{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:16:46Z","timestamp":1788171406071,"version":"build-2803163510"},"reference-count":56,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PI21\/00592"],"award-info":[{"award-number":["PI21\/00592"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"award":["PI21\/00592"],"award-info":[{"award-number":["PI21\/00592"]}],"id":[{"id":"https:\/\/ror.org\/05r0vyz12","id-type":"ROR","asserted-by":"publisher"}]},{"name":"CERCA Programme\/Generalitat de Catalunya"},{"id":[{"id":"https:\/\/ror.org\/01bg62x04","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Fibromyalgia is a chronic nociplastic pain disorder characterized by widespread pain and affective disturbances, in which oxidative stress and neuroinflammation are now recognized as central pathogenic mechanisms. However, current therapies provide only limited symptomatic relief. This study compared the therapeutic and molecular effects of dimethyl fumarate (DMF), an activator of nuclear factor erythroid 2-related factor 2 (NRF2), and cobalt protoporphyrin IX (CoPP), an inducer of heme oxygenase-1 (HO-1), in a reserpine-induced mouse model of fibromyalgia-like pain. Male and female C57BL\/6J mice received repeated reserpine administration to induce mechanical allodynia, thermal hyperalgesia, cold allodynia, and depressive-like behaviors. Therapeutic efficacy was evaluated by behavioral testing and molecular analyses of the periaqueductal gray (PAG), anterior cingulate cortex (ACC), and spinal cord (SC). DMF produced a faster antinociceptive response than CoPP, although both compounds ultimately reversed nociceptive hypersensitivity and depressive-like behaviors in male and female mice. These behavioral alterations were associated with increased NLRP3 expression and activated AKT signaling, together with region-specific redox dysregulation involving differential regulation of NADPH oxidases and endogenous antioxidant defenses. Both treatments differentially modulated region-specific redox alterations, enhanced selected antioxidant defenses, and attenuated inflammatory and nociception-related signaling. These findings identify region-specific redox dysregulation as a prominent feature of fibromyalgia-like pathology, providing new mechanistic insight into the molecular basis of nociplastic pain. Collectively, these results demonstrate that DMF and CoPP treatments remodel region-specific redox networks while inhibiting both sensory and affective manifestations of fibromyalgia-like pain, supporting endogenous antioxidant pathways as promising mechanism-based therapeutic targets for fibromyalgia.<\/jats:p>","DOI":"10.3390\/antiox15091080","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T18:33:52Z","timestamp":1787942032000},"page":"1080","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dimethyl Fumarate and Cobalt Protoporphyrin IX Inhibit Fibromyalgia-like Pain by Modulating Region-Specific Redox Pathways"],"prefix":"10.3390","volume":"15","author":[{"given":"Sylmara Esther","family":"Negrini-Ferrari","sequence":"first","affiliation":[{"name":"Grup de Neurofarmacologia Molecular, Institut de Recerca Sant Pau (IR SANT PAU), 08041 Barcelona, Spain"},{"name":"Grup de Neurofarmacologia Molecular, Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7118-362X","authenticated-orcid":false,"given":"Weitao","family":"Wang","sequence":"additional","affiliation":[{"name":"Grup de Neurofarmacologia Molecular, Institut de Recerca Sant Pau (IR SANT PAU), 08041 Barcelona, Spain"},{"name":"Grup de Neurofarmacologia Molecular, Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4621-8457","authenticated-orcid":false,"given":"Olga","family":"Pol","sequence":"additional","affiliation":[{"name":"Grup de Neurofarmacologia Molecular, Institut de Recerca Sant Pau (IR SANT PAU), 08041 Barcelona, Spain"},{"name":"Grup de Neurofarmacologia Molecular, Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Jurado-Priego, L.N., Cueto-Ure\u00f1a, C., Ram\u00edrez-Exp\u00f3sito, M.J., and Mart\u00ednez-Martos, J.M. (2024). Fibromyalgia: A Review of the Pathophysiological Mechanisms and Multidisciplinary Treatment Strategies. Biomedicines, 12.","DOI":"10.3390\/biomedicines12071543"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"15022","DOI":"10.1038\/nrdp.2015.22","article-title":"Fibromyalgia","volume":"1","author":"Ablin","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jpain.2010.01.002","article-title":"Comparative efficacy and harms of duloxetine, milnacipran, and pregabalin in fibromyalgia syndrome","volume":"11","author":"Petzke","year":"2010","journal-title":"J. Pain"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"30247","DOI":"10.1038\/s41598-024-81298-x","article-title":"Mitochondrial function in patients affected with fibromyalgia syndrome is impaired and correlates with disease severity","volume":"14","author":"Macchi","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"U\u00e7eyler, N., H\u00e4user, W., and Sommer, C. (2011). Systematic review with meta-analysis: Cytokines in fibromyalgia syndrome. BMC Musculoskelet. Disord., 12.","DOI":"10.1186\/1471-2474-12-245"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2147\/JPR.S128508","article-title":"Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma","volume":"10","author":"Tanum","year":"2017","journal-title":"J. Pain Res."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Siracusa, R., Di Paola, R., Cuzzocrea, S., and Impellizzeri, D. (2021). Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22083891"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Kelley, N., Jeltema, D., Duan, Y., and He, Y. (2019). The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133328"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1089\/ars.2013.5198","article-title":"NLRP3 inflammasome is activated in fibromyalgia: The effect of coenzyme Q10","volume":"20","author":"Cordero","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.2174\/1381612823666170210150147","article-title":"PI3K\/Akt Pathway: A Potential Therapeutic Target for Chronic Pain","volume":"23","author":"Chen","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"ref_11","first-page":"165","article-title":"Nitric oxide, lipid peroxidation products, and antioxidants in primary fibromyalgia and correlation with disease severity","volume":"39","author":"Shukla","year":"2020","journal-title":"J. Med. Biochem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/cbf.1548","article-title":"Levels of lipid peroxidation, nitric oxide, and antioxidant vitamins in plasma of patients with fibromyalgia","volume":"27","author":"Yalman","year":"2009","journal-title":"Cell Biochem. Funct."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/NNR.0000000000000480","article-title":"Influence of oxidative stress-related genes on susceptibility to fibromyalgia","volume":"70","author":"Rus","year":"2021","journal-title":"Nurs. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1582432","DOI":"10.1155\/2022\/1582432","article-title":"Oxidative stress in fibromyalgia: From pathology to treatment","volume":"2022","author":"Assavarittirong","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kallenborn-Gerhardt, W., Schr\u00f6der, K., and Schmidtko, A. (2022). NADPH oxidases in pain processing. Antioxidants, 11.","DOI":"10.3390\/antiox11061162"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"105280","DOI":"10.1016\/j.phrs.2020.105280","article-title":"Neuroinflammation, oxidative stress and their interplay in neuropathic pain: Focus on specialized pro-resolving mediators and NADPH oxidase inhibitors as potential therapeutic strategies","volume":"162","author":"Pinho","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbagen.2014.11.021","article-title":"Nrf2 regulates ROS production by mitochondria and NADPH oxidase","volume":"1850","author":"Kovac","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Fern\u00e1ndez, M., Su\u00e1rez-Rojas, I., Bai, X., Mart\u00ednez-Martel, I., Ciaffaglione, V., Pittal\u00e0, V., Salerno, L., and Pol, O. (2023). Novel heme oxygenase-1 inducers palliate inflammatory pain and emotional disorders by regulating NLRP3 inflammasome and activating the antioxidant pathway. Antioxidants, 12.","DOI":"10.3390\/antiox12101794"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Su\u00e1rez-Rojas, I., P\u00e9rez-Fern\u00e1ndez, M., Bai, X., Mart\u00ednez-Martel, I., Intagliata, S., Pittal\u00e0, V., Salerno, L., and Pol, O. (2023). The inhibition of neuropathic pain incited by nerve injury and accompanying mood disorders by new heme oxygenase-1 inducers: Mechanisms implicated. Antioxidants, 12.","DOI":"10.3390\/antiox12101859"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Scuderi, S.A., Ardizzone, A., Paterniti, I., Esposito, E., and Campolo, M. (2020). Antioxidant and anti-inflammatory effect of Nrf2 inducer dimethyl fumarate in neurodegenerative diseases. Antioxidants, 9.","DOI":"10.3390\/antiox9070630"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s11033-026-11478-7","article-title":"Dimethyl fumarate as a versatile therapeutic agent: Molecular mechanisms and potential clinical applications","volume":"53","author":"Zingkou","year":"2026","journal-title":"Mol. Biol. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"17562864231180734","DOI":"10.1177\/17562864231180734","article-title":"Clinical use of dimethyl fumarate in multiple sclerosis treatment: An update to include China, using a modified Delphi method","volume":"16","author":"Gold","year":"2023","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Bresciani, G., Manai, F., Davinelli, S., Tucci, P., Saso, L., and Amadio, M. (2023). Novel Potential Pharmacological Applications of Dimethyl Fumarate\u2014An Overview and Update. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1264842"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1096\/fj.06-6346fje","article-title":"Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin","volume":"20","author":"Shan","year":"2006","journal-title":"FASEB J."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ryter, S.W. (2022). Heme oxygenase-1: An anti-inflammatory effector in cardiovascular, lung, and related metabolic disorders. Antioxidants, 11.","DOI":"10.3390\/antiox11030555"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Wang, B., and Otterbein, L.E. (2022). CO and pain management. Carbon Monoxide in Drug Discovery, John Wiley & Sons Inc.","DOI":"10.1002\/9781119783435"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10787-016-0307-y","article-title":"Anti-nociceptive and anti-inflammatory actions of sulforaphane in chronic constriction injury-induced neuropathic pain mice","volume":"25","author":"Wang","year":"2017","journal-title":"Inflammopharmacology"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Ferreira-Chamorro, P., Redondo, A., Riego, G., Le\u00e1nez, S., and Pol, O. (2018). Sulforaphane inhibited the nociceptive responses, anxiety- and depressive-like behaviors associated with neuropathic pain and improved the anti-allodynic effects of morphine in mice. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.01332"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/ALN.0000000000003077","article-title":"Oral dimethyl fumarate reduces peripheral neuropathic pain in rodents via NFE2L2 antioxidant signaling","volume":"132","author":"Li","year":"2020","journal-title":"Anesthesiology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/SPC.0000000000000055","article-title":"Descending pain modulation and chronification of pain","volume":"8","author":"Ossipov","year":"2014","journal-title":"Curr. Opin. Support. Palliat. Care"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Coulombe, M.A., Lawrence, K.S., Moulin, D.E., Morley-Forster, P., Shokouhi, M., Nielson, W.R., and Davis, K.D. (2017). Lower functional connectivity of the periaqueductal gray is related to negative affect and clinical manifestations of fibromyalgia. Front. Neuroanat., 11.","DOI":"10.3389\/fnana.2017.00047"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e71408","DOI":"10.1002\/brb3.71408","article-title":"Neuroplasticity-driven mechanisms and therapeutic targets in the anterior cingulate cortex in neuropathic pain","volume":"16","author":"Xiong","year":"2026","journal-title":"Brain Behav."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"9719","DOI":"10.1038\/s41598-022-13968-7","article-title":"Long-lasting reflexive and nonreflexive pain responses in two mouse models of fibromyalgia-like condition","volume":"12","author":"Deulofeu","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J. Neurosci. Methods"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: A new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: A new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Martel, I., Bai, X., Kordikowski, R., Leite-Panissi, C.R.A., and Pol, O. (2024). The combination of molecular hydrogen and heme oxygenase-1 effectively inhibits neuropathy caused by paclitaxel in mice. Antioxidants, 13.","DOI":"10.3390\/antiox13070856"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.pain.2009.05.024","article-title":"Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia","volume":"146","author":"Nagakura","year":"2009","journal-title":"Pain"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1124\/jpet.121.001051","article-title":"Therapeutic approaches to nociplastic pain based on findings in the reserpine-induced fibromyalgia-like animal model","volume":"381","author":"Nagakura","year":"2022","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Ho, T., Ryan, M., and Holle, J. (2025). Redox reactions in chronic pain: Mechanisms and relevance in fibromyalgia. Front. Pain Res., 6.","DOI":"10.3389\/fpain.2025.1593908"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Uslu, E.Y., Uslu, M.F., Y\u0131ld\u0131z, S., and Tabara, M.F. (2025). Evaluating oxidative stress in fibromyalgia: Diagnostic utility and its relationship with clinical and psychological parameters. Medicina, 61.","DOI":"10.3390\/medicina61071248"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.jad.2018.12.001","article-title":"Prevalence of depressive disorder among patients with fibromyalgia: Systematic review and meta-analysis","volume":"245","author":"Juhl","year":"2019","journal-title":"J. Affect. Disord."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/pm\/pnae030","article-title":"Brain compensatory mechanisms in depression and memory complaints in fibromyalgia: The role of theta oscillatory activity","volume":"25","author":"Teixeira","year":"2024","journal-title":"Pain Med."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Gau, S.Y., Hung, T.H., Chuang, M.F., and Wei, J.C. (2023). Depressive symptoms in patients with fibromyalgia: Current evidence and preventive approaches. J. Clin. Med., 12.","DOI":"10.3390\/jcm12123987"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s10787-023-01235-8","article-title":"The NLRP3 inflammasome: Role in the pathobiology of chronic pain","volume":"31","author":"Chen","year":"2023","journal-title":"Inflammopharmacology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"110704","DOI":"10.1016\/j.clim.2026.110704","article-title":"Immune dysregulation in fibromyalgia: Targeting the NLRP3 inflammasome-ferroptosis axis as a novel therapeutic strategy for chronic pain","volume":"285","author":"Fawzy","year":"2026","journal-title":"Clin. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/brain\/awaf307","article-title":"Brain signatures of nociplastic pain: Fibromyalgia Index and descending modulation at population level","volume":"149","author":"Kelleher","year":"2026","journal-title":"Brain"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"105362","DOI":"10.1016\/j.neubiorev.2023.105362","article-title":"Janus effect of the anterior cingulate cortex: Pain and emotion","volume":"153","author":"Mathis","year":"2023","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Tocchetto, B.F., Moreira, A.C.J., de Oliveira Franco, \u00c1., Torres, I.L.S., Fregni, F., and Caumo, W. (2025). Seed-based resting-state connectivity as a neurosignature in fibromyalgia and depression: A narrative systematic review. Front. Hum. Neurosci., 19.","DOI":"10.3389\/fnhum.2025.1548617"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1111\/bph.16413","article-title":"Schwann cell TRPA1 elicits reserpine-induced fibromyalgia pain in mice","volume":"181","author":"Brum","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Negrini-Ferrari, S.E., Mart\u00ednez-Martel, I., and Pol, O. (2026). Molecular hydrogen reverses nociplastic pain and depressive-like behaviors via region- and sex-dependent central mechanisms. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27073051"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41582-024-00966-8","article-title":"Deciphering nociplastic pain: Clinical features, risk factors and potential mechanisms","volume":"20","author":"Kaplan","year":"2024","journal-title":"Nat. Rev. Neurol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Findeisen, K., Guymer, E., and Littlejohn, G. (2025). Neuroinflammatory and immunological aspects of fibromyalgia. Brain Sci., 15.","DOI":"10.3390\/brainsci15020206"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1089\/neu.2022.0482","article-title":"Sex differences in pain: Spinal cord injury in female and male mice elicits behaviors related to neuropathic pain","volume":"40","author":"Lee","year":"2023","journal-title":"J. Neurotrauma"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s11739-026-04277-2","article-title":"The impact of sex and gender on fibromyalgia syndrome: Data from the Italian Fibromyalgia Registry","volume":"21","author":"Iannuccelli","year":"2026","journal-title":"Intern. Emerg. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"bqab109","DOI":"10.1210\/endocr\/bqab109","article-title":"Sensory neurons, neuroimmunity, and pain modulation by sex hormones","volume":"162","author":"Lenert","year":"2021","journal-title":"Endocrinology"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/9\/1080\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T09:34:27Z","timestamp":1788168867000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/9\/1080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":56,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["antiox15091080"],"URL":"https:\/\/doi.org\/10.3390\/antiox15091080","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]}}}