{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:25:22Z","timestamp":1788531922517,"version":"build-2803163510"},"reference-count":49,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Guangxi","award":["2026GXNSFAA00640029"],"award-info":[{"award-number":["2026GXNSFAA00640029"]}]},{"name":"Natural Science Foundation of Guangxi","award":["2025GXNSFBA069031"],"award-info":[{"award-number":["2025GXNSFBA069031"]}]},{"name":"Natural Science Foundation of Guangxi","award":["2023GXNSFBA026023"],"award-info":[{"award-number":["2023GXNSFBA026023"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32160171"],"award-info":[{"award-number":["32160171"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["32160171"],"award-info":[{"award-number":["32160171"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Cultivation Fund of the People\u2019s Hospital of Guangxi Zhuang Autonomous Region","award":["2026GPY0203"],"award-info":[{"award-number":["2026GPY0203"]}]},{"name":"Cultivation Fund of the People\u2019s Hospital of Guangxi Zhuang Autonomous Region","award":["2025GPY0115"],"award-info":[{"award-number":["2025GPY0115"]}]},{"award":["2026GPY0203"],"award-info":[{"award-number":["2026GPY0203"]}],"id":[{"id":"https:\/\/ror.org\/02aa8kj12","id-type":"ROR","asserted-by":"publisher"}]},{"award":["2025GPY0115"],"award-info":[{"award-number":["2025GPY0115"]}],"id":[{"id":"https:\/\/ror.org\/02aa8kj12","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Background: Postpartum hypogalactia is a prevalent obstetric complication worldwide, closely associated with excessive oxidative stress and impaired antioxidant defense in mammary tissue. Current hormone-based therapies carry endocrine disruption risks, while natural antioxidant bioactive agents such as extracellular vesicles (EVs) are largely limited by rapid in vivo clearance and poor tissue retention. Methods: We constructed an injectable gelatin methacryloyl (GelMA) hydrogel system to encapsulate chemically induced mammary epithelial cell-derived EVs (CiMECs-EVs) and systematically evaluated their antioxidant and lactogenic activities via multi-omics analysis, cellular functional assays and a bromocriptine-induced murine hypogalactia model. Results: CiMECs-EVs induced a functional mammary epithelial-like phenotype in fibroblasts in a dose-dependent manner with functional cargo enriched in glutathione metabolism and redox-regulatory miRNAs. The GelMA matrix protected EV integrity and enabled sustained release, and the composite system significantly ameliorated mammary duct structure and lactation function in vivo with specific mammary tropism and no systemic toxicity, outperforming free EV treatment. Conclusions: This study presents a safe protein biomacromolecule-based antioxidant delivery platform that effectively restores mammary redox balance and antioxidant defenses, providing a promising non-hormonal therapeutic strategy for postpartum hypogalactia.<\/jats:p>","DOI":"10.3390\/antiox15091115","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:50:44Z","timestamp":1788529844000},"page":"1115","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gelatin Methacryloyl Hydrogel Encapsulating CiMECs-Derived Extracellular Vesicles Ameliorates Lactation Function via Alleviating Mammary Oxidative Stress"],"prefix":"10.3390","volume":"15","author":[{"given":"Guodong","family":"Wang","sequence":"first","affiliation":[{"name":"Guangxi Zhuang Autonomous Region Engineering Research Center for 3D Printing in Smart Biomanufacturing and Application, Guangxi Academy of Medical Sciences, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Duan","sequence":"additional","affiliation":[{"name":"Guangxi Zhuang Autonomous Region Engineering Research Center for 3D Printing in Smart Biomanufacturing and Application, Guangxi Academy of Medical Sciences, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longfei","family":"Sun","sequence":"additional","affiliation":[{"name":"Guangxi Zhuang Autonomous Region Engineering Research Center for 3D Printing in Smart Biomanufacturing and Application, Guangxi Academy of Medical Sciences, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[{"name":"Center for Bio-Intelligent Manufacturing and Living Matter Bioprinting, Research Institute of Tsinghua University in Shenzhen, Tsinghua University, Shenzhen 518057, China"},{"name":"Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangxi Zhuang Autonomous Region Engineering Research Center for 3D Printing in Smart Biomanufacturing and Application, Guangxi Academy of Medical Sciences, Nanning 530021, China"},{"name":"Center for Bio-Intelligent Manufacturing and Living Matter Bioprinting, Research Institute of Tsinghua University in Shenzhen, Tsinghua University, Shenzhen 518057, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihao","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangxi Zhuang Autonomous Region Engineering Research Center for 3D Printing in Smart Biomanufacturing and Application, Guangxi Academy of Medical Sciences, Nanning 530021, China"},{"name":"Guangxi Key Laboratory of Electrochemical Energy Materials, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanhui","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Animal Science and Technology, Guangxi University, Nanning 530005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqin","family":"Qin","sequence":"additional","affiliation":[{"name":"School of Animal Science and Technology, Guangxi University, Nanning 530005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouyu","family":"Huo","sequence":"additional","affiliation":[{"name":"School of Animal Science and Technology, Guangxi University, Nanning 530005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqing","family":"Li","sequence":"additional","affiliation":[{"name":"School of Animal Science and Technology, Guangxi University, Nanning 530005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhen","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi Zhuang Autonomous Region Engineering Research Center for 3D Printing in Smart Biomanufacturing and Application, Guangxi Academy of Medical Sciences, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanqing","family":"Zou","sequence":"additional","affiliation":[{"name":"Guangxi Zhuang Autonomous Region Engineering Research Center for 3D Printing in Smart Biomanufacturing and Application, Guangxi Academy of Medical Sciences, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2834-6148","authenticated-orcid":false,"given":"Prasanna","family":"Kallingappa","sequence":"additional","affiliation":[{"name":"Vernon Jansen Unit, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1010, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7189-3518","authenticated-orcid":false,"given":"Dandan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangxi Zhuang Autonomous Region Engineering Research Center for 3D Printing in Smart Biomanufacturing and Application, Guangxi Academy of Medical Sciences, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7223-3984","authenticated-orcid":false,"given":"Ben","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangxi Zhuang Autonomous Region Engineering Research Center for 3D Printing in Smart Biomanufacturing and Application, Guangxi Academy of Medical Sciences, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2023). Improving Maternal and Newborn Health and Survival and Reducing Stillbirth: Progress Report 2023, World Health Organization."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Li, S., Gao, J., Liu, J., Hu, J., Chen, X., He, J., Tang, Y., Liu, X., Cao, Y., and Liu, X. (2021). Incidence and Risk Factors of Postpartum Hemorrhage in China: A Multicenter Retrospective Study. Front. Med., 8.","DOI":"10.3389\/fmed.2021.673500"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Liao, C.C., Chien, C.H., Hsu, T.J., and Li, J.M. (2024). Advancing breastfeeding promotion: Leveraging integrative natural galactagogues and unveiling their potential roles-Insights from a 19-year Taiwan nationwide registry to address lactation insufficiency in postpartum women. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1293735"},{"key":"ref_4","first-page":"4765310","article-title":"Breastfeeding and Postpartum Depression: An Overview and Methodological Recommendations for Future Research","volume":"2016","author":"Pope","year":"2016","journal-title":"Depress. Res. Treat."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/jmwh.13274","article-title":"Impaired Lactation: Review of Delayed Lactogenesis and Insufficient Lactation","volume":"66","author":"Farah","year":"2021","journal-title":"J. Midwifery Womens Health"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/ptr.6079","article-title":"Quercetin improves postpartum hypogalactia in milk-deficient mice via stimulating prolactin production in pituitary gland","volume":"32","author":"Lin","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e12888","DOI":"10.1111\/jne.12888","article-title":"Metabolic functions of prolactin: Physiological and pathological aspects","volume":"32","author":"Brie","year":"2020","journal-title":"J. Neuroendocrinol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41574-019-0194-6","article-title":"Prolactin\u2014A pleiotropic factor in health and disease","volume":"15","author":"Bernard","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Winkelmaier, G., Jabbari, K., Chien, L.C., Grabham, P., Parvin, B., and Pluth, J. (2023). Influence of Simulated Microgravity on Mammary Epithelial Cells Grown as 2D and 3D Cultures. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087615"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41586-023-06252-9","article-title":"A spatially resolved single-cell genomic atlas of the adult human breast","volume":"620","author":"Kumar","year":"2023","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"113644","DOI":"10.1016\/j.celrep.2023.113644","article-title":"PAPAS promotes differentiation of mammary epithelial cells and suppresses breast carcinogenesis","volume":"43","author":"Ren","year":"2024","journal-title":"Cell Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13058-021-01445-4","article-title":"Single cell transcriptome atlas of mouse mammary epithelial cells across development","volume":"23","author":"Pal","year":"2021","journal-title":"Breast Cancer Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s12020-017-1346-x","article-title":"Prolactin function and putative expression in the brain","volume":"57","year":"2017","journal-title":"Endocrine"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3345\/cep.2020.00311","article-title":"Pivotal roles of prolactin and other hormones in lactogenesis and the nutritional composition of human milk","volume":"63","author":"Kim","year":"2020","journal-title":"Clin. Exp. Pediatr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e3836","DOI":"10.1002\/dmrr.3836","article-title":"A Century of Prolactin: Emerging Perspectives as a Metabolic Regulator","volume":"40","author":"Wu","year":"2024","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"121075","DOI":"10.1016\/j.biomaterials.2021.121075","article-title":"Restoring mammary gland structures and functions with autogenous cell therapy","volume":"277","author":"Zhang","year":"2021","journal-title":"Biomaterials"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1161\/CIRCULATIONAHA.120.045765","article-title":"Extracellular Vesicle-Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models","volume":"142","author":"Yang","year":"2020","journal-title":"Circulation"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"eaau6977","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41392-023-01704-0","article-title":"Clinical applications of stem cell-derived exosomes","volume":"9","author":"Tan","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"115691","DOI":"10.1016\/j.bcp.2023.115691","article-title":"Application of exosome engineering modification in targeted delivery of therapeutic drugs","volume":"215","author":"Wang","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.7150\/thno.52570","article-title":"Engineering exosomes for targeted drug delivery","volume":"11","author":"Liang","year":"2021","journal-title":"Theranostics"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12929-024-01055-0","article-title":"Exosomes: A review of biologic function, diagnostic and targeted therapy applications, and clinical trials","volume":"31","author":"Chen","year":"2024","journal-title":"J. Biomed. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5802529","DOI":"10.1155\/2016\/5802529","article-title":"Stem Cell-Derived Exosomes: A Potential Alternative Therapeutic Agent in Orthopaedics","volume":"2016","author":"Burke","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1186\/s12951-023-02086-9","article-title":"Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis","volume":"21","author":"Zhao","year":"2023","journal-title":"J. Nanobiotechnology"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Papadopoulos, K.S., Piperi, C., and Korkolopoulou, P. (2024). Clinical Applications of Adipose-Derived Stem Cell (ADSC) Exosomes in Tissue Regeneration. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25115916"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"122858","DOI":"10.1016\/j.lfs.2024.122858","article-title":"Stem cell and exosome therapies for regenerating damaged myocardium in heart failure","volume":"351","author":"Yahyazadeh","year":"2024","journal-title":"Life Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"114882","DOI":"10.1016\/j.expneurol.2024.114882","article-title":"The role of exosomes derived from stem cells in nerve regeneration: A contribution to neurological repair","volume":"380","author":"Zhang","year":"2024","journal-title":"Exp. Neurol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41368-023-00274-9","article-title":"Emerging roles of exosomes in oral diseases progression","volume":"16","author":"Wang","year":"2024","journal-title":"Int. J. Oral Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.jconrel.2025.02.030","article-title":"3D mesenchymal stem cell exosome-functionalized hydrogels for corneal wound healing","volume":"380","author":"Xu","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.7150\/thno.92700","article-title":"Forskolin-driven conversion of human somatic cells into induced neurons through regulation of the cAMP-CREB1-JNK signaling","volume":"14","author":"Wang","year":"2024","journal-title":"Theranostics"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e12404","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41556-018-0250-9","article-title":"Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication","volume":"21","author":"Mathieu","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12964-021-00730-1","article-title":"The exosome journey: From biogenesis to uptake and intracellular signalling","volume":"19","author":"Gurung","year":"2021","journal-title":"Cell Commun. Signal."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.tcb.2023.01.002","article-title":"Extracellular vesicles and nanoparticles: Emerging complexities","volume":"33","author":"Jeppesen","year":"2023","journal-title":"Trends Cell Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41573-022-00410-w","article-title":"Therapeutically harnessing extracellular vesicles","volume":"21","author":"Cheng","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.clinre.2020.03.025","article-title":"MicroRNA-126-5p suppresses cell proliferation, invasion and migration by targeting EGFR in liver cancer","volume":"44","author":"Zhao","year":"2020","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"155021","DOI":"10.1016\/j.prp.2023.155021","article-title":"miR-30a-5p targets ITGA6 to inhibit oral squamous cell carcinoma progression","volume":"253","author":"Zhang","year":"2024","journal-title":"Pathol. Res. Pract."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Yi, D.Y., and Kim, S.Y. (2021). Human Breast Milk Composition and Function in Human Health: From Nutritional Components to Microbiome and MicroRNAs. Nutrients, 13.","DOI":"10.3390\/nu13093094"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Cimmino, F., Catapano, A., Petrella, L., Villano, I., Tudisco, R., and Cavaliere, G. (2023). Role of Milk Micronutrients in Human Health. Front. Biosci. (Landmark Ed.), 28.","DOI":"10.31083\/j.fbl2802041"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"11386","DOI":"10.3168\/jds.2020-18542","article-title":"Feeding rumen-protected lysine prepartum increases energy-corrected milk and milk component yields in Holstein cows during early lactation","volume":"103","author":"Fehlberg","year":"2020","journal-title":"J. Dairy Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"8530","DOI":"10.1021\/acsnano.3c00839","article-title":"Biotin-Avidin System-Based Delivery Enhances the Therapeutic Performance of MSC-Derived Exosomes","volume":"17","author":"Deng","year":"2023","journal-title":"ACS Nano"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e2300184","DOI":"10.1002\/mnfr.202300184","article-title":"Soybean Isoflavones Ameliorates Lactation Performance in Postpartum Mice by Alleviating Oxidative Stress and Regulating Gut Microflora","volume":"68","author":"Shao","year":"2024","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"0469","DOI":"10.34133\/research.0469","article-title":"Mesenchymal Stem Cell Exosome-Integrated Antibacterial Hydrogels for Nasal Mucosal Injury Treatment","volume":"7","author":"Li","year":"2024","journal-title":"Research"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13287-022-02811-5","article-title":"The therapeutic potential of stem cell-derived exosomes in the ulcerative colitis and colorectal cancer","volume":"13","author":"Guo","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"120264","DOI":"10.1016\/j.biomaterials.2020.120264","article-title":"MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system","volume":"257","author":"Wang","year":"2020","journal-title":"Biomaterials"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.2217\/nnm-2021-0025","article-title":"Bone mesenchymal stem cell-derived exosome-loaded injectable hydrogel for minimally invasive treatment of spinal cord injury","volume":"16","author":"Cheng","year":"2021","journal-title":"Nanomedicine"},{"key":"ref_47","first-page":"331","article-title":"Ultrasound-triggered three dimensional hyaluronic acid hydrogel promotes in vitro and in vivo reprogramming into induced pluripotent stem cells","volume":"38","author":"Kim","year":"2024","journal-title":"Bioact. Mater."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"9603","DOI":"10.2147\/IJN.S218120","article-title":"Reduced Graphene Oxide Incorporated GelMA Hydrogel Promotes Angiogenesis for Wound Healing Applications","volume":"14","author":"Rehman","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e2501254","DOI":"10.1002\/adma.202501254","article-title":"Dynamic GelMA\/DNA Dual-Network Hydrogels Promote Woven Bone Organoid Formation and Enhance Bone Regeneration","volume":"37","author":"Zhu","year":"2025","journal-title":"Adv. Mater."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/9\/1115\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:55:26Z","timestamp":1788530126000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/9\/1115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,4]]},"references-count":49,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["antiox15091115"],"URL":"https:\/\/doi.org\/10.3390\/antiox15091115","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,4]]}}}