{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:25:37Z","timestamp":1788531937255,"version":"build-2803163510"},"reference-count":249,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Bialystok, Poland","award":["B.SUB.25.141"],"award-info":[{"award-number":["B.SUB.25.141"]}]},{"name":"Medical University of Bialystok, Poland","award":["B.SUB.25.250"],"award-info":[{"award-number":["B.SUB.25.250"]}]},{"award":["B.SUB.25.141"],"award-info":[{"award-number":["B.SUB.25.141"]}],"id":[{"id":"https:\/\/ror.org\/00y4ya841","id-type":"ROR","asserted-by":"publisher"}]},{"award":["B.SUB.25.250"],"award-info":[{"award-number":["B.SUB.25.250"]}],"id":[{"id":"https:\/\/ror.org\/00y4ya841","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Minister of Education and Science in Poland","award":["SKN\/SP\/602789\/2024"],"award-info":[{"award-number":["SKN\/SP\/602789\/2024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Skin aging is a complex process influenced by oxidative stress, protein glycation, chronic inflammation, and increased extracellular matrix remodeling. Intensive research is underway on new anti-aging substances with multi-target mechanisms of action while maintaining safety and efficacy. Ergothioneine, selenoneine, and ovothiol A are natural histidine derivatives of marine origin, in which the oxygen atom of the hydroxyl group has been replaced with sulphur or selenium. In recent years, a broad spectrum of their biological activity has been demonstrated. Despite the well-documented antioxidant potential of these compounds, their anti-aging effects, particularly in terms of antiglycation and anti-inflammatory activity, remain insufficiently understood. This study presents the current state of knowledge regarding the biological activity of ergothioneine, selenoneine, and ovothiol A, and discusses available cosmetic preparations and dietary supplements containing these compounds. Meanwhile, significant research gaps have been identified regarding their potential use in the prevention and treatment of skin aging.<\/jats:p>","DOI":"10.3390\/antiox15091118","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:50:44Z","timestamp":1788529844000},"page":"1118","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Natural Histidine Derivatives\u2014From Basic Research to Potential Applications in Cosmetics and Nutricosmetics"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6416-9990","authenticated-orcid":false,"given":"Edyta","family":"Go\u0142a\u015b","sequence":"first","affiliation":[{"name":"Students\u2019 Scientific Club \u201cBiochemistry of Lifestyle Diseases\u201d at the Department of Hygiene, Epidemiology and Environmental Health, Medical University of Bialystok, 2c Mickiewicza Street, 15-233 Bialystok, Poland"},{"name":"Department of Hygiene, Epidemiology and Environmental Health, Medical University of Bialystok, 2c Mickiewicza Street, 15-233 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5609-3187","authenticated-orcid":false,"given":"Mateusz","family":"Maciejczyk","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Environmental Health, Medical University of Bialystok, 2c Mickiewicza Street, 15-233 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s10522-022-09959-w","article-title":"Biochemical, Structural and Physical Changes in Aging Human Skin, and Their Relationship","volume":"23","author":"Park","year":"2022","journal-title":"Biogerontology"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Theodorakis, N., Nikolaou, M., Hitas, C., Anagnostou, D., Kreouzi, M., Kalantzi, S., Spyridaki, A., Triantafylli, G., Metheniti, P., and Papaconstantinou, I. 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