{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:05:08Z","timestamp":1785405908576,"version":"3.56.0"},"reference-count":172,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2014Next-Generation EU, \u2014\u201cCall MUR PRIN2022\u201d","award":["2022LW54KC"],"award-info":[{"award-number":["2022LW54KC"]}]},{"name":"European Union\u2014Next-Generation EU, \u2014\u201cCall MUR PRIN2022\u201d","award":["CUP J53D23009070006"],"award-info":[{"award-number":["CUP J53D23009070006"]}]},{"award":["2022LW54KC"],"award-info":[{"award-number":["2022LW54KC"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"publisher"}]},{"award":["CUP J53D23009070006"],"award-info":[{"award-number":["CUP J53D23009070006"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Call MUR PRIN2022","award":["20222W7P7S"],"award-info":[{"award-number":["20222W7P7S"]}]},{"name":"Call MUR PRIN2022","award":["CUP J53d23007280006"],"award-info":[{"award-number":["CUP J53d23007280006"]}]},{"name":"call MISE HIGHFOOD","award":["F\/250018\/00\/X50"],"award-info":[{"award-number":["F\/250018\/00\/X50"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Agri-food processing generates large quantities of residues that are increasingly recognized as sustainable sources of bioactive ingredients for high-value applications. This narrative review examines agri-food by-products as sources of antioxidant compounds and provides an integrated mechanistic perspective on their applications in skin, oral, and hair care. By highlighting the shared antioxidant mechanisms of action underlying these applications, the review offers a comprehensive framework for understanding the cosmeceutical potential of agri-food-derived bioactive compounds. Peer-reviewed studies published mainly between 2015 and 2026 were considered, focusing on the chemical composition of by-products, green recovery strategies, biological mechanisms, and evidence from in vitro, ex vivo, in vivo, and clinical studies. Fruit and vegetable peels, seeds, skins, pomaces, and other agro-industrial residues contain polyphenols, flavonoids, phenolic acids, tannins, carotenoids, vitamins, lipids, peptides, and polysaccharides with antioxidant, anti-inflammatory, antimicrobial, photoprotective, anti-aging, moisturizing, and pigmentation-modulating properties. These compounds can reduce oxidative stress, support endogenous antioxidant defences, modulate redox-sensitive signaling pathways, attenuate inflammation, preserve extracellular matrix integrity, and improve skin barrier-related outcomes. Green extraction technologies, including ultrasound-assisted extraction, microwave-assisted extraction, supercritical fluid extraction, pressurized liquid extraction, and natural deep eutectic solvents, enhance their sustainable recovery. Overall, agri-food by-products represent promising resources for circular cosmeceutical innovation, although extract standardization, safety, stability, skin bioavailability, formulation performance, and controlled clinical validation remain essential for translation.<\/jats:p>","DOI":"10.3390\/antiox15080949","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:32:13Z","timestamp":1785403933000},"page":"949","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Waste to Beauty: Agri-Food By-Products as Sources of Antioxidant Compounds for Cosmeceutical Applications"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2085-2334","authenticated-orcid":false,"given":"Alessia","family":"Silla","sequence":"first","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy"},{"name":"Biostructures and Biosystems National Institute (INBB), 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5686-0470","authenticated-orcid":false,"given":"Maria Cristina","family":"Barbalace","sequence":"additional","affiliation":[{"name":"Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, 47921 Rimini, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6740-5331","authenticated-orcid":false,"given":"Cristiana","family":"Caliceti","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy"},{"name":"Biostructures and Biosystems National Institute (INBB), 00165 Rome, Italy"},{"name":"Interdepartmental Centre for Renewable Sources, Environment, Sea and Energy (CIRI FRAME), Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy"},{"name":"Interdepartmental Centre for Industrial Agrofood Research-CIRI Agrofood, University of Bologna, 47521 Cesena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3026-6830","authenticated-orcid":false,"given":"Angela","family":"Punzo","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy"},{"name":"Biostructures and Biosystems National Institute (INBB), 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7857-4512","authenticated-orcid":false,"given":"Silvana","family":"Hrelia","sequence":"additional","affiliation":[{"name":"Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, 47921 Rimini, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6731-6187","authenticated-orcid":false,"given":"Cristina","family":"Angeloni","sequence":"additional","affiliation":[{"name":"Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, 47921 Rimini, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0349-7772","authenticated-orcid":false,"given":"Marco","family":"Malaguti","sequence":"additional","affiliation":[{"name":"Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, 47921 Rimini, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Rao, S., and Nagendra, A. 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