{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T05:24:09Z","timestamp":1787203449072,"version":"build-2736575974"},"reference-count":159,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["PK.1.1.10.0003"],"award-info":[{"award-number":["PK.1.1.10.0003"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"award":["PK.1.1.10.0003"],"award-info":[{"award-number":["PK.1.1.10.0003"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Testicular torsion is a time-critical urological emergency in which surgical detorsion, the only accepted treatment, simultaneously rescues and injures the gonad. Restoration of blood flow triggers a burst of reactive oxygen and nitrogen species, neutrophil recruitment, inflammasome activation, and regulated germ cell death, so that a substantial proportion of anatomically salvaged testes still undergo atrophy and functional loss. A large experimental literature, running to several hundred reports, has shown that antioxidants of almost every chemical class attenuate this injury in rodent models, yet no antioxidant has entered routine clinical use as an adjunct to detorsion in humans, and we are not aware of any adequately powered randomized trial in this setting. This narrative review integrates the redox pathophysiology of testicular ischemia\u2013reperfusion injury with an appraisal of the agents tested against it, and then asks why the translational gap has proved so durable. We examine model heterogeneity, the dominance of pretreatment designs that cannot be reproduced in an emergency department, the reliance on short-term surrogate biochemistry rather than fertility endpoints, and the sobering precedents of neuroprotection and cardioprotection. We close with a roadmap for first-in-human evaluation, covering candidate prioritization, route and timing of administration, biomarker selection, and a feasible trial architecture.<\/jats:p>","DOI":"10.3390\/antiox15081029","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:11:57Z","timestamp":1787058717000},"page":"1029","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antioxidant Strategies in Testicular Ischemia\u2013Reperfusion Injury\u2014Translational Insights and Clinical Implications for Testicular Torsion Management"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4218-6184","authenticated-orcid":false,"given":"Marko","family":"Ba\u0161kovi\u0107","sequence":"first","affiliation":[{"name":"School of Medicine, Catholic University of Croatia, Ilica 242, 10000 Zagreb, Croatia"},{"name":"Department of Pediatric Surgery, Children\u2019s Hospital Zagreb, Ulica Vjekoslava Klai\u0107a 16, 10000 Zagreb, Croatia"},{"name":"School of Medicine, University of Zagreb, \u0160alata 3, 10000 Zagreb, Croatia"},{"name":"Scientific Centre of Excellence for Reproductive and Regenerative Medicine, School of Medicine, University of Zagreb, \u0160alata 3, 10000 Zagreb, Croatia"},{"name":"Croatian Academy of Medical Sciences, Kaptol 15, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1528-5462","authenticated-orcid":false,"given":"Davor","family":"Je\u017eek","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Zagreb, \u0160alata 3, 10000 Zagreb, Croatia"},{"name":"Scientific Centre of Excellence for Reproductive and Regenerative Medicine, School of Medicine, University of Zagreb, \u0160alata 3, 10000 Zagreb, Croatia"},{"name":"Department of Histology and Embryology, School of Medicine, University of Zagreb, \u0160alata 3, 10000 Zagreb, Croatia"},{"name":"Department of Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Ki\u0161pati\u0107eva 12, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1177\/145749690709600112","article-title":"A 19-year review of paediatric patients with acute scrotum","volume":"96","author":"Rajakorpi","year":"2007","journal-title":"Scand. J. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000474799","article-title":"Etiology of acute scrotum at surgical exploration in children, adolescents and adults","volume":"21","author":"Leibovitch","year":"1992","journal-title":"Eur. Urol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.suc.2016.08.012","article-title":"Pediatric testicular torsion","volume":"97","author":"Bowlin","year":"2017","journal-title":"Surg. Clin. N. Am."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1016\/j.juro.2011.07.024","article-title":"Pediatric testicular torsion epidemiology using a national database. Incidence, risk of orchiectomy and possible measures toward improving the quality of care","volume":"186","author":"Zhao","year":"2011","journal-title":"J. Urol."},{"key":"ref_5","first-page":"835","article-title":"Testicular torsion. Diagnosis, evaluation, and management","volume":"88","author":"Sharp","year":"2013","journal-title":"Am. Fam. Physician"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1055\/a-0826-4885","article-title":"Validation of a TWIST score in diagnosis of testicular torsion. Single-center experience","volume":"231","year":"2019","journal-title":"Klin. Padiatr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.21037\/tau.2017.09.10","article-title":"Degree of twisting and duration of symptoms are prognostic factors of testis salvage during episodes of testicular torsion","volume":"6","author":"Howe","year":"2017","journal-title":"Transl. Androl. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ajem.2023.01.031","article-title":"High risk and low prevalence diseases. Testicular torsion","volume":"66","author":"Lacy","year":"2023","journal-title":"Am. J. Emerg. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/humrep\/deac271","article-title":"Testicular torsion and subsequent testicular function in young men from the general population","volume":"38","author":"Hansen","year":"2023","journal-title":"Hum. Reprod."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"T\u00f6rzs\u00f6k, P., Steiner, C., Pallauf, M., Abenhardt, M., Milinovic, L., Plank, B., R\u00fcckl, A., Sieberer, M., Lusuardi, L., and Deininger, S. (2022). Long-term follow-up after testicular torsion. Prospective evaluation of endocrine and exocrine testicular function, fertility, oxidative stress and erectile function. J. Clin. Med., 11.","DOI":"10.3390\/jcm11216507"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrurol.2014.135","article-title":"Mechanisms of testicular torsion and potential protective agents","volume":"11","author":"Karaguzel","year":"2014","journal-title":"Nat. Rev. Urol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.mam.2004.02.020","article-title":"Spermatic torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury","volume":"25","author":"Filho","year":"2004","journal-title":"Mol. Asp. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1097\/01.ju.0000144203.30718.19","article-title":"The molecular pathology of experimental testicular torsion suggests adjunct therapy to surgical repair","volume":"172","author":"Turner","year":"2004","journal-title":"J. Urol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"488","DOI":"10.2164\/jandrol.108.005132","article-title":"Oxidative stress. A common factor in testicular dysfunction","volume":"29","author":"Turner","year":"2008","journal-title":"J. Androl."},{"key":"ref_15","first-page":"16","article-title":"Testicular torsion, oxidative stress and the role of antioxidant therapy","volume":"48","author":"Dokmeci","year":"2006","journal-title":"Folia Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1095\/biolreprod57.6.1267","article-title":"Acute testicular ischemia results in germ cell-specific apoptosis in the rat","volume":"57","author":"Turner","year":"1997","journal-title":"Biol. Reprod."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1095\/biolreprod63.5.1465","article-title":"Molecular pathway of germ cell apoptosis following ischemia\/reperfusion of the rat testis","volume":"63","author":"Lysiak","year":"2000","journal-title":"Biol. Reprod."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1095\/biolreprod65.3.718","article-title":"Essential role of neutrophils in germ cell-specific apoptosis following ischemia\/reperfusion injury of the mouse testis","volume":"65","author":"Lysiak","year":"2001","journal-title":"Biol. Reprod."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1111\/andr.13418","article-title":"Testicular torsion in vivo models. Mechanisms and treatments","volume":"11","author":"Minas","year":"2023","journal-title":"Andrology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/iju.13110","article-title":"Testicular torsion-detorsion and potential therapeutic treatments. A possible role for ischemic postconditioning","volume":"23","author":"Shimizu","year":"2016","journal-title":"Int. J. Urol."},{"key":"ref_21","first-page":"CD007411","article-title":"Antioxidants for male subfertility","volume":"5","author":"Smits","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.fertnstert.2019.11.008","article-title":"The effect of antioxidants on male factor infertility. The Males, Antioxidants, and Infertility (MOXI) randomized clinical trial","volume":"113","author":"Steiner","year":"2020","journal-title":"Fertil. Steril."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/j.1464-410X.2010.09557.x","article-title":"Outcomes of scrotal exploration for acute scrotal pain suspicious of testicular torsion. A consecutive case series of 173 patients","volume":"107","author":"Molokwu","year":"2011","journal-title":"BJU Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.juro.2016.09.087","article-title":"Improving organ salvage in testicular torsion. Comparative study of patients undergoing vs not undergoing preoperative manual detorsion","volume":"197","author":"Riccetto","year":"2017","journal-title":"J. Urol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1177\/03915603241229800","article-title":"Manual detorsion in pediatric testicular torsion. A narrative review of the literature","volume":"91","author":"Scheier","year":"2024","journal-title":"Urologia"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"298","DOI":"10.5534\/wjmh.190037","article-title":"The impact of testicular torsion on testicular function","volume":"38","author":"Jacobsen","year":"2020","journal-title":"World J. Mens Health"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"M\u00e4kel\u00e4, E.P., Roine, R.P., and Taskinen, S. (2020). Paternity, erectile function, and health-related quality of life in patients operated for pediatric testicular torsion. J. Pediatr. Urol., 16.","DOI":"10.1016\/j.jpurol.2019.10.008"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/S0140-6736(84)92056-7","article-title":"Testicular exocrine malfunction after torsion","volume":"2","author":"Thomas","year":"1984","journal-title":"Lancet"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/j.1939-4640.1995.tb00539.x","article-title":"Endocrine and exocrine effects of testicular torsion in the prepubertal and adult rat","volume":"16","author":"Becker","year":"1995","journal-title":"J. Androl."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0022-5347(01)65374-6","article-title":"Rescue of testicular function after acute experimental torsion","volume":"157","author":"Prillaman","year":"1997","journal-title":"J. Urol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1590\/S0102-86502009000200008","article-title":"Ipsilateral testicular necrosis and atrophy after 1080-degree torsion of the spermatic cord in rats","volume":"24","author":"Romero","year":"2009","journal-title":"Acta Cir. Bras."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/j.1939-4640.1985.tb00817.x","article-title":"Acute experimental testicular torsion. No effect on the contralateral testis","volume":"6","author":"Turner","year":"1985","journal-title":"J. Androl."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/j.1939-4640.1984.tb00781.x","article-title":"The effect of prepubertal spermatic cord torsion on subsequent fertility in rats","volume":"5","author":"Cosentino","year":"1984","journal-title":"J. Androl."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000475039","article-title":"Is ipsilateral testis mandatory for the occurrence of contralateral intratesticular biochemical changes indicative of hypoxia after unilateral spermatic cord torsion?","volume":"28","year":"1995","journal-title":"Eur. Urol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1464-410X.1989.tb05949.x","article-title":"Contralateral testicular blood flow during unilateral testicular torsion","volume":"63","author":"Tanyel","year":"1989","journal-title":"Br. J. Urol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00383-006-1854-x","article-title":"Effect of testicular ischemia-reperfusion on recruitment of neutrophils, E-selectin expression and germ cell apoptosis in the contralateral testis in a rat","volume":"23","author":"Sukhotnik","year":"2007","journal-title":"Pediatr. Surg. Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1097\/PEC.0000000000001287","article-title":"A systematic review of testicle survival time after a torsion event","volume":"35","author":"Mellick","year":"2019","journal-title":"Pediatr. Emerg. Care"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ajem.2020.11.023","article-title":"Duration of symptoms is the only predictor of testicular salvage following testicular torsion in children: A case-control study","volume":"41","author":"Zvizdic","year":"2021","journal-title":"Am. J. Emerg. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/j.1939-4640.1986.tb00862.x","article-title":"Histopathology of prepubertal rat testes subjected to various durations of spermatic cord torsion","volume":"7","author":"Cosentino","year":"1986","journal-title":"J. Androl."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0022-5347(17)39462-4","article-title":"The effect of various degrees of unilateral spermatic cord torsion on fertility in the rat","volume":"144","author":"Heindel","year":"1990","journal-title":"J. Urol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Kurt, O., Yazici, C.M., Erboga, M., Turan, C., Bozdemir, Y., Akbas, A., Turker, P., Aktas, C., Aydin, M., and Yesildag, E. (2016). Mannitol has a protective effect on testicular torsion. An experimental rat model. J. Pediatr. Urol., 12.","DOI":"10.1016\/j.jpurol.2016.01.004"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-0035-1566096","article-title":"Factors predicting testicular atrophy after testicular salvage following torsion","volume":"26","author":"Lian","year":"2016","journal-title":"Eur. J. Pediatr. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e13477","DOI":"10.1111\/and.13477","article-title":"Prognosis of testicular torsion orchiopexy","volume":"52","author":"He","year":"2020","journal-title":"Andrologia"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.urology.2018.03.009","article-title":"Prospective evaluation of predictors of testis atrophy after surgery for testis torsion in children","volume":"116","author":"Grimsby","year":"2018","journal-title":"Urology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/ajum.12325","article-title":"Prediction of testicular atrophy based on sonographic findings immediately after successful manual detorsion","volume":"26","author":"Hosokawa","year":"2023","journal-title":"Australas. J. Ultrasound Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e26057","DOI":"10.1097\/MD.0000000000026057","article-title":"Ultrasound evaluation of long-term outcome in boys operated on due to testicular torsion","volume":"100","author":"Osemlak","year":"2021","journal-title":"Medicine"},{"key":"ref_47","first-page":"988","article-title":"Antisperm antibodies induced by testicular torsion and its influence on testicular function","volume":"12","author":"Fu","year":"2006","journal-title":"Zhonghua Nan Ke Xue"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/bjs.1800720332","article-title":"Testicular torsion does not cause autoimmunization in man","volume":"72","author":"Fraser","year":"1985","journal-title":"Br. J. Surg."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/j.1464-410X.1986.tb05916.x","article-title":"The fate of the human testes following unilateral torsion of the spermatic cord","volume":"58","author":"Anderson","year":"1986","journal-title":"Br. J. Urol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<255::AID-PATH526>3.0.CO;2-6","article-title":"Pathophysiology of ischaemia-reperfusion injury","volume":"190","author":"Carden","year":"2000","journal-title":"J. Pathol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.freeradbiomed.2011.11.002","article-title":"Role of reactive oxygen and nitrogen species in the vascular responses to inflammation","volume":"52","author":"Kvietys","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases. Physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1016\/j.sjbs.2020.04.024","article-title":"Inhibition of NADPH oxidase alleviates germ cell apoptosis and ER stress during testicular ischemia reperfusion injury","volume":"27","author":"Khashab","year":"2020","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Almarzouq, D., and Al-Maghrebi, M. (2023). NADPH oxidase-mediated testicular oxidative imbalance regulates the TXNIP\/NLRP3 inflammasome axis activation after ischemia reperfusion injury. Antioxidants, 12.","DOI":"10.3390\/antiox12010145"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"9376","DOI":"10.1074\/jbc.M111.314955","article-title":"NOX5 in human spermatozoa. Expression, function, and regulation","volume":"287","author":"Musset","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.stem.2013.04.001","article-title":"ROS are required for mouse spermatogonial stem cell self-renewal","volume":"12","author":"Morimoto","year":"2013","journal-title":"Cell Stem Cell"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1095\/biolreprod.114.127647","article-title":"ROS-generating oxidase Nox3 regulates the self-renewal of mouse spermatogonial stem cells","volume":"92","author":"Morimoto","year":"2015","journal-title":"Biol. Reprod."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/mrd.1080420311","article-title":"Differential incorporation of fatty acids into and peroxidative loss of fatty acids from phospholipids of human spermatozoa","volume":"42","author":"Alvarez","year":"1995","journal-title":"Mol. Reprod. Dev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/mrd.22871","article-title":"Reactive oxygen species as mediators of sperm capacitation and pathological damage","volume":"84","author":"Aitken","year":"2017","journal-title":"Mol. Reprod. Dev."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1007\/BF00869238","article-title":"Changes in the ultrastructure of components of the blood-testis barrier in circulatory hypoxia","volume":"88","author":"Gritsulyak","year":"1979","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Guazzone, V.A., and Lustig, L. (2023). Varicocele and testicular cord torsion. Immune testicular microenvironment imbalance. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1282579"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1111\/andr.13068","article-title":"Testicular torsion-detorsion causes dysfunction of mitochondrial oxidative phosphorylation","volume":"9","author":"Shih","year":"2021","journal-title":"Andrology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1159\/000020060","article-title":"Immunologic aspect of testicular torsion: Detection of antisperm antibodies in contralateral testicle","volume":"36","author":"Ataoglu","year":"1999","journal-title":"Eur. Urol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0022-5347(17)49750-3","article-title":"The effect of testicular torsion on the contralateral testis and the production of antibodies in rabbits","volume":"132","author":"Cerasaro","year":"1984","journal-title":"J. Urol."},{"key":"ref_65","first-page":"49","article-title":"Autoantibodies against Leydig cells in patients after spermatic cord torsion","volume":"55","author":"Zanchetta","year":"1984","journal-title":"Clin. Exp. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"528","DOI":"10.2164\/jandrol.106.002097","article-title":"Late hormonal levels, semen parameters, and presence of antisperm antibodies in patients treated for testicular torsion","volume":"28","author":"Arap","year":"2007","journal-title":"J. Androl."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/s41390-021-01382-0","article-title":"Testicular torsion: Its effect on autoimmunisation, pituitary-testis axis and correlation with primary gonadal dysfunction in boys","volume":"90","author":"Osemlak","year":"2021","journal-title":"Pediatr. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1124\/jpet.115.226936","article-title":"NLRP3 inflammasome involvement in the organ damage and impaired spermatogenesis induced by testicular ischemia and reperfusion in mice","volume":"355","author":"Minutoli","year":"2015","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2183026","DOI":"10.1155\/2016\/2183026","article-title":"ROS-mediated NLRP3 inflammasome activation in brain, heart, kidney, and testis ischemia\/reperfusion injury","volume":"2016","author":"Minutoli","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Al-Kandari, N., Fadel, F., Al-Saleh, F., Khashab, F., and Al-Maghrebi, M. (2019). The thioredoxin system is regulated by the ASK-1\/JNK\/p38\/survivin pathway during germ cell apoptosis. Molecules, 24.","DOI":"10.3390\/molecules24183333"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Ning, J.Z., He, K.X., Cheng, F., Li, W., Yu, W.M., Li, H.Y., Rao, T., and Ruan, Y. (2021). Long non-coding RNA MEG3 promotes pyroptosis in testicular ischemia-reperfusion injury by targeting MiR-29a to modulate PTEN expression. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.671613"},{"key":"ref_72","first-page":"3051","article-title":"Ferroptosis is associated with oxygen-glucose deprivation\/reoxygenation-induced Sertoli cell death","volume":"41","author":"Li","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Jiang, Y.P., Liu, B.G., Dang, Y., Liu, L.J., Pang, Y., Bai, X.D., Sun, F., Kang, T.H., and Zhao, Z.H. (2024). Integrative analysis of transcriptomics and metabolomics reveals the protective effect and mechanism of salidroside on testicular ischemia-reperfusion injury. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1377836"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Alotaibi, S.R., Renno, W.M., and Al-Maghrebi, M. (2024). c-Jun N-terminal kinase supports autophagy in testicular ischemia but triggers apoptosis in ischemia-reperfusion injury. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms251910446"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"23420","DOI":"10.1038\/s41598-024-74756-z","article-title":"Effect of sulforaphane on testicular ischemia-reperfusion injury induced by testicular torsion-detorsion in rats","volume":"14","author":"Wei","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/j.juro.2007.01.015","article-title":"The protective role of heme oxygenase-1 induction on testicular tissues after testicular torsion and detorsion","volume":"177","author":"Yang","year":"2007","journal-title":"J. Urol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Alnajem, A., and Al-Maghrebi, M. (2023). The regulatory effects of JAK2\/STAT3 on spermatogenesis and the redox Keap1\/Nrf2 axis in an animal model of testicular ischemia reperfusion injury. Cells, 12.","DOI":"10.3390\/cells12182292"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Antonuccio, P., Pallio, G., Marini, H.R., Irrera, N., Romeo, C., Puzzolo, D., Freni, J., Santoro, G., Pirrotta, I., and Squadrito, F. (2022). Involvement of hypoxia-inducible factor 1-alpha in experimental testicular ischemia and reperfusion. Effects of polydeoxyribonucleotide and selenium. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232113144"},{"key":"ref_79","first-page":"2","article-title":"Testicular biopsy score count. A method for registration of spermatogenesis in human testes. Normal values and results in 335 hypogonadal males","volume":"1","author":"Johnsen","year":"1970","journal-title":"Hormones"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"479","DOI":"10.4103\/0970-1591.91436","article-title":"Oxidative and antioxidative defense system in testicular torsion\/detorsion","volume":"27","author":"Elshaari","year":"2011","journal-title":"Indian J. Urol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e13012","DOI":"10.1111\/and.13012","article-title":"Reactive oxygen species impact on sperm DNA and its role in male infertility","volume":"50","author":"Bui","year":"2018","journal-title":"Andrologia"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/2090598X.2019.1599624","article-title":"Oxidative stress and sperm function. A systematic review on evaluation and management","volume":"17","author":"Dutta","year":"2019","journal-title":"Arab J. Urol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00240-004-0436-4","article-title":"Raxofelast, a hydrophilic vitamin E-like antioxidant, reduces testicular ischemia-reperfusion injury","volume":"32","author":"Romeo","year":"2004","journal-title":"Urol. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.juro.2006.06.086","article-title":"Lipid peroxidation activates mitogen-activated protein kinases in testicular ischemia-reperfusion injury","volume":"176","author":"Antonuccio","year":"2006","journal-title":"J. Urol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1620\/tjem.218.141","article-title":"Lycopene, an antioxidant carotenoid, attenuates testicular injury caused by ischemia\/reperfusion in rats","volume":"218","author":"Hekimoglu","year":"2009","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.jpedsurg.2015.11.008","article-title":"Effectiveness of lycopene on experimental testicular torsion","volume":"51","author":"Aras","year":"2016","journal-title":"J. Pediatr. Surg."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Ba\u0161kovi\u0107, M., Katu\u0161i\u0107 Bojanac, A., Sin\u010di\u0107, N., Himelreich Peri\u0107, M., Krsnik, D., and Je\u017eek, D. (2021). The effect of astaxanthin on testicular torsion-detorsion injury in rats. Detailed morphometric evaluation of histological sections. J. Pediatr. Urol., 17.","DOI":"10.1016\/j.jpurol.2021.03.020"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Ba\u0161kovi\u0107, M., Krsnik, D., Himelreich Peri\u0107, M., Katu\u0161i\u0107 Bojanac, A., Sin\u010di\u0107, N., Sonicki, Z., and Je\u017eek, D. (2022). Astaxanthin relieves testicular ischemia-reperfusion injury. Immunohistochemical and biochemical analyses. J. Clin. Med., 11.","DOI":"10.3390\/jcm11051284"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1439-0272.2009.01028.x","article-title":"Effects of co-administration of dopamine and vitamin C on ischaemia-reperfusion injury after experimental testicular torsion-detorsion in rats","volume":"43","author":"Azizollahi","year":"2011","journal-title":"Andrologia"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00383-009-2538-0","article-title":"The effects of N-acetylcysteine on testicular damage in experimental testicular ischemia\/reperfusion injury","volume":"26","author":"Bulut","year":"2010","journal-title":"Pediatr. Surg. Int."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"489248","DOI":"10.1100\/2012\/489248","article-title":"The effects of alpha-lipoic acid against testicular ischemia-reperfusion injury in rats","volume":"2012","author":"Ozbal","year":"2012","journal-title":"Sci. World J."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.urology.2007.09.030","article-title":"Beneficial effect of taurine on testicular ischemia-reperfusion injury in rats","volume":"70","author":"Wei","year":"2007","journal-title":"Urology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1007\/s00383-012-3168-5","article-title":"Beneficial effects of taurine and carnosine in experimental ischemia\/reperfusion injury in testis","volume":"28","author":"Kalaz","year":"2012","journal-title":"Pediatr. Surg. Int."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/andr.12268","article-title":"Comparison of combined antioxidants and thymoquinone in the prevention of testis ischemia-reperfusion injury","volume":"5","author":"Erol","year":"2017","journal-title":"Andrology"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.fertnstert.2007.04.065","article-title":"Effect of melatonin on testicular ischemia\/reperfusion injury in rats. Is this effect related to the proinflammatory cytokines?","volume":"89","author":"Kurcer","year":"2008","journal-title":"Fertil. Steril."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.jpedsurg.2008.01.065","article-title":"Effects of melatonin on spermatogenesis and testicular ischemia-reperfusion injury after unilateral testicular torsion-detorsion","volume":"43","author":"Abasiyanik","year":"2008","journal-title":"J. Pediatr. Surg."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1016\/j.jpedsurg.2008.11.043","article-title":"Efficacy of antioxidant treatment in the prevention of testicular atrophy in experimental testicular torsion","volume":"44","author":"Abasiyanik","year":"2009","journal-title":"J. Pediatr. Surg."},{"key":"ref_98","first-page":"582","article-title":"Effects of melatonin on testis histology, oxidative stress and spermatogenesis after experimental testis ischemia-reperfusion in rats","volume":"16","author":"Koksal","year":"2012","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_99","first-page":"141","article-title":"Protective effects of melatonin on testis histology following acute torsion-detorsion in rats","volume":"15","author":"Mirhoseini","year":"2017","journal-title":"Int. J. Reprod. Biomed."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"314","DOI":"10.4103\/1008-682X.122202","article-title":"The biochemical effects of ischemia-reperfusion injury in the ipsilateral and contralateral testes of rats and the protective role of melatonin","volume":"16","author":"Parlaktas","year":"2014","journal-title":"Asian J. Androl."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.urology.2012.06.049","article-title":"Comparison of melatonin and ozone in the prevention of reperfusion injury following unilateral testicular torsion in rats","volume":"80","author":"Ekici","year":"2012","journal-title":"Urology"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.jpedsurg.2016.11.035","article-title":"The effects of melatonin and colchicine on ischemia-reperfusion injury in experimental rat testicular torsion model","volume":"52","author":"Sekmenli","year":"2017","journal-title":"J. Pediatr. Surg."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Asghari, A., Akbari, G., Meghdadi, A., and Mortazavi, P. (2016). Effects of melatonin and metformin co-administration on testicular ischemia\/reperfusion injury in rats. J. Pediatr. Urol., 12.","DOI":"10.1016\/j.jpurol.2016.06.017"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1439-0272.2008.00806.x","article-title":"Antiapoptotic effects of dehydroepiandrosterone on testicular torsion\/detorsion in rats","volume":"40","author":"Yapanoglu","year":"2008","journal-title":"Andrologia"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00345-007-0200-9","article-title":"Protective role of erythropoietin during testicular torsion of the rats","volume":"25","author":"Yazihan","year":"2007","journal-title":"World J. Urol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s11255-013-0569-x","article-title":"Comparison of erythropoietin and sildenafil protective role against ischemia\/reperfusion injury of the testis in adult rats","volume":"46","author":"Zavras","year":"2014","journal-title":"Int. Urol. Nephrol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.bbrc.2016.09.091","article-title":"Characterization of urocortin as an anti-apoptotic protein in experimental ischemia-reperfusion model of the rat testis","volume":"479","author":"Sumii","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1210\/en.2011-1016","article-title":"Melanocortin 4 receptor activation protects against testicular ischemia-reperfusion injury by triggering the cholinergic antiinflammatory pathway","volume":"152","author":"Minutoli","year":"2011","journal-title":"Endocrinology"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1439-0272.2010.01044.x","article-title":"Protective effects of quercetin on testicular torsion\/detorsion-induced ischaemia-reperfusion injury in rats","volume":"42","author":"Aktoz","year":"2010","journal-title":"Andrologia"},{"key":"ref_110","first-page":"225","article-title":"The role of apigenin in testicular damage in experimental ischemia-reperfusion injury in rats","volume":"19","author":"Skondras","year":"2015","journal-title":"Hippokratia"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"928","DOI":"10.5114\/aoms.2015.47697","article-title":"Protective effects of hesperidin in experimental testicular ischemia\/reperfusion injury in rats","volume":"12","author":"Celik","year":"2016","journal-title":"Arch. Med. Sci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.jpedsurg.2012.01.069","article-title":"Beneficial effects of (-)-epigallocatechin gallate on ischemia-reperfusion testicular injury in rats","volume":"47","author":"Sugiyama","year":"2012","journal-title":"J. Pediatr. Surg."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00210-019-01776-2","article-title":"Epigallocatechin-3-gallate modulates germ cell apoptosis through the SAFE\/Nrf2 signaling pathway","volume":"393","author":"Alnajem","year":"2020","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_114","first-page":"129","article-title":"Genistein alleviates testicular ischemia and reperfusion injury-induced spermatogenic damage and oxidative stress by suppressing abnormal testicular matrix metalloproteinase system via the Notch 2\/Jagged 1\/Hes-1 and caspase-8 pathways","volume":"67","author":"Renno","year":"2016","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"7680182","DOI":"10.1155\/2022\/7680182","article-title":"Attenuation effect of salvianolic acid B on testicular ischemia-reperfusion injury in rats","volume":"2022","author":"Wei","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"20395","DOI":"10.1038\/s41598-023-47210-9","article-title":"Protective effect of ligustrazine on oxidative stress and apoptosis following testicular torsion in rats","volume":"13","author":"Chen","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"102459","DOI":"10.1016\/j.tice.2024.102459","article-title":"Proanthocyanidin alleviates testicular torsion\/detorsion-induced ischemia\/reperfusion injury in rats","volume":"89","author":"Kazak","year":"2024","journal-title":"Tissue Cell"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00345-013-1049-8","article-title":"The protective effects of grape seed extract on MDA, AOPP, apoptosis and eNOS expression in testicular torsion. An experimental study","volume":"31","author":"Bayatli","year":"2013","journal-title":"World J. Urol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"794","DOI":"10.4111\/kju.2010.51.11.794","article-title":"Effect of Korean red ginseng on testicular tissue injury after torsion and detorsion","volume":"51","author":"Kim","year":"2010","journal-title":"Korean J. Urol."},{"key":"ref_120","first-page":"2727","article-title":"The protective effect of goji berry extract in ischemic reperfusion in testis torsion","volume":"8","author":"Dursun","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1590\/S0102-86502011000400014","article-title":"Ternatin pretreatment attenuates testicular injury induced by torsion\/detorsion in Wistar rats","volume":"26","author":"Santos","year":"2011","journal-title":"Acta Cir. Bras."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.juro.2014.11.086","article-title":"The protective effect of apocynin on testicular ischemia-reperfusion injury","volume":"193","author":"Ozbek","year":"2015","journal-title":"J. Urol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jpurol.2013.08.007","article-title":"Investigation of tyrphostin AG 556 for testicular torsion-induced ischemia reperfusion injury in rat","volume":"10","author":"Karaguzel","year":"2014","journal-title":"J. Pediatr. Urol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"E104","DOI":"10.5489\/cuaj.3160","article-title":"An experimental study on effects of pyrrolidine dithiocarbamate on ischemia-reperfusion injury in testis","volume":"10","author":"Kemahli","year":"2016","journal-title":"Can. Urol. Assoc. J."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.juro.2010.03.103","article-title":"Simvastatin attenuates testicular injury induced by torsion-detorsion","volume":"184","author":"Yang","year":"2010","journal-title":"J. Urol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1159\/000321492","article-title":"Effects of vardenafil on testicular torsion\/detorsion damage. An experimental study in pigs","volume":"86","author":"Istanbulluoglu","year":"2011","journal-title":"Urol. Int."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/and.12499","article-title":"Protective effects of udenafil citrate, piracetam and dexmedetomidine treatment on testicular torsion\/detorsion-induced ischaemia\/reperfusion injury in rats","volume":"48","author":"Tuglu","year":"2016","journal-title":"Andrologia"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000273476","article-title":"Effect of dexmedetomidine on testicular torsion\/detorsion damage in rats","volume":"84","author":"Hanci","year":"2010","journal-title":"Urol. Int."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1111\/j.1399-6576.2006.01145.x","article-title":"The preventive effects of thiopental and propofol on testicular ischemia-reperfusion injury","volume":"50","author":"Yagmurdur","year":"2006","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/and.12464","article-title":"Effects of amlodipine on ischaemia\/reperfusion injury in the rat testis","volume":"48","author":"Dogan","year":"2016","journal-title":"Andrologia"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3109\/00365591003636588","article-title":"Comparison of the protective effects of papaverine, lidocaine and verapamil on the sperm quality of the testis after induced torsion-detorsion in rats","volume":"44","author":"Shirazi","year":"2010","journal-title":"Scand. J. Urol. Nephrol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1590\/S1677-5538.IBJU.2014.01.16","article-title":"The effects of carvedilol on ischemia-reperfusion injury in the rat testis","volume":"40","author":"Parlaktas","year":"2014","journal-title":"Int. Braz. J. Urol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1590\/S0102-865020160060000008","article-title":"Protective effect of metformin on testicular ischemia\/reperfusion injury in rats","volume":"31","author":"Asghari","year":"2016","journal-title":"Acta Cir. Bras."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00204-007-0189-2","article-title":"Protective effects of ibuprofen on testicular torsion\/detorsion-induced ischemia\/reperfusion injury in rats","volume":"81","author":"Dokmeci","year":"2007","journal-title":"Arch. Toxicol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jss.2015.12.035","article-title":"FTY720 inhibits germ cell apoptosis in testicular torsion\/detorsion","volume":"202","author":"Shih","year":"2016","journal-title":"J. Surg. Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00383-006-1871-9","article-title":"The protective effect of dexpanthenol on testicular atrophy at 60th day following experimental testicular torsion","volume":"23","author":"Etensel","year":"2007","journal-title":"Pediatr. Surg. Int."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1016\/j.juro.2012.01.029","article-title":"Protective effects of hydrogen rich saline solution on experimental testicular ischemia-reperfusion injury in rats","volume":"187","author":"Jiang","year":"2012","journal-title":"J. Urol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jpedsurg.2011.09.035","article-title":"Inhaled hydrogen gas therapy for prevention of testicular ischemia\/reperfusion injury in rats","volume":"47","author":"Lee","year":"2012","journal-title":"J. Pediatr. Surg."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Lv, Y., Liu, Y.J., Yang, C., Hu, H.J., Meng, X.E., Li, M.X., and Pan, S.Y. (2013). Hyperbaric oxygen therapy in rats attenuates ischemia-reperfusion testicular injury through blockade of oxidative stress, suppression of inflammation, and reduction of nitric oxide formation. Urology, 82.","DOI":"10.1016\/j.urology.2013.04.016"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/s13287-020-01813-5","article-title":"Human umbilical cord multipotent mesenchymal stromal cells alleviate acute ischemia-reperfusion injury of spermatogenic cells via reducing inflammatory response and oxidative stress","volume":"11","author":"Zhong","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"8065771","DOI":"10.1155\/2022\/8065771","article-title":"Adipose mesenchymal stromal cell-derived exosomes prevent testicular torsion injury via activating PI3K\/AKT and MAPK\/ERK1\/2 pathways","volume":"2022","author":"Liu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Chen, F., Yin, C., Dimitropoulou, C., and Fulton, D.J.R. (2016). Cloning, characteristics, and functional analysis of rabbit NADPH oxidase 5. Front. Physiol., 7.","DOI":"10.3389\/fphys.2016.00284"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1161\/01.STR.0000254462.75851.22","article-title":"Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke","volume":"38","author":"Sena","year":"2007","journal-title":"Stroke"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1097\/00004647-199907000-00008","article-title":"Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat","volume":"19","author":"Kuroda","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.03.015","article-title":"NXY-059, a failed stroke neuroprotectant, offers no protection to stem cell-derived human neurons","volume":"27","author":"Antonic","year":"2018","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/ana.25643","article-title":"Why most acute stroke studies are positive in animals but not in patients. A systematic comparison of preclinical, early phase, and phase 3 clinical trials of neuroprotective agents","volume":"87","author":"Bonberg","year":"2020","journal-title":"Ann. Neurol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.neuropharm.2007.12.007","article-title":"Neuroprotection for ischemic stroke. Past, present and future","volume":"55","author":"Ginsberg","year":"2008","journal-title":"Neuropharmacology"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"H1723","DOI":"10.1152\/ajpheart.00553.2011","article-title":"Pathophysiology of myocardial reperfusion injury. Preconditioning, postconditioning, and translational aspects of protective measures","volume":"301","author":"Sanada","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5534\/wjmh.220067","article-title":"Impact of antioxidant therapy on natural pregnancy outcomes and semen parameters in infertile men. A systematic review and meta-analysis of randomized controlled trials","volume":"41","author":"Agarwal","year":"2023","journal-title":"World J. Mens Health"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","article-title":"Nrf2-Keap1 signaling in oxidative and reductive stress","volume":"1865","author":"Bellezza","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1001\/jama.2011.1437","article-title":"Vitamin E and the risk of prostate cancer. The Selenium and Vitamin E Cancer Prevention Trial (SELECT)","volume":"306","author":"Klein","year":"2011","journal-title":"JAMA"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/15563650802665587","article-title":"Adverse reactions associated with acetylcysteine","volume":"47","author":"Sandilands","year":"2009","journal-title":"Clin. Toxicol."},{"key":"ref_154","unstructured":"(2026, August 14). ASCOR (Ascorbic Acid Injection), Prescribing Information; DailyMed, U.S. National Library of Medicine: Bethesda, MD, USA, Available online: https:\/\/dailymed.nlm.nih.gov\/dailymed\/lookup.cfm?setid=388aad52-fc01-4784-9791-1dbc80c69306."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Sae-khow, K., Charoensappakit, A., Chiewchengchol, D., and Leelahavanichkul, A. (2023). High-dose intravenous ascorbate in sepsis, a pro-oxidant enhanced microbicidal activity and the effect on neutrophil functions. Biomedicines, 11.","DOI":"10.3390\/biomedicines11010051"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1056\/NEJMoa2200644","article-title":"Intravenous vitamin C in adults with sepsis in the intensive care unit","volume":"386","author":"Lamontagne","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/aas.14311","article-title":"Intravenous vitamin C therapy in adult patients with sepsis: A rapid practice guideline","volume":"67","author":"Alhazzani","year":"2023","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/s41419-018-0436-x","article-title":"The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2\/ARE signaling pathway","volume":"9","author":"Hu","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1096\/fj.201601209R","article-title":"Combination therapy with liposomal neuroprotectants and tissue plasminogen activator for treatment of ischemic stroke","volume":"31","author":"Fukuta","year":"2017","journal-title":"FASEB J."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/8\/1029\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T04:37:59Z","timestamp":1787200679000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/8\/1029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,18]]},"references-count":159,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["antiox15081029"],"URL":"https:\/\/doi.org\/10.3390\/antiox15081029","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,18]]}}}