{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:19:54Z","timestamp":1790824794395,"version":"4.1.0"},"reference-count":73,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Endometriosis, a chronic inflammatory condition affecting up to 10% of reproductive-age individuals, is characterized by the presence of endometrial-like tissue outside the uterine cavity. Current treatments are based primarily on hormonal therapy, analgesia, and surgery, while additional biologically targeted approaches remain under investigation. This review examines polyphenols in relation to endometriosis-associated redox dysregulation and inflammation. Rather than acting simply as antioxidants, individual polyphenols may function as context-dependent redox and signaling modulators. Preclinical studies suggest effects on NF-\u03baB and MAPK signaling, Nrf2-related stress responses, angiogenesis, apoptosis, immune-cell activity, and hormone-related pathways, but the direction and magnitude of these effects differ substantially among compounds, doses, metabolites, and experimental models. Resveratrol and quercetin have generated the greatest clinical interest; however, human evidence remains sparse and heterogeneous, quercetin has been evaluated mainly in multicomponent formulations, and the only double-blind placebo-controlled randomized trial of resveratrol did not demonstrate superiority over placebo for pain reduction. Low and variable bioavailability, compound-specific metabolism, phytoestrogenic and pro-oxidant effects at some exposures, heterogeneous formulations, and limited long-term safety data remain major translational barriers. Polyphenols should therefore be regarded as potential adjunctive approaches whose clinical efficacy in endometriosis remains to be established.<\/jats:p>","DOI":"10.3390\/antiox15091186","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:03:47Z","timestamp":1789977827000},"page":"1186","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Polyphenols as Modulators of Oxidative Stress and Inflammation in Endometriosis: Molecular Mechanisms and Clinical Perspectives"],"prefix":"10.3390","volume":"15","author":[{"given":"Cristian Ioan","family":"Iuhas","sequence":"first","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"St\u0103nil\u0103","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-5057","authenticated-orcid":false,"given":"Carmen","family":"Socaciu","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad N.","family":"Dudric","sequence":"additional","affiliation":[{"name":"Department of Surgery, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, V-th Surgical Clinic, 400139 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5999-1214","authenticated-orcid":false,"given":"Corina","family":"Danciu","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Research and Processing Center of Medicinal and Aromatic Plants, Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5226-5543","authenticated-orcid":false,"given":"Melania Florina","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, \u201cVasile Goldi\u015f\u201d Western University of Arad, B-dul Revolu\u021biei 94-96, 310025 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u0103zvan","family":"Ciortea","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0726-8993","authenticated-orcid":false,"given":"Cristina Mihaela","family":"Ormindean","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8745-9348","authenticated-orcid":false,"given":"Andrei","family":"M\u0103lu\u021ban","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5325-3859","authenticated-orcid":false,"given":"Zori\u021ba","family":"Diaconeasa","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Mihu","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1577-4861","authenticated-orcid":false,"given":"Liora","family":"Colobatiu","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Smolarz, B., Szyllo, K., and Romanowicz, H. 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