{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:12:18Z","timestamp":1769922738482,"version":"3.49.0"},"reference-count":67,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Plant polyphenols, with broadly known antioxidant properties, represent very effective agents against environmental oxidative stressors, including mercury. This heavy metal irreversibly binds thiol groups, sequestering endogenous antioxidants, such as glutathione. Increased incidence of food-derived mercury is cause for concern, given the many severe downstream effects, ranging from kidney to cardiovascular diseases. Therefore, the possible beneficial properties of Feijoa sellowiana against mercury toxicity were tested using intact human red blood cells (RBC) incubated in the presence of HgCl2. Here, we show that phenol-rich (10\u2013200 \u00b5g\/mL) extracts from the Feijoa sellowiana fruit potently protect against mercury-induced toxicity and oxidative stress. Peel and pulp extracts are both able to counteract the oxidative stress and thiol decrease induced in RBC by mercury treatment. Nonetheless, the peel extract had a greater protective effect compared to the pulp, although to a different extent for the different markers analyzed, which is at least partially due to the greater proportion and diversity of polyphenols in the peel. Furthermore, Fejioa sellowiana extracts also prevent mercury-induced morphological changes, which are known to enhance the pro-coagulant activity of these cells. These novel findings provide biochemical bases for the pharmacological use of Fejioa sellowiana-based functional foods in preventing and combating mercury-related illnesses.<\/jats:p>","DOI":"10.3390\/antiox8070220","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T11:28:28Z","timestamp":1562844508000},"page":"220","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Phenol-Rich Feijoa sellowiana (Pineapple Guava) Extracts Protect Human Red Blood Cells from Mercury-Induced Cellular Toxicity"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7594-102X","authenticated-orcid":false,"given":"Fabiana","family":"Tortora","sequence":"first","affiliation":[{"name":"Department of Precision Medicine, School of Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, via Luigi de Crecchio, 80138 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosaria","family":"Notariale","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine, School of Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, via Luigi de Crecchio, 80138 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Maresca","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Naples Federico II, via Cupa Nuova Cinthia, 80126 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9889-4852","authenticated-orcid":false,"given":"Katrina Vanessa","family":"Good","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Microbiology, University of Victoria, Victoria, BC V8W 3R4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Sorbo","sequence":"additional","affiliation":[{"name":"Ce.S.M.A, Microscopy Section, University of Naples Federico II, via Cupa Nuova Cinthia, 80126 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Basile","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Naples Federico II, via Cupa Nuova Cinthia, 80126 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-6952","authenticated-orcid":false,"given":"Marina","family":"Piscopo","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Naples Federico II, via Cupa Nuova Cinthia, 80126 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9603-0017","authenticated-orcid":false,"given":"Caterina","family":"Manna","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine, School of Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, via Luigi de Crecchio, 80138 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,11]]},"reference":[{"key":"ref_1","first-page":"134","article-title":"Feijoa history and improvement","volume":"106","author":"Sharpe","year":"1996","journal-title":"Proc. Fla. State Hort. Soc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.foodchem.2010.01.047","article-title":"Bioactive products from fruit of the feijoa (Feijoa sellowiana, Myrtaceae): A review","volume":"121","author":"Weston","year":"2010","journal-title":"Food Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.tifs.2018.09.008","article-title":"Chemical and biological properties of feijoa (Acca sellowiana)","volume":"81","author":"Zhu","year":"2018","journal-title":"Trends Food Sci. Technol."},{"key":"ref_4","first-page":"353","article-title":"Nutritional characteristics of Feijoa sellowiana fruit. The iodine content","volume":"30","author":"Ferrara","year":"2001","journal-title":"Riv. Di Sci. Dell Aliment. (Italy)"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Koch, W. (2019). Dietary Polyphenols-Important Non-Nutrients in the Prevention of Chronic Noncommunicable Diseases. A Systematic Review. Nutrients, 11.","DOI":"10.3390\/nu11051039"},{"key":"ref_6","first-page":"1065","article-title":"Total phenolic compounds and antioxidant capacity of leaf, dry fruit and fresh fruit of feijoa (Acca sellowiana, Myrtaceae)","volume":"4","author":"Beyhan","year":"2010","journal-title":"J. Med. Plants Res."},{"key":"ref_7","first-page":"69","article-title":"Inhibitory activity of feijoa sellowiana fruits of human pmn oxidative metabolism","volume":"35","author":"Ielpo","year":"1997","journal-title":"Pharmacol. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3109\/13880209.2011.608074","article-title":"The effects of Feijoa sellowiana fruits on the antioxidant defense system, lipid peroxidation, and tissue morphology in rats","volume":"50","author":"Keles","year":"2012","journal-title":"Pharm. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1021\/jf070510d","article-title":"Inhibition of Inducible Nitric Oxide Synthase Expression by an Acetonic Extract fromFeijoa sellowiana Berg. Fruits","volume":"55","author":"Rossi","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0924-8579(99)00122-3","article-title":"Antimicrobial and antioxidant activities of Feijoa sellowiana fruit","volume":"13","author":"Vuotto","year":"2000","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.indcrop.2017.12.051","article-title":"Phytochemical characterization, antioxidant, antimicrobial and pharmacological activities of Feijoa sellowiana leaves growing in Tunisia","volume":"112","author":"Mosbah","year":"2018","journal-title":"Ind. Crop. Prod."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1089\/jmf.2012.0262","article-title":"Feijoa sellowiana Berg Fruit Juice: Anti-Inflammatory Effect and Activity on Superoxide Anion Generation","volume":"17","author":"Monforte","year":"2014","journal-title":"J. Med. Food"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Peng, Y., Bishop, K.S., Ferguson, L.R., and Quek, S.Y. (2018). Screening of Cytotoxicity and Anti-Inflammatory Properties of Feijoa Extracts Using Genetically Modified Cell Models Targeting TLR2, TLR4 and NOD2 Pathways, and the Implication for Inflammatory Bowel Disease. Nutrients, 10.","DOI":"10.3390\/nu10091188"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Piscopo, M., Tenore, G.C., Notariale, R., Maresca, V., Maisto, M., De Ruberto, F., Heydari, M., Sorbo, S., and Basile, A. (2019). Antimicrobial and antioxidant activity of proteins from Feijoa sellowiana Berg. fruit before and after in vitro gastrointestinal digestion. Nat. Prod. Res., 1\u20135.","DOI":"10.1080\/14786419.2018.1543686"},{"key":"ref_15","first-page":"4323","article-title":"Biological activity of feijoa peel extracts","volume":"20","author":"Motohashi","year":"2000","journal-title":"Anticancer Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1002\/ptr.5629","article-title":"Acetonic Extract from the Feijoa sellowiana Berg. Fruit Exerts Antioxidant Properties and Modulates Disaccharidases Activities in Human Intestinal Epithelial Cells","volume":"30","author":"Turco","year":"2016","journal-title":"Phytother. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/j.1365-2621.2010.02499.x","article-title":"The development of fruit-based functional foods targeting the health and wellness market: A review","volume":"46","year":"2011","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_18","first-page":"1041","article-title":"Correlation between Sun Protection Factor and Antioxidant Activity, Phenol and Flavonoid Contents of some Medicinal Plants","volume":"13","author":"Ebrahimzadeh","year":"2014","journal-title":"Iran. J. Pharm. Res. IJPR"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.1021\/es305071v","article-title":"Mercury as a Global Pollutant: Sources, Pathways, and Effects","volume":"47","author":"Driscoll","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0140-6736(17)31810-X","article-title":"New mercury pollution threats: A global health caution","volume":"390","author":"Spiegel","year":"2017","journal-title":"Lancet"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Sundseth, K., Pacyna, J.M., Pacyna, E.G., Pirrone, N., and Thorne, R.J. (2017). Global Sources and Pathways of Mercury in the Context of Human Health. Int. J. Environ. Res. Public Health, 14.","DOI":"10.3390\/ijerph14010105"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"26185","DOI":"10.1007\/s11356-017-9304-y","article-title":"The biological response chain to pollution: A case study from the \u201cItalian Triangle of Death\u201d assessed with the liverwort Lunularia cruciata","volume":"24","author":"Basile","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.ecoenv.2018.07.122","article-title":"Functional and structural biomarkers to monitor heavy metal pollution of one of the most contaminated freshwater sites in Southern Europe","volume":"163","author":"Maresca","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s12210-016-0564-0","article-title":"Selectivity of metal bioaccumulation and its relationship with glutathione S-transferase levels in gonadal and gill tissues of Mytilus galloprovincialis exposed to Ni (II), Cu (II) and Cd (II)","volume":"27","author":"Piscopo","year":"2016","journal-title":"Rend. Lincei"},{"key":"ref_25","first-page":"6","article-title":"Nutritional Aspects of Food Toxicology: Mercury Toxicity and Protective Effects of Olive Oil Hydroxytyrosol","volume":"6","author":"Officioso","year":"2016","journal-title":"J. Nutr. Food Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/mus.26055","article-title":"Toenail mercury Levels are associated with amyotrophic lateral sclerosis risk","volume":"58","author":"Andrew","year":"2018","journal-title":"Muscle Nerve"},{"key":"ref_27","first-page":"1","article-title":"Mercury toxicity and neurodegenerative effects","volume":"Volume 229","author":"Carocci","year":"2014","journal-title":"Reviews of Environmental Contamination and Toxicology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1053\/j.ajkd.2013.02.372","article-title":"Mercury-associated nephrotic syndrome: A case report and systematic review of the literature","volume":"62","author":"Miller","year":"2013","journal-title":"Am. J. Kidney Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.taap.2004.11.035","article-title":"Mercury and autoimmunity: Implications for occupational and environmental health","volume":"207","author":"Silbergeld","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10534-015-9823-2","article-title":"Mercury and metabolic syndrome: A review of experimental and clinical observations","volume":"28","author":"Tinkov","year":"2015","journal-title":"Biometals"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.reprotox.2019.02.012","article-title":"Exposure to mercury and human reproductive health: A systematic review","volume":"85","author":"Henriques","year":"2019","journal-title":"Reprod. Toxicol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/mrd.23141","article-title":"Molecular effects on spermatozoa of Mytilus galloprovincialis exposed to hyposaline conditions","volume":"86","author":"Lettieri","year":"2019","journal-title":"Mol. Reprod. Dev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"7414","DOI":"10.1038\/s41598-018-25784-z","article-title":"Relevance of arginine residues in Cu(II)-induced DNA breakage and Proteinase K resistance of H1 histones","volume":"8","author":"Piscopo","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1089\/dna.2014.2631","article-title":"New insights into protamine-like component organization in Mytilus galloprovincialis\u2019 sperm chromatin","volume":"34","author":"Vassalli","year":"2015","journal-title":"DNA Cell Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.ecoenv.2018.11.069","article-title":"Alterations in the properties of sperm protamine-like II protein after exposure of Mytilus galloprovincialis (Lamarck 1819) to sub-toxic doses of cadmium","volume":"169","author":"Puoti","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4172\/2329-9517.1000170","article-title":"The Role of Mercury in Cardiovascular Disease","volume":"2","author":"Houston","year":"2014","journal-title":"J. Cardiovasc. Dis. Diagn."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Genchi, G., Sinicropi, M.S., Carocci, A., Lauria, G., and Catalano, A. (2017). Mercury Exposure and Heart Diseases. Int. J. Environ. Res. Public Health, 14.","DOI":"10.3390\/ijerph14010074"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"076002","DOI":"10.1289\/EHP2863","article-title":"Mercury Exposure, Blood Pressure, and Hypertension: A Systematic Review and Dose\u2013response Meta-analysis","volume":"126","author":"Hu","year":"2018","journal-title":"Environ. Heal. Perspect."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.tox.2007.02.016","article-title":"The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury","volume":"234","author":"Rooney","year":"2007","journal-title":"Toxicology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1021\/tx9501896","article-title":"The formation of constants of mercury(II)--glutathione complexes","volume":"9","author":"Oram","year":"1996","journal-title":"Chem. Res. Toxicol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.fct.2015.04.029","article-title":"The protective role of olive oil hydroxytyrosol against oxidative alterations induced by mercury in human erythrocytes","volume":"82","author":"Tagliafierro","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.fct.2016.01.003","article-title":"Hydroxytyrosol inhibits phosphatidylserine exposure and suicidal death induced by mercury in human erythrocytes: Possible involvement of the glutathione pathway","volume":"89","author":"Officioso","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"9042192","DOI":"10.1155\/2018\/9042192","article-title":"Comparative Analysis of the Effects of Olive Oil Hydroxytyrosol and Its 5-S-Lipoyl Conjugate in Protecting Human Erythrocytes from Mercury Toxicity","volume":"2018","author":"Officioso","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_44","first-page":"1314","article-title":"Erythrocyte nitric oxide synthase as a surrogate marker for mercury-induced vascular damage: The modulatory effects of naringin","volume":"29","author":"Harisa","year":"2014","journal-title":"Environ. Toxicol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1007\/s11356-018-04062-5","article-title":"Mercury chloride toxicity in human erythrocytes: Enhanced generation of ROS and RNS, hemoglobin oxidation, impaired antioxidant power, and inhibition of plasma membrane redox system","volume":"26","author":"Ahmad","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1289\/ehp.0901473","article-title":"Low-level mercury can enhance procoagulant activity of erythrocytes: A new contributing factor for mercury-related thrombotic disease","volume":"118","author":"Lim","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0891-5849(92)90102-M","article-title":"Kinetics and site specificity of hydroperoxide-induced oxidative damage in red blood cells","volume":"12","author":"Lubin","year":"1992","journal-title":"Free Radic. Biol. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1159\/000335798","article-title":"Regulation of phosphatidylserine exposure in red blood cells","volume":"28","author":"Nguyen","year":"2011","journal-title":"Cell Physiol Biochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1016\/j.fct.2012.04.016","article-title":"Dietary exposure to trace elements and health risk assessment in the 2nd French Total Diet Study","volume":"50","author":"Arnich","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jtemb.2016.01.007","article-title":"Dietary intake of metals by the young adult population of Eastern Poland: Results from a market basket study","volume":"35","author":"Koch","year":"2016","journal-title":"J. Trace. Elem. Med. Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1080\/10408398.2017.1291491","article-title":"Hazardous properties and toxicological update of mercury: From fish food to human health safety perspective","volume":"58","author":"Okpala","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00411-011-0352-2","article-title":"Protective effects of selenocystine against \u03b3-radiation-induced genotoxicity in Swiss albino mice","volume":"50","author":"Kunwar","year":"2011","journal-title":"Radiat. Environ. Biophys"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.fct.2013.01.024","article-title":"Mercuric chloride-induced testicular toxicity in rats and the protective role of sodium selenite and vitamin E","volume":"55","author":"Kalender","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jhazmat.2004.10.021","article-title":"Removal and preconcentration of inorganic and methyl mercury from aqueous media using a sorbent prepared from the plant Coriandrum sativum","volume":"118","author":"Karunasagar","year":"2005","journal-title":"J. Hazard. Mater."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1021\/acs.jafc.5b05191","article-title":"Efficient Binding of Heavy Metals by Black Sesame Pigment: Toward Innovative Dietary Strategies to Prevent Bioaccumulation","volume":"64","author":"Manini","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Peng, Y., Bishop, K.S., and Quek, S.Y. (2019). Extraction Optimization, Antioxidant Capacity and Phenolic Profiling of Extracts from Flesh, Peel and Whole Fruit of New Zealand Grown Feijoa Cultivars. Antioxidants, 8.","DOI":"10.3390\/antiox8050141"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.scienta.2011.01.032","article-title":"Phenolic compounds and antioxidant activity of the apple flesh and peel of eleven cultivars grown in Brazil","volume":"128","author":"Vieira","year":"2011","journal-title":"Sci. Hortic."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1080\/10408398.2015.1046546","article-title":"Dietary antioxidant synergy in chemical and biological systems","volume":"57","author":"Wang","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Ria\u00f1o, A.M., Solanilla-Duque, J.F., M\u00e9ndez-Arteaga, J.J., and V\u00e1quiro-Herrera, H.A. (2019). Bioactive potential of colombian feijoa in physiological ripening stage. J. Saudi Soc. Agric. Sci.","DOI":"10.1016\/j.jssas.2019.05.002"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Sobeh, M., Petruk, G., Osman, S., El Raey, M.A., Imbimbo, P., Monti, D.M., and Wink, M. (2019). Isolation of Myricitrin and 3, 5-di-O-Methyl Gossypetin from Syzygium samarangense and Evaluation of their Involvement in Protecting Keratinocytes against Oxidative Stress via Activation of the Nrf-2 Pathway. Molecules, 24.","DOI":"10.3390\/molecules24091839"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.fct.2018.01.031","article-title":"High resolution UPLC-MS\/MS profiling of polyphenolics in the methanol extract of Syzygium samarangense leaves and its hepatoprotective activity in rats with CCl4-induced hepatic damage","volume":"113","author":"Sobeh","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3389\/fphar.2018.00566","article-title":"Syzygium aqueum: A Polyphenol- Rich Leaf Extract Exhibits Antioxidant, Hepatoprotective, Pain-Killing and Anti-inflammatory Activities in Animal Models","volume":"9","author":"Sobeh","year":"2018","journal-title":"Front. Pharm."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1007\/s11947-012-0978-3","article-title":"Utilisation Potential of Feijoa Fruit Wastes as Ingredients for Functional Foods","volume":"6","author":"Wang","year":"2013","journal-title":"Food Bioprocess Technol."},{"key":"ref_65","first-page":"85","article-title":"Study of the Hepatoprotective Activity of Methanolic Extract of Feijoa sellowiana Fruits Against MDMA using the Isolated Rat Liver Perfusion System","volume":"12","author":"Karami","year":"2013","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_66","first-page":"69","article-title":"Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice","volume":"17","author":"Karami","year":"2014","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1007\/s13197-017-2678-5","article-title":"Inhibition of foodborne bacteria by antibacterial coatings printed onto food packaging films","volume":"54","author":"Widsten","year":"2017","journal-title":"J. Food Sci. Technol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/8\/7\/220\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:04:42Z","timestamp":1760187882000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/8\/7\/220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,11]]},"references-count":67,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,7]]}},"alternative-id":["antiox8070220"],"URL":"https:\/\/doi.org\/10.3390\/antiox8070220","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,11]]}}}