{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T04:26:54Z","timestamp":1787286414021,"version":"build-2736575974"},"reference-count":59,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009562","name":"Berthold Leibinger Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009562","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Peritoneal dialysis (PD) is an effective renal replacement therapy; however, its long-term use is limited by the detrimental effects of glucose-based PD fluids on the peritoneal membrane, contributing to fibrosis and ultrafiltration failure. Previous studies have demonstrated that high-glucose exposure promotes oxidative DNA damage through upregulation of thioredoxin-interacting protein (TXNIP) expression, resulting in reduced thioredoxin (Trx) activity. This study investigated strategies to reduce oxidative stress in human peritoneal mesothelial cells exposed to high glucose concentrations. TXNIP expression, Trx activity, intracellular oxidative stress levels, and oxidative DNA damage were analyzed. High-glucose exposure caused a dose-dependent increase in TXNIP expression, a 5\u201315% reduction in Trx activity, and increased intracellular oxidative stress levels and oxidative DNA damage. Pre-treatment with the ROS scavenger N-acetylcysteine (NAC) reduced these effects. These findings demonstrate that glucose-induced TXNIP upregulation disrupts cellular redox homeostasis, resulting in increased intracellular oxidative stress and oxidative damage. Antioxidant compounds may therefore represent promising therapeutic strategies to protect the peritoneal membrane and improve long-term outcomes in PD.<\/jats:p>","DOI":"10.3390\/antiox15081032","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T09:30:53Z","timestamp":1787131853000},"page":"1032","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["N-Acetylcysteine Protects HPMCs from High-Glucose-Induced Oxidative DNA Damage"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8887-1198","authenticated-orcid":false,"given":"Tina","family":"Oberacker","sequence":"first","affiliation":[{"name":"Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, Germany"},{"name":"University of T\u00fcbingen, Geschwister-Scholl-Platz, 72074 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Leibold","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, Robert Bosch Hospital Stuttgart, Auerbachstr. 110, 70376 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Salega","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, Robert Bosch Hospital Stuttgart, Auerbachstr. 110, 70376 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"Kraft","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Nephrology, Robert Bosch Hospital Stuttgart, Auerbachstr. 110, 70376 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7300-8132","authenticated-orcid":false,"given":"Moritz","family":"Schanz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Nephrology, Robert Bosch Hospital Stuttgart, Auerbachstr. 110, 70376 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Ketteler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Geriatrics, Robert Bosch Hospital Stuttgart, Hohenheimer Str. 21, 70184 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Latus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Nephrology, Robert Bosch Hospital Stuttgart, Auerbachstr. 110, 70376 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6770-3056","authenticated-orcid":false,"given":"Severin","family":"Schricker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Nephrology, Robert Bosch Hospital Stuttgart, Auerbachstr. 110, 70376 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1093\/ndt\/gfi159","article-title":"ESRD patients in 2004: Global overview of patient numbers, treatment modalities and associated trends","volume":"20","author":"Grassmann","year":"2005","journal-title":"Nephrol. 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