{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:30:35Z","timestamp":1789659035745,"version":"4.0.1"},"reference-count":70,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Victor Babes University of Medicine and Pharmacy, Timisoara","id":[{"id":"https:\/\/ror.org\/00afdp487","id-type":"ROR","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/00afdp487","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>(1) Background: Endothelial nitric oxide synthase (eNOS\/NOS3), the main source of vascular nitric oxide (NO), generates superoxide instead of NO when oxidative stress uncouples it. Circulating eNOS in the early puerperium is uncharacterised. (2) Methods:In a single-centre cross-sectional study (Timi\u0219oara, Romania, July 2022), 40 mother\u2013newborn dyads were evaluated. Maternal serum eNOS protein was quantified by ELISA on postpartum day 1, alongside pre-delivery laboratory data and Edinburgh Postnatal Depression Scale (EPDS) screening. Analyses (Spearman correlation, linear regression, prevalence odds) were unadjusted for multiplicity; only correlations of |\u03c1| \u2265 0.44 were detectable at 80% power. (3) Results:Median serum eNOS was 8.997 ng\/mL (interquartile range 4.091\u201327.985). eNOS correlated inversely with total and LDL cholesterol (\u03c1 = \u22120.368, p = 0.027; \u03c1 = \u22120.412, p = 0.013) and positively with erythrocyte count (\u03c1 = 0.326, p = 0.046). The association with maternal age was similar in magnitude but non-significant (\u03c1 = \u22120.303, p = 0.061). Multivariable models were not significant, and eNOS was unrelated to EPDS score (\u03c1 = 0.111, p = 0.512). (4) Conclusions:Lower circulating eNOS protein, not enzyme activity, accompanied a less favourable lipid profile, but not depressive symptoms. These single-centre Romanian findings are hypothesis-generating and should not be generalised.<\/jats:p>","DOI":"10.3390\/antiox15091176","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:09:17Z","timestamp":1789553357000},"page":"1176","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circulating Endothelial Nitric Oxide Synthase on the First Postpartum Day: An Exploratory Cross-Sectional Study of Its Association with Maternal Age, Redox-Relevant Haematological and Lipid Markers, and Postnatal Depression Screening"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4746-625X","authenticated-orcid":false,"given":"Cristina","family":"Dragomir","sequence":"first","affiliation":[{"name":"Doctoral School of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania"},{"name":"ANAPATMOL Research Center, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Mitule\u021bu","sequence":"additional","affiliation":[{"name":"ANAPATMOL Research Center, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania"},{"name":"Department II Microscopic Morphology, Cell and Molecular Biology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Muntean","sequence":"additional","affiliation":[{"name":"ANAPATMOL Research Center, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania"},{"name":"Department II Microscopic Morphology, Cell and Molecular Biology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0497-0405","authenticated-orcid":false,"given":"C\u0103lin","family":"Muntean","sequence":"additional","affiliation":[{"name":"Department of Informatics and Medical Biostatistics, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Seropian","sequence":"additional","affiliation":[{"name":"Clinic of Obstetrics and Gynecology, Klinikum Freudenstadt, 72250 Freudenstadt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3240-4793","authenticated-orcid":false,"given":"Ionu\u021b-Marcel","family":"Cobec","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Medical Center-University of Freiburg, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9387-1141","authenticated-orcid":false,"given":"Roxana","family":"Popescu","sequence":"additional","affiliation":[{"name":"ANAPATMOL Research Center, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania"},{"name":"Department II Microscopic Morphology, Cell and Molecular Biology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2026, May 08). 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