{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:16:41Z","timestamp":1788430601753,"version":"build-2803163510"},"reference-count":46,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["24-74-10081"],"award-info":[{"award-number":["24-74-10081"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"award":["24-74-10081"],"award-info":[{"award-number":["24-74-10081"]}],"id":[{"id":"https:\/\/ror.org\/03y2gwe85","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002674","name":"Russian Academy of Sciences","doi-asserted-by":"publisher","award":["075-03-2026-098"],"award-info":[{"award-number":["075-03-2026-098"]}],"id":[{"id":"10.13039\/501100002674","id-type":"DOI","asserted-by":"publisher"}]},{"award":["075-03-2026-098"],"award-info":[{"award-number":["075-03-2026-098"]}],"id":[{"id":"https:\/\/ror.org\/05qrfxd25","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Current Parkinson\u2019s disease (PD) therapies like Levodopa (L-DOPA) only provide symptomatic relief, highlighting the need for multi-target neuroprotective agents. This study investigates the mechanisms and preclinical effects of trans-vitisin B (tVB), an oligomeric stilbene, in PD models. In LPS-stimulated HMC3 and RAW 264.7 cells, tVB (0.1\u201310.0 \u00b5M) significantly suppressed reactive oxygen species (ROS), nitric oxide (NO), COX-2, and pro-inflammatory cytokines (IL-1\u03b2, TNF-\u03b1), while restoring HSP70 chaperone levels to normalize proteostasis. These findings were validated in vivo using C57BL\/6 mice with rotenone-induced chronic PD. Administration of tVB attenuated motor deficits (Cylinder test) and reduced pathological freezing (Open Field) and working memory impairments (Y-maze) in this model, without inducing the dyskinesia-like side effects of L-DOPA treatment in rodents. Histologically, tVB mitigated the loss of dopaminergic neurons (TH+) in the substantia nigra, reduced microglial activation (IBA-1+) and neuronal NO synthase, and suppressed pathological phosphorylated Tau protein (p-TauSer202) accumulation. Unlike L-DOPA\u2019s direct dopaminergic stimulation, tVB\u2019s neuroprotective efficacy is mediated through multilevel regulation of key PD pathogenetic pathways, including neuroinflammation, oxidative stress, and impaired proteostasis.<\/jats:p>","DOI":"10.3390\/antiox15091112","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:20:43Z","timestamp":1788427243000},"page":"1112","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trans-Vitisin B Targets Neuroinflammation, Oxidative Stress, and Tau Pathology to Improve Behavioral Outcomes in a Mouse Model of Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3558-0821","authenticated-orcid":false,"given":"Evgeny","family":"Pislyagin","sequence":"first","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Manzhulo","sequence":"additional","affiliation":[{"name":"A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok 690041, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5587-2610","authenticated-orcid":false,"given":"Irina","family":"Agafonova","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3502-0450","authenticated-orcid":false,"given":"Anna","family":"Starinets","sequence":"additional","affiliation":[{"name":"A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok 690041, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Menchinskaya","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0093-5757","authenticated-orcid":false,"given":"Ekaterina","family":"Chingizova","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1769-3627","authenticated-orcid":false,"given":"Darya","family":"Tarbeeva","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4199-2099","authenticated-orcid":false,"given":"Sergey","family":"Fedoreyev","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1073-4994","authenticated-orcid":false,"given":"Dmitry","family":"Aminin","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1111\/febs.14607","article-title":"Determinants of dopaminergic neuron loss in Parkinson\u2019s disease","volume":"285","author":"Surmeier","year":"2018","journal-title":"FEBS J."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Little, J.W., Falace, D.A., Miller, C.S., and Rhodus, N.L. (2013). Chapter 27\u2014Neurologic Disorders. Little and Falace\u2019s Dental Management of the Medically Compromised Patient, Mosby. [8th ed.].","DOI":"10.1016\/B978-0-323-08028-6.00027-0"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Pardo-Moreno, T., Garc\u00eda-Morales, V., Suleiman-Martos, S., Rivas-Dom\u00ednguez, A., Mohamed-Mohamed, H., Ramos-Rodr\u00edguez, J.J., Melguizo-Rodr\u00edguez, L., and Gonz\u00e1lez-Acedo, A. (2023). Current Treatments and New, Tentative Therapies for Parkinson\u2019s Disease. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15030770"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"B\u00e9raud, D., Twomey, M., Bloom, B., Mittereder, A., Ton, V., Neitzke, K., Chasovskikh, S., Mhyre, T.R., and Maguire-Zeiss, K.A. (2011). \u03b1-Synuclein Alters Toll-Like Receptor Expression. Front. Neurosci., 5.","DOI":"10.3389\/fnins.2011.00080"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.3233\/JAD-221081","article-title":"The Role of Interferon-\u03b1 in Neurodegenerative Diseases: A Systematic Review","volume":"94","author":"Hui","year":"2023","journal-title":"J. Alzheimers Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s12640-021-00345-x","article-title":"Interferon-\u03b3 Involvement in the Neuroinflammation Associated with Parkinson\u2019s Disease and L-DOPA-Induced Dyskinesia","volume":"39","author":"Ferrari","year":"2021","journal-title":"Neurotox. Res."},{"key":"ref_7","first-page":"2117","article-title":"Role of NLRP3 Inflammasome in Parkinson\u2019s Disease and Therapeutic Considerations","volume":"12","author":"Nguyen","year":"2022","journal-title":"J. Park. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s41419-022-04786-w","article-title":"Targeted P2X7\/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy","volume":"13","author":"Kong","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Pislyagin, E.A., Tarbeeva, D.V., Yurchenko, E.A., Menchinskaya, E.S., Gorpenchenko, T.Y., Pokhilo, N.D., Kalinovskiy, A.I., Aminin, D.L., and Fedoreyev, S.A. (2025). Neuroprotective Activity of Oligomeric Stilbenes from Alpha Grape Stems in In Vitro Models of Parkinson\u2019s Disease. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26062411"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"150358","DOI":"10.1016\/j.bbrc.2024.150358","article-title":"Pterostilbene alleviates MPTP-induced neurotoxicity by targeting neuroinflammation and oxidative stress","volume":"729","author":"Fan","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Wen, H., Fu, Z., Wei, Y., Zhang, X., Ma, L., Gu, L., and Li, J. (2018). Antioxidant Activity and Neuroprotective Activity of Stilbenoids in Rat Primary Cortex Neurons via the PI3K\/Akt Signalling Pathway. Molecules, 23.","DOI":"10.3390\/molecules23092328"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1007\/s12035-022-02859-7","article-title":"Resveratrol and neuroprotection: An insight into prospective therapeutic approaches against Alzheimer\u2019s disease from bench to bedside","volume":"59","author":"Islam","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6490","DOI":"10.4049\/jimmunol.169.11.6490","article-title":"Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation","volume":"169","author":"Ashikawa","year":"2002","journal-title":"J. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Al-Khayri, J.M., Mascarenhas, R., Harish, H.M., Gowda, Y., Lakshmaiah, V.V., Nagella, P., Al-Mssallem, M.Q., Alessa, F.M., Almaghasla, M.I., and Rezk, A.A. (2023). Stilbenes, a Versatile Class of Natural Metabolites for Inflammation-An Overview. Molecules, 28.","DOI":"10.3390\/molecules28093786"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s12640-019-00147-2","article-title":"NF-\u03baB-Mediated Neuroinflammation in Parkinson\u2019s Disease and Potential Therapeutic Effect of Polyphenols","volume":"37","author":"Singh","year":"2020","journal-title":"Neurotox. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"119019","DOI":"10.1016\/j.biopha.2026.119019","article-title":"Vitisin B, extracted from Vitis vinifera, enhances memory function and neuroprotective effects in scopolamine-induced memory-impaired mice","volume":"196","author":"Kim","year":"2026","journal-title":"Biomed. Pharmacother."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"105685","DOI":"10.1016\/j.nbd.2022.105685","article-title":"Rotenone induces regionally distinct \u03b1-synuclein protein aggregation and activation of glia prior to loss of dopaminergic neurons in C57Bl\/6 mice","volume":"167","author":"Rocha","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1002\/jssc.201500071","article-title":"Development and validation of a liquid chromatography with tandem mass spectrometry method for the quantification of vitisin B in rat plasma and urine","volume":"38","author":"Choi","year":"2015","journal-title":"J. Sep. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1021\/cn400094w","article-title":"Neuroprotective properties and mechanisms of resveratrol in in vitro and in vivo experimental cerebral stroke models","volume":"4","author":"Singh","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/s41386-020-0631-1","article-title":"Optogenetic reactivation of prefrontal social neural ensembles mimics social buffering of fear","volume":"45","author":"Gutzeit","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"113652","DOI":"10.1016\/j.physbeh.2021.113652","article-title":"A review of behavioral methods for the evaluation of cognitive performance in animal models: Current techniques and links to human cognition","volume":"244","author":"Ghafarimoghadam","year":"2022","journal-title":"Physiol. Behav."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Faisal, M., Rusetskaya, A., V\u00e4li, L., Taba, P., Minajeva, A., and Hickey, M.A. (2024). No Evidence of Sensory Neuropathy in a Traditional Mouse Model of Idiopathic Parkinson\u2019s Disease. Cells, 13.","DOI":"10.20944\/preprints202403.0625.v1"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"9592","DOI":"10.1523\/JNEUROSCI.5610-12.2013","article-title":"MHCII is required for \u03b1-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration","volume":"33","author":"Harms","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/j.euroneuro.2015.08.004","article-title":"Microglial activation in the rat brain following chronic antipsychotic treatment at clinically relevant doses","volume":"25","author":"Cotel","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s12640-019-00043-9","article-title":"Suppressing nNOS Enzyme by Small-Interfering RNAs Protects SH-SY5Y Cells and Nigral Dopaminergic Neurons from 6-OHDA Injury","volume":"36","author":"Ferreira","year":"2019","journal-title":"Neurotox. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/978-981-13-9913-8_13","article-title":"Microglia in Parkinson\u2019s Disease","volume":"1175","author":"Ho","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.7150\/ijbs.102032","article-title":"Targeting Neurological Disorders with Stilbenes: Bridging the Preclinical-Clinical Gap","volume":"20","author":"Begh","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.intimp.2004.08.008","article-title":"Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia","volume":"5","author":"Bi","year":"2005","journal-title":"Int. Immunopharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Leal, M.C., Casabona, J.C., Puntel, M., and Pitossi, F.J. (2013). Interleukin-1\u03b2 and tumor necrosis factor-\u03b1: Reliable targets for protective therapies in Parkinson\u2019s Disease?. Front. Cell. Neurosci., 7.","DOI":"10.3389\/fncel.2013.00053"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Lv, J., Chen, F., Zhang, C., Kang, Y., Yang, Y., and Zhang, C. (2024). Role of Peroxynitrite in the Pathogenesis of Parkinson\u2019s Disease and Its Fluorescence Imaging-Based Detection. Biosensors, 14.","DOI":"10.3390\/bios14100506"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1021\/acsptsci.0c00040","article-title":"Inhibiting the PGE2 Receptor EP2 Mitigates Excitotoxicity and Ischemic Injury","volume":"3","author":"Li","year":"2020","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00213-022-06077-w","article-title":"L-DOPA administration shifts the stability-flexibility balance towards attentional capture by distractors during a visual search task","volume":"239","author":"Riedel","year":"2022","journal-title":"Psychopharmacology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"21951","DOI":"10.1038\/s41598-022-25790-2","article-title":"Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein","volume":"12","author":"Dening","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1038\/s41598-022-07909-7","article-title":"An assessment of the rescue action of resveratrol in parkin loss of function-induced oxidative stress in Drosophila melanogaster","volume":"12","author":"Adedara","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"15207","DOI":"10.1038\/s41598-018-33474-z","article-title":"Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age","volume":"8","author":"Brekk","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s40478-022-01475-9","article-title":"Repetitive mild TBI causes pTau aggregation in nigra without altering preexisting fibril induced Parkinson\u2019s-like pathology burden","volume":"10","author":"Delic","year":"2022","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2021.08.213","article-title":"GSK3\u03b2 is involved in promoting Alzheimer\u2019s disease pathologies following chronic systemic exposure to Porphyromonas gingivalis lipopolysaccharide in amyloid precursor proteinNL-F\/NL-F knock-in mice","volume":"98","author":"Jiang","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Bartolome, F., Carro, E., and Alquezar, C. (2022). Oxidative Stress in Tauopathies: From Cause to Therapy. Antioxidants, 11.","DOI":"10.3390\/antiox11081421"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Temsamani, H., Krisa, S., Decossas-Mendoza, M., Lambert, O., M\u00e9rillon, J.M., and Richard, T. (2016). Piceatannol and Other Wine Stilbenes: A Pool of Inhibitors against \u03b1-Synuclein Aggregation and Cytotoxicity. Nutrients, 8.","DOI":"10.3390\/nu8060367"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6414","DOI":"10.1039\/C8FO00964C","article-title":"Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T \u03b1-synuclein mouse model of Parkinson\u2019s disease","volume":"9","author":"Zhang","year":"2018","journal-title":"Food Funct."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1002\/mnfr.201600111","article-title":"Resveratrol alleviates MPTP-induced motor impairments and pathological changes by autophagic degradation of \u03b1-synuclein via SIRT1-deacetylated LC3","volume":"60","author":"Guo","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"134678","DOI":"10.1016\/j.neulet.2019.134678","article-title":"HSP70 and HSP90 in neurodegenerative diseases","volume":"716","author":"Gupta","year":"2020","journal-title":"Neurosci. Lett."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"10300","DOI":"10.1021\/bi2009147","article-title":"Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport","volume":"50","author":"Patterson","year":"2011","journal-title":"Biochemistry"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s001340050786","article-title":"Endotoxin inhibits heat shock protein 70 (HSP7O) expression in peripheral blood mononuclear cells of patients with severe sepsis","volume":"25","author":"Bischoff","year":"1999","journal-title":"Intensive Care Med."},{"key":"ref_45","first-page":"542","article-title":"HSP70 alleviates spinal cord injury by activating the NF-kB pathway","volume":"21","author":"Xu","year":"2021","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"119186","DOI":"10.1016\/j.ecoenv.2025.119186","article-title":"Mechanism analysis of rotenone toxic exposure inducing neurotoxicity through the MAPK\/MMPs signaling pathway","volume":"305","author":"Xu","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/9\/1112\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:38:22Z","timestamp":1788428302000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/9\/1112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":46,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["antiox15091112"],"URL":"https:\/\/doi.org\/10.3390\/antiox15091112","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]}}}