{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T14:35:08Z","timestamp":1776782108028,"version":"3.51.2"},"reference-count":49,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T00:00:00Z","timestamp":1565827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["123"],"award-info":[{"award-number":["123"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["scholarship"],"award-info":[{"award-number":["scholarship"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Myrciaria species are widely studied to identify their chemical composition and evaluate their biological activity. Since evidence supporting the potential antioxidant and antiproliferative activity of Myrciaria tenella is lacking, the aim of this work was to evaluate these activities in six different leaf extracts: hexane (CHE), chloroform (CCE), ethanolic (CEE), methanolic (CME), aqueous final (CFAE), and only aqueous (CAE). The presence of phenolic compounds, tannin, saponin, and ursolic acid was determined by thin layer chromatography (TLC). CEE, CME, and CFAE showed in vitro antioxidant activity at the initiation, propagation, and termination stages of oxidative damage. Moreover, no toxicity was observed in the 3T3 non-cancerous cell line. On the other hand, all extracts promoted cell death in the tumor cell lines human cervical adenocarcinoma cell line (HeLa) and human stomach gastric adenocarcinoma cell line (AGS). Based on these results, the effect of CEE on the AGS cell line was analyzed using flow cytometry, and necrosis and late apoptosis were observed. Finally, the Caenorhabditis elegans model showed that CEE was able to reduce the basal reactive oxygen species (ROS) level. Ultra-performance liquid chromatography (UPLC) analysis showed rutin as the major compound in CEE. Therefore, Myrciaria tenella fresh leaves may be potential sources of molecules possessing antioxidant and antiproliferative activities.<\/jats:p>","DOI":"10.3390\/antiox8080310","type":"journal-article","created":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T11:11:00Z","timestamp":1565867460000},"page":"310","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Myrciaria tenella (DC.) O. Berg (Myrtaceae) Leaves as a Source of Antioxidant Compounds"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-9784","authenticated-orcid":false,"given":"Ana Raquel Carneiro","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte-UFRN, Centro de Bioci\u00eancias, Natal, Rio Grande do Norte (RN) 59.072-970, Brazil"},{"name":"Laborat\u00f3rio de Transforma\u00e7\u00e3o de Plantas e An\u00e1lise de Microscopia (LTPAM), Departamento de Biologia Celular e Gen\u00e9tica, Centro de Bioci\u00eancias, UFRN, Natal-RN 59.072-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria L\u00facia da Silva","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte-UFRN, Centro de Bioci\u00eancias, Natal, Rio Grande do Norte (RN) 59.072-970, Brazil"},{"name":"Laborat\u00f3rio de Transforma\u00e7\u00e3o de Plantas e An\u00e1lise de Microscopia (LTPAM), Departamento de Biologia Celular e Gen\u00e9tica, Centro de Bioci\u00eancias, UFRN, Natal-RN 59.072-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa Marina Pereira","family":"Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Produtos Naturais (PNBio), Departamento de Farm\u00e1cia, Centro da Sa\u00fade, UFRN, Natal-RN 59012-570, Brazil"},{"name":"Laborat\u00f3rio de Controle de Qualidade de Medicamentos (LCQMed), Departamento de Farm\u00e1cia, Centro da Sa\u00fade, UFRN, Natal-RN 59012-570, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar Orlando Munoz","family":"Cadavid","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00e9tica Bioqu\u00edmica (LGB), Departamento de Biologia Celular e Gen\u00e9tica, Centro de Bioci\u00eancias, UFRN, Natal-RN 59.072-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Bas\u00edlio de Oliveira","family":"Caland","sequence":"additional","affiliation":[{"name":"Instituto Federal de Educa\u00e7\u00e3o, Ci\u00eancia e Tecnologia do Piau\u00ed \u2013 IFPI, Terezina-PI 64000.00, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5560-9687","authenticated-orcid":false,"given":"Mar\u00edlia Medeiros","family":"Fernandes-Negreiros","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte-UFRN, Centro de Bioci\u00eancias, Natal, Rio Grande do Norte (RN) 59.072-970, Brazil"},{"name":"Laborat\u00f3rio de Biotecnologia de Pol\u00edmeros Naturais (BIOPOL), Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, UFRN, Natal-RN 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