{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:07:13Z","timestamp":1789189633008,"version":"build-2803163510"},"reference-count":60,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Community","doi-asserted-by":"publisher","award":["266044"],"award-info":[{"award-number":["266044"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008968","name":"National Research Council","doi-asserted-by":"publisher","award":["BA.AD005.225"],"award-info":[{"award-number":["BA.AD005.225"]}],"id":[{"id":"10.13039\/100008968","id-type":"DOI","asserted-by":"publisher"}]},{"award":["BA.AD005.225"],"award-info":[{"award-number":["BA.AD005.225"]}],"id":[{"id":"https:\/\/ror.org\/04zaypm56","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","award":["PE0000003"],"award-info":[{"award-number":["PE0000003"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"award":["PE0000003"],"award-info":[{"award-number":["PE0000003"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The widespread consumption of ultra-processed foods increases exposure to advanced glycation end-products (AGEs), key mediators of oxidative stress and chronic low-grade inflammation. Although AGEs contribute to adult metabolic dysfunction, their early molecular correlates in pediatric populations remain insufficiently defined. Extracellular vesicle (EV)-associated miRNAs represent stable, non-invasive indicators of systemic stress responses. This study evaluated the association between urinary AGEs and urinary EV-associated miRNAs in 94 Italian children and adolescents from the I.Family cohort. Fluorescent AGEs were quantified via spectrofluorimetry, and EV-enriched urinary miRNAs were profiled using next-generation sequencing. Differential expression and multivariable generalised linear models (adjusted for age, sex, BMI z-score, and hs-CRP) were performed. Differential expression analysis revealed a significant upregulation of hsa-miR-4516 in participants with high versus low urinary AGE levels (fold change = 2.31; FDR = 0.024). In multivariable continuous models, hsa-miR-4516 remained the primary AGE-associated miRNA, though the association attenuated following adjustment for BMI z-score and hs-CRP. Functional enrichment and network analyses highlighted pathways governing oxidative stress responses, proteostasis, and cellular survival. Overall, urinary EV-associated miRNAs may reflect coordinated biological responses to dietary AGE burden rather than serving as direct exposure biomarkers, offering integrated, non-invasive insights into early metabolic and inflammatory adaptations in children.<\/jats:p>","DOI":"10.3390\/antiox15091150","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:04:57Z","timestamp":1789045497000},"page":"1150","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Urinary Extracellular Vesicle-Derived miRNAs Reveal a Coordinated Stress-Response Network Linked to Advanced Glycation End-Products in Children and Adolescents"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1663-1582","authenticated-orcid":false,"given":"Fabio","family":"Lauria","sequence":"first","affiliation":[{"name":"Institute of Food Sciences, National Research Council, 83100 Avellino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3603-0143","authenticated-orcid":false,"given":"Paola","family":"Russo","sequence":"additional","affiliation":[{"name":"Institute of Food Sciences, National Research Council, 83100 Avellino, Italy"},{"name":"Department of Precision Medicine, School of Medicine and Surgery, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9797-2943","authenticated-orcid":false,"given":"Alfonso","family":"Siani","sequence":"additional","affiliation":[{"name":"Institute of Food Sciences, National Research Council, 83100 Avellino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6408-4990","authenticated-orcid":false,"given":"Ivana","family":"Sirangelo","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine, School of Medicine and Surgery, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilenia","family":"D\u2019Orsi","sequence":"additional","affiliation":[{"name":"Institute of Food Sciences, National Research Council, 83100 Avellino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Marena","sequence":"additional","affiliation":[{"name":"Institute of Food Sciences, National Research Council, 83100 Avellino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7354-5958","authenticated-orcid":false,"given":"Antje","family":"Hebestreit","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Prevention Research and Epidemiology, 28359 Bremen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2216-6653","authenticated-orcid":false,"given":"Ronja","family":"Foraita","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Prevention Research and Epidemiology, 28359 Bremen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5231-2231","authenticated-orcid":false,"given":"Giuseppe","family":"Iacomino","sequence":"additional","affiliation":[{"name":"Institute of Food Sciences, National Research Council, 83100 Avellino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104538","DOI":"10.1016\/j.numecd.2025.104538","article-title":"Dietary Advanced Glycation End Products (dAGEs): Pathogenesis and nutritional strategies for health longevity\u2014A critical view","volume":"36","author":"Russo","year":"2026","journal-title":"Nutr. 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