{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:26:57Z","timestamp":1786512417539,"version":"build-2736575974"},"reference-count":52,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Yanping Zhong, Youjiang Medical University for Nationalities, Baise, China","award":["1\/2024"],"award-info":[{"award-number":["1\/2024"]}]},{"DOI":"10.13039\/501100004704","name":"Distinguished Research Professor Somdet Srichairatanakool, National Research Council of Thailand","doi-asserted-by":"publisher","award":["N42A670732"],"award-info":[{"award-number":["N42A670732"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002842","name":"Chiang Mai University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002842","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/05m2fqn25","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Green tea extract (GTE) contains catechin polyphenols with potent antioxidant and iron-chelating activities. This study investigated whether GTE could attenuate oxidative stress and improve red blood cell (RBC) survival in iron-overloaded \u03b2-thalassemic mice. Catechin composition and antioxidant activity of GTE and black tea extract (BTE) were evaluated using HPLC-photodiode array detection and ABTS radical scavenging assays. Anti-hemolytic effects were examined in RBC from healthy subjects and transfusion-dependent \u03b2-thalassemia patients. In vivo studies were performed using male C57BL\/6J wild-type (WT) and heterozygous \u03b2-globin knockout (BKO) mice fed a ferrocene-enriched diet to induce iron overload. Mice subsequently received oral GTE (300 mg\/kg\/day) or deferiprone (DFP, 50 mg\/kg\/day) for 12 weeks. GTE contained markedly higher levels of catechin derivatives, particularly epigallocatechin-3-gallate, and exhibited stronger antioxidant activity than BTE. GTE significantly reduced RBC hemolysis, reactive oxygen species, malondialdehyde, and plasma non-transferrin-bound iron levels while restoring glutathione concentrations and prolonging RBC survival in iron-overloaded mice. The protective effects of GTE were comparable to DFP treatment. These findings suggest that GTE may serve as a promising natural adjunctive strategy for reducing oxidative injuries in \u03b2-thalassemia and iron-overload disorders.<\/jats:p>","DOI":"10.3390\/antiox15080990","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:38:09Z","timestamp":1786361889000},"page":"990","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Green Tea Extract Attenuates Oxidative Stress and Prolongs Red Blood Cell Survival in Iron-Overloaded \u03b2-Thalassemic Mice"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7074-8789","authenticated-orcid":false,"given":"Yanping","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"School of Medical Technology and Artificial Intelligence, Youjiang Medical University for Nationalities, Baise 533000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9067-2051","authenticated-orcid":false,"given":"Sakaewan","family":"Ounjaijean","sequence":"additional","affiliation":[{"name":"Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5022-9838","authenticated-orcid":false,"given":"Sirichai","family":"Srichairatanakool","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narisara","family":"Paradee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suphatta","family":"Yubo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Youjiang Medical University for Nationalities, Baise 533000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6119-7009","authenticated-orcid":false,"given":"Pimpisid","family":"Koonyosying","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phatchariya","family":"Phannasil","sequence":"additional","affiliation":[{"name":"Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhon Pathom 73170, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saovaros","family":"Svasti","sequence":"additional","affiliation":[{"name":"Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhon Pathom 73170, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5706-8781","authenticated-orcid":false,"given":"Somdet","family":"Srichairatanakool","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e732","DOI":"10.1097\/HS9.0000000000000732","article-title":"2021 Thalassaemia International Federation Guidelines for the Management of Transfusion-dependent Thalassemia","volume":"6","author":"Farmakis","year":"2022","journal-title":"Hemasphere"},{"key":"ref_2","unstructured":"Taher, A.T., Farmakis, D., Porter, J.B., Cappellini, M.D., and Musallam, K.M. 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