{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T05:23:29Z","timestamp":1787289809721,"version":"build-2736575974"},"reference-count":77,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Cancer metastasis, characterized by the dissemination of malignant cells from the primary tumor to distant organs, remains the leading cause of cancer-related mortality in solid tumors. In colorectal cancer (CRC), increasing attention has been directed toward therapeutic strategies aimed at suppressing cancer cell migration and invasion rather than solely reducing tumor mass, giving rise to the concept of migrastatic therapies. In the present study, green-synthesized silver nanoparticles (AgNPs), previously obtained using aqueous extracts of Filipendula ulmaria (L.) Maxim. and Salvia verticillata L., were evaluated for their antimigratory and anti-inflammatory potential in human colorectal carcinoma HCT-116 cells. Treatment with AgNPs induced considerable perturbations in cellular redox homeostasis, as evidenced by increased intracellular reactive oxygen species (ROS), lipid peroxidation (LPO), glutathione (GSH), and nitric oxide (NO) levels. These redox alterations were accompanied by a significant inhibition of cancer cell migration, together with reduced expression of matrix metalloproteinases MMP-2 and MMP-9, key mediators of extracellular matrix remodeling associated with tumor progression. AgNP exposure was associated with activation of the cytoprotective transcription factor Nrf-2 and suppression of the pro-inflammatory NF-\u03baB\/COX-2 signaling axis, indicating coordinated modulation of redox-sensitive pathways linked to tumor cell motility and inflammatory responses. Collectively, these findings demonstrate that green-synthesized AgNPs derived from F. ulmaria and S. verticillata exert multi-level regulatory effects on redox balance, inflammatory signaling, and migration-associated molecular markers in colorectal cancer cells. This study supports their potential as promising migrastatic nanocarriers for further investigation in colorectal cancer research.<\/jats:p>","DOI":"10.3390\/antiox15081035","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:12:58Z","timestamp":1787155978000},"page":"1035","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Green-Synthesized Silver Nanoparticles from Filipendula ulmaria and Salvia verticillata Extracts Exert Antimetastatic and Anti-Inflammatory Effects Through Redox-Mediated Nrf-2\/NF-\u03baB\/MMP-2\/9 Signaling in Human Colon Cancer Cells"],"prefix":"10.3390","volume":"15","author":[{"given":"Milo\u0161","family":"Mati\u0107","sequence":"first","affiliation":[{"name":"Department of Biology and Ecology, Faculty of Science, University of Kragujevac, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1557-7497","authenticated-orcid":false,"given":"Milica","family":"Paunovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Biology and Ecology, Faculty of Science, University of Kragujevac, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branka","family":"Ognjanovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Biology and Ecology, Faculty of Science, University of Kragujevac, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0216-5816","authenticated-orcid":false,"given":"Nikola","family":"Sre\u0107kovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, University of Kragujevac, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9105-7680","authenticated-orcid":false,"given":"Nevena","family":"Mihailovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, University of Kragujevac, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4113-6804","authenticated-orcid":false,"given":"Vladimir","family":"Mihailovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, University of Kragujevac, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6372-1062","authenticated-orcid":false,"given":"Ana","family":"Obradovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Biology and Ecology, Faculty of Science, University of Kragujevac, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102750","DOI":"10.1016\/j.micron.2019.102750","article-title":"Silver nanoparticles induce cell death of colon cancer cells through impairing cytoskeleton and membrane nanostructure","volume":"126","author":"Xiao","year":"2019","journal-title":"Micron"},{"key":"ref_2","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","first-page":"1","article-title":"Metastasis Inhibition in Cancer","volume":"Volume 2","author":"Rezaei","year":"2024","journal-title":"Cancerous Cells: Handbook of Cancer and Immunology"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Shibata, M.A., and Taniguchi, K. (2023). Metastasis Inhibition. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087123"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Di Carlo, E., and Sorrentino, C. (2024). Oxidative Stress and Age-Related Tumors. Antioxidants, 13.","DOI":"10.3390\/antiox13091109"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3390\/oxygen2040030","article-title":"RONS and Oxidative Stress: An Overview of Basic Concepts","volume":"2","year":"2022","journal-title":"Oxygen"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Mustafa, S., Koran, S., and Al Omair, L. (2022). Insights Into the Role of Matrix Metalloproteinases in Cancer and its Various Therapeutic Aspects: A Review. Front. Mol. Biosci., 9.","DOI":"10.3389\/fmolb.2022.896099"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"15330338221105736","DOI":"10.1177\/15330338221105736","article-title":"Role of NRF2 in Colorectal Cancer Prevention and Treatment","volume":"21","author":"Li","year":"2022","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5985","DOI":"10.2147\/JIR.S479794","article-title":"The Dual Role of NRF2 in Colorectal Cancer: Targeting NRF2 as a Potential Therapeutic Approach","volume":"17","author":"Hu","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1600-065X.2012.01099.x","article-title":"NF-\u03baB and the link between inflammation and cancer","volume":"246","author":"DiDonato","year":"2012","journal-title":"Immunol. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1038\/s41417-024-00811-6","article-title":"NF-\u03baB role on tumor proliferation, migration, invasion and immune escape","volume":"31","author":"Khan","year":"2024","journal-title":"Cancer Gene Ther."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Lukas, K., Nguyen, J., Necas, C., Dave, K., and Venketaraman, V. (2025). Targeting the NF-\u03baB Pathway in Cancer: Mechanisms, Resistance, and Therapeutic Potential Across Tumor Types. Pharmaceuticals, 18.","DOI":"10.3390\/ph18111764"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Gao, W., Guo, L., Yang, Y., Wang, Y., Xia, S., Gong, H., Zhang, B.K., and Yan, M. (2022). Dissecting the Crosstalk Between Nrf2 and NF-\u03baB Response Pathways in Drug-Induced Toxicity. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.809952"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/BST20150014","article-title":"Dissecting molecular cross-talk between Nrf2 and NF-\u03baB response pathways","volume":"43","author":"Wardyn","year":"2015","journal-title":"Biochem. Soc. Trans."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Hossain, M.S., Karuniawati, H., Jairoun, A.A., Urbi, Z., Ooi, D.J., John, A., Lim, Y.C., Kibria, K.M.K., Mohiuddin, A.K.M., and Ming, L.C. (2022). Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies. Cancers, 14.","DOI":"10.3390\/cancers14071732"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"115351","DOI":"10.1016\/j.inoche.2025.115351","article-title":"Advances in plant-based nanomaterials for targeted Cancer therapy: Advances, mechanistic insights, and future prospects (2018\u20132022)","volume":"182","author":"Verma","year":"2025","journal-title":"Inorg. Chem. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Andleeb, A., Andleeb, A., Asghar, S., Zaman, G., Tariq, M., Mehmood, A., Nadeem, M., Hano, C., Lorenzo, J.M., and Abbasi, B.H. (2021). A Systematic Review of Biosynthesized Metallic Nanoparticles as a Promising Anti-Cancer-Strategy. Cancers, 13.","DOI":"10.3390\/cancers13112818"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Eker, F., Akdas\u00e7i, E., Duman, H., Bechelany, M., and Karav, S. (2025). Green Synthesis of Silver Nanoparticles Using Plant Extracts: A Comprehensive Review of Physicochemical Properties and Multifunctional Applications. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26136222"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"9420031","DOI":"10.26599\/FMH.2025.9420031","article-title":"Preparation and biological activity of polysaccharide metal ion complex and feasibility analysis of Tremella fuciformis polysaccharide with metal ions","volume":"2","author":"Bai","year":"2025","journal-title":"Food Med. Homol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1039\/D2MA01105K","article-title":"Green Synthesis of Silver Nanoparticles: Methods, Biological Applications, Delivery and Toxicity","volume":"4","author":"Vidyasagar","year":"2023","journal-title":"Mater. Adv."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"9420022","DOI":"10.26599\/FMH.2025.9420022","article-title":"Co-assembly strategies of natural plant compounds for improving their bioavailability","volume":"2","author":"Miao","year":"2025","journal-title":"Food Med. Homol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"118546","DOI":"10.1016\/j.jenvman.2023.118546","article-title":"Preferential Role of Distinct Phytochemicals in Biosynthesis and Antibacterial Activity of Silver Nanoparticles","volume":"344","author":"Liu","year":"2023","journal-title":"J. Environ. Manag."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Mati\u0107, M., Obradovi\u0107, A., Paunovi\u0107, M., Ognjanovi\u0107, B., Mihailovi\u0107, V., Sre\u0107kovi\u0107, N., and Stankovi\u0107, M. (2025). Green-synthesized silver nanoparticles using Filipendula ulmaria (L.) Maxim. and Salvia verticillata L. extracts inhibit migration and modulate redox homeostasis in human breast cancer cells via Nrf-2 signaling pathway. Antioxidants, 14.","DOI":"10.3390\/antiox14040469"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"153100","DOI":"10.1016\/j.bbrc.2025.153100","article-title":"Green synthesis of chitosan-coated silver nanoparticles from Tephrosia apollinea plant: A promising sustainable approach to colorectal cancer treatment","volume":"795","author":"Malik","year":"2026","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"100666","DOI":"10.1016\/j.hybadv.2026.100666","article-title":"Influence of plant-derived extracts on the synthesis, physicochemical properties, and applications of metal and metal oxide nanoparticles","volume":"13","author":"Baba","year":"2026","journal-title":"Hybrid Adv."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"113594","DOI":"10.1016\/j.inoche.2024.113594","article-title":"Recent Advancements in the Plant-Based Synthesis and Mechanistic Insights of Noble Metal Nanoparticles and Their Therapeutic Applications","volume":"171","author":"Khan","year":"2025","journal-title":"Inorg. Chem. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jep.2016.10.015","article-title":"In vitro and in vivo assessment of meadowsweet (Filipendula ulmaria) as anti-inflammatory agent","volume":"193","author":"Boroja","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1039\/C4FO01208A","article-title":"Bioactivity, stability and phenolic characterization of Filipendula ulmaria (L.) Maxim","volume":"6","author":"Boroja","year":"2015","journal-title":"Food Funct."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.foodchem.2005.10.062","article-title":"Antioxidant potentials and rosmarinic acid levels of the methanolic extracts of Salvia verticillata (L.) subsp. verticillata and S. verticillata (L.) subsp. amasiaca (Freyn & Bornm.) Bornm","volume":"100","author":"Tepe","year":"2007","journal-title":"Food Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"111932","DOI":"10.1016\/j.indcrop.2019.111932","article-title":"Bioactivity, biocompatibility and phytochemical assessment of lilac sage, Salvia verticillata L. (Lamiaceae)\u2014A plant rich in rosmarinic acid","volume":"143","author":"Imbimbo","year":"2020","journal-title":"Ind. Crops Prod."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Brindisi, M., Bouzidi, C., Frattaruolo, L., Loizzo, M.R., Cappello, M.S., Dugay, A., Deguin, B., Lauria, G., Cappello, A.R., and Tundis, R. (2021). New Insights into the Antioxidant and Anti-Inflammatory Effects of Italian Salvia officinalis Leaf and Flower Extracts in Lipopolysaccharide and Tumor-Mediated Inflammation Models. Antioxidants, 10.","DOI":"10.3390\/antiox10020311"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Mihailovi\u0107, V., Sre\u0107kovi\u0107, N., Nedi\u0107, Z.P., Dimitrijevi\u0107, S., Mati\u0107, M., Obradovi\u0107, A., Selakovi\u0107, D., Rosi\u0107, G., and Katani\u0107 Stankovi\u0107, J.S. (2023). Green Synthesis of Silver Nanoparticles Using Salvia verticillata and Filipendula ulmaria Extracts: Optimization of Synthesis, Biological Activities, and Catalytic Properties. Molecules, 28.","DOI":"10.3390\/molecules28020808"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.trecan.2017.04.008","article-title":"Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges","volume":"3","author":"Rosel","year":"2017","journal-title":"Trends Cancer"},{"key":"ref_34","unstructured":"Greenwald, R.E. (1985). Nitroblue Tetrazolium Reduction. CRC Handbook of Methods for Oxygen Radical Research, CRC Press."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/cber.187901201117","article-title":"Bemerkungen zu der Abhandlung der HH. Weselsky und Benedikt \u201cUeber einige Azoverbindungen\u201d","volume":"12","author":"Griess","year":"1879","journal-title":"Berichte Dtsch. Chem. Ges."},{"key":"ref_36","unstructured":"Bergmeyen, H.V. (1975). Reduced Glutathione (GSH). Red Blood Cell Metabolism: A Manual of Biochemical Methods, Grune and Stratton."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1038\/nprot.2006.378","article-title":"Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method","volume":"1","author":"Rahman","year":"2006","journal-title":"Nat. Protoc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"ref_39","first-page":"15","article-title":"Boyden chamber assay","volume":"294","author":"Chen","year":"2005","journal-title":"Methods Mol. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.2174\/1871520619666190425180610","article-title":"Anti-Tumor Mechanisms of Novel 3-(4-Substituted Benzyl)-5-Isopropil-5-Phenylhydantoin Derivatives on Human Colon Cancer Cell Line","volume":"19","year":"2019","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1002\/humu.22060","article-title":"A diagnostic genetic test for the physical mapping of germline rearrangements in the susceptibility breast cancer genes BRCA1 and BRCA2","volume":"33","author":"Cheeseman","year":"2012","journal-title":"Hum. Mutat."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Janion, K., Strzelczyk, J.K., Walkiewicz, K.W., Biernacki, K., Copija, A., Szczepa\u0144ska, E., and Nowakowska-Zajdel, E. (2022). Evaluation of Malondialdehyde Level, Total Oxidant\/Antioxidant Status and Oxidative Stress Index in Colorectal Cancer Patients. Metabolites, 12.","DOI":"10.3390\/metabo12111118"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1186\/s40001-025-02734-w","article-title":"NF-\u03baB and apoptosis: Colorectal cancer progression and novel strategies for treatment","volume":"30","author":"Sadati","year":"2025","journal-title":"Eur. J. Med. Res."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Mesas, C., Qui\u00f1onero, F., Revueltas, F., Cabeza, L., Perazzoli, G., Melguizo, C., and Prados, J. (2023). Plant-Mediated Inorganic Nanoparticles for Anti-Tumor Therapy in Colorectal Cancer: A Systematic Review. Appl. Sci., 13.","DOI":"10.3390\/app131810156"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1007\/s12672-025-02664-3","article-title":"Nanotechnology in oncology: Advances in biosynthesis, drug delivery, and theranostics","volume":"16","author":"Ammar","year":"2025","journal-title":"Discov. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"14308","DOI":"10.1021\/acs.jmedchem.0c01055","article-title":"Cytotoxic Effect of Silver Nanoparticles Synthesized by Green Methods in Cancer","volume":"63","author":"Morais","year":"2020","journal-title":"J. Med. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Cameron, S.J., Hosseinian, F., and Willmore, W.G. (2018). A Current Overview of the Biological and Cellular Effects of Nanosilver. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19072030"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.niox.2008.04.006","article-title":"Molecular mechanisms for discrete nitric oxide levels in cancer","volume":"19","author":"Ridnour","year":"2008","journal-title":"Nitric Oxide"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nrc1910","article-title":"The role of nitric oxide in tumor progression","volume":"6","author":"Fukumura","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1152\/physrev.00023.2017","article-title":"The KEAP1-NRF2 System: A Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis","volume":"98","author":"Yamamoto","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s12276-024-01180-8","article-title":"Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer","volume":"56","author":"Bae","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Chen, F., Xiao, M., Hu, S., and Wang, M. (2024). Keap1-Nrf2 pathway: A key mechanism in the occurrence and development of cancer. Front. Oncol., 14.","DOI":"10.3389\/fonc.2024.1381467"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1007\/s12013-025-01821-3","article-title":"The Central Role of NRF2 in Cancer Metabolism and Redox Signaling: Novel Insights into Crosstalk with ER Stress and Therapeutic Modulation","volume":"83","author":"Joof","year":"2025","journal-title":"Cell Biochem. Biophys."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"113429","DOI":"10.1016\/j.phytochem.2022.113429","article-title":"Antioxidant and anti-inflammation effects of dietary phytochemicals: The Nrf2\/NF-\u03baB signalling pathway and upstream factors of Nrf2","volume":"204","author":"Wu","year":"2022","journal-title":"Phytochemistry"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Gonzalez-Avila, G., Sommer, B., Garc\u00eda-Hernandez, A.A., Ramos, C., and Flores-Soto, E. (2022). Nanotechnology and Matrix Metalloproteinases in Cancer Diagnosis and Treatment. Front. Mol. Biosci., 9.","DOI":"10.3389\/fmolb.2022.918789"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Yang, M., Li, W.Y., Xie, J., Wang, Z.L., Wen, Y.L., Zhao, C.C., Tao, L., Li, L.F., Tian, Y., and Sheng, J. (2021). Astragalin Inhibits the Proliferation and Migration of Human Colon Cancer HCT116 Cells by Regulating the NF-\u03baB Signaling Pathway. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.639256"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"108720","DOI":"10.1016\/j.biotechadv.2025.108720","article-title":"Gene expression and protein abundance: Just how associated are these molecular traits?","volume":"86","author":"Samih","year":"2026","journal-title":"Biotechnol. Adv."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Augoff, K., Hryniewicz-Jankowska, A., Tabola, R., and Stach, K. (2022). MMP9: A Tough Target for Targeted Therapy for Cancer. Cancers, 14.","DOI":"10.3390\/cancers14071847"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12645-022-00132-z","article-title":"Using green biosynthesized kaempferol-coated sliver nanoparticles to inhibit cancer cells growth: An in vitro study using hepatocellular carcinoma (HepG2)","volume":"13","author":"Alyami","year":"2022","journal-title":"Cancer Nanotechnol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Shinde, A., Tang, X., Singh, R., and Brindley, D.N. (2023). Infliximab, a Monoclonal Antibody against TNF-\u03b1, Inhibits NF-\u03baB Activation, Autotaxin Expression and Breast Cancer Metastasis to Lungs. Cancers, 16.","DOI":"10.3390\/cancers16010052"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1186\/s40001-024-02168-w","article-title":"NF-\u03baB pathway and angiogenesis: Insights into colorectal cancer development and therapeutic targets","volume":"29","author":"Bahrami","year":"2024","journal-title":"Eur. J. Med. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1158\/0008-5472.CAN-09-3912","article-title":"Activation of NF-\u03baB signaling by inhibitor of NF-\u03baB kinase beta increases aggressiveness of ovarian cancer","volume":"70","author":"Hernandez","year":"2010","journal-title":"Cancer Res."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Cao, Y., Yi, Y., Han, C., and Shi, B. (2024). NF-\u03baB signaling pathway in tumor microenvironment. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1476030"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Veljkovic, A., Stanojevic, G., Brankovic, B., Roumeliotis, S., Leivaditis, K., Djordjevic, B., Li, X., Klisic, A., Hadzi-Djokic, J., and Kocic, G. (2025). MMP-9 Activation via ROS\/NF-\u03baB Signaling in Colorectal Cancer Progression: Molecular Insights and Prognostic-Therapeutic Perspectives. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47070557"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0014-5793(98)01034-5","article-title":"Synergistic upregulation of metalloproteinase-9 by growth factors and infammatory cytokines: An absolute requirement for transcription factor NF-kB","volume":"435","author":"Bond","year":"1998","journal-title":"FEBS Lett."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"8836355","DOI":"10.1155\/2021\/8836355","article-title":"The Activation of ROS\/NF-\u03baB\/MMP-9 Pathway Promotes Calcium-Induced Kidney Crystal Deposition","volume":"2021","author":"Wu","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"122007","DOI":"10.1016\/j.lfs.2023.122007","article-title":"The crosstalk between Nrf2 and NF-\u03baB pathways in coronary artery disease: Can it be regulated by SIRT6?","volume":"330","author":"Casper","year":"2023","journal-title":"Life Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s40164-024-00529-z","article-title":"Versatile function of NF-\u0138B in inflammation and cancer","volume":"13","author":"Ma","year":"2024","journal-title":"Exp. Hematol. Oncol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"8309698","DOI":"10.1155\/2018\/8309698","article-title":"Nrf2 Deficiency Unmasks the Significance of Nitric Oxide Synthase Activity for Cardioprotection","volume":"15","author":"Erkens","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"6751","DOI":"10.21873\/anticanres.14698","article-title":"Nitric Oxide Inhibits NF-\u03baB-mediated Survival Signaling: Possible Role in Overcoming TRAIL Resistance","volume":"40","author":"Bauer","year":"2020","journal-title":"Anticancer Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.yjmcc.2005.06.012","article-title":"A negative feedback mechanism involving nitric oxide and nuclear factor \u03ba-B modulates endothelial nitric oxide synthase transcription","volume":"39","author":"Grumbach","year":"2005","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1007\/s13204-021-02130-w","article-title":"Green fabrication of silver nanoparticles from Salvia species extracts: Characterization and anticancer activities against A549 human lung cancer cell line","volume":"13","author":"Rajendran","year":"2023","journal-title":"Appl. Nanosci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10876-020-01766-y","article-title":"Plant-Based Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Salvia officinalis: Characterization and its Antiplasmodial Activity","volume":"32","author":"Okaiyeto","year":"2021","journal-title":"J. Clust. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"110161","DOI":"10.1016\/j.inoche.2022.110161","article-title":"Introducing a novel chemotherapeutic supplement prepared by silver nanoparticles green-formulated by Salvia officinalis leaf aqueous extract to treat the human oral squamous cell carcinoma","volume":"146","author":"Yan","year":"2022","journal-title":"Inorg. Chem. Commun."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/8\/1035\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T04:24:10Z","timestamp":1787286250000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/8\/1035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":77,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["antiox15081035"],"URL":"https:\/\/doi.org\/10.3390\/antiox15081035","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,19]]}}}