{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:28:29Z","timestamp":1792801709223,"version":"4.5.0"},"reference-count":105,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1128381"],"award-info":[{"award-number":["GNT1128381"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1162553"],"award-info":[{"award-number":["GNT1162553"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stafford Fox Medical Research Foundation","award":["SF1"],"award-info":[{"award-number":["SF1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Mitochondria are critical for the energetic demands of virtually every cellular process within nucleated eukaryotic cells. They harbour multiple copies of their own genome (mtDNA), as well as the protein-synthesing systems required for the translation of vital subunits of the oxidative phosphorylation machinery used to generate adenosine triphosphate (ATP). Molecular lesions to the mtDNA cause severe metabolic diseases and have been proposed to contribute to the progressive nature of common age-related diseases such as cancer, cardiomyopathy, diabetes, and neurodegenerative disorders. As a consequence of playing a central role in cellular energy metabolism, mitochondria produce reactive oxygen species (ROS) as a by-product of respiration. Here we review the evidence that mutations in the mtDNA exacerbate ROS production, contributing to disease.<\/jats:p>","DOI":"10.3390\/antiox8090392","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T11:26:34Z","timestamp":1568201194000},"page":"392","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":148,"title":["Mitochondrial Genome (mtDNA) Mutations that Generate Reactive Oxygen Species"],"prefix":"10.3390","volume":"8","author":[{"given":"Anne","family":"Hahn","sequence":"first","affiliation":[{"name":"Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, 4072 Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3551-6790","authenticated-orcid":false,"given":"Steven","family":"Zuryn","sequence":"additional","affiliation":[{"name":"Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, 4072 Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,11]]},"reference":[{"key":"ref_1","first-page":"1424","article-title":"Diversity of mitochondrial genome organization","volume":"77","author":"Kolesnikov","year":"2012","journal-title":"Biochemistry"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1105\/tpc.111.087189","article-title":"Origins and recombination of the bacterial-sized multichromosomal mitochondrial genome of cucumber","volume":"23","author":"Alverson","year":"2011","journal-title":"Plant. 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