","article-title":"Air pollution and cardiovascular diseases: Mechanisms, evidence, and mitigation strategies","volume":"18","author":"Krismanuel","year":"2025","journal-title":"J. Med. Life"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Kumar, V.S.H., Huligowda, L.K.D., Umesh, M., Chakraborty, P., Thazeem, B., and Singh, A.P. (2025). Environmental Pollutants as Emerging Concerns for Cardiac Diseases: A Review on Their Impacts on Cardiac Health. Biomedicines, 13.","DOI":"10.3390\/biomedicines13010241"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12989-020-00391-x","article-title":"The critical role of endothelial function in fine particulate matter-induced atherosclerosis","volume":"17","author":"Liang","year":"2020","journal-title":"Part Fibre Toxicol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"H1836","DOI":"10.1152\/ajpheart.00881.2020","article-title":"Fine particulate matter (PM2.5) inhalation-induced alterations in the plasma lipidome as promoters of vascular inflammation and insulin resistance","volume":"320","author":"Hill","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11869-010-0101-8","article-title":"Particulate air pollution, systemic oxidative stress, inflammation, and atherosclerosis","volume":"4","author":"Araujo","year":"2010","journal-title":"Air Qual. Atmos. Health"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1001\/jamasurg.2024.2906","article-title":"Intraoperative Oxygen Treatment, Oxidative Stress, and Organ Injury Following Cardiac Surgery: A Randomized Clinical Trial","volume":"159","author":"Lopez","year":"2024","journal-title":"JAMA Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"158","DOI":"10.2174\/1872213X13666190724112644","article-title":"Inflammatory Response and Endothelial Dysfunction Following Cardiopulmonary Bypass: Pathophysiology and Pharmacological Targets","volume":"13","author":"Giacinto","year":"2019","journal-title":"Recent Pat. Inflamm. Allergy Drug Discov."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Urbanowicz, T., Skotak, K., Olasi\u0144ska-Wi\u015bniewska, A., Filipiak, K.J., P\u0142achta-Krasi\u0144ska, A., Piecek, J., Krasi\u0144ska, B., Krasi\u0144ski, Z., Tykarski, A., and Jemielity, M. (2024). The Possible Role of PM2.5 Chronic Exposure on 5-Year Survival in Patients with Left Ventricular Dysfunction Following Coronary Artery Bypass Grafting. Toxics, 12.","DOI":"10.3390\/toxics12100697"},{"key":"ref_18","first-page":"e96384","article-title":"Redox Imbalance in Coronary Artery Bypass Grafting: The Clinical Significance of Aminothiols","volume":"17","author":"Sidik","year":"2025","journal-title":"Cureus"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Skeffington, K.L., Moscarelli, M., Abdul-Ghani, S., Fiorentino, F., Emanueli, C., Reeves, B.C., Punjabi, P.P., Angelini, G.D., and Suleiman, M.S. (2022). Pathology-related changes in cardiac energy metabolites, inflammatory response and reperfusion injury following cardioplegic arrest in patients undergoing open-heart surgery. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.911557"},{"key":"ref_20","first-page":"ivaf221","article-title":"Prospective observational study comparing systemic inflammatory responses across different perfusion systems during isolated on-pump Coronary Artery Bypass Grafting","volume":"40","year":"2025","journal-title":"Interdiscip. Cardiovasc. Thorac. Surg."},{"key":"ref_21","first-page":"417","article-title":"Oxidative stress in coronary artery bypass surgery","volume":"30","author":"Dias","year":"2015","journal-title":"Rev. Bras. Cir. Cardiovasc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1017\/S0265021507003043","article-title":"Endocrine stress response and inflammatory activation during CABG surgery. A randomized trial comparing remifentanil infusion to intermittent fentanyl","volume":"25","author":"Winterhalter","year":"2008","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10571-025-01553-1","article-title":"Circulating Biomarkers to Predict Post-Operative Cognitive Decline in Patients Undergoing Coronary Artery Bypass Grafting","volume":"45","author":"Miceli","year":"2025","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Hatami, S., Hefler, J., and Freed, D.H. (2022). Inflammation and Oxidative Stress in the Context of Extracorporeal Cardiac and Pulmonary Support. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.831930"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00441-017-2785-7","article-title":"Neutrophils in tissue injury and repair","volume":"371","author":"Wang","year":"2018","journal-title":"Cell Tissue Res."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Janakiram, N.B., Valerio, M.S., Goldman, S.M., and Dearth, C.L. (2021). The Role of the Inflammatory Response in Mediating Functional Recovery Following Composite Tissue Injuries. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222413552"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6614009","DOI":"10.1155\/2021\/6614009","article-title":"Role of Oxidative Stress in Reperfusion following Myocardial Ischemia and Its Treatments","volume":"2021","author":"Xiang","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Dhalla, N.S., Ostadal, P., and Tappia, P.S. (2025). Involvement of Oxidative Stress and Antioxidants in Modification of Cardiac Dysfunction due to Ischemia-Reperfusion Injury. Antioxidants, 14.","DOI":"10.20944\/preprints202501.1136.v1"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"104944","DOI":"10.1016\/j.yexmp.2024.104944","article-title":"Pathobiology of myocardial and cardiomyocyte injury in ischemic heart disease: Perspective from seventy years of cell injury research","volume":"140","author":"Buja","year":"2024","journal-title":"Exp. Mol. Pathol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Han, D.Y., Ahn, H.S., and Park, H.J. (2026). Myocardial Ischemia-Reperfusion Injury-Mechanistic Insights and Novel Therapeutics. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27052106"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/MOT.0000000000001015","article-title":"Mitochondria and ischemia reperfusion injury","volume":"27","author":"Panconesi","year":"2022","journal-title":"Curr. Opin. Organ. Transplant."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"101974","DOI":"10.1016\/j.mito.2024.101974","article-title":"Fighting ischemia-reperfusion injury: Focusing on mitochondria-derived ferroptosis","volume":"79","author":"Tian","year":"2024","journal-title":"Mitochondrion"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.freeradbiomed.2021.01.036","article-title":"Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia\/reperfusion injury","volume":"165","author":"Dambrova","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.freeradbiomed.2023.05.014","article-title":"Energy substrate metabolism, mitochondrial structure and oxidative stress after cardiac ischemia-reperfusion in mice lacking UCP3","volume":"205","author":"Mata","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.redox.2015.08.020","article-title":"Reperfusion injury and reactive oxygen species: The evolution of a concept","volume":"6","author":"Granger","year":"2015","journal-title":"Redox Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41392-023-01688-x","article-title":"Ischemia-reperfusion injury: Molecular mechanisms and therapeutic targets","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev-pharmtox-010715-103335","article-title":"Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies","volume":"57","author":"Lesnefsky","year":"2017","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Doyle, A.J., and Hunt, B.J. (2018). Current Understanding of How Extracorporeal Membrane Oxygenators Activate Haemostasis and Other Blood Components. Front. Med., 5.","DOI":"10.3389\/fmed.2018.00352"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/imr.13148","article-title":"Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop","volume":"313","author":"Ekdahl","year":"2023","journal-title":"Immunol. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1182\/blood.2022015596","article-title":"Hemolysis, free hemoglobin toxicity, and scavenger protein therapeutics","volume":"140","author":"Vallelian","year":"2022","journal-title":"Blood"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ferreira, L.O., Vasconcelos, V.W., Lima, J.S., Vieira Neto, J.R., da Costa, G.E., Esteves, J.C., de Sousa, S.C., Moura, J.A., Santos, F.R.S., and Leit\u00e3o Filho, J.M. (2023). Biochemical Changes in Cardiopulmonary Bypass in Cardiac Surgery: New Insights. J. Pers. Med., 13.","DOI":"10.3390\/jpm13101506"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.hlc.2022.12.006","article-title":"Relationships Between Systemic Inflammation, Intestinal Damage and Postoperative Organ Dysfunction in Adults Undergoing Low-Risk Cardiac Surgery","volume":"32","author":"Habes","year":"2023","journal-title":"Heart Lung Circ."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Kant, S., Banerjee, D., Sabe, S.A., Sellke, F., and Feng, J. (2023). Microvascular dysfunction following cardiopulmonary bypass plays a central role in postoperative organ dysfunction. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1110532"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Kanuparthy, M., Manthana, R., Kaushik, H., Xiang, K., Hamze, J., Marimekala, D., Feng, J., and Sellke, F.W. (2025). Microvascular Dysfunction Following Cardioplegic Arrest and Cardiopulmonary Bypass: Impacts of Diabetes and Hypertension. Biomedicines, 13.","DOI":"10.3390\/biomedicines13020409"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1053\/j.jvca.2024.12.013","article-title":"Impact of Inflammation After Cardiac Surgery on 30-Day Mortality and Machine Learning Risk Prediction","volume":"39","author":"Squiccimarro","year":"2025","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s10047-022-01338-z","article-title":"Prediction of postoperative atrial fibrillation with the systemic immune-inflammation index in patients undergoing cardiac surgery using cardiopulmonary bypass: A retrospective, single-center study","volume":"26","author":"Hinoue","year":"2023","journal-title":"J. Artif. Organs"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/s13019-025-03514-7","article-title":"The impact of systemic inflammation index on prolonged mechanical ventilation after cardiac surgery: A retrospective study","volume":"20","author":"Liu","year":"2025","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"37899","DOI":"10.1038\/s41598-025-21786-w","article-title":"The association between air pollution and cardiovascular health in middle-aged and older Chinese adults: Cross-sectional and prospective analyses","volume":"15","author":"Xu","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Pan, Y., Bi, J., Sun, Z., Xin, J., and He, X. (2025). Associations of air pollutant exposures with Cardio-Kidney-Metabolic syndrome in Chinese middle-aged and older adults: A cross-sectional study based on CHARLS. BMC Public Health, 25.","DOI":"10.1186\/s12889-025-25654-0"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"100782","DOI":"10.1016\/j.jacadv.2023.100782","article-title":"All the Risk You Cannot See: Residual Risk of Airborne PM2.5 After CABG","volume":"3","author":"Bevan","year":"2023","journal-title":"JACC Adv."},{"key":"ref_51","first-page":"16847","article-title":"Five-year mortality disparities across urban and rural areas in patients treated with coronary artery bypass grafting","volume":"134","author":"Urbanowicz","year":"2024","journal-title":"Pol. Arch. Intern. Med."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Urbanowicz, T., Skotak, K., Krasi\u0144ska-P\u0142achta, A., Kowalewski, M., Olasi\u0144ska-Wi\u015bniewska, A., Szczepa\u0144ski, K., Tykarski, A., Krasi\u0144ska, B., Krasi\u0144ski, Z., and Jemielity, M. (2024). Long-Term Nitrogen Dioxide Exposure as a Possible 5-Year Mortality Risk Factor in Diabetic Patients Treated Using Off-Pump Surgical Revascularization-A Retrospective Analysis. Medicina, 60.","DOI":"10.3390\/medicina60081326"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Lavezzi, A.M., and Ramos-Molina, B. (2023). Environmental Exposure Science and Human Health. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20105764"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1093\/aje\/kwv325","article-title":"Use of the \u201cExposome\u201d in the Practice of Epidemiology: A Primer On-Omic Technologies","volume":"184","author":"DeBord","year":"2016","journal-title":"Am. J. Epidemiol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Wang, J., Kou, L., Kwan, M.P., Shakespeare, R.M., Lee, K., and Park, Y.M. (2021). An Integrated Individual Environmental Exposure Assessment System for Real-Time Mobile Sensing in Environmental Health Studies. Sensors, 21.","DOI":"10.3390\/s21124039"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1161\/CIR.0b013e3181dbece1","article-title":"Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association","volume":"121","author":"Brook","year":"2010","journal-title":"Circulation"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss6613a1","article-title":"Rural and Urban Differences in Air Quality, 2008\u20132012, and Community Drinking Water Quality, 2010\u20132015\u2014United States","volume":"66","author":"Strosnider","year":"2017","journal-title":"MMWR Surveill. Summ."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"119813","DOI":"10.1016\/j.ecoenv.2026.119813","article-title":"Mitochondrial dysfunction exacerbates environmental dose of PM2.5-induced vascular endothelial cells injury via oxidative stress: Findings from intervention study and cell experiment","volume":"310","author":"Jiang","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"128368","DOI":"10.1016\/j.jhazmat.2022.128368","article-title":"Adverse outcome pathway of fine particulate matter leading to increased cardiovascular morbidity and mortality: An integrated perspective from toxicology and epidemiology","volume":"430","author":"Yu","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Lim, E.Y., and Kim, G.D. (2024). Particulate Matter-Induced Emerging Health Effects Associated with Oxidative Stress and Inflammation. Antioxidants, 13.","DOI":"10.3390\/antiox13101256"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Lang, T., Lipp, A.M., and Wechselberger, C. (2025). Xenobiotic Toxicants and Particulate Matter: Effects, Mechanisms, Impacts on Human Health, and Mitigation Strategies. J. Xenobiot., 15.","DOI":"10.3390\/jox15040131"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1007\/s13762-021-03267-5","article-title":"A review of the potentiality of biochar technology to abate emissions of particulate matter originating from agriculture","volume":"19","author":"Luyima","year":"2022","journal-title":"Int. J. Environ. Sci. Technol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Hantrakool, S., Kumfu, S., Chattipakorn, S.C., and Chattipakorn, N. (2022). Effects of Particulate Matter on Inflammation and Thrombosis: Past Evidence for Future Prevention. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19148771"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/15287394.2016.1157539","article-title":"Increases in ambient particulate matter air pollution, acute changes in platelet function, and effect modification by aspirin and omega-3 fatty acids: A panel study","volume":"79","author":"Becerra","year":"2016","journal-title":"J. Toxicol. Environ. Health A"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s12665-026-12876-7","article-title":"Quantitative assessment of meteorological and air quality variables using airport monitoring data: Istanbul International Airports","volume":"85","author":"Birinci","year":"2026","journal-title":"Environ. Earth Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"106217","DOI":"10.1016\/j.envint.2020.106217","article-title":"Regional and seasonal variations in household and personal exposures to air pollution in one urban and two rural Chinese communities: A pilot study to collect time-resolved data using static and wearable devices","volume":"146","author":"Chan","year":"2021","journal-title":"Environ. Int."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e40651","DOI":"10.1016\/j.heliyon.2024.e40651","article-title":"Spatio-temporal variability and trends of air pollutants in the Metropolitan Area of Curitiba","volume":"10","author":"Krecl","year":"2024","journal-title":"Heliyon"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Dimitrovski, D., Markov, Z., Uler-Zefikj, M., Lazarevikj, M., and Stojkovski, A. (2026). Numerical Modelling of Urban Air Pollution from Residential Heating: A Case Study of Skopje. Amtosphere, 17.","DOI":"10.3390\/atmos17030291"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Li, Y., Wu, J., Xu, Y., Dong, J., Xing, B., Wang, Y., Zhou, Z., Sun, B., Li, J., and Yu, L. (2026). Cold exposure and the cardiovascular system: From physiological adaptation to pathological risk. Front. Physiol., 16.","DOI":"10.3389\/fphys.2025.1740919"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Zhang, J.J., Wei, Y., and Fang, Z. (2019). Ozone Pollution: A Major Health Hazard Worldwide. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.02518"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"149603","DOI":"10.1016\/j.scitotenv.2021.149603","article-title":"Photochemical ozone pollution in five Chinese megacities in summer 2018","volume":"801","author":"Liu","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_72","first-page":"277","article-title":"Ozone pollution, oxidative stress, synaptic plasticity, and neurodegeneration","volume":"37","year":"2022","journal-title":"Neurol. (Engl. Ed.)"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Clavo, B., Mart\u00ednez-S\u00e1nchez, G., Rodr\u00edguez-Esparrag\u00f3n, F., Rodr\u00edguez-Abreu, D., Galv\u00e1n, S., Aguiar-Bujanda, D., D\u00edaz-Garrido, J.A., Ca\u00f1as, S., Torres-Mata, L.B., and Fabelo, H. (2021). Modulation by Ozone Therapy of Oxidative Stress in Chemotherapy-Induced Peripheral Neuropathy: The Background for a Randomized Clinical Trial. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22062802"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"266","DOI":"10.4103\/1947-2714.110430","article-title":"Winter cardiovascular diseases phenomenon","volume":"5","author":"Fares","year":"2013","journal-title":"N. Am. J. Med. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Urbanowicz, T., Aboul-Hassan, S.S., Skotak, K., Luszczyn, M., Moskal, \u0141., Bratkowski, J., Bartkowski, J., Perek, B., Wilczy\u0144ski, M., and Filipiak, K.J. (2026). Winter Temperature and Long-Term Mortality After Coronary Artery Bypass Grafting: A Multicenter Cohort Study. JCM, 15.","DOI":"10.3390\/jcm15114216"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1089\/ars.2017.7394","article-title":"Effect of Particulate Matter Air Pollution on Cardiovascular Oxidative Stress Pathways","volume":"28","author":"Rao","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.freeradbiomed.2020.01.004","article-title":"Oxidative stress and the cardiovascular effects of air pollution","volume":"151","author":"Miller","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1093\/eurheartj\/ehy481","article-title":"Effects of gaseous and solid constituents of air pollution on endothelial function","volume":"39","author":"Gori","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_79","first-page":"E8","article-title":"Air particulate matter and cardiovascular disease: The epidemiological, biomedical and clinical evidence","volume":"8","author":"Du","year":"2016","journal-title":"J. Thorac. Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"438","DOI":"10.5271\/sjweh.832","article-title":"Chronic inflammation induced by organic dust and related metabolic cardiovascular disease risk factors","volume":"30","author":"Cormier","year":"2004","journal-title":"Scand. J. Work. Environ. Health"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/ina.12259","article-title":"Chronic exposure to biomass fuel smoke and markers of endothelial inflammation","volume":"26","author":"Caravedo","year":"2016","journal-title":"Indoor Air"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3109\/08958370903144105","article-title":"Exposure to nitrogen dioxide is not associated with vascular dysfunction in man","volume":"22","author":"Langrish","year":"2010","journal-title":"Inhal. Toxicol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1002\/tox.22200","article-title":"Inflammatory response and endothelial dysfunction in the hearts of mice co-exposed to SO2, NO2, and PM2.5","volume":"31","author":"Zhang","year":"2016","journal-title":"Environ. Toxicol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Karoui, A., Crochemore, C., Harouki, N., Corbi\u00e8re, C., Preterre, D., Vendeville, C., Richard, V., Fardel, O., Lecureur, V., and Vaugeois, J.M. (2020). Nitrogen Dioxide Inhalation Exposures Induce Cardiac Mitochondrial Reactive Oxygen Species Production, Impair Mitochondrial Function and Promote Coronary Endothelial Dysfunction. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17155526"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1001\/jamainternmed.2017.2842","article-title":"Association of Ozone Exposure with Cardiorespiratory Pathophysiologic Mechanisms in Healthy Adults","volume":"177","author":"Day","year":"2017","journal-title":"JAMA Intern. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.fmre.2024.02.016","article-title":"Ozone exposure and cardiovascular disease: A narrative review of epidemiology evidence and underlying mechanisms","volume":"5","author":"Hua","year":"2024","journal-title":"Fundam. Res."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Balmes, J.R., Arjomandi, M., Bromberg, P.A., Costantini, M.G., Dagincourt, N., Hazucha, M.J., Hollenbeck-Pringle, D., Rich, D.Q., Stark, P., and Frampton, M.W. (2019). Ozone effects on blood biomarkers of systemic inflammation, oxidative stress, endothelial function, and thrombosis: The Multicenter Ozone Study in oldEr Subjects (MOSES). PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0222601"},{"key":"ref_88","first-page":"00141","article-title":"Does lung function mediate the role of environmental pollution on overall and cardiovascular disease mortality?","volume":"10","year":"2024","journal-title":"ERJ Open Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/s12276-020-0403-3","article-title":"The health effects of ultrafine particles","volume":"52","author":"Schraufnagel","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"230259","DOI":"10.1183\/16000617.0259-2023","article-title":"Fine particulate matter manipulates immune response to exacerbate microbial pathogenesis in the respiratory tract","volume":"33","author":"Ma","year":"2024","journal-title":"Eur. Respir. Rev."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Chee, Y.J., Dalan, R., and Cheung, C. (2025). The Interplay Between Immunity, Inflammation and Endothelial Dysfunction. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26041708"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1152\/physiol.00017.2020","article-title":"Air Pollution-Induced Autonomic Modulation","volume":"35","year":"2020","journal-title":"Physiology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0161-813X(01)00062-6","article-title":"Neurogenic inflammation and particulate matter (PM) air pollutants","volume":"22","author":"Verones","year":"2001","journal-title":"Neurotoxicology"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.scitotenv.2017.10.168","article-title":"Analysis of major pollutants and physico-chemical characteristics of PM2.5 at an urban site in Rome","volume":"616\u2013617","author":"Fanizza","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_95","first-page":"5","article-title":"Evaluating heterogeneity in indoor and outdoor air pollution using land-use regression and constrained factor analysis","volume":"152","author":"Levy","year":"2010","journal-title":"Res. Rep. Health Eff. Inst."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev-med-042220-011549","article-title":"Cardiovascular Effects of Particulate Air Pollution","volume":"73","author":"Bhatnagar","year":"2022","journal-title":"Annu. Rev. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"111857","DOI":"10.1016\/j.mad.2023.111857","article-title":"Impact of air pollution on cardiovascular aging","volume":"214","author":"Kuntic","year":"2023","journal-title":"Mech. Ageing Dev."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Yang, X., Du, Y., Chen, L., Dong, J., Hu, T., Sun, N., Sun, Q., Liang, W., and Wei, X. (2025). Global cardiovascular disease burden attributable to particulate matter pollution, 1990\u20132021: An analysis of the global burden of disease study 2021 and forecast to 2045. BMC Cardiovasc. Disord., 25.","DOI":"10.1186\/s12872-025-04724-6"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"dyae140","DOI":"10.1093\/ije\/dyae140","article-title":"Long-term exposure to PM2.5 and mortality: A national health insurance cohort study","volume":"53","author":"Moon","year":"2024","journal-title":"Int. J. Epidemiol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"035019","DOI":"10.1088\/1748-9326\/abe82b","article-title":"Estimating PM2.5-related premature mortality and morbidity associated with future wildfire emissions in the western US","volume":"16","author":"Neumann","year":"2021","journal-title":"Environ. Res. Lett."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Yang, L., Li, C., and Tang, X. (2020). The Impact of PM2.5 on the Host Defense of Respiratory System. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.00091"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Pryor, J.T., Cowley, L.O., and Simonds, S.E. (2022). The Physiological Effects of Air Pollution: Particulate Matter, Physiology and Disease. Front. Public Health, 10.","DOI":"10.3389\/fpubh.2022.882569"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/10937404.2020.1822971","article-title":"Effects of ambient particulate matter on vascular tissue: A review","volume":"23","author":"Shkirkova","year":"2020","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s13181-011-0203-1","article-title":"Clearing the air: A review of the effects of particulate matter air pollution on human health","volume":"8","author":"Anderson","year":"2012","journal-title":"J. Med. Toxicol."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Farina, F., Sancini, G., Battaglia, C., Tinaglia, V., Mantecca, P., Camatini, M., and Palestini, P. (2013). Milano summer particulate matter (PM10) triggers lung inflammation and extra pulmonary adverse events in mice. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0056636"},{"key":"ref_106","first-page":"2","article-title":"The interplay between airway epithelium and the immune system\u2014A primer for the respiratory clinician","volume":"38","author":"Weinstock","year":"2021","journal-title":"Paediatr. Respir. Rev."},{"key":"ref_107","first-page":"213","article-title":"Verification of expected trends in urban traffic NOx emissions from long-term measurements of ambient NO2 concentrations in urban air","volume":"189\u2013190","author":"Svanberg","year":"1996","journal-title":"Sci. Total Environ."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.envpol.2014.02.026","article-title":"Limited effect of urban tree vegetation on NO2 and O3 concentrations near a traffic route","volume":"189","author":"Pleijel","year":"2014","journal-title":"Environ. Pollut."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ccc.2019.12.009","article-title":"Nitric Oxide and Endothelial Dysfunction","volume":"36","author":"Cyr","year":"2020","journal-title":"Crit. Care Clin."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.yjmcc.2022.04.011","article-title":"Targeting endothelial dysfunction and inflammation","volume":"168","author":"Wang","year":"2022","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_111","first-page":"101601","article-title":"Environmental exposure to air pollution and pollen and the risk of perioperative respiratory adverse events in paediatric anaesthesia: A narrative review","volume":"44","author":"Sommerfield","year":"2025","journal-title":"Anaesth. Crit. Care Pain Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"e46591","DOI":"10.2196\/46591","article-title":"Association Between Long-Term Exposure to Air Pollution and the Rate of Mortality After Hip Fracture Surgery in Patients Older Than 60 Years: Nationwide Cohort Study in Taiwan","volume":"10","author":"Chuang","year":"2024","journal-title":"JMIR Public Health Surveill."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s12012-021-09652-3","article-title":"Particulate Matter-Induced Cardiovascular Dysfunction: A Mechanistic Insight","volume":"21","author":"Ain","year":"2021","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/micc.12260","article-title":"Side-by-Side Alterations in Glycocalyx Thickness and Perfused Microvascular Density During Acute Microcirculatory Alterations in Cardiac Surgery","volume":"23","author":"Koning","year":"2016","journal-title":"Microcirculation"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e70268","DOI":"10.1002\/mco2.70268","article-title":"Oxidative Stress: Signaling Pathways, Biological Functions, and Disease","volume":"6","author":"Liu","year":"2025","journal-title":"MedComm"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"104694","DOI":"10.1016\/j.neuint.2020.104694","article-title":"Impairment of mitochondrial function by particulate matter: Implications for the brain","volume":"135","author":"Chew","year":"2020","journal-title":"Neurochem. Int."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Alsadder, L., and Hamadah, A. (2025). Cardiac Ischaemia-Reperfusion Injury: Pathophysiology, Therapeutic Targets and Future Interventions. Biomedicines, 13.","DOI":"10.3390\/biomedicines13092084"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Sierra-Vargas, M.P., Montero-Vargas, J.M., Debray-Garc\u00eda, Y., Vizuet-de-Rueda, J.C., Loaeza-Rom\u00e1n, A., and Ter\u00e1n, L.M. (2023). Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010853"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"123675","DOI":"10.1016\/j.envpol.2024.123675","article-title":"Particulate matter stimulates the NADPH oxidase system via AhR-mediated epigenetic modifications","volume":"347","author":"Kang","year":"2024","journal-title":"Environ. Pollut."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1161\/CIRCRESAHA.111.243972","article-title":"Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system","volume":"110","author":"Griendling","year":"2012","journal-title":"Circ. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/ki.2012.439","article-title":"Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease","volume":"83","author":"Ruiz","year":"2013","journal-title":"Kidney Int."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Ngo, V., and Duennwald, M.L. (2022). Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease. Antioxidants, 11.","DOI":"10.3390\/antiox11122345"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"28525","DOI":"10.1007\/s11356-023-25156-9","article-title":"Air pollution exposure and vascular endothelial function: A systematic review and meta-analysis","volume":"30","author":"Li","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Shaito, A., Aramouni, K., Assaf, R., Parenti, A., Orekhov, A., Yazbi, A.E., Pintus, G., and Eid, A.H. (2022). Oxidative Stress-Induced Endothelial Dysfunction in Cardiovascular Diseases. Front. Biosci. (Landmark Ed.), 27.","DOI":"10.31083\/j.fbl2703105"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1089\/ars.2023.0006","article-title":"Vascular Redox Signaling, Endothelial Nitric Oxide Synthase Uncoupling, and Endothelial Dysfunction in the Setting of Transportation Noise Exposure or Chronic Treatment with Organic Nitrates","volume":"38","author":"Daiber","year":"2023","journal-title":"Antioxid. Redox Signal."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"4836","DOI":"10.18632\/aging.102906","article-title":"Nrf2 deficiency aggravates PM2.5-induced cardiomyopathy by enhancing oxidative stress, fibrosis and inflammation via RIPK3-regulated mitochondrial disorder","volume":"12","author":"Ge","year":"2020","journal-title":"Aging"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e09","DOI":"10.15420\/ecr.2022.41","article-title":"Noise, Air, and Heavy Metal Pollution as Risk Factors for Endothelial Dysfunction","volume":"18","author":"Hahad","year":"2023","journal-title":"Eur. Cardiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.2174\/138161210792062867","article-title":"Oxidative stress and endothelial dysfunction: Say NO to cigarette smoking!","volume":"16","author":"Grassi","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"H927","DOI":"10.1152\/ajpheart.01138.2003","article-title":"Effect of NADPH oxidase inhibition on cardiopulmonary bypass-induced lung injury","volume":"287","author":"Welsh","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1161\/CIRCRESAHA.110.237560","article-title":"Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways","volume":"108","author":"Kampfrath","year":"2011","journal-title":"Circ. Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1161\/HYPERTENSIONAHA.123.20617","article-title":"Noise and Air Pollution as Risk Factors for Hypertension: Part II-Pathophysiologic Insight","volume":"80","author":"Hahad","year":"2023","journal-title":"Hypertension"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Mo, B., Ding, Y., and Ji, Q. (2025). NLRP3 inflammasome in cardiovascular diseases: An update. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1550226"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Kelley, N., Jeltema, D., Duan, Y., and He, Y. (2019). The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133328"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41423-021-00670-3","article-title":"An update on the regulatory mechanisms of NLRP3 inflammasome activation","volume":"18","author":"Paik","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"115054","DOI":"10.1016\/j.biopha.2023.115054","article-title":"The impact of particulate matters on apoptosis in various organs: Mechanistic and therapeutic perspectives","volume":"165","author":"Nia","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","article-title":"Cell biology of ischemia\/reperfusion injury","volume":"298","author":"Kalogeris","year":"2012","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1584745","DOI":"10.3389\/fcvm.2025.1584745","article-title":"Bridging inflammation and venous thrombosis: The NLRP3 inflammasome connection","volume":"12","author":"Wu","year":"2025","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Penna, C., and Pagliaro, P. (2025). Endothelial Dysfunction: Redox Imbalance, NLRP3 Inflammasome, and Inflammatory Responses in Cardiovascular Diseases. Antioxidants, 14.","DOI":"10.3390\/antiox14030256"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"e70084","DOI":"10.1111\/imr.70084","article-title":"Cellular Senescence, Inflammaging and Cardiovascular Disease","volume":"337","author":"Zanders","year":"2026","journal-title":"Immunol. Rev."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.2174\/1568026623666230502140614","article-title":"Oxidative Stress Biomarkers in Coronary Artery Disease","volume":"23","author":"Simantiris","year":"2023","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.redox.2013.07.006","article-title":"Biological markers of oxidative stress: Applications to cardiovascular research and practice","volume":"1","author":"Ho","year":"2013","journal-title":"Redox Biol."},{"key":"ref_143","first-page":"120","article-title":"8-hydroxy-2\u2032-deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis","volume":"27","author":"Valavanidis","year":"2009","journal-title":"J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1161\/RES.0000000000000110","article-title":"Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association","volume":"119","author":"Griendling","year":"2016","journal-title":"Circ. Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1089\/ars.2006.8.1523","article-title":"Regulation of novel superoxide-producing NAD(P)H oxidases","volume":"8","author":"Takeya","year":"2006","journal-title":"Antioxid. Redox Signal."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1096\/fasebj.14.9.1215","article-title":"The pro-oxidative activity of SOD and nitroxide SOD mimics","volume":"14","author":"Offer","year":"2000","journal-title":"FASEB J."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"12752","DOI":"10.1021\/acs.jafc.9b05373","article-title":"Pterostilbene Attenuates Experimental Atherosclerosis through Restoring Catalase-Mediated Redox Balance in Vascular Smooth Muscle Cells","volume":"67","author":"Wang","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"343","DOI":"10.24976\/Discov.Med.202436181.32","article-title":"Foam Cell Targeted Liposomes Co-Encapsulating Superoxide Dismutase and Catalase to Attenuate Atherosclerosis by Inhibiting Oxidative Stress","volume":"36","author":"Zhang","year":"2024","journal-title":"Discov. Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1177\/1358836X0501000104","article-title":"Asymmetric dimethylarginine (ADMA) and cardiovascular disease: Insights from prospective clinical trials","volume":"10","year":"2005","journal-title":"Vasc. Med."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"723","DOI":"10.2217\/nnm-2023-0282","article-title":"VCAM-1-targeted nanoparticles to diagnose, monitor and treat atherosclerosis","volume":"19","author":"Castro","year":"2024","journal-title":"Nanomedicine"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.yjmcc.2022.06.001","article-title":"ICAM-1-related noncoding RNA accelerates atherosclerosis by amplifying NF-\u03baB signaling","volume":"170","author":"Ding","year":"2022","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1161\/01.CIR.100.1.96","article-title":"C-reactive protein as a cardiovascular risk factor: More than an epiphenomenon?","volume":"100","author":"Lagrand","year":"1999","journal-title":"Circulation"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41569-020-0431-7","article-title":"Ageing and atherosclerosis: Vascular intrinsic and extrinsic factors and potential role of IL-6","volume":"18","author":"Tyrrell","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_154","first-page":"1238","article-title":"Effects of TNF-\u03b1 Inhibitors on Subclinical Atherosclerosis and Endothelial Function in Patients with Psoriatic Arthritis: A Systematic Review","volume":"103","author":"Makhlouf","year":"2025","journal-title":"Tunis. Med."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2174\/1570161119666211029110813","article-title":"Epicardial Adipocyte-derived TNF-\u03b1 Modulates Local Inflammation in Patients with Advanced Coronary Artery Disease","volume":"20","author":"Karampetsou","year":"2022","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/s41423-023-01086-x","article-title":"Mitochondrial DNA-triggered innate immune response: Mechanisms and diseases","volume":"20","author":"Hu","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s10495-007-0756-2","article-title":"Mitochondria, oxidative stress and cell death","volume":"12","author":"Ott","year":"2007","journal-title":"Apoptosis"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/toxsci\/kfu250","article-title":"Air pollution as a risk factor for type 2 diabetes","volume":"143","author":"Rao","year":"2015","journal-title":"Toxicol. Sci."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.jacc.2018.07.099","article-title":"Air Pollution and Cardiovascular Disease: JACC State-of-the-Art Review","volume":"72","author":"Rajagopalan","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.athoracsur.2024.12.013","article-title":"Causes of Death After Coronary Revascularization in Patients with Diabetes","volume":"119","author":"Godoy","year":"2025","journal-title":"Ann. Thorac. Surg."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1093\/eurheartj\/eht149","article-title":"Diabetes and vascular disease: Pathophysiology, clinical consequences, and medical therapy: Part I","volume":"34","author":"Paneni","year":"2013","journal-title":"Eur. Heart J."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Boieriu, A.M., Luca, C.D., Neculoiu, C.D., Bisoc, A., and \u021a\u00een\u021b, D. (2025). Endothelial Dysfunction and Oxidative Stress in Patients with Severe Coronary Artery Disease: Does Diabetes Play a Contributing Role?. Medicina, 61.","DOI":"10.3390\/medicina61010135"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2174\/157339911797415585","article-title":"The role of oxidative stress in the pathogenesis of type 2 diabetes mellitus micro- and macrovascular complications: Avenues for a mechanistic-based therapeutic approach","volume":"7","author":"Folli","year":"2011","journal-title":"Curr. Diabetes Rev."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1038\/ki.2008.516","article-title":"Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease","volume":"111","author":"Cachofeiro","year":"2008","journal-title":"Kidney Int. Suppl."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S1010-7940(01)00941-1","article-title":"Off-pump versus on-pump coronary artery bypass grafting: Oxidative stress and renal function","volume":"20","author":"Gerritsen","year":"2001","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_166","first-page":"428","article-title":"Off-pump versus On-pump Coronary Artery Bypass Grafting in Frail Patients: Study Protocol for the FRAGILE Multicenter Randomized Controlled Trial","volume":"32","author":"Deininger","year":"2017","journal-title":"Braz. J. Cardiovasc. Surg."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta18440","article-title":"Coronary artery bypass grafting in high-RISk patients randomised to off- or on-Pump surgery: A randomised controlled trial (the CRISP trial)","volume":"18","author":"Rogers","year":"2014","journal-title":"Health Technol. Assess."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/ehjqcco\/qcab099","article-title":"Bilateral internal thoracic artery coronary grafting: Risks and benefits in elderly patients","volume":"8","author":"Zhou","year":"2022","journal-title":"Eur. Heart J. Qual. Care Clin. Outcomes."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1111\/jocs.16396","article-title":"Outcomes of cardiac surgery in nonagenarians","volume":"37","author":"Elsisy","year":"2022","journal-title":"J. Card. Surg."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1055\/s-0041-1739186","article-title":"Bilateral Internal Thoracic Artery Minimally Invasive CABG Management in COPD","volume":"11","author":"Assmann","year":"2022","journal-title":"Thorac. Cardiovasc. Surg. Rep."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1696441","DOI":"10.3389\/fmed.2025.1696441","article-title":"A cross-sectional study of pulmonary and quality of life outcomes in patients with CABG and COPD","volume":"12","author":"Cakirkose","year":"2026","journal-title":"Front. Med."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1016\/j.jtcvs.2020.08.018","article-title":"Adverse events after coronary artery bypass grafting in patients with preoperative metabolic syndrome: A 10-year follow-up of the Veterans Affairs Database","volume":"163","author":"Deo","year":"2022","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/jocs.14470","article-title":"Effects and outcomes of cardiac surgery in patients with cardiometabolic syndrome","volume":"35","author":"Zapata","year":"2020","journal-title":"J. Card. Surg."},{"key":"ref_174","first-page":"17033","article-title":"Obesity rather than metabolic syndrome as a possible 5-year mortality risk factor in off-pump surgical revascularization: A retrospective analysis","volume":"135","author":"Urbanowicz","year":"2025","journal-title":"Pol. Arch. Intern. Med."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"163352","DOI":"10.1016\/j.scitotenv.2023.163352","article-title":"Impact of particulate matter on the incidence of atrial fibrillation and the risk of adverse clinical outcomes: A review","volume":"880","author":"Lip","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1161\/CIRCRESAHA.123.323477","article-title":"Environmental Exposome and Atrial Fibrillation: Emerging Evidence and Future Directions","volume":"134","author":"Wass","year":"2024","journal-title":"Circ. Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.4103\/aian.aian_1130_21","article-title":"Air Pollution and Ischaemic Stroke","volume":"25","author":"Ho","year":"2022","journal-title":"Ann. Indian. Acad. Neurol."},{"key":"ref_178","first-page":"e46694","article-title":"Effect of Air Pollution Particulate Matter on Ischemic and Hemorrhagic Stroke: A Scoping Review","volume":"15","author":"Ge","year":"2023","journal-title":"Cureus"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"41302","DOI":"10.1289\/EHP12860","article-title":"Invited Perspective: Still Hazy? Air Pollution and Acute Kidney Injury","volume":"131","author":"Hsu","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"47008","DOI":"10.1289\/EHP10729","article-title":"Air Pollution and Acute Kidney Injury in the U.S. Medicare Population: A Longitudinal Cohort Study","volume":"131","author":"Lee","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Basith, S., Manavalan, B., Shin, T.H., Park, C.B., Lee, W.S., Kim, J., and Lee, G. (2022). The Impact of Fine Particulate Matter 2.5 on the Cardiovascular System: A Review of the Invisible Killer. Nanomaterials, 12.","DOI":"10.3390\/nano12152656"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"e46419","DOI":"10.1097\/MD.0000000000046419","article-title":"Global burden of stroke attributable to air pollution (1990\u20132021): An analysis of GBD 2021 data","volume":"104","author":"Feng","year":"2025","journal-title":"Medicine"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"100781","DOI":"10.1016\/j.jacadv.2023.100781","article-title":"Air Pollution and Adverse Cardiovascular Events After Coronary Artery Bypass Grafting: A 10-Year Nationwide Study","volume":"3","author":"Deo","year":"2023","journal-title":"JACC Adv."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Rusciano, D., Gagliano, C., Avitabile, A., and Maya-Vetencourt, J.F. (2026). Environmental enrichment as a mitochondria-targeting systems strategy across neurodegenerative diseases and retinal dystrophies. Front. Neurosci., 20.","DOI":"10.3389\/fnins.2026.1744873"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1177\/0192623312464531","article-title":"Epidemiological and experimental links between air pollution and type 2 diabetes","volume":"41","author":"Liu","year":"2013","journal-title":"Toxicol. Pathol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13098-025-01638-3","article-title":"Association between air pollution and cardiovascular disease risk in middle-aged and elderly individuals with diabetes: Inflammatory lipid ratio accelerate this progression","volume":"17","author":"Yan","year":"2025","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1067\/mva.2001.111806","article-title":"Human vascular smooth muscle cells of diabetic origin exhibit increased proliferation, adhesion, and migration","volume":"33","author":"Faries","year":"2001","journal-title":"J. Vasc. Surg."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Mallah, M.A., Soomro, T., Ali, M., Noreen, S., Khatoon, N., Kafle, A., Feng, F., Wang, W., Naveed, M., and Zhang, Q. (2023). Cigarette smoking and air pollution exposure and their effects on cardiovascular diseases. Front. Public Health, 11.","DOI":"10.3389\/fpubh.2023.967047"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.hrtlng.2016.08.001","article-title":"Association between air pollution and development of atrial fibrillation: A meta-analysis of observational studies","volume":"45","author":"Shao","year":"2016","journal-title":"Heart Lung"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.amjcard.2020.11.031","article-title":"Periprocedural Stroke After Coronary Revascularization (from the CREDO-Kyoto PCI\/CABG Registry Cohort-3)","volume":"142","author":"Yamamoto","year":"2021","journal-title":"Am. J. Cardiol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1161\/STROKEAHA.122.035498","article-title":"Ambient Air Pollution and Stroke: An Updated Review","volume":"54","author":"Kulick","year":"2023","journal-title":"Stroke"},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Jiang, W., Su, Y., Su, Y., Xu, J., Fang, Y., Teng, J., Ding, X., Luo, Z., and Xu, X. (2024). Assessing the predictive value of elevated postoperative syndecan-1 levels for progressive acute kidney injury and kidney replacement therapy necessity in adult cardiac surgery patients. BMC Cardiovasc. Disord., 24.","DOI":"10.1186\/s12872-024-04061-0"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"e23610","DOI":"10.1002\/jbt.23610","article-title":"Association of air pollution and risk of chronic kidney disease: A systematic review and meta-analysis","volume":"38","author":"Xu","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"580","DOI":"10.5830\/CVJA-2025-079","article-title":"The role of inflammatory markers in predicting acute kidney injury after coronary artery bypass surgery: Platelet-lymphocyte and neutrophil-lymphocyte ratios","volume":"36","author":"Gemalmaz","year":"2025","journal-title":"Cardiovasc. J. Afr."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"102094","DOI":"10.1016\/j.cpcardiol.2023.102094","article-title":"Particulate Matter Air Pollution is a Significant Risk Factor for Cardiovascular Disease","volume":"49","author":"Henning","year":"2024","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1213\/ANE.0b013e3182147e3c","article-title":"Review article: Implications of vascular aging","volume":"112","author":"Barodka","year":"2011","journal-title":"Anesth. Analg."},{"key":"ref_197","first-page":"e96145","article-title":"The Role of Aminothiols as Biomarkers of Oxidative Stress and Clinical Outcomes in Coronary Artery Bypass Grafting (CABG): A Narrative Review","volume":"17","author":"Dontsov","year":"2025","journal-title":"Cureus"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ijcard.2018.12.048","article-title":"Long-term exposure of fine particulate matter air pollution and incident atrial fibrillation in the general population: A nationwide cohort study","volume":"283","author":"Kim","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"147106","DOI":"10.1016\/j.scitotenv.2021.147106","article-title":"The relationship between exposure to PM2.5 and atrial fibrillation in older adults: A systematic review and meta-analysis","volume":"784","author":"Wang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.eehl.2024.05.006","article-title":"Long-term exposure to air pollution and incidence risk of various arrhythmias: A prospective cohort study","volume":"3","author":"Zhou","year":"2024","journal-title":"Eco Environ. Health"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.tins.2009.05.009","article-title":"Air pollution: Mechanisms of neuroinflammation and CNS disease","volume":"32","author":"Block","year":"2009","journal-title":"Trends Neurosci."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"141275","DOI":"10.1016\/j.jhazmat.2026.141275","article-title":"PM2.5 impairs gliovascular coupling via endothelial AHR-mitochondrial signaling in mice","volume":"504","author":"Kim","year":"2026","journal-title":"J. Hazard. Mater."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"h1295","DOI":"10.1136\/bmj.h1295","article-title":"Short term exposure to air pollution and stroke: Systematic review and meta-analysis","volume":"350","author":"Shah","year":"2015","journal-title":"BMJ"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1289\/ehp.1307301","article-title":"Long-term exposure to ambient air pollution and incidence of cerebrovascular events: Results from 11 European cohorts within the ESCAPE project","volume":"122","author":"Stafoggia","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"107156","DOI":"10.1016\/j.envint.2022.107156","article-title":"Associations of long-term exposure to fine particulate matter and its constituents with cardiovascular mortality: A prospective cohort study in China","volume":"162","author":"Liang","year":"2022","journal-title":"Environ. Int."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"114537","DOI":"10.1016\/j.isci.2025.114537","article-title":"Risk of PM2.5 and its constituents for cardiovascular diseases: A cohort study of over 5.8 million participants","volume":"29","author":"Feng","year":"2025","journal-title":"iScience"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jjcc.2019.11.004","article-title":"Long-term fine particulate matter exposure and cardiovascular mortality in the general population: A nationwide cohort study","volume":"75","author":"Kim","year":"2020","journal-title":"J. Cardiol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.21037\/jtd-22-497","article-title":"Comparison of the mid-term clinical efficacy and short-term complications of Y-type coronary artery bypass grafting and sequential bypass grafting of the great saphenous vein: A retrospective cohort study","volume":"14","author":"Dai","year":"2022","journal-title":"J. Thorac. Dis."},{"key":"ref_209","first-page":"e38413","article-title":"Survival and Independent Predictors of Mortality Following Coronary Artery Bypass Graft Surgery in a Single-Unit Practice in the United Kingdom Over 20 Years","volume":"15","author":"Momin","year":"2023","journal-title":"Cureus"},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Lichtenberg, D., Pinchuk, I., Yonassi, E., Weber, D., and Grune, T. (2023). Oxidative Stress Is a Concept, Not an Indication for Selective Antioxidant Treatment. Antioxidants, 12.","DOI":"10.3390\/antiox12061188"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.2174\/092986712802884312","article-title":"Oxidized-LDL and paraoxonase-1 as biomarkers of coronary artery disease in patients with sleep-disordered breathing","volume":"19","author":"Hackenhaar","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1567-5688(03)00033-3","article-title":"ADMA and oxidative stress","volume":"4","author":"Sydow","year":"2003","journal-title":"Atheroscler. Suppl."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"2842S","DOI":"10.1093\/jn\/134.10.2842S","article-title":"Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the \u201cL-arginine paradox\u201d and acts as a novel cardiovascular risk factor","volume":"134","year":"2004","journal-title":"J. Nutr."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases: Regulation and function","volume":"33","author":"Sessa","year":"2012","journal-title":"Eur. Heart J."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41419-024-07166-8","article-title":"Inflammation in atherosclerosis: Pathophysiology and mechanisms","volume":"15","author":"Ajoolabady","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/nm.2538","article-title":"Atherosclerosis: Current pathogenesis and therapeutic options","volume":"17","author":"Weber","year":"2011","journal-title":"Nat. Med."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"112893","DOI":"10.1016\/j.biopha.2022.112893","article-title":"Protective effects of natural products against myocardial ischemia\/reperfusion: Mitochondria-targeted therapeutics","volume":"149","author":"Su","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Singh, D.D., Yadav, D.K., and Shin, D. (2026). Next-Generation Antioxidants in Cardiovascular Disease: Mechanistic Insights and Emerging Therapeutic Strategies. Antioxidants, 15.","DOI":"10.3390\/antiox15020164"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1089\/ars.2013.5430","article-title":"Statins as regulators of redox state in the vascular endothelium: Beyond lipid lowering","volume":"20","author":"Margaritis","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"152","DOI":"10.5114\/aoms.2018.74026","article-title":"Renin-angiotensin system inhibitor attenuates oxidative stress induced human coronary artery endothelial cell dysfunction via the PI3K\/AKT\/mTOR pathway","volume":"15","author":"Shi","year":"2019","journal-title":"Arch. Med. Sci."},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Koumallos, N., Sigala, E., Milas, T., Baikoussis, N.G., Aragiannis, D., Sideris, S., and Tsioufis, K. (2023). Angiotensin Regulation of Vascular Homeostasis: Exploring the Role of ROS and RAS Blockers. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241512111"},{"key":"ref_223","first-page":"53","article-title":"Sodium-glucose cotransporter 2 inhibitors and mitochondrial functions: State of the art","volume":"22","author":"Yaribeygi","year":"2023","journal-title":"EXCLI J."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"118210","DOI":"10.1016\/j.biopha.2025.118210","article-title":"Special focus on the mitochondria in endothelial cells: A novel therapeutic target for gliflozins?","volume":"188","author":"Tarnawska","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"He, F., Ru, X., and Wen, T. (2020). NRF2, a Transcription Factor for Stress Response and Beyond. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21134777"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"105430","DOI":"10.1016\/j.envint.2019.105430","article-title":"The contribution of improved air quality to reduced cardiovascular mortality: Declines in socioeconomic differences over time","volume":"136","author":"Wyatt","year":"2020","journal-title":"Environ. Int."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"e2209490119","DOI":"10.1073\/pnas.2209490119","article-title":"Impact of lowering fine particulate matter from major emission sources on mortality in Canada: A nationwide causal analysis","volume":"119","author":"Chen","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"110877","DOI":"10.1016\/j.biopha.2020.110877","article-title":"Pharmacodynamics of malondialdehyde as indirect oxidative stress marker after arrested-heart cardiopulmonary bypass surgery","volume":"132","author":"Kotnik","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_229","doi-asserted-by":"crossref","unstructured":"Katsioupa, M., Kourampi, I., Oikonomou, E., Tsigkou, V., Theofilis, P., Charalambous, G., Marinos, G., Gialamas, I., Zisimos, K., and Anastasiou, A. (2023). Novel Biomarkers and Their Role in the Diagnosis and Prognosis of Acute Coronary Syndrome. Life, 13.","DOI":"10.3390\/life13101992"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"902","DOI":"10.33963\/KP.a2022.0143","article-title":"Neopterin as a predictive biomarker of postoperative atrial fibrillation following coronary artery bypass grafting","volume":"80","author":"Perek","year":"2022","journal-title":"Kardiol. Pol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"110338","DOI":"10.1016\/j.intimp.2023.110338","article-title":"Oxidized low-density lipoprotein regulates macrophage polarization in atherosclerosis","volume":"120","author":"He","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/mas.21381","article-title":"Protein carbonylation as a major hallmark of oxidative damage: Update of analytical strategies","volume":"33","author":"Fedorova","year":"2014","journal-title":"Mass. Spectrom. Rev."},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Mokoena, H., Choshi, J., Hanser, S., Mabhida, S.E., Steel, H.C., Mokgalaboni, K., Phoswa, W.N., Maarman, G., Nkambule, B.B., and Dludla, P.V. (2025). Sustained Activation of Myeloperoxidase Is Associated with Oxidative Stress and Inflammation in People Living with the Human Immunodeficiency Virus at Risk of Cardiovascular Disease. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262110285"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"689","DOI":"10.33963\/v.phj.100994","article-title":"Oxidative stress and atherosclerosis: Basic and clinical open issues","volume":"82","author":"Violi","year":"2024","journal-title":"Kardiol. Pol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"708","DOI":"10.33963\/v.phj.100609","article-title":"Elevated carbonylated proteins are associated with major cardiovascular events in patients with chronic coronary syndrome: A cohort study","volume":"82","author":"Paszek","year":"2024","journal-title":"Kardiol. Pol."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1126\/science.aay3164","article-title":"The exposome and health: Where chemistry meets biology","volume":"367","author":"Vermeulen","year":"2020","journal-title":"Science"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41569-023-00873-3","article-title":"The contribution of the exposome to the burden of cardiovascular disease","volume":"20","author":"Hahad","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1089\/ars.2017.7118","article-title":"The Adverse Effects of Environmental Noise Exposure on Oxidative Stress and Cardiovascular Risk","volume":"28","author":"Schmidt","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.3390\/jcm15093272","article-title":"Residential Environmental Composition and Risk of Acute Cellular Rejection After Heart Transplantation: A Multi-Scale Buffer Analysis","volume":"15","author":"Urbanowicz","year":"2026","journal-title":"J. Clin. Med."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/8\/930\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:26:08Z","timestamp":1785169568000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/8\/930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":239,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["antiox15080930"],"URL":"https:\/\/doi.org\/10.3390\/antiox15080930","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]}}}