{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:26:46Z","timestamp":1770726406128,"version":"3.49.0"},"reference-count":54,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["111"],"award-info":[{"award-number":["111"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["scholarship"],"award-info":[{"award-number":["scholarship"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Cactaceae plants are important due to their nutritional and therapeutic values. This study aimed to identify the phytochemical profile and biological activities of six Melocactus zehntneri pulp extracts: hexane extract (HE), chloroform extract (CE), ethanol extract (EE), methanol extract (ME), final water extract (FWE), and water extract (WE). Sugar, phenolic compounds, and protein content of the extracts were determined. Then thin layer chromatography (TLC) was performed to detect the presence of terpenes (ursolic and oleanolic acids), saponins, sugars, and glycoproteins. These extracts were analyzed for antioxidant activity via in vitro assay. HE showed 75% ferric chelating activity. All extracts showed 80\u2013100% superoxide and hydroxyl radical-scavenging activities, respectively. Further, all extracts at 25 \u00b5g\/mL showed 60% activity against DPPH. Moreover, in the 3T3 cells lines, no cytotoxicity was observed; however, therapeutic activity against the effects of the H2O2 treatment was exhibited. Finally, the polar extracts (EE, ME, FWE, and WE), particularly WE, elicited activity against the biofilms of Staphylococcus epidermidis, and HE and CE expressed a capacity for solar protection.<\/jats:p>","DOI":"10.3390\/antiox8100439","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T11:11:16Z","timestamp":1569928276000},"page":"439","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["In Vitro Antioxidant, Anti-Biofilm, and Solar Protection Activities of Melocactus zehntneri (Britton &amp; Rose) Pulp Extract"],"prefix":"10.3390","volume":"8","author":[{"given":"Ver\u00f4nica Giuliani de Queiroz","family":"Aquino-Martins","sequence":"first","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, CEP 59078-970, Brazil"},{"name":"Laborat\u00f3rio de Transforma\u00e7\u00e3o de Planta e An\u00e1lise em Microscopia (LTPAM), Departamento de Biologia Celular e Gen\u00e9tica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, CEP 59078-970, Brazil"},{"name":"Laborat\u00f3rio de Biotecnologia de Pol\u00edmeros Naturais (BIOPOL), Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, CEP 59078-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana Fentanes Moura de","family":"Melo","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, CEP 59078-970, Brazil"},{"name":"Laborat\u00f3rio de Transforma\u00e7\u00e3o de Planta e An\u00e1lise em Microscopia (LTPAM), Departamento de Biologia Celular e Gen\u00e9tica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, CEP 59078-970, Brazil"},{"name":"Laborat\u00f3rio de Biotecnologia de Pol\u00edmeros Naturais (BIOPOL), Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, CEP 59078-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa Marina Pereira","family":"Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Produtos Naturais e Bioativos (PNBio), Departamento de Farm\u00e1cia, UFRN, Natal, CEP 59078-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thales Rodrigo","family":"Targino de Lima","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ensaios Antimicrobianos e de Citotoxicidades (LEAC), Departamento Microbiologia e Parasitologia, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, CEP 59078-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moacir","family":"Fernandes Queiroz","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, CEP 59078-970, Brazil"},{"name":"Laborat\u00f3rio de Biotecnologia de Pol\u00edmeros Naturais (BIOPOL), Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, CEP 59078-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rony Lucas Silva","family":"Viana","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, CEP 59078-970, Brazil"},{"name":"Laborat\u00f3rio de Biotecnologia de Pol\u00edmeros Naturais (BIOPOL), Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, CEP 59078-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana Maria","family":"Zucolotto","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Produtos Naturais e Bioativos (PNBio), Departamento de Farm\u00e1cia, UFRN, Natal, CEP 59078-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vania Sousa","family":"Andrade","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ensaios Antimicrobianos e de Citotoxicidades (LEAC), Departamento Microbiologia e Parasitologia, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, CEP 59078-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo Alexandre Oliveira","family":"Rocha","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, CEP 59078-970, Brazil"},{"name":"Laborat\u00f3rio de Biotecnologia de Pol\u00edmeros Naturais (BIOPOL), Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, CEP 59078-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia Castanho","family":"Scortecci","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, CEP 59078-970, Brazil"},{"name":"Laborat\u00f3rio de Transforma\u00e7\u00e3o de Planta e An\u00e1lise em Microscopia (LTPAM), Departamento de Biologia Celular e Gen\u00e9tica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, CEP 59078-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2174\/1381612825666190319114641","article-title":"Cellular stress 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