{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T10:20:42Z","timestamp":1781864442911,"version":"3.54.5"},"reference-count":64,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T00:00:00Z","timestamp":1536969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P42 ES013661"],"award-info":[{"award-number":["P42 ES013661"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R15 ES022781"],"award-info":[{"award-number":["R15 ES022781"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20 GM109005"],"award-info":[{"award-number":["P20 GM109005"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Although the production of polychlorinated biphenyls (PCBs) is prohibited, the inadvertent production of certain lower-chlorinated PCB congeners still threatens human health. We and others have identified 3,3\u2019-dichlorobiphenyl (PCB11) and its metabolite, 3,3\u2019-dichlorobiphenyl-4-ol (4OH-PCB11), in human blood, and there is a correlation between exposure to this metabolite and mitochondrial oxidative stress in mammalian cells. Here, we evaluated the downstream effects of 4OH-PCB11 on mitochondrial metabolism and function in the presence and absence of functional Sirtuin 3 (SIRT3), a mitochondrial fidelity protein that protects redox homeostasis. A 24 h exposure to 3 \u03bcM 4OH-PCB11 significantly decreased the cellular growth and mitochondrial membrane potential of SIRT3-knockout mouse embryonic fibroblasts (MEFs). Only wild-type cells demonstrated an increase in Manganese superoxide dismutase (MnSOD) activity in response to 4OH-PCB11\u2013induced oxidative injury. This suggests the presence of a SIRT3-mediated post-translational modification to MnSOD, which was impaired in SIRT3-knockout MEFs, which counters the PCB insult. We found that 4OH-PCB11 increased mitochondrial respiration and endogenous fatty-acid oxidation-associated oxygen consumption in SIRT3-knockout MEFs; this appeared to occur because the cells exhausted their reserve respiratory capacity. To determine whether these changes in mitochondrial respiration were accompanied by similar changes in the regulation of fatty acid metabolism, we performed quantitative real-time polymerase chain reaction (qRT-PCR) after a 24 h treatment with 4OH-PCB11. In SIRT3-knockout MEFs, 4OH-PCB11 significantly increased the expression of ten genes controlling fatty acid biosynthesis, metabolism, and transport. When we overexpressed MnSOD in these cells, the expression of six of these genes returned to the baseline level, suggesting that the protective role of SIRT3 against 4OH-PCB11 is partially governed by MnSOD activity.<\/jats:p>","DOI":"10.3390\/antiox7090121","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T10:42:20Z","timestamp":1537180940000},"page":"121","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["PCB11 Metabolite, 3,3\u2019-Dichlorobiphenyl-4-ol, Exposure Alters the Expression of Genes Governing Fatty Acid Metabolism in the Absence of Functional Sirtuin 3: Examining the Contribution of MnSOD"],"prefix":"10.3390","volume":"7","author":[{"given":"Sinthia","family":"Alam","sequence":"first","affiliation":[{"name":"Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendolyn S.","family":"Carter","sequence":"additional","affiliation":[{"name":"Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly J.","family":"Krager","sequence":"additional","affiliation":[{"name":"Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0881-5381","authenticated-orcid":false,"given":"Xueshu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, College of Public Health, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-927X","authenticated-orcid":false,"given":"Hans-Joachim","family":"Lehmler","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, College of Public Health, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8574-4102","authenticated-orcid":false,"given":"Nukhet","family":"Aykin-Burns","sequence":"additional","affiliation":[{"name":"Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1476-069X-7-58","article-title":"Facing the Challenge of Data Transfer from Animal Models to Humans: The Case of Persistent Organohalogens","volume":"7","author":"Suvorov","year":"2008","journal-title":"Environ. Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ecoenv.2004.06.003","article-title":"The public health implications of polychlorinated biphenyls (PCBs) in the environment. Ecotoxicol","volume":"59","author":"Ross","year":"2004","journal-title":"Environ. Saf."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7873","DOI":"10.1021\/es801823r","article-title":"Discovery of non-aroclor PCB (3,3\u2019-dichlorobiphenyl) in Chicago air","volume":"42","author":"Hu","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1021\/es901155h","article-title":"Evidence for unique and ubiquitous environmental sources of 3,3\u2019-dichlorobiphenyl (PCB 11)","volume":"44","author":"Rodenburg","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1021\/es902413k","article-title":"Inadvertent polychlorinated biphenyls in commercial paint pigments","volume":"44","author":"Hu","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"13459","DOI":"10.1021\/es502490w","article-title":"Variability in PCB and OH-PCB serum levels in children and their mothers in urban and rural U.S. communities","volume":"48","author":"Marek","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/toxsci\/kfx100","article-title":"Detection of 3,3\u2019-Dichlorobiphenyl in Human Maternal Plasma and Its Effects on Axonal and Dendritic Growth in Primary Rat Neurons","volume":"158","author":"Sethi","year":"2017","journal-title":"Toxicol. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/toxsci\/kft186","article-title":"A new player in environmentally induced oxidative stress: Polychlorinated biphenyl congener, 3,3\u2019-dichlorobiphenyl (PCB11)","volume":"136","author":"Zhu","year":"2013","journal-title":"Toxicol. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.freeradbiomed.2010.03.012","article-title":"Polychlorinated biphenyl induced ROS signaling delays the entry of quiescent human breast epithelial cells into the proliferative cycle","volume":"49","author":"Chaudhuri","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.etap.2007.10.025","article-title":"Role of oxidative stress in the promoting activities of pcbs","volume":"25","author":"Glauert","year":"2008","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.envint.2009.11.002","article-title":"Acute toxicity of 3,3\u2019,4,4\u2019,5-pentachlorobiphenyl (PCB 126) in male Sprague-Dawley rats: Effects on hepatic oxidative stress, glutathione and metals status","volume":"36","author":"Lai","year":"2010","journal-title":"Environ. Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.freeradbiomed.2009.09.024","article-title":"Polychlorinated-biphenyl-induced oxidative stress and cytotoxicity can be mitigated by antioxidants after exposure","volume":"47","author":"Zhu","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ccr.2009.11.023","article-title":"SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress","volume":"17","author":"Kim","year":"2010","journal-title":"Cancer Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.cmet.2010.11.015","article-title":"Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation","volume":"12","author":"Qiu","year":"2010","journal-title":"Cell Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.molcel.2010.12.013","article-title":"Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress","volume":"40","author":"Tao","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.freeradbiomed.2010.07.009","article-title":"SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity","volume":"49","author":"Bao","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1007\/s00125-013-2851-y","article-title":"Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients","volume":"56","author":"Caton","year":"2013","journal-title":"Diabetologia"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1080\/15548627.2015.1052208","article-title":"SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin","volume":"11","author":"Pi","year":"2015","journal-title":"Autophagy"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"H1602","DOI":"10.1152\/ajpheart.00027.2014","article-title":"SIRT3 deficiency exacerbates ischemia-reperfusion injury: Implication for aged hearts","volume":"306","author":"Porter","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Zeng, H., Li, L., and Chen, J.X. (2014). Loss of Sirt3 limits bone marrow cell-mediated angiogenesis and cardiac repair in post-myocardial infarction. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0107011"},{"key":"ref_21","first-page":"1045","article-title":"Synthesis of Sterically Hindered Polychlorinated Biphenyl Derivatives","volume":"7","author":"Joshi","year":"2011","journal-title":"Synthesis"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1021\/tx00043a012","article-title":"A new strategy for the synthesis of polychlorinated biphenyl metabolites","volume":"8","author":"Bauer","year":"1995","journal-title":"Chem. Res. Toxicol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"16508","DOI":"10.1007\/s11356-017-1162-0","article-title":"Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: Polychlorinated biphenyls as an example","volume":"25","author":"Li","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1667\/RR1617.1","article-title":"Mitochondrial complex II dysfunction can contribute significantly to genomic instability after exposure to ionizing radiation","volume":"172","author":"Dayal","year":"2009","journal-title":"Radiat. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1042\/BJ20081258","article-title":"Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation","volume":"418","author":"Ahmad","year":"2009","journal-title":"Biochem. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0003-2697(89)90192-9","article-title":"An assay for superoxide dismutase activity in mammalian tissue homogenates","volume":"179","author":"Spitz","year":"1989","journal-title":"Anal. Biochem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.freeradbiomed.2015.09.022","article-title":"The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes","volume":"89","author":"Banerjee","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.toxrep.2017.02.005","article-title":"Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes","volume":"4","author":"Banerjee","year":"2017","journal-title":"Toxicol. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"148791","DOI":"10.1155\/2015\/148791","article-title":"Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity","volume":"2015","author":"Krager","year":"2015","journal-title":"Evid. Based Complement Alternat. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.redox.2014.01.014","article-title":"Peroxynitrite induced mitochondrial biogenesis following MnSOD knockdown in normal rat kidney (NRK) cells","volume":"2","author":"Marine","year":"2014","journal-title":"Redox Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.bbabio.2010.10.022","article-title":"Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells","volume":"1807","author":"Pike","year":"2011","journal-title":"Biochim. Biophys. Acta."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nature08778","article-title":"SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation","volume":"464","author":"Hirschey","year":"2010","journal-title":"Nature"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"42436","DOI":"10.1074\/jbc.R112.404863","article-title":"Mitochondrial protein acylation and intermediary metabolism: Regulation by sirtuins and implications for metabolic disease","volume":"287","author":"Newman","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/embor.2011.65","article-title":"Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS","volume":"12","author":"Chen","year":"2011","journal-title":"EMBO Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0300-483X(00)00141-4","article-title":"PCB 118 induces ultrastructural alterations in the rat liver","volume":"145","author":"Gallant","year":"2000","journal-title":"Toxicology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.toxlet.2006.09.006","article-title":"Cell death mechanisms in AtT20 pituitary cells exposed to polychlorinated biphenyls (PCB 126 and PCB 153) and methylmercury","volume":"167","author":"Johansson","year":"2006","journal-title":"Toxicol. Lett."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0300-483X(94)02793-T","article-title":"Cytotoxic effects of Aroclor 1254 on ultrastructure and biochemical parameters in cultured foetal rat hepatocytes","volume":"98","author":"Thome","year":"1995","journal-title":"Toxicology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0024-3205(86)90056-1","article-title":"The effects of tetrachlorobiphenyls on the electron transfer reaction of isolated rat liver mitochondria","volume":"38","author":"Nishihara","year":"1986","journal-title":"Life Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1016\/0006-2952(87)90325-X","article-title":"4-Chloro-4\u2019-biphenylol as an uncoupler and an inhibitor of mitochondrial oxidative phosphorylation","volume":"36","author":"Nishihara","year":"1987","journal-title":"Biochem. Pharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cbi.2007.02.011","article-title":"Molecular cytotoxic mechanisms of catecholic polychlorinated biphenyl metabolites in isolated rat hepatocytes","volume":"167","author":"Chan","year":"2007","journal-title":"Chem. Biol. Interact."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/toxsci\/kfh119","article-title":"Ortho-substituted PCBs kill cells by altering membrane structure","volume":"80","author":"Tan","year":"2004","journal-title":"Toxicol. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jglr.2011.03.001","article-title":"Sedimentary Records of Non-Aroclor and Aroclor PCB mixtures in the Great Lakes","volume":"37","author":"Hu","year":"2011","journal-title":"J. Great Lakes Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"11875","DOI":"10.1021\/acs.est.5b02865","article-title":"Toxicity Evaluation of Exposure to an Atmospheric Mixture of Polychlorinated Biphenyls by Nose-Only and Whole-Body Inhalation Regimens","volume":"49","author":"Hu","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.envint.2013.10.017","article-title":"The fate of inhaled (14)C-labeled PCB11 and its metabolites in vivo","volume":"63","author":"Hu","year":"2014","journal-title":"Environ. Int."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.cmet.2018.01.016","article-title":"The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications","volume":"27","author":"Carrico","year":"2018","journal-title":"Cell Metab."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"16022","DOI":"10.1038\/npjamd.2016.22","article-title":"Increased oxidative phosphorylation in response to acute and chronic DNA damage","volume":"2","author":"Brace","year":"2016","journal-title":"NPJ Aging Mech. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/cvr\/cvu156","article-title":"Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling","volume":"103","author":"Alrob","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.1021\/acs.biochem.5b00375","article-title":"Lysine Acetylation Activates Mitochondrial Aconitase in the Heart","volume":"54","author":"Fernandes","year":"2015","journal-title":"Biochemistry"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.ccr.2011.02.014","article-title":"SIRT3 opposes reprogramming of cancer cell metabolism through HIF1alpha destabilization","volume":"19","author":"Finley","year":"2011","journal-title":"Cancer Cell"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0163-7827(97)00004-0","article-title":"Fatty acid activation","volume":"36","author":"Watkins","year":"1997","journal-title":"Prog Lipid Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"9557","DOI":"10.1074\/jbc.M310512200","article-title":"ATP-citrate lyase deficiency in the mouse","volume":"279","author":"Beigneux","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"34259","DOI":"10.1074\/jbc.M103848200","article-title":"Transcriptional regulation of the murine acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1","volume":"276","author":"Ikeda","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"26458","DOI":"10.1074\/jbc.M004160200","article-title":"Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins","volume":"275","author":"Luong","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.ygeno.2003.09.018","article-title":"Gene structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b","volume":"83","author":"Onishi","year":"2004","journal-title":"Genomics"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"16442","DOI":"10.1073\/pnas.0405809101","article-title":"3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in \u201creal-time\u201d","volume":"101","author":"Theisen","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1194\/jlr.R800085-JLR200","article-title":"Regulation of fatty acid uptake into tissues: Lipoprotein lipase- and CD36-mediated pathways","volume":"50","author":"Goldberg","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/(SICI)1520-7560(199911\/12)15:6<412::AID-DMRR72>3.0.CO;2-8","article-title":"Ketone bodies: A review of physiology, pathophysiology and application of monitoring to diabetes","volume":"15","author":"Laffel","year":"1999","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_58","first-page":"28","article-title":"The fatty acid transport function of fatty acid-binding proteins","volume":"1486","author":"Storch","year":"2000","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Cell Biol. Lipids"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1194\/jlr.R056705","article-title":"Recent insights into the biological functions of liver fatty acid binding protein 1","volume":"56","author":"Wang","year":"2015","journal-title":"J. Lipid Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/oxfordjournals.aje.a113024","article-title":"Metabolic consequences of exposure to polychlorinated biphenyls (PCB) in sewage sludge","volume":"112","author":"Baker","year":"1980","journal-title":"Am. J. Epidemiol."},{"key":"ref_61","first-page":"109","article-title":"Clinical and metabolic abnormalities associated with occupational exposure to polychlorinated biphenyls (PCBs)","volume":"24","author":"Chase","year":"1982","journal-title":"J. Occup Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1289\/ehp.0901480","article-title":"Low dose of some persistent organic pollutants predicts type 2 diabetes: A nested case-control study","volume":"118","author":"Lee","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Lee, D.H., Steffes, M.W., Sjodin, A., Jones, R.S., Needham, L.L., and Jacobs, J.D.R. (2011). Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0015977"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1289\/ehp.8670255","article-title":"Evaluation of potential health effects associated with serum polychlorinated biphenyl levels","volume":"70","author":"Welty","year":"1986","journal-title":"Environ. Health Perspect."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/7\/9\/121\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:20:42Z","timestamp":1760196042000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/7\/9\/121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,15]]},"references-count":64,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9]]}},"alternative-id":["antiox7090121"],"URL":"https:\/\/doi.org\/10.3390\/antiox7090121","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,15]]}}}