{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:16:46Z","timestamp":1788171406871,"version":"build-2803163510"},"reference-count":60,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Postdoctoral Science Foundation of Heilongjiang Province","award":["LBH-Z23079"],"award-info":[{"award-number":["LBH-Z23079"]}]},{"name":"Key Research and Development Project of Hubei Province","award":["2024BBB093"],"award-info":[{"award-number":["2024BBB093"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Population aging has made sarcopenia a growing concern in geriatric health. Protein\u2013polyphenol non-covalent complexes can serve as carrier systems that improve the stability and bioactivity of natural antioxidants. This study refined the preparation parameters for the non-covalent complex of whey protein isolate (WPI) and resveratrol (RES), achieving protein digestibility of 83.60 \u00b1 0.50% and DPPH scavenging of 52.41 \u00b1 0.58% at pH 7.0, a WPI:RES molar ratio of 1:1, and a reaction time of 1.5 h. Relative to free WPI, the complex improved DPPH scavenging by 21.66% while preserving protein digestibility. The binding mode, interaction forces, and conformational evolution were investigated via spectroscopic experiments, docking studies and molecular dynamics simulations. RES selectively bound to the surface of \u03b2-lactoglobulin in WPI through hydrophobic interactions and hydrogen bonding, with a docking score of \u22126.366 kcal\/mol and an MM-GBSA binding free energy of \u221230.48 kcal\/mol. The complex maintained a highly stable conformation throughout the 100 ns molecular dynamics simulation. In conclusion, this study elucidated the structural changes of WPI upon non-covalent resveratrol binding. The WPI-RES complex exhibited enhanced DPPH radical scavenging activity while preserving protein digestibility, with potential implications for functional food development in sarcopenia management.<\/jats:p>","DOI":"10.3390\/antiox15091096","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T09:21:19Z","timestamp":1788168079000},"page":"1096","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural and Antioxidant Comparison Between Native WPI and WPI-Resveratrol Non-Covalent Complex"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2245-5116","authenticated-orcid":false,"given":"Juexi","family":"Liu","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China"},{"name":"Hubei Key Laboratory for Processing and Transformation of Agricultural Products, Wuhan 430023, 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