{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:05:59Z","timestamp":1790759159867,"version":"4.1.0"},"reference-count":145,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1I1A2A01045132"],"award-info":[{"award-number":["2019R1I1A2A01045132"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Small and Medium-Sized Enterprises and Startups, Republic of Korea","award":["S2643749"],"award-info":[{"award-number":["S2643749"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Antioxidants are deemed useful in controlling oxidative stress associated with extrinsic skin aging and pigmentation disorders. Resveratrol is a polyphenol compound found in many edible plants such as Vitis vinifera, and its inhibitory effects on the catalytic activity, gene expression, and posttranslational modifications of tyrosinase, a key enzyme in the melanin biosynthetic pathway, provide a mechanistic basis for its antimelanogenic effects seen in melanocytic cells, three-dimensionally reconstituted skin models, and in vivo animal models. As a potent antioxidant and a modulator of nuclear factor erythroid 2-related factor 2 (Nrf2), and sirtuin 1, resveratrol can also regulate multiple signaling pathways associated with inflammation and premature aging. Recent clinical studies have supported the efficacy of resveratrol and its analogs, such as resveratryl triacetate (RTA) and resveratryl triglycolate (RTG), in human skin lightening and antiaging. These findings suggest that resveratrol and its analogs are potentially useful as skin lightening and antiaging agents in cosmetics.<\/jats:p>","DOI":"10.3390\/antiox8090332","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T10:15:07Z","timestamp":1566555307000},"page":"332","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9895-2066","authenticated-orcid":false,"given":"Yong Chool","family":"Boo","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea"},{"name":"Brain Korea (BK) 21 Plus Kyungpook National University (KNU) Biomedical Convergence Program, Kyungpook National University, Daegu 41944, Korea"},{"name":"Cell and Matrix Research Institute, Kyungpook National University, Daegu 41944, Korea"},{"name":"Ruby Crown Co., Ltd., Daegu 41061, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.7748\/ns2012.09.27.3.35.c9299","article-title":"The integumentary system: Anatomy, physiology and function of skin","volume":"27","author":"McLafferty","year":"2012","journal-title":"Nurs. Stand."},{"key":"ref_2","first-page":"414","article-title":"The skin health and beauty pyramid: A clinically based guide to selecting topical skincare products","volume":"13","author":"Mayoral","year":"2014","journal-title":"J. Drugs Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2147\/ciia.2006.1.2.115","article-title":"Aging and cosmetic enhancement","volume":"1","author":"Honigman","year":"2006","journal-title":"Clin. Interv. Aging"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"308","DOI":"10.4161\/derm.22804","article-title":"Skin anti-aging strategies","volume":"4","author":"Ganceviciene","year":"2012","journal-title":"Dermatoendocrinology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.clindermatol.2013.05.013","article-title":"Anti-aging cosmetics: Facts and controversies","volume":"31","author":"Celem","year":"2013","journal-title":"Clin. Dermatol."},{"key":"ref_6","first-page":"177","article-title":"Overview of skin aging and photoaging","volume":"20","author":"Helfrich","year":"2008","journal-title":"Dermatol. Nurs."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jdermsci.2007.03.007","article-title":"Comparison of age-related changes in facial wrinkles and sagging in the skin of Japanese, Chinese and Thai women","volume":"47","author":"Tsukahara","year":"2007","journal-title":"J. Dermatol. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.fsc.2016.08.011","article-title":"Skin Color and Pigmentation in Ethnic Skin","volume":"25","author":"Visscher","year":"2017","journal-title":"Facial Plast Surg. Clin. N. Am."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/ics.12466","article-title":"Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentation","volume":"40","author":"Serre","year":"2018","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.2174\/0929867323666160627094938","article-title":"Melanogenesis Inhibitors: Strategies for Searching for and Evaluation of Active Compounds","volume":"23","author":"Popiol","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4284","DOI":"10.1039\/C7FO01300K","article-title":"A comprehensive review of the health perspectives of resveratrol","volume":"8","author":"Rauf","year":"2017","journal-title":"Food Funct."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4161\/oxim.2.5.9498","article-title":"Plant polyphenols as dietary antioxidants in human health and disease","volume":"2","author":"Pandey","year":"2009","journal-title":"Oxidat. Med. Cell. Longev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4062\/biomolther.2013.081","article-title":"Inhibitory effects of resveratrol on melanin synthesis in ultraviolet B-induced pigmentation in Guinea pig skin","volume":"22","author":"Lee","year":"2014","journal-title":"Biomol. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1468-3083.2011.04414.x","article-title":"Resveratrate protects human skin from damage due to repetitive ultraviolet irradiation","volume":"27","author":"Wu","year":"2013","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00403-015-1556-0","article-title":"A study of the human skin-whitening effects of resveratryl triacetate","volume":"307","author":"Ryu","year":"2015","journal-title":"Arch. Dermatol. Res."},{"key":"ref_16","first-page":"72","article-title":"Clinical evaluation of skin whitening effect of a cream containing resveratryl triacetate","volume":"2016","author":"Boo","year":"2016","journal-title":"Fragr. J. Korea"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/ics.12458","article-title":"Human skin-depigmenting effects of resveratryl triglycolate, a hybrid compound of resveratrol and glycolic acid","volume":"40","author":"Jo","year":"2018","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.biocel.2010.03.023","article-title":"Signaling pathways in melanosome biogenesis and pathology","volume":"42","author":"Schiaffino","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1111\/j.0022-202X.2005.23929.x","article-title":"Keratinocyte growth factor promotes melanosome transfer to keratinocytes","volume":"125","author":"Cardinali","year":"2005","journal-title":"J. Investig. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00403-007-0807-0","article-title":"Melanin mediated apoptosis of epidermal cells damaged by ultraviolet radiation: Factors influencing the incidence of skin cancer","volume":"300","author":"Yamaguchi","year":"2008","journal-title":"Arch. Dermatol. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-19683-6_1","article-title":"Sensing the environment: Regulation of local and global homeostasis by the skin\u2019s neuroendocrine system","volume":"212","author":"Slominski","year":"2012","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1096\/fj.06-6649rev","article-title":"Human skin pigmentation: Melanocytes modulate skin color in response to stress","volume":"21","author":"Costin","year":"2007","journal-title":"Faseb J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/j.0022-202X.2005.23760.x","article-title":"Mechanisms of skin tanning in different racial\/ethnic groups in response to ultraviolet radiation","volume":"124","author":"Tadokoro","year":"2005","journal-title":"J. Investig. Dermatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.ygeno.2014.09.010","article-title":"Genome-wide transcriptome analysis of human epidermal melanocytes","volume":"104","author":"Haltaufderhyde","year":"2014","journal-title":"Genomics"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s00414-006-0112-z","article-title":"Population differences of two coding SNPs in pigmentation-related genes SLC24A5 and SLC45A2","volume":"121","author":"Soejima","year":"2007","journal-title":"Int. J. Leg. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5486","DOI":"10.1074\/jbc.M707521200","article-title":"SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis","volume":"283","author":"Ginger","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/jid.2008.211","article-title":"Analysis of cultured human melanocytes based on polymorphisms within the SLC45A2\/MATP, SLC24A5\/NCKX5, and OCA2\/P loci","volume":"129","author":"Cook","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1152\/physrev.00044.2003","article-title":"Melanin pigmentation in mammalian skin and its hormonal regulation","volume":"84","author":"Slominski","year":"2004","journal-title":"Physiol. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1610-0387.2009.07137.x","article-title":"Disorders of pigmentation","volume":"8","author":"Fistarol","year":"2010","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1755-148X.2009.00636.x","article-title":"New insights into the active site structure and catalytic mechanism of tyrosinase and its related proteins","volume":"22","author":"Olivares","year":"2009","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1755-148X.2009.00610.x","article-title":"Current challenges in understanding melanogenesis: Bridging chemistry, biological control, morphology, and function","volume":"22","author":"Simon","year":"2009","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1001\/archderm.139.11.1479","article-title":"Modern aspects of cutaneous neurogenic inflammation","volume":"139","author":"Steinhoff","year":"2003","journal-title":"Arch. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1034\/j.1600-0749.2000.130203.x","article-title":"Cyclic AMP a key messenger in the regulation of skin pigmentation","volume":"13","author":"Busca","year":"2000","journal-title":"Pigment Cell Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1034\/j.1600-0749.2000.130404.x","article-title":"MITF: A stream flowing for pigment cells","volume":"13","author":"Tachibana","year":"2000","journal-title":"Pigment Cell Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.3390\/ijms10094066","article-title":"Mechanisms regulating skin pigmentation: The rise and fall of complexion coloration","volume":"10","author":"Ebanks","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1006\/excr.2000.4803","article-title":"Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9","volume":"255","author":"Xu","year":"2000","journal-title":"Exp. Cell Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cellsig.2017.09.004","article-title":"Recent development of signaling pathways inhibitors of melanogenesis","volume":"40","author":"Pillaiyar","year":"2017","journal-title":"Cell. Signal."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"D\u2019Mello, S.A., Finlay, G.J., Baguley, B.C., and Askarian-Amiri, M.E. (2016). Signaling Pathways in Melanogenesis. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17071144"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/1346-8138.14172","article-title":"Correlating the Dermatology Life Quality Index and Skin Discoloration Impact Evaluation Questionnaire tools in disorders of hyperpigmentation","volume":"45","author":"Maymone","year":"2018","journal-title":"J. Dermatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/01.DER.0000438425.56740.8a","article-title":"Hydroquinone-induced depigmentation: Case report and review of the literature","volume":"25","author":"Jow","year":"2014","journal-title":"Dermatitis"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jdermsci.2009.06.003","article-title":"Effects of hydroquinone and its glucoside derivatives on melanogenesis and antioxidation: Biosafety as skin whitening agents","volume":"55","author":"Hu","year":"2009","journal-title":"J. Dermatol. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/jdv.13595","article-title":"Overview of skin whitening agents with an insight into the illegal cosmetic market in Europe","volume":"30","author":"Desmedt","year":"2016","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/14756366.2016.1256882","article-title":"Skin whitening agents: Medicinal chemistry perspective of tyrosinase inhibitors","volume":"32","author":"Pillaiyar","year":"2017","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/14756366.2018.1545767","article-title":"A comprehensive review on tyrosinase inhibitors","volume":"34","author":"Zolghadri","year":"2019","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/ptr.2761","article-title":"Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds","volume":"23","author":"Hosseinzadeh","year":"2009","journal-title":"Phytother. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1002\/fsn3.855","article-title":"Resveratrol: A miraculous natural compound for diseases treatment","volume":"6","author":"Koushki","year":"2018","journal-title":"Food Sci. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1111\/jcmm.12633","article-title":"Resveratrol, a polyphenol phytoalexin, protects against doxorubicin-induced cardiotoxicity","volume":"19","author":"Gu","year":"2015","journal-title":"J. Cell Mol. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.drup.2004.11.001","article-title":"Chemotherapeutic potential of the chemopreventive phytoalexin resveratrol","volume":"7","author":"Pervaiz","year":"2004","journal-title":"Drug Resist. Updates"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4161\/oxim.3.2.11147","article-title":"Multifaceted approach to resveratrol bioactivity: Focus on antioxidant action, cell signaling and safety","volume":"3","author":"Kovacic","year":"2010","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1163\/156856706775012941","article-title":"Scavenging of reactive oxygen radicals by resveratrol: Antioxidant effect","volume":"32","author":"Mahal","year":"2006","journal-title":"Res. Chem. Intermed."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.bcp.2010.06.027","article-title":"Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite","volume":"80","author":"Holthoff","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s11064-017-2421-7","article-title":"Resveratrol Attenuates the Cytotoxicity Induced by Amyloid-beta(1-42) in PC12 Cells by Upregulating Heme Oxygenase-1 via the PI3K\/Akt\/Nrf2 Pathway","volume":"43","author":"Yang","year":"2018","journal-title":"Neurochem. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"H18","DOI":"10.1152\/ajpheart.00260.2010","article-title":"Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2","volume":"299","author":"Ungvari","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_54","first-page":"4339","article-title":"Resveratrol protects against oxidative stress by activating the Keap-1\/Nrf2 antioxidant defense system in obese-asthmatic rats","volume":"16","author":"Li","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.freeradbiomed.2014.10.510","article-title":"Skin resistance to oxidative stress induced by resveratrol: From Nrf2 activation to GSH biosynthesis","volume":"78","author":"Soeur","year":"2015","journal-title":"Free Radic Biol. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1473-2165.2008.00354.x","article-title":"Anti-aging properties of resveratrol: Review and report of a potent new antioxidant skin care formulation","volume":"7","author":"Baxter","year":"2008","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_57","first-page":"1389","article-title":"Resveratrol: A unique antioxidant offering a multi-mechanistic approach for treating aging skin","volume":"12","author":"Farris","year":"2013","journal-title":"J. Drugs Dermatol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Na, J.I., Shin, J.W., Choi, H.R., Kwon, S.H., and Park, K.C. (2019). Resveratrol as a Multifunctional Topical Hypopigmenting Agent. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20040956"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2005.05.010","article-title":"Photoaging: Mechanisms and repair","volume":"55","author":"Rabe","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1001\/archderm.138.11.1462","article-title":"Mechanisms of photoaging and chronological skin aging","volume":"138","author":"Fisher","year":"2002","journal-title":"Arch. Dermatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1080\/03008200802585622","article-title":"Role of matrix metalloproteinases in skin ageing","volume":"50","author":"Sardy","year":"2009","journal-title":"Connect. Tissue Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1111\/j.1600-0625.2008.00747.x","article-title":"UV-induced DNA damage initiates release of MMP-1 in human skin","volume":"17","author":"Dong","year":"2008","journal-title":"Exp. Dermatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1111\/1750-3841.14643","article-title":"Grape Peel Extract and Resveratrol Inhibit Wrinkle Formation in Mice Model Through Activation of Nrf2\/HO-1 Signaling Pathway","volume":"84","author":"Kim","year":"2019","journal-title":"J. Food Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/cvr\/cvp337","article-title":"Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype","volume":"85","author":"Villarreal","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Gertz, M., Giang, T.T.N., Fischer, F., Suenkel, B., Schlicker, C., Franzel, B., Tomaschewski, J., Aladini, F., Becker, C., and Wolters, D. (2012). A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0049761"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1007\/s00296-012-2657-0","article-title":"Resveratrol inhibits TNF-alpha-induced IL-1beta, MMP-3 production in human rheumatoid arthritis fibroblast-like synoviocytes via modulation of PI3kinase\/Akt pathway","volume":"33","author":"Tian","year":"2013","journal-title":"Rheumatol. Int."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Zhu, X., Liu, Q., Wang, M., Liang, M., Yang, X., Xu, X., Zou, H., and Qiu, J. (2011). Activation of Sirt1 by resveratrol inhibits TNF-alpha induced inflammation in fibroblasts. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027081"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"8379539","DOI":"10.1155\/2017\/8379539","article-title":"Resveratrol-Enriched Rice Attenuates UVB-ROS-Induced Skin Aging via Downregulation of Inflammatory Cascades","volume":"2017","author":"Subedi","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Abbas, H., and Kamel, R. (2019). Potential role of resveratrol-loaded elastic sorbitan monostearate nanovesicles for the prevention of UV-induced skin damage. J. Liposome Res., 1\u20139.","DOI":"10.1080\/08982104.2019.1580721"},{"key":"ref_70","first-page":"249","article-title":"Effects of Resveratrol and Resveratryl Triacetate on The Inflammatory Responses of Human Epidermal Keratinocytes Exposed to Airborne Particulate Matter PM10","volume":"44","author":"Choi","year":"2018","journal-title":"J. Soc. Cosmet. Sci. Korea"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"568","DOI":"10.4103\/1673-5374.155429","article-title":"Resveratrol inhibits matrix metalloproteinases to attenuate neuronal damage in cerebral ischemia: A molecular docking study exploring possible neuroprotection","volume":"10","author":"Pandey","year":"2015","journal-title":"Neural. Regen. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"16340","DOI":"10.1074\/jbc.M200678200","article-title":"Oxyresveratrol and hydroxystilbene compounds. Inhibitory effect on tyrosinase and mechanism of action","volume":"277","author":"Kim","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1006\/bbrc.1998.8169","article-title":"Oxyresveratrol as the potent inhibitor on dopa oxidase activity of mushroom tyrosinase","volume":"243","author":"Shin","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.fitote.2012.06.001","article-title":"Tyrosinase inhibition constituents from the roots of Morus australis","volume":"83","author":"Zheng","year":"2012","journal-title":"Fitoterapia"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1248\/bpb.30.2007","article-title":"Piceatannol inhibits melanogenesis by its antioxidative actions","volume":"30","author":"Yokozawa","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1177\/0960327114559989","article-title":"Oxyresveratrol suppresses lipopolysaccharide-induced inflammatory responses in murine macrophages","volume":"34","author":"Lee","year":"2015","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cbi.2015.06.024","article-title":"Oxyresveratrol abrogates oxidative stress by activating ERK-Nrf2 pathway in the liver","volume":"245","author":"Choi","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/ptr.2324","article-title":"Anthraquinones from Polygonum cuspidatum as tyrosinase inhibitors for dermal use","volume":"22","author":"Leu","year":"2008","journal-title":"Phytother. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1248\/bpb.35.993","article-title":"Inhibitory effect of gnetin C, a resveratrol dimer from melinjo (Gnetum gnemon), on tyrosinase activity and melanin biosynthesis","volume":"35","author":"Yanagihara","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Lin, Y.S., Chen, H.J., Huang, J.P., Lee, P.C., Tsai, C.R., Hsu, T.F., and Huang, W.Y. (2017). Kinetics of Tyrosinase Inhibitory Activity Using Vitis vinifera Leaf Extracts. Biomed. Res. Int., 2017.","DOI":"10.1155\/2017\/5232680"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.1073\/pnas.84.21.7473","article-title":"Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locus","volume":"84","author":"Kwon","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s00253-002-1194-2","article-title":"Cloning, expression and characterisation of two tyrosinase cDNAs from Agaricus bisporus","volume":"61","author":"Wichers","year":"2003","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"191","DOI":"10.5650\/jos.57.191","article-title":"Human tyrosinase inhibitor in rum distillate wastewater","volume":"57","author":"Takara","year":"2008","journal-title":"J. Oleo Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/ptr.3095","article-title":"p-coumaric acid not only inhibits human tyrosinase activity in vitro but also melanogenesis in cells exposed to UVB","volume":"24","author":"An","year":"2010","journal-title":"Phytother. Res."},{"key":"ref_85","first-page":"515","article-title":"Use of non-melanocytic HEK293 cells stably expressing human tyrosinase for the screening of anti-melanogenic agents","volume":"62","author":"Kim","year":"2011","journal-title":"J. Cosmet. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1468-2494.2012.00704.x","article-title":"Screening of plant extracts for human tyrosinase inhibiting effects","volume":"34","author":"Kim","year":"2012","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_87","first-page":"645257","article-title":"Isolation of resveratrol from vitis viniferae caulis and its potent inhibition of human tyrosinase","volume":"2013","author":"Park","year":"2013","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/bjd.14496","article-title":"Antimelanogenic effects of luteolin 7-sulfate isolated from Phyllospadix iwatensis Makino","volume":"175","author":"Kwak","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Boo, Y.C. (2019). p-Coumaric Acid as An Active Ingredient in Cosmetics: A Review Focusing on its Antimelanogenic Effects. Antioxidants, 8.","DOI":"10.3390\/antiox8080275"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1467-2494.2000.00019.x","article-title":"Resveratrol: An original mechanism on tyrosinase inhibition","volume":"22","author":"Bernard","year":"2000","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1021\/jp209753q","article-title":"Spectroscopy and kinetics of tyrosinase catalyzed trans-resveratrol oxidation","volume":"116","author":"Gonzalvez","year":"2012","journal-title":"J. Phys. Chem. B"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.bmc.2011.11.030","article-title":"Resveratrol as a kcat type inhibitor for tyrosinase: Potentiated melanogenesis inhibitor","volume":"20","author":"Satooka","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Ito, S., Fujiki, Y., Matsui, N., Ojika, M., and Wakamatsu, K. (2019). Tyrosinase-catalyzed oxidation of resveratrol produces a highly reactive ortho-quinone: Implications for melanocyte toxicity. Pigment. Cell Melanoma Res.","DOI":"10.1111\/pcmr.12808"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/iub.1439","article-title":"Kinetic characterization of oxyresveratrol as a tyrosinase substrate","volume":"67","author":"Berna","year":"2015","journal-title":"Iubmb Life"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jdermsci.2015.07.010","article-title":"Effects of rhododendrol and its metabolic products on melanocytic cell growth","volume":"80","author":"Okura","year":"2015","journal-title":"J. Dermatol. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00403-014-1440-3","article-title":"Effects of resveratrol, oxyresveratrol, and their acetylated derivatives on cellular melanogenesis","volume":"306","author":"Park","year":"2014","journal-title":"Arch. Dermatol. Res."},{"key":"ref_97","first-page":"542","article-title":"Hypopigmentary effects of 4-n-butylresorcinol and resveratrol in combination","volume":"67","author":"Kim","year":"2012","journal-title":"Pharmazie"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Wang, Y., Hao, M.M., Sun, Y., Wang, L.F., Wang, H., Zhang, Y.J., Li, H.Y., Zhuang, P.W., and Yang, Z. (2018). Synergistic Promotion on Tyrosinase Inhibition by Antioxidants. Molecules, 23.","DOI":"10.3390\/molecules23010106"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/nyas.12196","article-title":"Resveratrol analogs: Promising chemopreventive agents","volume":"1290","author":"Ogas","year":"2013","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1517\/13543776.2013.834888","article-title":"Resveratrol derivatives: A patent review (2009\u20132012)","volume":"23","author":"Pezzuto","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"4882","DOI":"10.1016\/j.bmcl.2010.06.087","article-title":"A newly synthesized, potent tyrosinase inhibitor: 5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol","volume":"20","author":"Choi","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"11816","DOI":"10.3390\/molecules171011816","article-title":"Inhibitory effects of resveratrol analogs on mushroom tyrosinase activity","volume":"17","author":"Franco","year":"2012","journal-title":"Molecules"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"16933","DOI":"10.3390\/molecules200916933","article-title":"Synthesis and Biological Evaluation of Resveratrol Derivatives as Melanogenesis Inhibitors","volume":"20","author":"Liu","year":"2015","journal-title":"Molecules"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.ejmech.2017.10.014","article-title":"Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents","volume":"143","author":"Zhu","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.3390\/molecules14072514","article-title":"Tyrosinase inhibitor activity of coumarin-resveratrol hybrids","volume":"14","author":"Fais","year":"2009","journal-title":"Molecules"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00403-016-1644-9","article-title":"Anti-melanogenic effects of resveratryl triglycolate, a novel hybrid compound derived by esterification of resveratrol with glycolic acid","volume":"308","author":"Park","year":"2016","journal-title":"Arch. Dermatol. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3746\/pnf.2016.21.2.155","article-title":"Comparative Depigmentation Effects of Resveratrol and Its Two Methyl Analogues in alpha-Melanocyte Stimulating Hormone-Triggered B16\/F10 Murine Melanoma Cells","volume":"21","author":"Yoon","year":"2016","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1755-148X.2008.00505.x","article-title":"Novel MITF targets identified using a two-step DNA microarray strategy","volume":"21","author":"Hoek","year":"2008","journal-title":"Pigment. Cell Melanoma Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1046\/j.1523-1747.2002.19615.x","article-title":"Modulation of microphthalmia-associated transcription factor gene expression alters skin pigmentation","volume":"119","author":"Lin","year":"2002","journal-title":"J. Investig. Dermatol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Hori, Y.S., Kuno, A., Hosoda, R., and Horio, Y. (2013). Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0073875"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Kwon, S.H., Choi, H.R., Kang, Y.A., and Park, K.C. (2017). Depigmenting Effect of Resveratrol Is Dependent on FOXO3a Activation without SIRT1 Activation. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18061213"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.2174\/092986711795029708","article-title":"Resveratrol, a phytochemical inducer of multiple cell death pathways: Apoptosis, autophagy and mitotic catastrophe","volume":"18","author":"Delmas","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Khandia, R., Dadar, M., Munjal, A., Dhama, K., Karthik, K., Tiwari, R., Yatoo, M.I., Iqbal, H.M.N., Singh, K.P., and Joshi, S.K. (2019). A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy. Cells, 8.","DOI":"10.3390\/cells8070674"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/exd.12337","article-title":"Autophagy induced by resveratrol suppresses alpha-MSH-induced melanogenesis","volume":"23","author":"Kim","year":"2014","journal-title":"Exp. Dermatol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/jcp.1040990318","article-title":"Tyrosinase maturation and pigment expression in B16 melanoma: Relation to theophylline treatment and intracellular cyclic AMP","volume":"99","author":"White","year":"1979","journal-title":"J. Cell. Physiol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1083\/jcb.97.2.480","article-title":"Regulation of tyrosinase in human melanocytes grown in culture","volume":"97","author":"Halaban","year":"1983","journal-title":"J. Cell Biol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1038\/sj.jid.5700840","article-title":"Post-transcriptional regulation of melanin biosynthetic enzymes by cAMP and resveratrol in human melanocytes","volume":"127","author":"Newton","year":"2007","journal-title":"J. Investig. Dermatol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.micpath.2017.09.029","article-title":"Resveratrol inhibits proliferation, promotes differentiation and melanogenesis in HT-144 melanoma cells through inhibition of MEK\/ERK kinase pathway","volume":"111","author":"Lei","year":"2017","journal-title":"Microb. Pathog."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"431","DOI":"10.4062\/biomolther.2014.098","article-title":"Resveratrol-Enriched Rice Down-Regulates Melanin Synthesis in UVB-Induced Guinea Pigs Epidermal Skin Tissue","volume":"22","author":"Lee","year":"2014","journal-title":"Biomol. Ther."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4062\/biomolther.2015.165","article-title":"Anti-Melanogenic Potentials of Nanoparticles from Calli of Resveratrol-Enriched Rice against UVB-Induced Hyperpigmentation in Guinea Pig Skin","volume":"24","author":"Lee","year":"2016","journal-title":"Biomol. Ther."},{"key":"ref_121","first-page":"161","article-title":"Skin Anti-aging Effects of a Cream Containing Resveratryl Triacetate (RTA)","volume":"44","author":"Choi","year":"2018","journal-title":"J. Soc. Cosmet. Sci. Korea"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0926-9959(97)00183-9","article-title":"EEMCO guidance for the assessment of skin colour","volume":"10","author":"Pierard","year":"1998","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.foodchem.2013.08.034","article-title":"Strategies to improve the solubility and stability of stilbene antioxidants: A comparative study between cyclodextrins and bile acids","volume":"145","author":"Silva","year":"2014","journal-title":"Food Chem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ejpb.2015.04.002","article-title":"Stability and solubility of trans-resveratrol are strongly influenced by pH and temperature","volume":"93","author":"Zupancic","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1021\/jf903009f","article-title":"Preformulation stability of trans-resveratrol and trans-resveratrol glucoside (Piceid)","volume":"58","author":"Jensen","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/carcin\/bgq230","article-title":"Control of prostate cell growth, DNA damage and repair and gene expression by resveratrol analogues, in vitro","volume":"32","author":"Hsieh","year":"2011","journal-title":"Carcinogenesis"},{"key":"ref_127","first-page":"1116","article-title":"The study of human skin irritation of a novel herbal skin care product and ingredients by human single closed patch testing","volume":"90","author":"Wattanakrai","year":"2007","journal-title":"J. Med. Assoc. Thai."},{"key":"ref_128","first-page":"416","article-title":"Evaluation of skin susceptibility to irritancy by routine patch testing with sodium lauryl sulfate","volume":"11","author":"Loffler","year":"2001","journal-title":"Eur. J. Dermatol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0190-9622(79)70001-6","article-title":"The soap chamber test. A new method for assessing the irritancy of soaps","volume":"1","author":"Frosch","year":"1979","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/ics.12095","article-title":"Primary irritation index and safety zone of cosmetics: Retrospective analysis of skin patch tests in 7440 Korean women during 12 years","volume":"36","author":"An","year":"2014","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_131","first-page":"s16","article-title":"Evaluation of a hydroquinone-free skin brightening product using in vitro inhibition of melanogenesis and clinical reduction of ultraviolet-induced hyperpigmentation","volume":"12","author":"Makino","year":"2013","journal-title":"J. Drugs Dermatol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2147\/CCID.S68424","article-title":"Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: A double-blind and placebo-controlled clinical trial in healthy women","volume":"7","author":"Watanabe","year":"2014","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1365-2230.2010.03983.x","article-title":"Effects of p-coumaric acid on erythema and pigmentation of human skin exposed to ultraviolet radiation","volume":"36","author":"Seo","year":"2011","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1001\/jamadermatol.2015.0351","article-title":"Fitzpatrick Skin Type, Individual Typology Angle, and Melanin Index in an African Population: Steps Toward Universally Applicable Skin Photosensitivity Assessments","volume":"151","author":"Wilkes","year":"2015","journal-title":"Jama Dermatol."},{"key":"ref_135","first-page":"199","article-title":"3D in-vivo optical skin imaging for topographical quantitative assessment of non-ablative laser technology","volume":"28","author":"Friedman","year":"2002","journal-title":"Dermatol. Surg."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1600-0846.2008.00292.x","article-title":"Development of a new evaluation method for cheek sagging using a Moire 3D analysis system","volume":"14","author":"Saito","year":"2008","journal-title":"Ski. Res. Technol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1600-0846.2008.00302.x","article-title":"Influence of age and regional differences on skin elasticity as measured by the Cutometer","volume":"14","author":"Ryu","year":"2008","journal-title":"Ski. Res. Technol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.3892\/etm.2016.3447","article-title":"Instrumental evaluation of anti-aging effects of cosmetic formulations containing palmitoyl peptides, Silybum marianum seed oil, vitamin E and other functional ingredients on aged human skin","volume":"12","author":"Hahn","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"ref_139","first-page":"426","article-title":"Multi-Center, Double-Blind, Vehicle-Controlled Clinical Trial of an Alpha and Beta Defensin-Containing Anti-Aging Skin Care Regimen With Clinical, Histopathologic, Immunohistochemical, Photographic, and Ultrasound Evaluation","volume":"17","author":"Taub","year":"2018","journal-title":"J. Drugs Dermatol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/1523-1747.ep12524316","article-title":"Evaluation of the skin surface hydration in vivo by electrical measurement","volume":"75","author":"Tagami","year":"1980","journal-title":"J. Investig. Dermatol."},{"key":"ref_141","first-page":"72","article-title":"Physicochemical Stability of Compounded Creams Containing a-Hydroxy Acids","volume":"4","author":"Narsai","year":"2000","journal-title":"Int. J. Pharm. Compd."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2147\/CCID.S34029","article-title":"Glycolic acid peel therapy\u2014A current review","volume":"6","author":"Sharad","year":"2013","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/pcmr.12443","article-title":"FK506 regulates pigmentation by maturing the melanosome and facilitating their transfer to keratinocytes","volume":"29","author":"Jung","year":"2016","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.0906-6705.2005.00309.x","article-title":"Effective inhibition of melanosome transfer to keratinocytes by lectins and niacinamide is reversible","volume":"14","author":"Greatens","year":"2005","journal-title":"Exp. Dermatol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1046\/j.1523-1747.2000.00035.x","article-title":"Inhibition of melanosome transfer results in skin lightening","volume":"115","author":"Seiberg","year":"2000","journal-title":"J. Investig. Dermatol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/8\/9\/332\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:13:07Z","timestamp":1760188387000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/8\/9\/332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,22]]},"references-count":145,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9]]}},"alternative-id":["antiox8090332"],"URL":"https:\/\/doi.org\/10.3390\/antiox8090332","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,22]]}}}