{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:24:19Z","timestamp":1785435859020,"version":"3.56.0"},"reference-count":79,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32403041"],"award-info":[{"award-number":["32403041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["32403041"],"award-info":[{"award-number":["32403041"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","award":["2025GXNSFBA069093"],"award-info":[{"award-number":["2025GXNSFBA069093"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangxi Budding Scholars Universal Research Start-up Grants","award":["ZX02080033424004"],"award-info":[{"award-number":["ZX02080033424004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>This study aimed to investigate the effects of luteolin on the growth performance and intestinal health of juvenile Genetically Improved Farmed Tilapia (GIFT, Oreochromis niloticus). A total of 450 juvenile GIFT tilapia (initial body weight 8.12 \u00b1 0.04 g) were randomly assigned to five groups (90 fish per group; three replicate tanks of 30 fish each) and fed diets containing luteolin at 0, 50, 150, 300, or 600 mg\/kg (CG, LG50, LG150, LG300, and LG600, respectively) for 56 days. The results showed that with increasing luteolin supplementation, the weight gain rate (WGR) and specific growth rate (SGR) first increased and then decreased; the LG300 group had the highest WGR and SGR (significantly higher than the CG and LG600 groups, p &lt; 0.05) and the lowest feed conversion ratio. Based on broken-line and quadratic polynomial regression analyses of the WGR and SGR, the optimal dietary luteolin supplementation level was determined to be 274.14\u2013303.39 mg\/kg. For intestinal antioxidant enzyme activities and oxidative stress, total superoxide dismutase (T-SOD) activity in the LG150 and LG300 groups was significantly higher than in the CG and LG600 groups (p &lt; 0.05), and superoxide anion (O2\u2212) content in the LG300 group was significantly lower than in the CG, LG50, and LG600 groups (p &lt; 0.05). Histological analysis of the intestine revealed that muscular layer thickness was significantly greater in the LG300 group than in the CG group (p &lt; 0.05). Intestinal microbiota analysis indicated that compared with the CG group, the LG300 group showed lower relative abundances of the potential pathogens Plesiomonas and Bosea, whereas it had a higher relative abundance of the potentially beneficial bacteria Bacteroidota and Romboutsia. Intestinal untargeted metabolomics revealed that, compared with the CG group, the beneficial metabolites Chrysoeriol, Laricitrin, and Docosahexaenoylethanolamine were significantly up-regulated, whereas the biotoxins Aplysiatoxin, 17-Debromo- and Pectenotoxin 3 were significantly down-regulated in the LG300 group (p-adjust &lt; 0.05), with the up-regulated metabolites significantly enriched in the flavone and flavonol biosynthesis pathway (p-adjust &lt; 0.05). Collectively, dietary supplementation with an appropriate level (300 mg\/kg) of luteolin can effectively improve the growth performance and intestinal health of juvenile GIFT tilapia.<\/jats:p>","DOI":"10.3390\/antiox15080933","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:45:26Z","timestamp":1785239126000},"page":"933","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Dietary Luteolin on the Growth Performance and Intestinal Health of Juvenile GIFT Tilapia"],"prefix":"10.3390","volume":"15","author":[{"given":"Xiangli","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Aquatic Healthy Breeding and Nutrition Regulation of Guangxi Universities, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huige","family":"Ren","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aquatic Healthy Breeding and Nutrition Regulation of Guangxi Universities, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianting","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aquatic Healthy Breeding and Nutrition Regulation of Guangxi Universities, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggang","family":"Mo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aquatic Healthy Breeding and Nutrition Regulation of Guangxi Universities, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Du","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aquatic Healthy Breeding and Nutrition Regulation of Guangxi Universities, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Qian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aquatic Healthy Breeding and Nutrition Regulation of Guangxi Universities, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Peng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aquatic Healthy Breeding and Nutrition Regulation of Guangxi Universities, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihe","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aquatic Healthy Breeding and Nutrition Regulation of Guangxi Universities, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanxia","family":"Qin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aquatic Healthy Breeding and Nutrition Regulation of Guangxi Universities, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengrui","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aquatic Healthy Breeding and Nutrition Regulation of Guangxi Universities, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aquatic Healthy Breeding and Nutrition Regulation of Guangxi Universities, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangxi Xinshengtai Biotechnology Co., Ltd., Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9215-0871","authenticated-orcid":false,"given":"Weihao","family":"Ou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aquatic Healthy Breeding and Nutrition Regulation of Guangxi Universities, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102422","DOI":"10.1016\/j.foodpol.2023.102422","article-title":"A global view of aquaculture policy","volume":"116","author":"Naylor","year":"2023","journal-title":"Food Policy"},{"key":"ref_2","unstructured":"FAO (2024). 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