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Shengmai Yin (SMY) is a botanical formulation with reported antioxidant activity, but its effects on HH-induced erythrocyte injury remain unclear. Male C57BL\/6J mice received SMY in drinking water for 3 days before 24 h of simulated HH equivalent to 6000 m. Complementary in vivo and in vitro experiments assessed redox indices, lipid peroxidation, hemoglobin redox status, erythrocyte morphology, arterial oxygenation, and Band 3-associated protein interactions. HH increased serum DHE-derived fluorescence, nitric oxide, and malondialdehyde, reduced antioxidant capacity, induced echinocytosis, decreased oxyhemoglobin, and increased methemoglobin. Among the tested redox challenges, 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO) most closely reproduced the combined morphological and hemoglobin abnormalities. SMY scavenged DPPH, hydroxyl-radical, and superoxide-related signals in cell-free assays; reduced PTIO- and hypoxia-induced erythrocyte damage; and reversed established echinocytosis within 30 min in vitro. In mice, SMY reduced echinocytosis and improved arterial oxygenation without detectable short-term hepatic, renal, or histological toxicity. SMY also normalized HH- and PTIO-induced changes in Band 3 interactions with Syk and SHP2. These findings support SMY as a redox-modulating intervention that preserves erythrocyte structure and function during acute HH.<\/jats:p>","DOI":"10.3390\/antiox15091205","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:03:47Z","timestamp":1789977827000},"page":"1205","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Shengmai Yin Attenuates Hypobaric Hypoxia-Induced Erythrocyte Echinocytosis by Restoring Redox Homeostasis and Normalizing Band 3\u2013Syk\/SHP2 Interactions"],"prefix":"10.3390","volume":"15","author":[{"given":"Jie","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Hypoxic Biomedicine, Institute of Special Environmental Medicine, Nantong University, Nantong 226001, 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(2022). Hsp70 in redox homeostasis. Cells, 11.","DOI":"10.3390\/cells11050829"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Mao, Z., Ji, Q., Chen, P., Zhong, K., and Zeng, X. (2024). Hydrogen sulfide protects against toxicant acrolein-induced ferroptotic cell death in Sertoli cells. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1440147"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Wu, J., Shi, Y., Zhou, M., Chen, M., Ji, S., Liu, X., Zhou, M., Xia, R., Zheng, X., and Wang, W. (2024). Nutrient vitamins enabled metabolic regulation of ferroptosis via reactive oxygen species biology. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1434088"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.freeradbiomed.2019.12.022","article-title":"How the redox state regulates immunity","volume":"157","author":"Mullen","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00484-020-02037-1","article-title":"High-altitude hypoxia-induced reactive oxygen species generation, signaling, and mitigation approaches","volume":"65","author":"Gaur","year":"2021","journal-title":"Int. J. Biometeorol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"108675","DOI":"10.1016\/j.intimp.2022.108675","article-title":"A bioactive gypenoside (GP-14) alleviates neuroinflammation and blood-brain barrier disruption by inhibiting NF-kappaB signaling in a mouse high-altitude cerebral edema model","volume":"107","author":"Geng","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"175137","DOI":"10.1016\/j.ejphar.2022.175137","article-title":"Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice","volume":"929","author":"Lu","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1089\/ham.2016.0119","article-title":"Oxidative stress in acute hypobaric hypoxia","volume":"18","author":"Irarrazaval","year":"2017","journal-title":"High Alt. Med. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Mrakic-Sposta, S., Biagini, D., Bondi, D., Pietrangelo, T., Vezzoli, A., Lomonaco, T., Di Francesco, F., and Verratti, V. (2022). OxInflammation at high altitudes: A proof of concept from the Himalayas. Antioxidants, 11.","DOI":"10.3390\/antiox11020368"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.1021\/acs.jproteome.6b00733","article-title":"AltitudeOmics: Red blood cell metabolic adaptation to high-altitude hypoxia","volume":"15","author":"Nemkov","year":"2016","journal-title":"J. Proteome Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Udroiu, I. (2024). A simplified method for calculating surface area of mammalian erythrocytes. Methods Protoc., 7.","DOI":"10.3390\/mps7010011"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.phoj.2024.02.003","article-title":"Red cell membranopathies: Case series and review of literature","volume":"9","author":"Sharma","year":"2024","journal-title":"Pediatr. Hematol. Oncol. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bcmd.2013.10.004","article-title":"New insights provided by a comparison of impaired deformability with erythrocyte oxidative stress for sickle cell disease","volume":"52","author":"Barodka","year":"2014","journal-title":"Blood Cells Mol. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Mohanty, J.G., Nagababu, E., and Rifkind, J.M. (2014). Red blood cell oxidative stress impairs oxygen delivery and induces red blood cell aging. Front. Physiol., 5.","DOI":"10.3389\/fphys.2014.00084"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.1182\/blood-2007-09-113902","article-title":"Red blood cells induce hypoxic lung inflammation","volume":"111","author":"Kiefmann","year":"2008","journal-title":"Blood"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1042\/BJ20120869","article-title":"Oxygen regulates the Band 3-ankyrin bridge in the human erythrocyte membrane","volume":"449","author":"Stefanovic","year":"2013","journal-title":"Biochem. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00424-002-0967-x","article-title":"Hypobaric hypoxia-reoxygenation diminishes Band 3 protein functions in human erythrocytes","volume":"445","author":"Gonzalez","year":"2002","journal-title":"Pflug. Arch."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1080\/07853890.2023.2184859","article-title":"Evaluation of blood cellular and biochemical parameters in rats under a chronic hypoxic environment at high altitude","volume":"55","author":"Yan","year":"2023","journal-title":"Ann. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1177\/000331978403500708","article-title":"Changes in the rheologic properties of blood after a high-altitude expedition","volume":"35","author":"Palareti","year":"1984","journal-title":"Angiology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00484-010-0304-6","article-title":"Oxidative stress in erythrocytes: Effect of antioxidant mixtures during intermittent exposures to high altitude","volume":"54","author":"Vani","year":"2010","journal-title":"Int. J. Biometeorol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.bcp.2007.07.012","article-title":"Modulation of glyceraldehyde 3 phosphate dehydrogenase activity and tyr-phosphorylation of Band 3 in human erythrocytes treated with ferriprotoporphyrin IX","volume":"74","author":"Cortelezzi","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bcmd.2016.02.001","article-title":"Plasmodium falciparum infection induces dynamic changes in the erythrocyte phospho-proteome","volume":"58","author":"Bouyer","year":"2016","journal-title":"Blood Cells Mol. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/bloodadvances.2023009964","article-title":"Phosphoproteomics and morphology of stored human red blood cells treated by protein tyrosine phosphatases inhibitor","volume":"8","author":"Bardyn","year":"2024","journal-title":"Blood Adv."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1182\/blood-2007-07-100180","article-title":"Characterization of the deoxyhemoglobin binding site on human erythrocyte Band 3: Implications for O2 regulation of erythrocyte properties","volume":"111","author":"Chu","year":"2008","journal-title":"Blood"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.abb.2008.10.025","article-title":"Peroxynitrite signaling in human erythrocytes: Synergistic role of hemoglobin oxidation and Band 3 tyrosine phosphorylation","volume":"484","author":"Metere","year":"2009","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1681\/ASN.V76961","article-title":"An application of electron paramagnetic resonance to evaluate nitric oxide and its quenchers","volume":"7","author":"Yoshioka","year":"1996","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Remigante, A., Spinelli, S., Straface, E., Gambardella, L., Caruso, D., Falliti, G., Dossena, S., Marino, A., and Morabito, R. (2022). Antioxidant activity of quercetin in a H2O2-induced oxidative stress model in red blood cells: Functional role of Band 3 protein. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231910991"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Spinelli, S., Marino, A., Remigante, A., and Morabito, R. (2025). Redox homeostasis in red blood cells: From molecular mechanisms to antioxidant strategies. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47080655"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"155529","DOI":"10.1016\/j.phymed.2024.155529","article-title":"Rhodiola crenulata alleviates hypobaric hypoxia-induced brain injury by maintaining blood-brain barrier integrity and balancing energy metabolism dysfunction","volume":"128","author":"Hou","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"155229","DOI":"10.1016\/j.phymed.2023.155229","article-title":"Preventive mechanisms of Chinese Tibetan medicine Triphala against nonalcoholic fatty liver disease","volume":"123","author":"Jiang","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"115288","DOI":"10.1016\/j.jep.2022.115288","article-title":"A comprehensive review of the ethnobotanical, phytochemical, and pharmacological aspects of Rhus chinensis Mill","volume":"293","author":"Li","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"112380","DOI":"10.1016\/j.jep.2019.112380","article-title":"Yueju-Ganmaidazao Decoction confers rapid antidepressant-like effects through suppression of NMDA\/NO\/cGMP signaling","volume":"250","author":"Zhang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13020-024-00906-0","article-title":"LanGui tea protects against binge alcohol-induced acute liver injury by activating AMPK-NLRP3 signaling","volume":"19","author":"Gu","year":"2024","journal-title":"Chin. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"117930","DOI":"10.1016\/j.jep.2024.117930","article-title":"Amelioration of nitroglycerin-induced migraine in mice via Wuzhuyu decoction: Inhibition of the MZF1\/PGK1 pathway and activation of the NRF2 antioxidant response","volume":"326","author":"Xu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"116597","DOI":"10.1016\/j.biopha.2024.116597","article-title":"Zhen-Wu-Tang ameliorates lupus nephritis by diminishing renal tissue-resident memory CD8+ T cells through suppression of the IL-15\/STAT3 pathway","volume":"174","author":"Liang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"155785","DOI":"10.1016\/j.phymed.2024.155785","article-title":"Ginseng total saponin improves red blood cell oxidative stress injury by regulating tyrosine phosphorylation and glycolysis","volume":"130","author":"Zhao","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"154433","DOI":"10.1016\/j.phymed.2022.154433","article-title":"Shengmai San-derived compound prescriptions: A review of chemical constituents, pharmacokinetics, quality control, and pharmacological properties","volume":"107","author":"Ouyang","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/j.freeradbiomed.2012.08.568","article-title":"Zinc and the modulation of redox homeostasis","volume":"53","author":"Oteiza","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Grujicic, J., and Allen, A.R. (2025). Manganese superoxide dismutase: Structure, function, and implications in human disease. Antioxidants, 14.","DOI":"10.3390\/antiox14070848"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Cepeda, V., Rodenas-Munar, M., Garcia, S., Bouzas, C., and Tur, J.A. (2025). Unlocking the power of magnesium: A systematic review and meta-analysis regarding its role in oxidative stress and inflammation. Antioxidants, 14.","DOI":"10.3390\/antiox14060740"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e70059","DOI":"10.1111\/cns.70059","article-title":"Decreased cold-inducible RNA-binding protein binding to GluR1 on neuronal membranes mediates memory impairment resulting from prolonged hypobaric hypoxia exposure","volume":"30","author":"Jiang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"20254","DOI":"10.1038\/s41598-023-47596-6","article-title":"Hypobaric hypoxia induces iron mobilization from liver and spleen and increases serum iron via activation of ghrelin\/GHSR1a\/MAPK signaling in mice","volume":"13","author":"Yang","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1097\/CM9.0000000000002533","article-title":"Acyl-CoA synthase ACSL4: An essential target in ferroptosis and fatty acid metabolism","volume":"136","author":"Ding","year":"2023","journal-title":"Chin. Med. J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.freeradbiomed.2024.06.006","article-title":"GSH exhaustion via inhibition of the xCT-GSH-GPX4 pathway synergistically enhances DSF\/Cu-induced cuproptosis in myelodysplastic syndromes","volume":"222","author":"Li","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.bcmd.2009.11.005","article-title":"Cellular redox potential and hemoglobin S-glutathionylation in human and rat erythrocytes: A comparative study","volume":"44","author":"Colombo","year":"2010","journal-title":"Blood Cells Mol. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"109315","DOI":"10.1016\/j.isci.2024.109315","article-title":"Metabolite and protein shifts in mature erythrocytes under hypoxia","volume":"27","author":"Jin","year":"2024","journal-title":"iScience"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00421-002-0732-z","article-title":"Long-term exposure to intermittent hypoxia results in increased hemoglobin mass, reduced plasma volume, and elevated erythropoietin levels in humans","volume":"88","author":"Heinicke","year":"2003","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"101052","DOI":"10.1016\/j.mam.2021.101052","article-title":"Altitude acclimatization, hemoglobin-oxygen affinity, and circulatory oxygen transport in hypoxia","volume":"84","author":"Storz","year":"2022","journal-title":"Mol. Asp. Med."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Anastasiadi, A.T., Stamoulis, K., Kriebardis, A.G., and Tzounakas, V.L. (2024). Molecular modifications to mitigate oxidative stress and improve red blood cell storability. Front. Physiol., 15.","DOI":"10.3389\/fphys.2024.1499308"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1182\/blood.2024023983","article-title":"Genetic regulation of carnitine metabolism controls lipid damage repair and aging RBC hemolysis in vivo and in vitro","volume":"143","author":"Nemkov","year":"2024","journal-title":"Blood"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"5998","DOI":"10.1182\/blood-2010-11-317024","article-title":"Regulation of membrane-cytoskeletal interactions by tyrosine phosphorylation of erythrocyte Band 3","volume":"117","author":"Ferru","year":"2011","journal-title":"Blood"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1182\/blood.V96.4.1550","article-title":"Sequential phosphorylation of protein Band 3 by Syk and Lyn tyrosine kinases in intact human erythrocytes: Identification of primary and secondary phosphorylation sites","volume":"96","author":"Brunati","year":"2000","journal-title":"Blood"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/9\/1205\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:37:47Z","timestamp":1790051867000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/9\/1205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,20]]},"references-count":52,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["antiox15091205"],"URL":"https:\/\/doi.org\/10.3390\/antiox15091205","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,20]]}}}