{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:56:47Z","timestamp":1792789007890,"version":"4.5.0"},"reference-count":47,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Gansu Province","award":["26JRRA080"],"award-info":[{"award-number":["26JRRA080"]}]},{"name":"Natural Science Foundation of Gansu Province","award":["24JRRA838"],"award-info":[{"award-number":["24JRRA838"]}]},{"name":"National Natural Science Foundation of China","award":["32560446"],"award-info":[{"award-number":["32560446"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"award":["32560446"],"award-info":[{"award-number":["32560446"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"China Agricultural University Corresponding Support Research Joint Fund","award":["GSAU-DKZY-2024-005"],"award-info":[{"award-number":["GSAU-DKZY-2024-005"]}],"id":[{"id":"https:\/\/ror.org\/04v3ywz14","id-type":"ROR","asserted-by":"crossref"}]},{"award":["GSAU-DKZY-2024-005"],"award-info":[{"award-number":["GSAU-DKZY-2024-005"]}],"id":[{"id":"https:\/\/ror.org\/04v3ywz14","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Earmarked Fund for China Agriculture Research System","award":["CARS-09-P14"],"award-info":[{"award-number":["CARS-09-P14"]}],"id":[{"id":"https:\/\/ror.org\/03p5eky76","id-type":"ROR","asserted-by":"crossref"}]},{"award":["CARS-09-P14"],"award-info":[{"award-number":["CARS-09-P14"]}],"id":[{"id":"https:\/\/ror.org\/03p5eky76","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Key Talent Program of Gansu Province","award":["2025RCXM117"],"award-info":[{"award-number":["2025RCXM117"]}]},{"name":"State Key Laboratory of Aridland Crop Science of China","award":["GSCS-2025-06"],"award-info":[{"award-number":["GSCS-2025-06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Cadmium pollution severely suppresses potato growth, impairs photosynthesis, and disrupts cellular redox balance, threatening crop yield and food safety. Exogenous small-molecule regulators represent low-cost strategies to alleviate heavy-metal phytotoxicity, yet systematic comparisons of N-acetyl-L-cysteine (NAC), L-tryptophan (Trp), and melatonin (MT) on Cd-stressed potatoes remain insufficient. In this study, two rounds of concentration-gradient screening using morphological and physiological assays identified 5 \u03bcM of melatonin as the optimal treatment to alleviate cadmium-induced damage in potato seedlings. This concentration significantly restored shoot height, root length, fresh weight, and chlorophyll content. Relative to the Cd-only control, 5 \u03bcM of MT reduced MDA and cadmium accumulation by 51.88% and 49.26%, respectively, while increasing proline content by 40.99%. Transcriptomic analysis revealed that MT reversed Cd-induced suppression of photosynthesis and carbon fixation pathways and activated carbohydrate metabolism. Weighted gene co-expression network analysis identified four key modules significantly correlated with Cd tolerance and MT-mediated recovery. Eight hub genes, including StANNAT1 (Ca2+-ROS homeostasis), StNRT1.1 (nitrogen transport), StSWEET10 (carbon allocation), and StHMG1 (MVA pathway), were validated by qPCR, confirming their involvement in Ca2+-ROS signaling, membrane integrity, and photosynthetic recovery. Mechanistically, MT rebalanced cellular redox status, promoted Cd sequestration, optimized carbon\u2013nitrogen distribution, and enhanced antioxidant defense. These findings demonstrate that exogenous MT alleviates Cd toxicity through coordinated regulation of multiple pathways, providing a practical strategy for safe potato cultivation in Cd-contaminated soils and establishing a molecular framework for understanding MT-mediated heavy-metal tolerance in crops.<\/jats:p>","DOI":"10.3390\/antiox15091180","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:59:03Z","timestamp":1789639143000},"page":"1180","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Melatonin Attenuates Cadmium-Induced Oxidative Stress in Potato by Remodeling Redox Homeostasis and Activating Multi-Pathway Antioxidant Networks"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1291-3555","authenticated-orcid":false,"given":"Panfeng","family":"Yao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou 730070, China"},{"name":"College of Agronomy\/Seed Industry Research Institute of Gansu Provincial University, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junmei","family":"Cui","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Horticulture, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou 730070, China"},{"name":"College of Agronomy\/Seed Industry Research Institute of Gansu Provincial University, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Bi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou 730070, China"},{"name":"College of Agronomy\/Seed Industry Research Institute of Gansu Provincial University, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou 730070, China"},{"name":"College of Agronomy\/Seed Industry Research Institute of Gansu Provincial University, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Agronomy\/Seed Industry Research Institute of Gansu Provincial University, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhui","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou 730070, China"},{"name":"College of Agronomy\/Seed Industry Research Institute of Gansu Provincial University, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangping","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Lanzhou Institute of Technology, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1080\/10643389.2023.2210985","article-title":"Interactions between cadmium and nutrients and their implications for safe crop production in Cd-contaminated soils","volume":"53","author":"Zhu","year":"2023","journal-title":"Crit. 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