{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:08:15Z","timestamp":1789981695911,"version":"4.0.1"},"reference-count":91,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00219399"],"award-info":[{"award-number":["RS-2023-00219399"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2026-25475300"],"award-info":[{"award-number":["RS-2026-25475300"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"award":["RS-2023-00219399"],"award-info":[{"award-number":["RS-2023-00219399"]}],"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"publisher"}]},{"award":["RS-2026-25475300"],"award-info":[{"award-number":["RS-2026-25475300"]}],"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Biomedical Research Institute Fund from Gyeongsang National University Hospital","award":["GNUHBRIF-2023-007"],"award-info":[{"award-number":["GNUHBRIF-2023-007"]}],"id":[{"id":"https:\/\/ror.org\/00gbcc509","id-type":"ROR","asserted-by":"crossref"}]},{"award":["GNUHBRIF-2023-007"],"award-info":[{"award-number":["GNUHBRIF-2023-007"]}],"id":[{"id":"https:\/\/ror.org\/00gbcc509","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Oxidative stress is a well-recognized contributor to male reproductive dysfunction, yet discussion of this mechanism has focused almost exclusively on sperm damage. This focus overlooks the somatic and stromal networks that support testicular development, steroidogenesis, tissue architecture, and erectile function. Platelet-derived growth factor receptor alpha (PDGFR\u03b1) is expressed in heterogeneous interstitial and progenitor-enriched populations and has established roles in testicular development. This narrative review examines the evidence on PDGFR\u03b1 in male reproductive tissues and considers the potential relevance of redox mechanisms identified predominantly in other organ systems. Genetic studies show that Pdgfa deficiency impairs the postnatal establishment of the adult Leydig-cell population, whereas Pdgfra deficiency disrupts fetal testis cord organization and Leydig-cell differentiation. Studies of the adult testis document receptor localization and, in cell-based models, downstream signaling capacity. Preclinical work has further identified PDGFR\u03b1-positive cavernosal fibroblasts associated with vascular remodeling in erectile dysfunction, although a receptor-specific function for these cells remains unproven. We propose that PDGFR-associated redox signaling may shape stromal responses to injury in the testis and penis; however, direct evidence for this mechanism in male reproductive tissue is currently lacking. Testing this hypothesis will require cell-resolved measurements of receptor phosphorylation and localized reactive oxygen species, together with lineage-restricted, receptor-specific perturbation. Establishing whether such a pathway exists could open a mechanistic link between oxidative stress and stromal, rather than purely germ-cell, contributions to male reproductive dysfunction\u2014with implications for both testicular endocrine failure and vasculogenic erectile dysfunction.<\/jats:p>","DOI":"10.3390\/antiox15091208","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:03:47Z","timestamp":1789977827000},"page":"1208","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Platelet-Derived Growth Factor Receptor Alpha in Male Reproductive Health and Oxidative Stress: Stromal Homeostasis, Injury, and Research Perspectives"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1585-6886","authenticated-orcid":false,"given":"Eun-A","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Medicine, Jeju National University, Jeju 63243, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3821-5237","authenticated-orcid":false,"given":"Jeong Seok","family":"Hwa","sequence":"additional","affiliation":[{"name":"Department of Urology, Gyeongsang National University Hospital, Jinju 52727, Republic of Korea"},{"name":"Department of Urology, College of Medicine, Gyeongsang National University, Jinju 52727, Republic of Korea"},{"name":"Institute of Medical Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7402-7298","authenticated-orcid":false,"given":"Dawon","family":"Kang","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea"},{"name":"Department of Physiology, College of Medicine, Gyeongsang National University, Jinju 52727, Republic of Korea"},{"name":"Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/mrd.22871","article-title":"Reactive Oxygen Species as Mediators of Sperm Capacitation and Pathological Damage","volume":"84","author":"Aitken","year":"2017","journal-title":"Mol. 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