{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T04:32:24Z","timestamp":1786509144141,"version":"build-2736575974"},"reference-count":30,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2024A1515110094"],"award-info":[{"award-number":["2024A1515110094"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32502175"],"award-info":[{"award-number":["32502175"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"award":["32502175"],"award-info":[{"award-number":["32502175"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015600","name":"Guangdong Ocean University","doi-asserted-by":"crossref","award":["060302042406"],"award-info":[{"award-number":["060302042406"]}],"id":[{"id":"10.13039\/501100015600","id-type":"DOI","asserted-by":"crossref"}]},{"award":["060302042406"],"award-info":[{"award-number":["060302042406"]}],"id":[{"id":"https:\/\/ror.org\/0462wa640","id-type":"ROR","asserted-by":"publisher"}]},{"name":"earmarked fund for CARS","award":["CARS-49"],"award-info":[{"award-number":["CARS-49"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Given the growing demand for health-promoting foods, there is increasing interest in the multi-dimensional regulatory effects and the mechanisms of food-derived bioactives. Here, we report that KSVSPKFLTG, an anti-inflammatory peptide from Magallana gigas with ACE2-binding properties, protects SHSY-5Y cells against MPP+\/FAC-induced neurotoxicity. The peptide attenuates oxidative stress damage in SHSY-5Y cells and improves the mitochondrial membrane potential. It also mitigates iron overload and upregulates ferroptosis-related protective proteins (GPX4, SLC7A11, BCBP2, SLC40A1) via activating the renin\u2013angiotensin system. These findings reveal an RAS-modulating neuroprotective mechanism of the oyster-derived anti-inflammatory peptide, simultaneously opening new avenues for alleviating nerve damage caused by inflammation through bioactive peptides.<\/jats:p>","DOI":"10.3390\/antiox15080992","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:35:16Z","timestamp":1786379716000},"page":"992","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroprotective Potential of Peptide KSVSPKFLTG from Magallana gigas via Activating the ACE2\/Ang-(1-7)\/Mas Axis in SHSY-5Y Cells"],"prefix":"10.3390","volume":"15","author":[{"given":"Junlong","family":"Lai","sequence":"first","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialong","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China"},{"name":"Shenzhen Institute of Guangdong Ocean University, Shenzhen 518108, China"},{"name":"National Research and Development Branch Center for Shellfish Processing (Zhanjiang), Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety, Guangdong Provincial Engineering Technology Research Center of Seafood, Zhanjiang 524088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China"},{"name":"Shenzhen Institute of Guangdong Ocean University, Shenzhen 518108, China"},{"name":"National Research and Development Branch Center for Shellfish Processing (Zhanjiang), Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety, Guangdong Provincial Engineering Technology Research Center of Seafood, Zhanjiang 524088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9823-2584","authenticated-orcid":false,"given":"Haisheng","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China"},{"name":"Shenzhen Institute of Guangdong Ocean University, Shenzhen 518108, China"},{"name":"National Research and Development Branch Center for Shellfish Processing (Zhanjiang), Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety, Guangdong Provincial Engineering Technology Research Center of Seafood, Zhanjiang 524088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2249-7092","authenticated-orcid":false,"given":"Zhongqin","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China"},{"name":"Shenzhen Institute of Guangdong Ocean University, Shenzhen 518108, China"},{"name":"National Research and Development Branch Center for Shellfish Processing (Zhanjiang), Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety, Guangdong Provincial Engineering Technology Research Center of Seafood, Zhanjiang 524088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China"},{"name":"Shenzhen Institute of Guangdong Ocean University, Shenzhen 518108, China"},{"name":"National Research and Development Branch Center for Shellfish Processing (Zhanjiang), Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety, Guangdong Provincial Engineering Technology Research Center of Seafood, Zhanjiang 524088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhong","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China"},{"name":"Shenzhen Institute of Guangdong Ocean University, Shenzhen 518108, China"},{"name":"National Research and Development Branch Center for Shellfish Processing (Zhanjiang), Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety, Guangdong Provincial Engineering Technology Research Center of Seafood, Zhanjiang 524088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3095-7124","authenticated-orcid":false,"given":"Xiaoyu","family":"Xia","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China"},{"name":"Shenzhen Institute of Guangdong Ocean University, Shenzhen 518108, China"},{"name":"National Research and Development Branch Center for Shellfish Processing (Zhanjiang), Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety, Guangdong Provincial Engineering Technology Research Center of Seafood, Zhanjiang 524088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.1038\/s41467-025-59248-6","article-title":"Neural representation of cytokines by vagal sensory 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