{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:26:04Z","timestamp":1791653164768,"version":"4.3.4"},"reference-count":79,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T00:00:00Z","timestamp":1544745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Investigaci\u00f3n en Salud Carlos III","award":["PI17\/0131"],"award-info":[{"award-number":["PI17\/0131"]}]},{"name":"CONSELLERIA EDUCA\u00c7I\u00d3, INVESTIGA\u00c7I\u00d3, CULTURA I ESPORT","award":["APOSTD\/2018\/A\/172"],"award-info":[{"award-number":["APOSTD\/2018\/A\/172"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Aerobic metabolism is highly efficient in providing energy for multicellular organisms. However, even under physiological conditions, an incomplete reduction of oxygen produces reactive oxygen species and, subsequently, oxidative stress. Some of these chemical species are highly reactive free radicals capable of causing functional and structural damage to cell components (protein, lipids, or nucleotides). Oxygen is the most used drug in ill-adapted patients during the newborn period. The use of oxygen may cause oxidative stress-related diseases that increase mortality and cause morbidity with adverse long-term outcomes. Conditions such as prematurity or birth asphyxia are frequently treated with oxygen supplementation. Both pathophysiological situations of hypoxia\u2013reoxygenation in asphyxia and hyperoxia in premature infants cause a burst of reactive oxygen species and oxidative stress. Recently developed analytical assays using mass spectrometry have allowed us to determine highly specific biomarkers with minimal samples. The detection of these metabolites will help improve the diagnosis, evolution, and response to therapy in oxidative stress-related conditions during the newborn period.<\/jats:p>","DOI":"10.3390\/antiox7120193","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T12:11:08Z","timestamp":1544789468000},"page":"193","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Oxidative Stress in the Newborn Period: Useful Biomarkers in the Clinical Setting"],"prefix":"10.3390","volume":"7","author":[{"given":"Iv\u00e1n","family":"Mill\u00e1n","sequence":"first","affiliation":[{"name":"Neonatal Research Group, Health Research Instituto La Fe, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 David","family":"Pi\u00f1ero-Ramos","sequence":"additional","affiliation":[{"name":"Neonatal Research Group, Health Research Instituto La Fe, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Lara","sequence":"additional","affiliation":[{"name":"Neonatal Research Group, Health Research Instituto La Fe, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Parra-Llorca","sequence":"additional","affiliation":[{"name":"Neonatal Research Group, Health Research Instituto La Fe, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Torres-Cuevas","sequence":"additional","affiliation":[{"name":"Neonatal Research Group, Health Research Instituto La Fe, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0061-4742","authenticated-orcid":false,"given":"M\u00e1ximo","family":"Vento","sequence":"additional","affiliation":[{"name":"Neonatal Research Group, Health Research Instituto La Fe, 46026 Valencia, Spain"},{"name":"Division of Neonatology, University and Polytechnic Hospital La Fe, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.clp.2016.04.001","article-title":"Fetal Physiology and the Transition to Extrauterine Life","volume":"43","author":"Morton","year":"2016","journal-title":"Clin. 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