{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:26:46Z","timestamp":1786685206706,"version":"build-2736575974"},"reference-count":123,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015690","name":"Universitas Padjadjaran","doi-asserted-by":"crossref","award":["4303\/ B3\/DT.03.08\/2025"],"award-info":[{"award-number":["4303\/ B3\/DT.03.08\/2025"]}],"id":[{"id":"10.13039\/501100015690","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100015690","name":"Universitas Padjadjaran","doi-asserted-by":"crossref","award":["3927\/UN6. RKT\/HK.07.00\/2025"],"award-info":[{"award-number":["3927\/UN6. 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RKT\/HK.07.00\/2025"]}],"id":[{"id":"https:\/\/ror.org\/00xqf8t64","id-type":"ROR","asserted-by":"publisher"}]},{"award":["3948\/UN6.3.1\/PT.00\/2025"],"award-info":[{"award-number":["3948\/UN6.3.1\/PT.00\/2025"]}],"id":[{"id":"https:\/\/ror.org\/00xqf8t64","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Breast cancer remains a major disease burden and a leading cause of cancer-related morbidity and mortality among women, while current therapies are often limited by toxicity, drug resistance, and recurrence. \u03b1-Mangostin (AM), a prenylated xanthone derived from Garcinia mangostana L., has attracted considerable interest because of its antioxidant, redox-modulating, and anticancer properties, which may contribute to improved health outcomes and patient well-being. This study systematically reviewed the therapeutic potential of AM against breast cancer based on evidence from in silico, in vitro, and in vivo studies focusing on biomedical and pharmaceutical applications. Relevant articles were retrieved from the Scopus and PubMed databases using predefined keywords and selection criteria. Eligible studies were extracted, categorized, and analyzed using Microsoft Word and EndNote to assess the pharmacological actions, target interactions, delivery systems, and therapeutic outcomes associated with AM, while the quality of animal studies was assessed using the ARRIVE guidelines. Twenty-nine studies met the inclusion criteria. Computational studies demonstrated favorable AM interactions with ER\u03b1, STAT3, RXR\u03b1, CXCR4, AKT1, CTNNB1, and HSP90AA1. In vitro studies showed that AM inhibited cancer cell viability, induced apoptosis and autophagy, modulated reactive oxygen species, and suppressed metastatic and immune-evasion markers. Furthermore, nano-formulations, radiolabeled derivatives, and combination approaches improved bioavailability, tumor targeting, and efficacy. In vivo studies reported inhibition of tumor-growth and metastasis, improved pharmacokinetic profiles, and prolonged survival. However, no clinical trials evaluating AM in breast cancer patients have been reported to date. Overall, AM represents a promising preclinical candidate for breast cancer treatment. Nevertheless, standardized pharmacokinetic, toxicological, and efficacy studies, followed by well-designed clinical trials, are essential to facilitate its translation into clinical practice.<\/jats:p>","DOI":"10.3390\/antiox15080998","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:02:11Z","timestamp":1786532531000},"page":"998","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Current Study of Alpha-Mangostin in Breast Cancer Therapy: Antioxidant Mechanisms and Redox Modulation from In Silico to In Vivo Studies"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6156-8025","authenticated-orcid":false,"given":"Muchtaridi","family":"Muchtaridi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia"},{"name":"Research Collaboration Center for Theranostic Radiopharmaceuticals, National Research and Innovation Agency (BRIN), Jl. KM Bandung-Sumedang KM 21, Sumedang, 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bintang Satrio","family":"Mahardika","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luthfi Utami","family":"Setyawati","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia"},{"name":"Research Collaboration Center for Theranostic Radiopharmaceuticals, National Research and Innovation Agency (BRIN), Jl. KM Bandung-Sumedang KM 21, Sumedang, 45363, Indonesia"},{"name":"Doctoral Program of Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5661-8841","authenticated-orcid":false,"given":"Dhania","family":"Novitasari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia"},{"name":"Research Collaboration Center for Theranostic Radiopharmaceuticals, National Research and Innovation Agency (BRIN), Jl. KM Bandung-Sumedang KM 21, Sumedang, 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasimah","family":"Jasimah","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2551-919X","authenticated-orcid":false,"given":"Febby","family":"Pratama","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia"},{"name":"Doctoral Program of Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4953-927X","authenticated-orcid":false,"given":"Nur Kusaira Khairul","family":"Ikram","sequence":"additional","affiliation":[{"name":"Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"ref_1","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/jama.2018.19323","article-title":"Breast Cancer Treatment: A Review","volume":"321","author":"Waks","year":"2019","journal-title":"JAMA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41572-019-0111-2","article-title":"Breast cancer","volume":"5","author":"Harbeck","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Majdalawieh, A.F., Terro, T.M., Ahari, S.H., and Abu-Yousef, I.A. (2024). \u03b1-Mangostin: A Xanthone Derivative in Mangosteen with Potent Anti-Cancer Properties. Biomolecules, 14.","DOI":"10.3390\/biom14111382"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"105107","DOI":"10.1016\/j.jff.2022.105107","article-title":"\u03b1-Mangostin suppresses proliferation and invasion in osteosarcoma cells via inhibiting fatty acid synthase","volume":"94","author":"Fan","year":"2022","journal-title":"J. Funct. Foods"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Zhu, X., Li, J., Ning, H., Yuan, Z., Zhong, Y., Wu, S., and Zeng, J.Z. (2021). \u03b1-Mangostin Induces Apoptosis and Inhibits Metastasis of Breast Cancer Cells via Regulating RXR\u03b1-AKT Signaling Pathway. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.739658"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/1476-4598-13-138","article-title":"Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells","volume":"13","author":"Li","year":"2014","journal-title":"Mol. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1007\/s11033-020-05435-1","article-title":"Role of PI3K\/AKT pathway in cancer: The framework of malignant behavior","volume":"47","author":"Jiang","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"106032","DOI":"10.1016\/j.phrs.2021.106032","article-title":"The purple mangosteen (Garcinia mangostana): Defining the anticancer potential of selected xanthones","volume":"175","author":"Nauman","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"672428","DOI":"10.1155\/2012\/672428","article-title":"Alterations in cell cycle and induction of apoptotic cell death in breast cancer cells treated with \u03b1-mangostin extracted from mangosteen pericarp","volume":"2012","author":"Kurose","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.3892\/ijo.2016.3399","article-title":"Antiproliferative and apoptosis induction of \u03b1-mangostin in T47D breast cancer cells","volume":"48","author":"Kritsanawong","year":"2016","journal-title":"Int. J. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"100089","DOI":"10.1016\/j.adcanc.2023.100089","article-title":"Alpha mangostin inhibits proliferation, migration, and invasion of human breast cancer cells via STAT3 inhibition","volume":"7","author":"Nalla","year":"2023","journal-title":"Adv. Cancer Biol. Metastasis"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Herdiana, Y., Wathoni, N., Shamsuddin, S., and Muchtaridi, M. (2021). \u03b1-Mangostin Nanoparticles Cytotoxicity and Cell Death Modalities in Breast Cancer Cell Lines. Molecules, 26.","DOI":"10.3390\/molecules26175119"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2147\/NSA.S243017","article-title":"Nanoparticle Drug Delivery Systems for \u03b1-Mangostin","volume":"13","author":"Wathoni","year":"2020","journal-title":"Nanotechnol. Sci. Appl."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Meylina, L., Muchtaridi, M., Joni, I.M., Mohammed, A.F.A., and Wathoni, N. (2021). Nanoformulations of \u03b1-Mangostin for Cancer Drug Delivery System. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13121993"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.3109\/10717544.2015.1092183","article-title":"Lipid-based nanocarriers for breast cancer treatment\u2014Comprehensive review","volume":"23","author":"Talluri","year":"2016","journal-title":"Drug Deliv."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"126307","DOI":"10.1016\/j.ijpharm.2025.126307","article-title":"Beyond nanomicelles and hydrogels: Exploring micelle-containing hydrogels as cutting-edge drug delivery system for effective breast cancer treatment","volume":"686","author":"Bishnoi","year":"2025","journal-title":"Int. J. Pharm."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Hanafy, N.A.N., El-Kemary, M., and Leporatti, S. (2018). Micelles Structure Development as a Strategy to Improve Smart Cancer Therapy. Cancers, 10.","DOI":"10.3390\/cancers10070238"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Suhandi, C., Wilar, G., Lesmana, R., Zulhendri, F., Suharyani, I., Hasan, N., and Wathoni, N. (2023). Propolis-Based Nanostructured Lipid Carriers for \u03b1-Mangostin Delivery: Formulation, Characterization, and In Vitro Antioxidant Activity Evaluation. Molecules, 28.","DOI":"10.3390\/molecules28166057"},{"key":"ref_22","first-page":"40","article-title":"\u03b1-Mangostin enhances cisplatin activity in drug-resistant breast cancer cells by targeting multidrug resistance-associated protein 2","volume":"15","author":"Khoothiam","year":"2025","journal-title":"J. Appl. Pharm. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"9217268","DOI":"10.1155\/2022\/9217268","article-title":"Alpha-Mangostin-Loaded Transferrin-Conjugated Lipid-Polymer Hybrid Nanoparticles: Development and Characterization for Tumor-Targeted Delivery","volume":"2022","author":"Sakpakdeejaroen","year":"2022","journal-title":"Sci. World J."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Li, L., Zeng, Y., Chen, M., and Liu, G. (2022). Application of Nanomicelles in Enhancing Bioavailability and Biological Efficacy of Bioactive Nutrients. Polymers, 14.","DOI":"10.3390\/polym14163278"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4103\/japtr.JAPTR_94_19","article-title":"The purity identification and radiolabeling of \u03b1-mangostin with technetium-99m","volume":"11","author":"Muchtaridi","year":"2020","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.2147\/DDDT.S479447","article-title":"Investigation of a Radio-Iodinated Alpha-Mangostin for Targeting Estrogen Receptor Alpha (ER\u03b1) in Breast Cancer: In Silico Design, Synthesis, and Biological Evaluation","volume":"18","author":"Muchtaridi","year":"2024","journal-title":"Drug Des. Devel Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s13659-025-00528-5","article-title":"Exploring the antineoplastic potential of \u03b1-mangostin in breast cancer","volume":"15","author":"Flores","year":"2025","journal-title":"Nat. Prod. Bioprospecting"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e3000410","DOI":"10.1371\/journal.pbio.3000410","article-title":"The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research","volume":"18","author":"Hurst","year":"2020","journal-title":"PLoS Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"173950","DOI":"10.1016\/j.ejphar.2021.173950","article-title":"A review on \u03b1-mangostin as a potential multi-target-directed ligand for Alzheimer\u2019s disease","volume":"897","author":"Yang","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12935-019-0869-z","article-title":"Alpha-mangostin induces endoplasmic reticulum stress and autophagy which count against fatty acid synthase inhibition mediated apoptosis in human breast cancer cells","volume":"19","author":"Huang","year":"2019","journal-title":"Cancer Cell Int."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Cruz-Gregorio, A., Aranda-Rivera, A.K., Aparicio-Trejo, O.E., Medina-Campos, O.N., Sciutto, E., Fragoso, G., and Pedraza-Chaverri, J. (2022). GK-1 Induces Oxidative Stress, Mitochondrial Dysfunction, Decreased Membrane Potential, and Impaired Autophagy Flux in a Mouse Model of Breast Cancer. Antioxidant, 12.","DOI":"10.3390\/antiox12010056"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4103\/JAPTR.JAPTR_49_24","article-title":"Potential target and mechanism exploration from \u03b1-mangostin against triple-negative breast cancer: An in silico study","volume":"15","author":"Rivaldo","year":"2024","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"7548191","DOI":"10.1155\/2022\/7548191","article-title":"Alpha-Mangostin Activates MOAP-1 Tumor Suppressor and Mitochondrial Signaling in MCF-7 Human Breast Cancer Cells","volume":"2022","author":"Simon","year":"2022","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_35","first-page":"e138856","article-title":"Different modes of mechanism of gamma-mangostin and alpha-mangostin to inhibit cell migration of triple-negative breast cancer cells concerning CXCR4 downregulation and ROS generation","volume":"22","author":"Sarmoko","year":"2023","journal-title":"Iran. J. Pharm. Res. IJPR"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1002\/ptr.7812","article-title":"\u03b1-Mangostin induces oxidative damage, mitochondrial dysfunction, and apoptosis in a triple-negative breast cancer model","volume":"37","author":"Sciutto","year":"2023","journal-title":"Phytother. Res."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Ibrahim, M.Y., Hashim, N.M., Omer, F.A.A., Abubakar, M.S., Mohammed, H.A., Salama, S.M., and Jayash, S.N. (2023). Potential Antitumor Effect of \u03b1-Mangostin against Rat Mammary Gland Tumors Induced by LA7 Cells. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241210283"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"109927","DOI":"10.1016\/j.biopha.2020.109927","article-title":"Doxorubicin and \u03b1-Mangostin oppositely affect luminal breast cancer cell stemness evaluated by a new retinaldehyde-dependent ALDH assay in MCF-7 tumor spheroids","volume":"124","author":"Bissoli","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"117365","DOI":"10.1016\/j.biopha.2024.117365","article-title":"Prenylated xanthones from mangosteen (Garcinia mangostana) target oxidative mitochondrial respiration in cancer cells","volume":"179","author":"Mohamed","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Vargas-Castro, R., Garc\u00eda-Becerra, R., D\u00edaz, L., Avila, E., Ordaz-Rosado, D., Bernadez-Vallejo, S.V., Cano-Col\u00edn, S., Camacho, J., Larrea, F., and Garc\u00eda-Quiroz, J. (2023). Enhancing tamoxifen therapy with \u03b1-mangostin: Synergistic antiproliferative effects on breast cancer cells and potential reduced endometrial impact. Pharmaceuticals, 16.","DOI":"10.3390\/ph16111576"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"52","DOI":"10.14715\/cmb\/2025.70.1.6","article-title":"Alpha-mangostin and nab-paclitaxel in breast cancer cell models: Improved antitumor efficacy through combination therapy","volume":"71","author":"Atalar","year":"2025","journal-title":"Cell. Mol. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Lara-Sotelo, G., D\u00edaz, L., Garc\u00eda-Becerra, R., Avila, E., Prado-Garcia, H., Morales-Guadarrama, G., Ibarra-S\u00e1nchez, M.d.J., Esparza-L\u00f3pez, J., Larrea, F., and Garc\u00eda-Quiroz, J. (2021). \u03b1-mangostin synergizes the antineoplastic effects of 5-fluorouracil allowing a significant dose reduction in breast cancer cells. Processes, 9.","DOI":"10.3390\/pr9030458"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Megantara, S., Wathoni, N., Mohammed, A.F.A., Suhandi, C., Ishmatullah, M.H., and Putri, M.F. (2022). In silico study: Combination of \u03b1-mangostin and chitosan conjugated with trastuzumab against human epidermal growth factor receptor 2. Polymers, 14.","DOI":"10.3390\/polym14132747"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Amalia, R., Dewi, C., Fristiohady, A., Fakih, T.M., and Muchtaridi, M. (2025). Unraveling the influence of \u03b1-mangostin on MDA-MB-231 cell line via WNT\/\u03b2-catenin signaling pathway: In silico and in vitro approaches. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1600281"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1021\/acs.molpharmaceut.5c01357","article-title":"Regulation of CAF by \u03b1-Mangostin Promotes the Penetration of Nanomedicine and Inhibits the Metastasis of Breast Tumor","volume":"23","author":"Wang","year":"2026","journal-title":"Mol. Pharm."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.56499\/jppres24.2214_13.4.1110","article-title":"Radioiodinated bis-(\u03b1-mangostin)-cobalt (II) ([131I]I-AM-Co): Radiolabelling, in vitro and in vivo evaluation for breast cancer radiopharmaceutical","volume":"13","author":"Mardianingrum","year":"2025","journal-title":"J. Pharm. Pharmacogn. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"423","DOI":"10.56499\/jppres23.1827_12.3.423","article-title":"Synthesis and computational study of metal complex of \u03b1-mangostin as an anticancer candidate","volume":"12","author":"Mardianingrum","year":"2025","journal-title":"J. Pharm. Pharmacogn. Res."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Nurhidayah, W., Widyasari, E.M., Daruwati, I., Mahendra, I., Subroto, T., Khairul Ikram, N.K., and Muchtaridi, M. (2023). Radiosynthesis, Stability, Lipophilicity, and Cellular Uptake Evaluations of [(131)I]Iodine-\u03b1-Mangostin for Breast Cancer Diagnosis and Therapy. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24108678"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Muchtaridi, M., Suryani, A.I., Wathoni, N., Herdiana, Y., Mohammed, A.F., Gazzali, A.M., Lesmana, R., and Joni, I.M. (2023). Chitosan\/Alginate Polymeric Nanoparticle-Loaded \u03b1-Mangostin: Characterization, Cytotoxicity, and In Vivo Evaluation against Breast Cancer Cells. Polymers, 15.","DOI":"10.3390\/polym15183658"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Meylina, L., Muchtaridi, M., Joni, I.M., Elamin, K.M., and Wathoni, N. (2023). Hyaluronic Acid-Coated Chitosan Nanoparticles as an Active Targeted Carrier of Alpha Mangostin for Breast Cancer Cells. Polymers, 15.","DOI":"10.3390\/polym15041025"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Herdiana, Y., Wathoni, N., Shamsuddin, S., and Muchtaridi, M. (2023). Cytotoxicity Enhancement of \u03b1-Mangostin with Folate-Conjugated Chitosan Nanoparticles in MCF-7 Breast Cancer Cells. Molecules, 28.","DOI":"10.3390\/molecules28227585"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Herdiana, Y., Wathoni, N., Shamsuddin, S., and Muchtaridi, M. (2022). Cytotoxicity Enhancement in MCF-7 Breast Cancer Cells with Depolymerized Chitosan Delivery of \u03b1-Mangostin. Polymers, 14.","DOI":"10.3390\/polym14153139"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"33","DOI":"10.7150\/ijms.28135","article-title":"Complete disaggregation of MCF-7-derived breast tumour spheroids with very low concentrations of \u03b1-mangostin loaded in CD44 thioaptamer-tagged nanoparticles","volume":"16","author":"Pazzini","year":"2019","journal-title":"Int. J. Med. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Wathoni, N., Meylina, L., Rusdin, A., Mohammed, A.F.A., Tirtamie, D., Herdiana, Y., Motoyama, K., Panatarani, C., Joni, I.M., and Lesmana, R. (2021). The potential cytotoxic activity enhancement of \u03b1-mangostin in chitosan-kappa carrageenan-loaded nanoparticle against MCF-7 cell line. Polymers, 13.","DOI":"10.3390\/polym13111681"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Fitriana, D., Setiawan, V.N., Raniaputri, S., Zafira, W.A., Sadaqa, E., Ahmadi, A., Riani, C., and Mudhakir, D. (2026). Refining in vitro cytotoxicity of \u03b1-mangostin against triple-negative breast cancer using dequalinium-modified liposomal nanocarrier. J. Liposome Res., 1\u201311.","DOI":"10.1080\/08982104.2026.2635603"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e16045","DOI":"10.1016\/j.heliyon.2023.e16045","article-title":"General toxicity studies of alpha mangostin from Garcinia mangostana: A systematic review","volume":"9","author":"Setyawati","year":"2023","journal-title":"Heliyon"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1158\/1055-9965.EPI-20-0016","article-title":"A complex systems model of breast cancer etiology: The paradigm II conceptual model","volume":"29","author":"Hiatt","year":"2020","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1186\/s12964-024-01863-9","article-title":"Targeting mutant p53: A key player in breast cancer pathogenesis and beyond","volume":"22","author":"Qayoom","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-024-02108-4","article-title":"Breast cancer: Pathogenesis and treatments","volume":"10","author":"Xiong","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_60","first-page":"198","article-title":"Family history of breast cancer and breast cancer risk between malays ethnicity in Malaysia and Indonesia: A meta-analysis","volume":"48","author":"Nindrea","year":"2019","journal-title":"Iran. J. Public Health"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Pfeiffer, R.M., Park, Y., Kreimer, A.R., Lacey, J.V., Pee, D., Greenlee, R.T., Buys, S.S., Hollenbeck, A., Rosner, B., and Gail, M.H. (2013). Risk prediction for breast, endometrial, and ovarian cancer in white women aged 50 y or older: Derivation and validation from population-based cohort studies. PLoS Med., 10.","DOI":"10.1371\/journal.pmed.1001492"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Johnson, K.E., Siewert, K.M., Klarin, D., Damrauer, S.M., Program, V.M.V., Chang, K.-M., Tsao, P.S., Assimes, T.L., Maxwell, K.N., and Voight, B.F. (2020). The relationship between circulating lipids and breast cancer risk: A Mendelian randomization study. PLoS Med., 17.","DOI":"10.1371\/journal.pmed.1003302"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1038\/s12276-021-00681-0","article-title":"Roles of circadian clocks in cancer pathogenesis and treatment","volume":"53","author":"Lee","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1039\/D4NA00086B","article-title":"Cutting-edge approaches for targeted drug delivery in breast cancer: Beyond conventional therapies","volume":"6","author":"Chaudhari","year":"2024","journal-title":"Nanoscale Adv."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Sun, X., Liu, K., Lu, S., He, W., and Du, Z. (2022). Targeted therapy and immunotherapy for heterogeneous breast cancer. Cancers, 14.","DOI":"10.3390\/cancers14215456"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11523-021-00796-4","article-title":"An overview of PARP inhibitors for the treatment of breast cancer","volume":"16","author":"Cortesi","year":"2021","journal-title":"Target. Oncol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s13205-023-03636-6","article-title":"Vinca alkaloids as a potential cancer therapeutics: Recent update and future challenges","volume":"13","author":"Banyal","year":"2023","journal-title":"3 Biotech."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"375","DOI":"10.14740\/wjon2586","article-title":"Mechanism of Action of Resveratrol Affecting the Biological Function of Breast Cancer Through the Glycolytic Pathway","volume":"16","author":"Gao","year":"2025","journal-title":"World J. Oncol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Osakwe, O. (2016). The Significance of Discovery Screening and Structure Optimization Studies, Elsevier.","DOI":"10.1016\/B978-0-12-802220-7.00005-3"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Chang, Y., Hawkins, B.A., Du, J.J., Groundwater, P.W., Hibbs, D.E., and Lai, F. (2022). A Guide to In Silico Drug Design. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15010049"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"124367","DOI":"10.1016\/j.jchromb.2024.124367","article-title":"Extension of impurity profiling on eltrombopag olamine to in-silico predictions: An effort to exploit correlated forced degradation products and known drug-related substances in drug discovery","volume":"1248","author":"Ganorkar","year":"2024","journal-title":"J. Chromatogr. B"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1080\/07391102.2022.2068074","article-title":"Alpha-mangostin as an inhibitor of GSK3\u03b2 in triple-negative breast cancer","volume":"41","author":"Citra","year":"2023","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.31788\/RJC.2019.1245391","article-title":"Antagonistic mechanism of \u03b1-mangostin derivatives against human estrogen receptor \u03b1 of breast cancer using molecular dynamics simulation","volume":"12","author":"Muchtaridi","year":"2019","journal-title":"Rasayan J. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.1021\/acs.jcim.1c00926","article-title":"Synthesis, Anticancer Activity, Structure\u2013Activity Relationship, and Molecular Modeling Studies of \u03b1-Mangostin Derivatives as hER\u03b1 Inhibitor","volume":"62","author":"Mardianingrum","year":"2022","journal-title":"J. Chem. Inf. Model."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Jain, A.K., Singh, D., Dubey, K., Maurya, R., Mittal, S., and Pandey, A.K. (2018). Models and Methods for In Vitro Toxicity, Elsevier Academic Press.","DOI":"10.1016\/B978-0-12-804667-8.00003-1"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Shingatgeri, V.M. (2018). Safety Concerns Using Cell-Based In Vitro Methods for Toxicity Assessment, Elsevier Academic Press.","DOI":"10.1016\/B978-0-12-804667-8.00010-9"},{"key":"ref_77","unstructured":"Castell, J.V., and G\u00f3mez-Lech\u00f3n, M.J. (1997). In Vitro Methods in Pharmaceutical Research, Academic Press."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"113858","DOI":"10.1016\/j.jconrel.2025.113858","article-title":"In vitro-in vivo relationship and microstructural insights into long-acting levonorgestrel intrauterine systems","volume":"383","author":"Fanse","year":"2025","journal-title":"J. Control Release"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"141257","DOI":"10.1016\/j.ijbiomac.2025.141257","article-title":"Acyl chitosan based self-nanoemulsifying drug delivery system of lipophilic drug with enhanced oral bioavailability and mucoadhesion: Formulation development, optimization and in vitro\/in vivo characterization","volume":"306","author":"Sabale","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"175980","DOI":"10.1016\/j.scitotenv.2024.175980","article-title":"Bioaccessibility and bioavailability assessment of cadmium in rice: In vitro simulators with\/without gut microbiota and validation through in vivo mouse and human data","volume":"953","author":"Xu","year":"2024","journal-title":"Sci. Total. Environ."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"100003","DOI":"10.1016\/j.namjnl.2024.100003","article-title":"New frontiers in anti-cancer drug testing: The need for a relevant In vitro testing model","volume":"1","author":"AM","year":"2025","journal-title":"NAM J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.toxlet.2024.11.007","article-title":"An overview of immunotoxicity in drug discovery and development","volume":"403","author":"Nandre","year":"2025","journal-title":"Toxicol. Lett."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jsps.2012.05.002","article-title":"Review on in vivo and in vitro methods evaluation of antioxidant activity","volume":"21","author":"Alam","year":"2013","journal-title":"Saudi Pharm. J."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Shibata, M.-A., Iinuma, M., Morimoto, J., Kurose, H., Akamatsu, K., Okuno, Y., Akao, Y., and Otsuki, Y. (2011). \u03b1-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation. BMC Med., 9.","DOI":"10.1186\/1741-7015-9-69"},{"key":"ref_85","first-page":"2485","article-title":"Panaxanthone isolated from pericarp of Garcinia mangostana L. suppresses tumor growth and metastasis of a mouse model of mammary cancer","volume":"29","author":"Doi","year":"2009","journal-title":"Anticancer. Res."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Dong, R., Wang, J., Guan, R., Sun, J., Jin, P., and Shen, J. (2025). Role of Oxidative Stress in the Occurrence, Development, and Treatment of Breast Cancer. Antioxidants, 14.","DOI":"10.3390\/antiox14010104"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"46","DOI":"10.61166\/clean.v2i2.13","article-title":"The Role of Oxidative Stress in Breast Cancer Pathogenesis and Progression","volume":"2","author":"Abdulrahim","year":"2025","journal-title":"Cleanliness J. Health Sci. Med. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4068\/cmj.2025.61.1.32","article-title":"Reactive Oxygen Species: Role in Pathophysiology, and Mechanism of Endogenous and Dietary Antioxidants during Oxidative Stress","volume":"61","author":"Sikder","year":"2025","journal-title":"Chonnam Med. J."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Manful, C.F., Fordjour, E., Subramaniam, D., Sey, A.A., Abbey, L., and Thomas, R. (2025). Antioxidants and Reactive Oxygen Species: Shaping Human Health and Disease Outcomes. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26157520"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch. Toxicol."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Kozlov, A.V., Javadov, S., and Sommer, N. (2024). Cellular ROS and Antioxidants: Physiological and Pathological Role. Antioxidants, 13.","DOI":"10.3390\/antiox13050602"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"101908","DOI":"10.1016\/j.nexres.2026.101908","article-title":"The significance of antioxidants and their cellular mechanisms that defend against oxidative stress: A review","volume":"10","author":"Dilshad","year":"2026","journal-title":"Next Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41420-024-02278-8","article-title":"Free radicals and their impact on health and antioxidant defenses: A review","volume":"11","author":"Chandimali","year":"2025","journal-title":"Cell Death Discov."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41392-026-02583-x","article-title":"Reactive oxygen species (ROS) in cancer: From mechanism to therapeutic implications","volume":"11","author":"Akter","year":"2026","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10549-022-06633-0","article-title":"Abundance of reactive oxygen species (ROS) is associated with tumor aggressiveness, immune response, and worse survival in breast cancer","volume":"194","author":"Oshi","year":"2022","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Wang, M., Xiao, Y., Miao, J., Zhang, X., Liu, M., Zhu, L., Liu, H., Shen, X., Wang, J., and Xie, B. (2025). Oxidative Stress and Inflammation: Drivers of Tumorigenesis and Therapeutic Opportunities. Antioxidants, 14.","DOI":"10.3390\/antiox14060735"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"104820","DOI":"10.1016\/j.critrevonc.2025.104820","article-title":"Autophagy and oxidative stress in solid tumors: Mechanisms and therapeutic opportunities","volume":"212","year":"2025","journal-title":"Crit. Rev. Oncol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Gri\u00f1an-Lison, C., Blaya-C\u00e1novas, J.L., L\u00f3pez-Tejada, A., \u00c1valos-Moreno, M., Navarro-Oc\u00f3n, A., Cara, F.E., Gonz\u00e1lez-Gonz\u00e1lez, A., Lorente, J.A., Marchal, J.A., and Granados-Principal, S. (2021). Antioxidants for the Treatment of Breast Cancer: Are We There Yet?. Antioxidants, 10.","DOI":"10.3390\/antiox10020205"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Li, Y., Zhang, X., Wang, Z., Li, B., and Zhu, H. (2023). Modulation of redox homeostasis: A strategy to overcome cancer drug resistance. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1156538"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"102754","DOI":"10.1016\/j.redox.2023.102754","article-title":"Drug-induced oxidative stress in cancer treatments: Angel or devil?","volume":"63","author":"Jiang","year":"2023","journal-title":"Redox Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/ijmm.2022.5176","article-title":"The metabolic and molecular mechanisms of \u03b1-mangostin in cardiometabolic disorders (Review)","volume":"50","author":"John","year":"2022","journal-title":"Int. J. Mol. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"21018","DOI":"10.1038\/srep21018","article-title":"Protective effect of alpha-mangostin against oxidative stress induced-retinal cell death","volume":"6","author":"Fang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12986-016-0148-0","article-title":"Alpha-mangostin from mangosteen (Garcinia mangostana Linn.) pericarp extract reduces high fat-diet induced hepatic steatosis in rats by regulating mitochondria function and apoptosis","volume":"13","author":"Tsai","year":"2016","journal-title":"Nutr. Metab."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Huang, W., Lv, Y., Zou, C., Ge, C., Zhan, S., Shen, X., Wu, L., Wang, X., Yuan, H., and Lin, G. (2025). Mangosteen Pericarp Extract Mitigates Diquat-Induced Hepatic Oxidative Stress by NRF2\/HO-1 Activation, Intestinal Barrier Integrity Restoration, and Gut Microbiota Modulation. Antioxidants, 14.","DOI":"10.3390\/antiox14091045"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Ngo, V., and Duennwald, M.L. (2022). Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease. Antioxidants, 11.","DOI":"10.3390\/antiox11122345"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Ruankham, W., Suwanjang, W., Phopin, K., Songtawee, N., Prachayasittikul, V., and Prachayasittikul, S. (2022). Modulatory Effects of Alpha-Mangostin Mediated by SIRT1\/3-FOXO3a Pathway in Oxidative Stress-Induced Neuronal Cells. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.714463"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"103","DOI":"10.32889\/actabioina.103","article-title":"The role of Nrf2 transcription factors in various physiological and pathological states","volume":"6","author":"Yastani","year":"2024","journal-title":"Acta Biochim. Indones."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e70013","DOI":"10.1002\/biof.70013","article-title":"The role of NRF2 transcription factor in inflammatory skin diseases","volume":"51","author":"Salman","year":"2025","journal-title":"Biofactors"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"47425","DOI":"10.18632\/oncotarget.17659","article-title":"Alpha-mangostin induces apoptosis through activation of reactive oxygen species and ASK1\/p38 signaling pathway in cervical cancer cells","volume":"8","author":"Lee","year":"2017","journal-title":"Oncotarget"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.fct.2014.01.040","article-title":"\u03b1-Mangostin-induced apoptosis is mediated by estrogen receptor \u03b1 in human breast cancer cells","volume":"66","author":"Won","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_111","first-page":"329635","article-title":"Mitochondria-ros crosstalk in the control of cell death and aging","volume":"2012","author":"Marchi","year":"2012","journal-title":"J. Signal Transduct."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"9051542","DOI":"10.1155\/2019\/9051542","article-title":"ROS-Mediated Cancer Cell Killing through Dietary Phytochemicals","volume":"2019","author":"NavaneethaKrishnan","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/aps.2014.43","article-title":"\u03b1-Mangostin suppresses human gastric adenocarcinoma cells in vitro via blockade of Stat3 signaling pathway","volume":"35","author":"Shan","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4314\/tjpr.v19i1.4","article-title":"\u03b1-Mangostin protects against myocardial ischemia reperfusion injury by suppressing the activation of HIF-1\u03b1","volume":"19","author":"Jiang","year":"2020","journal-title":"Trop. J. Pharm. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3985082","DOI":"10.1155\/2018\/3985082","article-title":"Induction of Apoptosis and Inhibition of Epithelial Mesenchymal Transition by \u03b1-Mangostin in MG-63 Cell Lines","volume":"2018","author":"Park","year":"2018","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"546353","DOI":"10.1155\/2014\/546353","article-title":"alpha-Mangostin Suppresses the Viability and Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells by Downregulating the PI3K\/Akt Pathway","volume":"2014","author":"Xu","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"7981397","DOI":"10.1155\/2016\/7981397","article-title":"Synergic Effect of \u03b1-Mangostin on the Cytotoxicity of Cisplatin in a Cervical Cancer Model","volume":"2016","author":"Jurado","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1177\/1535370218819743","article-title":"Acute toxicity and teratogenicity of \u03b1-mangostin in zebrafish embryos","volume":"243","author":"Kittipaspallop","year":"2018","journal-title":"Exp. Biol. Med."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Fazry, S., Noordin, M.A.M., Sanusi, S., Noor, M.M., Aizat, W.M., Lazim, A.M., Dyari, H.R.E., Jamar, N.H., Remali, J., and Othman, B.A. (2018). Cytotoxicity and Toxicity Evaluation of Xanthone Crude Extract on Hypoxic Human Hepatocellular Carcinoma and Zebrafish (Danio rerio) Embryos. Toxics, 6.","DOI":"10.3390\/toxics6040060"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1080\/07391102.2020.1841031","article-title":"\u03b1-Mangostin and its derivatives against estrogen receptor alpha","volume":"40","author":"Mardianingrum","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"24100","DOI":"10.1074\/jbc.M115.648345","article-title":"Modulator of Apoptosis 1 (MOAP-1) Is a Tumor Suppressor Protein Linked to the RASSF1A Protein","volume":"290","author":"Law","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1038\/s41388-017-0086-y","article-title":"Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein","volume":"37","author":"Cheng","year":"2018","journal-title":"Oncogene"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1158\/0008-5472.CAN-06-1794","article-title":"Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells","volume":"67","author":"Little","year":"2007","journal-title":"Cancer Res."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/8\/998\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:28:45Z","timestamp":1786681725000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/8\/998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":123,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["antiox15080998"],"URL":"https:\/\/doi.org\/10.3390\/antiox15080998","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]}}}