{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:59:08Z","timestamp":1786978748852,"version":"build-2736575974"},"reference-count":52,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172359"],"award-info":[{"award-number":["82172359"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372338"],"award-info":[{"award-number":["82372338"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["82172359"],"award-info":[{"award-number":["82172359"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"award":["82372338"],"award-info":[{"award-number":["82372338"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Science and Technology Project of Health Commission of Hubei Province of China","award":["WJ2025Q043"],"award-info":[{"award-number":["WJ2025Q043"]}]},{"name":"Joint Fund for Translational Medicine and Interdisciplinary Research of Zhongnan Hospital of Wuhan University of China","award":["ZNJC202409"],"award-info":[{"award-number":["ZNJC202409"]}]},{"award":["ZNJC202409"],"award-info":[{"award-number":["ZNJC202409"]}],"id":[{"id":"https:\/\/ror.org\/01v5mqw79","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Background: Neutrophil extracellular traps (NETs) have been known to be involved in the gestational diabetes mellitus (GDM), but the underlying role remains poorly understood. Methods: We conducted an integrated analysis of bulk RNA-seq data, single-cell transcriptomic sequencing (scRNA-seq) data, clinical laboratory findings, and cell models to identify hub genes linked to NET formation (NETosis) and to elucidate how NETs contribute to placental injury in GDM. Results: We found that circulating NET levels were increased in pregnant women with GDM both under fasting conditions and following an oral glucose tolerance test (OGTT). Primary neutrophils isolated from healthy pregnant women produced more NETs upon high-glucose stimulation in vitro. The mRNA expression of PADI4, a key regulator of NETosis, was upregulated and positively correlated with MMP8 mRNA in patients with GDM. Inhibition of MMP8 suppressed intracellular reactive oxygen species (ROS) generation and attenuated NETosis in neutrophils. scRNA-seq analysis of placental tissues from patients with GDM identified a neutrophil subset with higher PADI4 expression. In vitro stimulation with NETs induced functional impairment of HTR8\/SVneo cells. Conclusions: We uncovered that MMP8, a novel NETosis-promoting molecule, is a promising target for GDM intervention.<\/jats:p>","DOI":"10.3390\/antiox15080955","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:15:00Z","timestamp":1785428100000},"page":"955","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MMP8 Promotes NETosis in Gestational Diabetes Mellitus"],"prefix":"10.3390","volume":"15","author":[{"given":"Nan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Center for Gene Diagnosis and Program of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Center for Gene Diagnosis and Program of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Center for Gene Diagnosis and Program of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"},{"name":"Department of Pharmacy, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Center for Gene Diagnosis and Program of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Center for Gene Diagnosis and Program of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Wei","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Center for Gene Diagnosis and Program of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Center for Gene Diagnosis and Program of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan-Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"},{"name":"Clinical Research Center for Prenatal Diagnosis and Birth Health of Hubei Province, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-Mei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Center for Gene Diagnosis and Program of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"},{"name":"Clinical Research Center for Prenatal Diagnosis and Birth Health of Hubei Province, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1001\/jamainternmed.2025.7055","article-title":"Gestational Diabetes in the US From 2016 to 2024","volume":"186","author":"Lam","year":"2025","journal-title":"JAMA Intern. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/s41467-024-45336-6","article-title":"Gestational diabetes augments group B Streptococcus infection by disrupting maternal immunity and the vaginal microbiota","volume":"15","author":"Mejia","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1007\/s00125-021-05447-x","article-title":"Oestrogen receptor \u03b1 in T cells controls the T cell immune profile and glucose metabolism in mouse models of gestational diabetes mellitus","volume":"64","author":"Tanaka","year":"2021","journal-title":"Diabetologia"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12933-025-02744-2","article-title":"Integrating adipsin with novel cardiometabolic and inflammatory indices for enhanced early prediction of gestational diabetes mellitus: A prospective cohort study","volume":"24","author":"Cai","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1136\/gutjnl-2022-328406","article-title":"Gestational diabetes is driven by microbiota-induced inflammation months before diagnosis","volume":"72","author":"Pinto","year":"2023","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"eadi7337","DOI":"10.1126\/sciadv.adi7337","article-title":"Lachnospiraceae-derived butyrate mediates protection of high fermentable fiber against placental inflammation in gestational diabetes mellitus","volume":"9","author":"Huang","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s10020-023-00615-8","article-title":"RBM15 suppresses hepatic insulin sensitivity of offspring of gestational diabetes mellitus mice via m6A-mediated regulation of CLDN4","volume":"29","author":"Fang","year":"2023","journal-title":"Mol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Yao, T., Xiong, Y., Hu, Q., Chen, Y., Li, D., Yan, J., Yang, J., Wang, Y., Cao, H., and Zhang, F. (2026). Maternal gestational diabetes mellitus leads to adverse growth patterns and disease risk in offspring in vivo: Evidence from cross-generational effects on gut microbiota. BMC Microbiol., 26.","DOI":"10.1186\/s12866-025-04591-3"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"114311","DOI":"10.1016\/j.isci.2025.114311","article-title":"FTO-dependent m6A methylation mediates gestational diabetes mellitus-induced offspring cardiac senescent hypertrophy and dysfunction","volume":"29","author":"Yu","year":"2026","journal-title":"iScience"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s12016-020-08804-7","article-title":"A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics","volume":"61","author":"Mutua","year":"2021","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s43556-025-00337-9","article-title":"Neutrophil Extracellular Traps (NETs) in health and disease","volume":"6","author":"Shahzad","year":"2025","journal-title":"Mol. Biomed."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Schommer, N., Gendron, N., Krauel, K., Van Bruggen, S., Jarrot, P.A., Maier, A., Chan, W., Langer, H.F., Duerschmied, D., and Westermann, D. (2025). Neutrophil extracellular traps and peptidylarginine deiminase 4-mediated inflammasome activation link diabetes to cardiorenal injury and heart failure. Eur. Heart J., Online ahead of print.","DOI":"10.1093\/eurheartj\/ehaf963"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41423-025-01278-7","article-title":"Saturated fatty acid-induced neutrophil extracellular traps contribute to exacerbation and biologic therapy resistance in obesity-related psoriasis","volume":"22","author":"Xia","year":"2025","journal-title":"Cell Mol. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41392-024-01933-x","article-title":"Neutrophil extracellular traps in homeostasis and disease","volume":"9","author":"Wang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"116621","DOI":"10.1016\/j.biopha.2024.116621","article-title":"NETs induce ferroptosis of endothelial cells in LPS-ALI through SDC-1\/HS and downstream pathways","volume":"175","author":"Fei","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.freeradbiomed.2024.05.036","article-title":"Neutrophil extracellular trap-induced ferroptosis promotes abdominal aortic aneurysm formation via SLC25A11-mediated depletion of mitochondrial glutathione","volume":"221","author":"Qi","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Jia, H., Yue, G., Li, P., Peng, R., Jin, R., Chen, Y., Cao, H., Yang, K., Zhang, X., and Yi, X. (2025). Neutrophil extracellular traps license macrophage production of chemokines to facilitate CD8+ T cell infiltration in obstruction-induced renal fibrosis. Protein Cell, Online ahead of print.","DOI":"10.1093\/procel\/pwaf020"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.2337\/db21-0188","article-title":"The Choline Metabolite TMAO Inhibits NETosis and Promotes Placental Development in GDM of Humans and Mice","volume":"70","author":"Lin","year":"2021","journal-title":"Diabetes"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"110168","DOI":"10.1016\/j.cellsig.2021.110168","article-title":"Mechanism of neutrophil extracellular traps generation and their role in trophoblasts apoptosis in gestational diabetes mellitus","volume":"88","author":"Shen","year":"2021","journal-title":"Cell Signal"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Stoikou, M., Grimolizzi, F., Giaglis, S., Sch\u00e4fer, G., van Breda, S.V., Hoesli, I.M., Lapaire, O., Huhn, E.A., Hasler, P., and Rossi, S.W. (2017). Gestational Diabetes Mellitus Is Associated with Altered Neutrophil Activity. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.00702"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1038\/s41591-024-03073-9","article-title":"Spatial multiomic landscape of the human placenta at molecular resolution","volume":"30","author":"Ounadjela","year":"2024","journal-title":"Nat. Med."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Luo, F., Liu, F., Guo, Y., Xu, W., Li, Y., Yi, J., Fournier, T., Degrelle, S., Zitouni, H., and Hernandez, I. (2023). Single-cell profiling reveals immune disturbances landscape and HLA-F-mediated immune tolerance at the maternal-fetal interface in preeclampsia. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1234577"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/imm.13392","article-title":"Neutrophils in pregnancy: New insights into innate and adaptive immune regulation","volume":"164","author":"Bert","year":"2021","journal-title":"Immunology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/humupd\/dmae006","article-title":"Revealing the molecular landscape of human placenta: A systematic review and meta-analysis of single-cell RNA sequencing studies","volume":"30","author":"Derisoud","year":"2024","journal-title":"Hum. Reprod. Update"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1016\/j.ajog.2024.12.032","article-title":"The maternal-fetal interface at single-cell resolution: Uncovering the cellular anatomy of the placenta and decidua","volume":"232","author":"Levenson","year":"2025","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Zhou, Z., and Yang, X. (2024). An update review of the application of single-cell RNA sequencing in pregnancy-related diseases. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1415173"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"979","DOI":"10.12688\/f1000research.73600.1","article-title":"Doublet identification in single-cell sequencing data using scDblFinder","volume":"10","author":"Germain","year":"2021","journal-title":"F1000Res"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"lqac066","DOI":"10.1093\/nargab\/lqac066","article-title":"Celda: A Bayesian model to perform co-clustering of genes into modules and cells into subpopulations using single-cell RNA-seq data","volume":"4","author":"Wang","year":"2022","journal-title":"NAR. Genom. Bioinform."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Street, K., Risso, D., Fletcher, R.B., Das, D., Ngai, J., Yosef, N., Purdom, E., and Dudoit, S. (2018). Slingshot: Cell lineage and pseudotime inference for single-cell transcriptomics. BMC Genom., 19.","DOI":"10.1186\/s12864-018-4772-0"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"676","DOI":"10.2337\/dc10-0719","article-title":"International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy","volume":"33","author":"Metzger","year":"2010","journal-title":"Diabetes Care"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"103540","DOI":"10.1016\/j.redox.2025.103540","article-title":"Investigating neutrophil responses to stimuli: Comparative analysis of reactive species-dependent and independent mechanisms","volume":"81","author":"Reis","year":"2025","journal-title":"Redox Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s41423-024-01158-6","article-title":"Neutrophil-derived PAD4 induces citrullination of CKMT1 exacerbates mucosal inflammation in inflammatory bowel disease","volume":"21","author":"Wang","year":"2024","journal-title":"Cell Mol. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1183\/09031936.00062209","article-title":"Cigarette smoke induces CXCL8 production by human neutrophils via activation of TLR9 receptor","volume":"36","author":"Mortaz","year":"2010","journal-title":"Eur. Respir. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1182\/blood-2005-03-0859","article-title":"p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils","volume":"106","author":"Martyn","year":"2005","journal-title":"Blood"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5770","DOI":"10.1038\/s41467-023-41452-x","article-title":"Whole-genome screens reveal regulators of differentiation state and context-dependent migration in human neutrophils","volume":"14","author":"Belliveau","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Azzouz, D., and Palaniyar, N. (2024). How Do ROS Induce NETosis? Oxidative DNA Damage, DNA Repair, and Chromatin Decondensation. Biomolecules, 14.","DOI":"10.3390\/biom14101307"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e70825","DOI":"10.1002\/cns.70825","article-title":"IL-17A Promotes NETs Formation via the PKC\u03b6-ERK-ROS-PAD4 Pathway in a Mouse Model of Ischemic Stroke","volume":"32","author":"Liu","year":"2026","journal-title":"CNS Neurosci. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"165940","DOI":"10.1016\/j.bbadis.2020.165940","article-title":"Glucose induces metabolic reprogramming in neutrophils during type 2 diabetes to form constitutive extracellular traps and decreased responsiveness to lipopolysaccharides","volume":"1866","author":"Joshi","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"36362","DOI":"10.1038\/srep36362","article-title":"Elevated homocysteine levels in type 2 diabetes induce constitutive neutrophil extracellular traps","volume":"6","author":"Joshi","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e134796","DOI":"10.1172\/jci.insight.134796","article-title":"Neutrophil extracellular traps promote macrophage inflammation and impair atherosclerosis resolution in diabetic mice","volume":"5","author":"Josefs","year":"2020","journal-title":"JCI Insight"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1055\/s-0038-1675788","article-title":"Increased Neutrophil Activation and Plasma DNA Levels in Patients with Pre-Eclampsia","volume":"118","author":"Hu","year":"2018","journal-title":"Thromb. Haemost."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"179123","DOI":"10.1016\/j.ejphar.2026.179123","article-title":"GSK484 attenuates placental endothelial injury and improves gestation outcome in rats with preeclampsia by inhibiting PAD4-mediated neutrophil extracellular traps formation","volume":"1030","author":"Li","year":"2026","journal-title":"Eur. J. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e2407346","DOI":"10.1002\/advs.202407346","article-title":"Hyperglycemia-Enhanced Neutrophil Extracellular Traps Drive Mucosal Immunopathology at the Oral Barrier","volume":"11","author":"Wang","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_46","first-page":"257","article-title":"Novel neutrophil extracellular trap-related mechanisms in diabetic wounds inspire a promising treatment strategy with hypoxia-challenged small extracellular vesicles","volume":"27","author":"Chu","year":"2023","journal-title":"Bioact. Mater."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1080\/15592294.2020.1816774","article-title":"Cell-free DNA Methylation and Transcriptomic Signature Prediction of Pregnancies with Adverse Outcomes","volume":"16","author":"Li","year":"2021","journal-title":"Epigenetics"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jconrel.2024.06.050","article-title":"Exosomal miRNA-26b-5p from PRP suppresses NETs by targeting MMP-8 to promote diabetic wound healing","volume":"372","author":"Rui","year":"2024","journal-title":"J. Control Release"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Saucedo, R., Ortega-Camarillo, C., Ferreira-Hermosillo, A., D\u00edaz-Vel\u00e1zquez, M.F., Meixueiro-Calder\u00f3n, C., and Valencia-Ortega, J. (2023). Role of Oxidative Stress and Inflammation in Gestational Diabetes Mellitus. Antioxidants, 12.","DOI":"10.3390\/antiox12101812"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Buczy\u0144ska-Backiel, A., Ko\u015bciuszko, M., Kr\u0119towski, A.J., and Szelachowska, M. (2026). Assessment of the impact of oxidative stress and inflammation on placental angiogenesis in women with gestational diabetes mellitus (GDM). Rev. Endocr. Metab. Disord., Online ahead of print.","DOI":"10.1007\/s11154-026-10060-7"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41423-025-01380-w","article-title":"Neutrophils as critical orchestrators of chronic inflammation","volume":"23","author":"Torfs","year":"2026","journal-title":"Cell Mol. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Yang, Y., Guo, F., Peng, Y., Chen, R., Zhou, W., Wang, H., OuYang, J., Yu, B., and Xu, Z. (2021). Transcriptomic Profiling of Human Placenta in Gestational Diabetes Mellitus at the Single-Cell Level. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.679582"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/8\/955\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:02:23Z","timestamp":1786975343000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/8\/955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":52,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["antiox15080955"],"URL":"https:\/\/doi.org\/10.3390\/antiox15080955","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]}}}