{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:12:30Z","timestamp":1791000750000,"version":"4.1.0"},"reference-count":200,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T00:00:00Z","timestamp":1570320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["Project I3089-B28"],"award-info":[{"award-number":["Project I3089-B28"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH Grant SC1GM128210"],"award-info":[{"award-number":["NIH Grant SC1GM128210"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Mitochondria play a critical role in maintaining cellular function by ATP production. They are also a source of reactive oxygen species (ROS) and proapoptotic factors. The role of mitochondria has been established in many aspects of cell physiology\/pathophysiology, including cell signaling. Mitochondria may deteriorate under various pathological conditions, including ischemia-reperfusion (IR) injury. Mitochondrial injury can be one of the main causes for cardiac and other tissue injuries by energy stress and overproduction of toxic reactive oxygen species, leading to oxidative stress, elevated calcium and apoptotic and necrotic cell death. However, the interplay among these processes in normal and pathological conditions is still poorly understood. Mitochondria play a critical role in cardiac IR injury, where they are directly involved in several pathophysiological mechanisms. We also discuss the role of mitochondria in the context of mitochondrial dynamics, specializations and heterogeneity. Also, we wanted to stress the existence of morphologically and functionally different mitochondrial subpopulations in the heart that may have different sensitivities to diseases and IR injury. Therefore, various cardioprotective interventions that modulate mitochondrial stability, dynamics and turnover, including various pharmacologic agents, specific mitochondrial antioxidants and uncouplers, and ischemic preconditioning can be considered as the main strategies to protect mitochondrial and cardiovascular function and thus enhance longevity.<\/jats:p>","DOI":"10.3390\/antiox8100454","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T03:34:01Z","timestamp":1570419241000},"page":"454","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":173,"title":["The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury"],"prefix":"10.3390","volume":"8","author":[{"given":"Andrey V.","family":"Kuznetsov","sequence":"first","affiliation":[{"name":"Cardiac Surgery Research Laboratory, Department of Cardiac Surgery, Medical University of Innsbruck, Innsbruck A-6020, Austria"},{"name":"Department of Pediatrics I, Medical University of Innsbruck, Innsbruck A-6020, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7024-5383","authenticated-orcid":false,"given":"Sabzali","family":"Javadov","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR 00936-5067, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimund","family":"Margreiter","sequence":"additional","affiliation":[{"name":"Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck A-6020, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Grimm","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Research Laboratory, Department of Cardiac Surgery, Medical University of Innsbruck, Innsbruck A-6020, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1396-3407","authenticated-orcid":false,"given":"Judith","family":"Hagenbuchner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics II, Medical University of Innsbruck, Innsbruck A-6020, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1015-2302","authenticated-orcid":false,"given":"Michael J.","family":"Ausserlechner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics I, Medical University of Innsbruck, Innsbruck A-6020, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0092-8674(03)00116-8","article-title":"Mitochondria: Releasing power for life and unleashing the machineries of death","volume":"112","author":"Newmeyer","year":"2003","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"R551","DOI":"10.1016\/j.cub.2006.06.054","article-title":"Mitochondria: More than just a powerhouse","volume":"16","author":"McBride","year":"2006","journal-title":"Curr. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nrm2153","article-title":"The apoptosome: Signalling platform of cell death","volume":"8","author":"Riedl","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/74994","article-title":"Mitochondrial control of cell death","volume":"6","author":"Kroemer","year":"2000","journal-title":"Nat. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0968-0004(00)01745-X","article-title":"A mitochondrial perspective on cell death","volume":"26","author":"Bernardi","year":"2001","journal-title":"Trends Biochem. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/S0006-3495(98)77642-8","article-title":"Role of mitochondria in calcium regulation of spontaneously contracting cardiac muscle cells","volume":"75","author":"Bowser","year":"1998","journal-title":"Biophys. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1126\/science.280.5370.1763","article-title":"Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca2+ Responses","volume":"280","author":"Rizzuto","year":"1998","journal-title":"Science"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1083\/jcb.200604016","article-title":"Structural and functional features and significance of the physical linkage between ER and mitochondria","volume":"174","author":"Renken","year":"2006","journal-title":"J. Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"10753","DOI":"10.1074\/jbc.271.18.10753","article-title":"A role for calcium influx in the regulation of mitochondrial calcium in endothelial cells","volume":"271","author":"Lawrie","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/emboj\/18.1.96","article-title":"Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria","volume":"18","author":"Csordas","year":"1999","journal-title":"EMBO J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3389\/fphys.2018.00755","article-title":"ER-Mitochondria Microdomains in Cardiac Ischemia-Reperfusion Injury: A Fresh Perspective","volume":"9","author":"Zhou","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.2003.055095","article-title":"Energy metabolism in heart failure","volume":"555","author":"Garnier","year":"2004","journal-title":"J. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1113\/jphysiol.2003.045104","article-title":"Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles","volume":"551","author":"Garnier","year":"2003","journal-title":"J. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1146\/annurev.bi.61.070192.005523","article-title":"Diseases of the mitochondrial DNA","volume":"61","author":"Wallace","year":"1992","journal-title":"Annu. Rev. Biochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1126\/science.283.5407.1482","article-title":"Mitochondrial Diseases in Man and Mouse","volume":"283","author":"Wallace","year":"1999","journal-title":"Science"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2005.02.001","article-title":"Mitochondria, oxidants, and aging","volume":"120","author":"Balaban","year":"2005","journal-title":"Cell"},{"key":"ref_18","first-page":"H1633","article-title":"Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusion","volume":"286","author":"Kuznetsov","year":"2004","journal-title":"Am. J. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1006\/jmcc.2001.1378","article-title":"Mitochondrial dysfunction in cardiac disease: Ischemia-reperfusion, aging, and heart failure","volume":"33","author":"Lesnefsky","year":"2001","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1172\/JCI120842","article-title":"The role of mitochondria in aging","volume":"128","author":"Jang","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.2337\/diabetes.51.10.2944","article-title":"Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes","volume":"51","author":"Kelley","year":"2002","journal-title":"Diabetes"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1152\/jappl.1997.83.1.166","article-title":"Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM","volume":"83","author":"Simoneau","year":"1997","journal-title":"J. Appl. Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"11401","DOI":"10.1074\/jbc.273.19.11401","article-title":"Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss","volume":"273","author":"Cai","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1126\/science.275.5303.1132","article-title":"The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis","volume":"275","author":"Kluck","year":"1997","journal-title":"Science"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1126\/science.275.5303.1129","article-title":"Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked","volume":"275","author":"Yang","year":"1997","journal-title":"Science"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0005-2728(98)00121-2","article-title":"The role of mitochondria in the salvage and the injury of the ischemic myocardium","volume":"1366","author":"Canton","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000103747","article-title":"Mitochondrial permeability transition pore opening as an endpoint to initiate cell death and as a putative target for cardioprotection","volume":"20","author":"Javadov","year":"2007","journal-title":"Cell Physiol. Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1084\/jem.185.8.1481","article-title":"Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis","volume":"185","author":"Leist","year":"1997","journal-title":"J. Exp. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1007\/s12035-017-0503-9","article-title":"Mitochondrial Quality Control and Disease: Insights into Ischemia-Reperfusion Injury","volume":"55","author":"Anzell","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"8122","DOI":"10.1002\/jcp.27597","article-title":"Mitochondrial quality control in cardiac cells: Mechanisms and role in cardiac cell injury and disease","volume":"234","author":"Tahrir","year":"2019","journal-title":"Cell Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.emboj.7601963","article-title":"Fission and selective fusion govern mitochondrial segregation and elimination by autophagy","volume":"27","author":"Twig","year":"2008","journal-title":"EMBO J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.tibs.2012.02.004","article-title":"Mitochondrial quality control: An integrated network of pathways","volume":"37","author":"Fischer","year":"2012","journal-title":"Trends Biochem. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/sj.emboj.7601972","article-title":"Quality control of mitochondria: Protection against neurodegeneration and ageing","volume":"27","author":"Tatsuta","year":"2008","journal-title":"EMBO J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ceb.2014.09.010","article-title":"ROS-dependent signal transduction","volume":"33","author":"Reczek","year":"2015","journal-title":"Curr. Opin. Cell. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1128\/MCB.00683-07","article-title":"Survival signaling by C-RAF: Mitochondrial reactive oxygen species and Ca2+ are critical targets","volume":"28","author":"Kuznetsov","year":"2008","journal-title":"Mol. Cell Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1089\/ars.2006.8.1651","article-title":"A wave of reactive oxygen species (ROS)-induced ROS release in a sea of excitable mitochondria","volume":"8","author":"Brady","year":"2006","journal-title":"Antioxid. Redox Signal."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia-reperfusion injury: A neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1006834912257","article-title":"Permeabilised cell and skinned fiber techniques in studies of mitochondrial function in vivo","volume":"184","author":"Saks","year":"1998","journal-title":"Mol. Cell. Biochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0005-2728(87)90174-5","article-title":"Mitochondrial respiratory parameters in cardiac tissue: A novel method of assessment by using saponin-skinned fibers","volume":"892","author":"Veksler","year":"1987","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/0005-2728(93)90029-F","article-title":"Functional characterization of mitochondrial oxidative phosphorylation in saponin-skinned human muscle fibers","volume":"1144","author":"Kunz","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nprot.2008.61","article-title":"Analysis of mitochondrial function in situ, in permeabilized muscle fibers, tissues and cells","volume":"3","author":"Kuznetsov","year":"2008","journal-title":"Nat. Prot."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-3-319-55330-6_8","article-title":"Mitochondrial Bioenergetics During Ischemia and Reperfusion","volume":"982","author":"Consolini","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1097\/01.TP.0000115346.85679.34","article-title":"Functional heterogeneity of mitochondria after cardiac cold ischemia and reperfusion revealed by confocal imaging","volume":"77","author":"Kuznetsov","year":"2004","journal-title":"Transplantation"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1073\/pnas.95.4.1618","article-title":"Subcellular metabolic transients and mitochondrial redox waves in heart cells","volume":"95","author":"Romashko","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.bbabio.2006.03.014","article-title":"Mitochondrial subpopulations and heterogeneity revealed by confocal imaging: Possible physiological role?","volume":"1757","author":"Kuznetsov","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1023\/B:MCBI.0000009881.01943.68","article-title":"Subcellular heterogeneity of mitochondrial function and dysfunction: Evidence obtained by confocal imaging","volume":"256","author":"Kuznetsov","year":"2004","journal-title":"Mol. Cell Biochem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.bbabio.2017.03.001","article-title":"Synchronism in mitochondrial ROS flashes, membrane depolarization and calcium sparks in human carcinoma cells","volume":"1858","author":"Kuznetsov","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0091-679X(06)80014-2","article-title":"Imaging of mitochondrial polarization and depolarization with cationic fluorophores","volume":"80","author":"Lemasters","year":"2007","journal-title":"Methods Cell Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0006-3495(00)76272-2","article-title":"Mitochondrial calcium transients in adult rabbit cardiac myocytes: Inhibition by ruthenium red and artifacts caused by lysosomal loading of Ca(2+)-indicating fluorophores","volume":"79","author":"Trollinger","year":"2000","journal-title":"Biophys. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"C1083","DOI":"10.1152\/ajpcell.00276.2002","article-title":"Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death","volume":"284","author":"Knight","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1073\/pnas.052545099","article-title":"Fast 100-nm resolution three-dimensional microscope reveals structural plasticity of mitochondria in live yeast","volume":"99","author":"Egner","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.yjmcc.2014.03.011","article-title":"Mitochondrial reactive oxygen species production and elimination","volume":"73","author":"Nickel","year":"2014","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","article-title":"Mitochondrial formation of reactive oxygen species","volume":"552","author":"Turrens","year":"2003","journal-title":"J. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00018.2001","article-title":"Free radicals in the physiological control of cell function","volume":"82","author":"Droge","year":"2002","journal-title":"Physiol. Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1083\/jcb.141.6.1423","article-title":"The regulation of reactive oxygen species production during programmed cell death","volume":"141","author":"Tan","year":"1998","journal-title":"J. Cell Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1046\/j.0022-3042.2002.00744.x","article-title":"Generation of reactive oxygen species by the mitochondrial electron transport chain","volume":"80","author":"Liu","year":"2002","journal-title":"J. Neurochem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1161\/CIRCRESAHA.114.300559","article-title":"Cardiac mitochondria and reactive oxygen species generation","volume":"114","author":"Chen","year":"2014","journal-title":"Circ. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1161\/01.RES.85.4.357","article-title":"Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium","volume":"85","author":"Ide","year":"1999","journal-title":"Circ. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1074\/jbc.M310341200","article-title":"Characterization of superoxide-producing sites in isolated brain mitochondria","volume":"279","author":"Kudin","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"39414","DOI":"10.1074\/jbc.M406576200","article-title":"Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I)","volume":"279","author":"Lambert","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Park, J., Lee, J., and Choi, C. (2011). Mitochondrial network determines intracellular ROS dynamics and sensitivity to oxidative stress through switching inter-mitochondrial messengers. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023211"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1084\/jem.192.7.1001","article-title":"Reactive oxygen species (ROS)-induced ROS release: A new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes","volume":"192","author":"Zorov","year":"2000","journal-title":"J. Exp. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.cell.2008.06.017","article-title":"Superoxide flashes in single mitochondria","volume":"134","author":"Wang","year":"2008","journal-title":"Cell"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.bpj.2012.01.044","article-title":"Superoxide flashes reveal novel properties of mitochondrial reactive oxygen species excitability in cardiomyocytes","volume":"102","author":"Li","year":"2012","journal-title":"Biophys. J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.cell.2006.06.010","article-title":"Mitochondria: Dynamic organelles in disease, aging, and development","volume":"125","author":"Chan","year":"2006","journal-title":"Cell"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e149","DOI":"10.1038\/14101","article-title":"Dynamic mitochondria","volume":"1","author":"Yaffe","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"26185","DOI":"10.1074\/jbc.M503062200","article-title":"Disruption of fusion results in mitochondrial heterogeneity and dysfunction","volume":"280","author":"Chen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/cvr\/cvp181","article-title":"Mitochondrial OPA1, apoptosis, and heart failure","volume":"84","author":"Chen","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00395-010-0122-3","article-title":"Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: The effect of NHE-1 inhibition","volume":"106","author":"Javadov","year":"2011","journal-title":"Basic Res. Cardiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1083\/jcb.200211046","article-title":"Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development","volume":"160","author":"Chen","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1083\/jcb.147.4.699","article-title":"Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape","volume":"147","author":"Sesaki","year":"1999","journal-title":"J. Cell Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"14772","DOI":"10.1073\/pnas.232346999","article-title":"Cytoskeletal-assisted dynamics of the mitochondrial reticulum in living cells","volume":"99","author":"Knowles","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/cbf.974","article-title":"The regulation of mitochondrial physiology by organelle-associated GTP-binding proteins","volume":"20","author":"Thomson","year":"2002","journal-title":"Cell. Biochem. Funct."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nature05111","article-title":"Role of Bax and Bak in mitochondrial morphogenesis","volume":"443","author":"Karbowski","year":"2006","journal-title":"Nature"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.tcb.2005.02.005","article-title":"Mitochondrial fusion and fission in the control of apoptosis","volume":"15","author":"Perfettini","year":"2005","journal-title":"Trends Cell Biol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/sj.cdd.4401260","article-title":"Dynamics of mitochondrial morphology in healthy cells and during apoptosis","volume":"10","author":"Karbowski","year":"2003","journal-title":"Cell Death Differ."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.bbamcr.2006.04.003","article-title":"Mitochondrial dynamics and disease","volume":"1763","author":"Olichon","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"R283","DOI":"10.1093\/hmg\/ddi270","article-title":"Emerging functions of mammalian mitochondrial fusion and fission","volume":"14","author":"Chen","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1159\/000489241","article-title":"Current Mechanistic Concepts in Ischemia and Reperfusion Injury","volume":"46","author":"Wu","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbadis.2014.05.010","article-title":"The role of the autophagy in myocardial ischemia\/reperfusion injury","volume":"1852","author":"Ma","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.bbadis.2019.05.007","article-title":"Mitophagy and mitochondrial integrity in cardiac ischemia-reperfusion injury","volume":"1865","author":"Yang","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1161\/hh1401.093440","article-title":"Energetic crosstalk between organelles. Architectual integration of energy production and utilization","volume":"89","author":"Kaasik","year":"2001","journal-title":"Circ. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1083\/jcb.150.6.1283","article-title":"Desmin cytoskeleton linked to muscle mitochondrial distribution and respiratory function","volume":"150","author":"Milner","year":"2000","journal-title":"J. Cell Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.bbabio.2006.04.013","article-title":"The relationship between mitochondrial shape and function and the cytoskeleton","volume":"1757","author":"Anesti","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.bbabio.2011.01.010","article-title":"Mitochondria-cytoskeleton interaction: Distribution of \u03b2-tubulins in cardiomyocytes and HL-1 cells","volume":"1807","author":"Guzun","year":"2011","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1083\/jcb.200710151","article-title":"Plectin isoform 1b mediates mitochondrion-intermediate lament network linkage and controls organelle shape","volume":"181","author":"Winter","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.1093\/hmg\/ddv184","article-title":"Plectin isoform P1b and P1d deficiencies differentially affect mitochondrial morphology and function in skeletal muscle","volume":"24","author":"Winter","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.bbabio.2013.10.011","article-title":"Role of mitochondria-cytoskeleton interactions in respiration regulation and mitochondrial organization in striated muscles","volume":"1837","author":"Varikmaa","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1042\/BJ20071072","article-title":"Vimentin supports mitochondrial morphology and organization","volume":"410","author":"Tang","year":"2008","journal-title":"Biochem. J."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fphys.2013.00082","article-title":"Cytoskeleton and regulation of mitochondrial function: The role of beta-tubulin II","volume":"4","author":"Kuznetsov","year":"2013","journal-title":"Front. Physiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1093\/emboj\/20.15.4107","article-title":"Propagation of the apoptotic signal by mitochondrial waves","volume":"20","author":"Pacher","year":"2001","journal-title":"EMBO J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1093\/emboj\/21.7.1616","article-title":"Mitochondria are morphologically and functionally heterogeneous within cells","volume":"21","author":"Collins","year":"2002","journal-title":"EMBO J."},{"key":"ref_94","first-page":"98P","article-title":"Mitochondria are morphologically and functionally heterogeneous within single cells","volume":"539","author":"Collins","year":"2002","journal-title":"J. Physiol. Lond."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.3390\/ijms10041911","article-title":"Heterogeneity of mitochondria and mitochondrial function within cells as another level of mitochondrial complexity","volume":"10","author":"Kuznetsov","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.2337\/db06-0757","article-title":"Beta-cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels","volume":"56","author":"Wikstrom","year":"2007","journal-title":"Diabetes"},{"key":"ref_97","first-page":"36","article-title":"Functional heterogeneity of mitochondria in normal cells and after ischemia\/reperfusion revealed by confocal imaging","volume":"23","author":"Kuznetsov","year":"2005","journal-title":"Shock"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1093\/emboj\/20.8.1863","article-title":"Perinuclear, perigranular and sub-plasmalemmal mitochondria have distinct functions in the regulation of cellular calcium transport","volume":"20","author":"Park","year":"2001","journal-title":"EMBO J."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0003-9861(85)90675-7","article-title":"Biochemical differences between subsarcolemmal and interfibrillar mitochondria from rat cardiac muscle: Effects of procedural manipulations","volume":"236","author":"Palmer","year":"1985","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1046\/j.1432-1033.2002.02953.x","article-title":"Expression of uncoupling protein-3 in subsarcolemmal and intermyofibrillar mitochondria of various mouse muscle types and its modulation by fasting","volume":"269","author":"Jimenez","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1083\/jcb.140.5.1091","article-title":"Functional imaging of mitochondria in saponin-permeabilized mice muscle fibers","volume":"140","author":"Kuznetsov","year":"1998","journal-title":"J. Cell Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1046\/j.1471-4159.2002.01238.x","article-title":"Heterogeneity of the calcium-induced permeability transition in isolated non-synaptic brain mitochondria","volume":"83","author":"Kristian","year":"2002","journal-title":"J. Neurochem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cell.2005.05.011","article-title":"Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis","volume":"122","author":"Giorgio","year":"2005","journal-title":"Cell"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1126\/science.1135380","article-title":"Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc","volume":"315","author":"Pinton","year":"2007","journal-title":"Science"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00395-019-0738-x","article-title":"P66shc and its role in ischemic cardiovascular diseases","volume":"114","author":"Boengler","year":"2019","journal-title":"Basic Res. Cardiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1111\/bph.13478","article-title":"New aspects of p66Shc in ischaemia reperfusion injury and other cardiovascular diseases","volume":"174","author":"Giorgio","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0022-510X(94)00227-F","article-title":"Polarographic analyses of subsarcolemmal and intermyofibrillar mitochondria from rat skeletal and cardiac muscle","volume":"128","author":"Manneschi","year":"1995","journal-title":"J. Neurol. Sci."},{"key":"ref_108","first-page":"H1544","article-title":"Myocardial ischemia decreases oxidative phosphorylation through cytochrome oxidase in subsarcolemmal mitochondria","volume":"273","author":"Lesnefsky","year":"1997","journal-title":"Am. J. Physiol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/S0021-9258(19)68226-8","article-title":"Hamster cardiomyopathy. A defect in oxidative phosphorylation in the cardiac interfibrillar mitochondria","volume":"257","author":"Hoppel","year":"1982","journal-title":"J. Biol. Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"10156","DOI":"10.1073\/pnas.152259999","article-title":"Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer","volume":"99","author":"Dzeja","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"12909","DOI":"10.1074\/jbc.M309070200","article-title":"Modulation of [Ca2+]i signaling dynamics and metabolism by perinuclear mitochondria in mouse parotid acinar cells","volume":"279","author":"Bruce","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1007\/s00216-011-4764-2","article-title":"Mitochondrial ROS production under cellular stress: Comparison of different detection methods","volume":"400","author":"Kuznetsov","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1161\/01.RES.41.5.606","article-title":"Heterogeneity of the hypoxic state in perfused rat heart","volume":"41","author":"Steenbergen","year":"1977","journal-title":"Circ. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/1097-0320(20000701)40:3<189::AID-CYTO3>3.0.CO;2-6","article-title":"Mitochondrial heterogeneity during staurosporine-induced apoptosis in HL60 cells: Analysis at the single cell and single organelle level","volume":"40","author":"Salvioli","year":"2000","journal-title":"Cytometry"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1139\/o80-149","article-title":"Membrane changes induced by early myocardial ischemia in the dog","volume":"58","author":"Vasdev","year":"1980","journal-title":"Can. J. Biochem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1471-2121-3-14","article-title":"Negative regulation of mitochondrial VDAC channels by C-Raf kinase","volume":"3","author":"Le","year":"2002","journal-title":"BMC Cell Biol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nature05859","article-title":"RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels","volume":"447","author":"Yagoda","year":"2007","journal-title":"Nature"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"4350965","DOI":"10.1155\/2016\/4350965","article-title":"ROS and ROS-Mediated Cellular Signaling","volume":"2016","author":"Zhang","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.bbadis.2016.03.009","article-title":"The impact of cardiac ischemia\/reperfusion on the mitochondria-cytoskeleton interactions","volume":"1862","author":"Bagur","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"8254942","DOI":"10.1155\/2016\/8254942","article-title":"The role of mitochondrial reactive oxygen species in cardiovascular injury and protective strategies","volume":"2016","author":"Muntean","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/978-94-007-2869-1_11","article-title":"Mitochondria and heart disease","volume":"942","author":"Griffiths","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1073\/pnas.95.2.510","article-title":"Cardiac reperfusion injury: Aging, lipid peroxidation, and mitochondrial dysfunction","volume":"95","author":"Lucas","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev-pharmtox-010715-103335","article-title":"Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies","volume":"57","author":"Lesnefsky","year":"2017","journal-title":"Annu. Rev. Pharm. Toxicol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ajmg.1391","article-title":"Clinical spectrum and diagnosis of mitochondrial disorders","volume":"106","author":"Munnich","year":"2001","journal-title":"Am. J. Med. Genet."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.ceca.2009.03.012","article-title":"Role of cardiolipin peroxidation and Ca2+ in mitochondrial dysfunction and disease","volume":"45","author":"Paradies","year":"2009","journal-title":"Cell Calcium"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0891-5849(99)00032-5","article-title":"Lipid peroxidation and alterations to oxidative metabolism in mitochondria isolated from rat heart subjected to ischemia and reperfusion","volume":"27","author":"Paradies","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0014-5793(00)01082-6","article-title":"The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles","volume":"466","author":"Paradies","year":"2000","journal-title":"FEBS Lett."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1172\/JCI117504","article-title":"Reperfusion injury induces apoptosis in rabbit cardiomyocytes","volume":"94","author":"Gottlieb","year":"1994","journal-title":"J. Clin. Investig."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"C227","DOI":"10.1152\/ajpcell.00112.2001","article-title":"Reactive species mechanisms of cellular hypoxia-reoxygenation injury","volume":"282","author":"Li","year":"2002","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/00007890-199708270-00005","article-title":"Effect of prolonged hypothermic ischemia and reperfusion on oxygen consumption and total mechanical energy in rat myocardium: Participation of mitochondrial oxidative phosphorylation","volume":"64","author":"Kuwabara","year":"1997","journal-title":"Transplantation"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0022-5223(19)34755-5","article-title":"Axford-Gatley, R.A.; Salter, D.R. Prolonged hypothermic cardiac storage for transplantation. The effects on myocardial metabolism and mitochondrial function","volume":"104","author":"See","year":"1992","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1089\/152308604322899521","article-title":"Reactive oxygen species as mediators of signal transduction in ischemic preconditioning","volume":"6","author":"Otani","year":"2004","journal-title":"Antioxid. Redox Signal."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.redox.2017.05.017","article-title":"Mitochondria-meditated pathways of organ failure upon inflammation","volume":"13","author":"Kozlov","year":"2017","journal-title":"Redox Biol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"22042","DOI":"10.3390\/ijms141122042","article-title":"Impact of cold ischemia on mitochondrial function in porcine hearts and blood vessels","volume":"14","author":"Wiedemann","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_135","first-page":"173","article-title":"Intracellular energetic units in healthy and diseased hearts","volume":"10","author":"Seppet","year":"2005","journal-title":"Exp. Clin. Cardiol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0005-2728(98)00122-4","article-title":"Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart","volume":"1366","author":"Halestrap","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1152\/physrev.1999.79.4.1127","article-title":"Mitochondrial transport of cations: Channels, exchangers, and permeability transition","volume":"79","author":"Bernardi","year":"1999","journal-title":"Physiol. Rev."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0008-6363(03)00533-9","article-title":"Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection","volume":"61","author":"Halestrap","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"H237","DOI":"10.1152\/ajpheart.01192.2004","article-title":"Mitochondrial permeability transition pore as a target for cardioprotection in the human heart","volume":"289","author":"Shanmuganathan","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1016\/S0021-9258(19)67802-6","article-title":"The giant channel of the inner mitochondrial membrane is inhibited by Cyclosporin-A","volume":"266","author":"Szabo","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nature03317","article-title":"Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death","volume":"434","author":"Nakagawa","year":"2005","journal-title":"Nature"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3389\/fphys.2013.00076","article-title":"Mitochondrial permeability transition and cell death: The role of cyclophilin D","volume":"4","author":"Javadov","year":"2013","journal-title":"Front. Physiol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1124\/jpet.109.153213","article-title":"Mitochondrial permeability transition pore opening as a promising therapeutic target in cardiac diseases","volume":"330","author":"Javadov","year":"2009","journal-title":"J. Pharm. Exp. Ther."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Andrienko, T., Pasdois, P., Rossbach, A., and Halestrap, A.P. (2016). Real-Time Fluorescence Measurements of ROS and [Ca2+] in Ischemic\/Reperfused Rat Hearts: Detectable Increases Occur only after Mitochondrial Pore Opening and Are Attenuated by Ischemic Preconditioning. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0167300"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/0022-2828(91)90181-K","article-title":"Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A","volume":"23","author":"Nazareth","year":"1991","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/S0003-4975(03)00830-0","article-title":"Protection of myocardium by cyclosporin A and insulin: In vitro simulated ischemia study in human myocardium","volume":"76","author":"Schneider","year":"2003","journal-title":"Ann. Thorac. Surg."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"234104","DOI":"10.1155\/2015\/234104","article-title":"The mitochondrial translocator protein and arrhythmogenesis in ischemic heart disease","volume":"2015","author":"Motloch","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Holmuhamedov, E.L., Oberlin, A., Short, K., Terzic, A., and Jahangir, A. (2012). Cardiac subsarcolemmal and interfibrillar mitochondria display distinct responsiveness to protection by diazoxide. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0044667"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.yjmcc.2014.08.018","article-title":"The mitochondrial permeability transition: A current perspective on its identity and role in ischaemia\/reperfusion injury","volume":"78","author":"Halestrap","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.yjmcc.2014.09.023","article-title":"The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection","volume":"78","author":"Bernardi","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1007\/s00018-017-2502-4","article-title":"Mitochondrial permeability transition in cardiac ischemia-reperfusion: Whether cyclophilin D is a viable target for cardioprotection?","volume":"74","author":"Javadov","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.2174\/0929867322666150530210005","article-title":"Modulation of Mitochondrial Permeability Transition in Ischemia-Reperfusion Injury of the Heart. Advantages and Limitations","volume":"22","author":"Bernardi","year":"2015","journal-title":"Curr. Med. Chem."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1056\/NEJMoa071142","article-title":"Effect of cyclosporine on reperfusion injury in acute myocardial infarction","volume":"359","author":"Piot","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"H1654","DOI":"10.1152\/ajpheart.01378.2006","article-title":"Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice","volume":"293","author":"Gomez","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1136\/heartjnl-2013-304845","article-title":"The effect of cyclosporin-A on peri-operative myocardial injury in adult patients undergoing coronary artery bypass graft surgery: A randomised controlled clinical trial","volume":"100","author":"Hausenloy","year":"2014","journal-title":"Heart"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1159\/000494006","article-title":"Divergent Effects of Cyclophilin-D Inhibition on the Female Rat Heart: Acute Versus Chronic Post-Myocardial Infarction","volume":"50","author":"Javadov","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.yjmcc.2015.10.036","article-title":"Cyclophilin D regulates mitochondrial flashes and metabolism in cardiac myocytes","volume":"91","author":"Shang","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1089\/ars.2016.6635","article-title":"Elucidating Mitochondrial Electron Transport Chain Supercomplexes in the Heart During Ischemia-Reperfusion","volume":"27","author":"Jang","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.hlc.2018.01.008","article-title":"Increased Survival Time with SS-31 After Prolonged Cardiac Arrest in Rats","volume":"28","author":"Zhang","year":"2019","journal-title":"Heart Lung Circ."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2018.01.024","article-title":"ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection","volume":"117","author":"Cadenas","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_161","first-page":"6859523","article-title":"Mitochondrion-Permeable Antioxidants to Treat ROS-Burst-Mediated Acute Diseases","volume":"2016","author":"Zhang","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1007\/s00018-017-2609-7","article-title":"Melatonin as a mitochondria-targeted antioxidant: One of evolution\u2019s best ideas","volume":"74","author":"Reiter","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.biocel.2018.02.007","article-title":"Mitochondria: Targeting mitochondrial reactive oxygen species with mitochondriotropic polyphenolic-based antioxidants","volume":"97","author":"Teixeira","year":"2018","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"4763","DOI":"10.2174\/1381612822666160629070914","article-title":"Application of Mitochondria-Targeted Pharmaceuticals for the Treatment of Heart Disease","volume":"22","author":"Mailloux","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"34682","DOI":"10.1074\/jbc.M402999200","article-title":"Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury","volume":"279","author":"Zhao","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"e521","DOI":"10.1208\/aapsj080362","article-title":"Mitochondria-targeted peptide antioxidants: Novel neuroprotective agents","volume":"8","author":"Szeto","year":"2006","journal-title":"AAPS J."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.2174\/138161211796904777","article-title":"Mitochondrial therapeutics for cardioprotection","volume":"17","author":"Carreira","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1042\/bst0311300","article-title":"Mitochondrial matrix reactive oxygen species production is very sensitive to mild uncoupling","volume":"31","author":"Miwa","year":"2003","journal-title":"Biochem. Soc. Trans."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2174\/138945011795528778","article-title":"Mild mitochondrial uncoupling as a therapeutic strategy","volume":"12","author":"Cunha","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0008-6363(00)00069-9","article-title":"Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: Support for a mitochondrial role in cardioprotection","volume":"47","author":"Minners","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1038\/bjp.2008.45","article-title":"Dose-dependent protective effect of propofol against mitochondrial dysfunction in ischaemic\/reperfused rat heart: Role of cardiolipin","volume":"153","author":"Shao","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/biof.5520240114","article-title":"Hydroxynonenal and uncoupling proteins: A model for protection against oxidative damage","volume":"24","author":"Echtay","year":"2005","journal-title":"Biofactors"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cmet.2005.06.002","article-title":"Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3","volume":"2","author":"Brand","year":"2005","journal-title":"Cell Metab."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/978-3-319-55330-6_31","article-title":"Mitochondrial Transplantation in Myocardial Ischemia and Reperfusion Injury","volume":"982","author":"Shin","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1172\/JCI124944","article-title":"Mitochondrial transplantation in humans: \u201cMagical\u201d cure or cause for concern?","volume":"128","author":"Bertero","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev.med.47.1.21","article-title":"Myocardial preconditioning promises to be a novel approach to the treatment of ischemic heart disease","volume":"47","author":"Cohen","year":"1996","journal-title":"Annu. Rev. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1161\/01.RES.86.5.541","article-title":"Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion","volume":"86","author":"Becker","year":"2000","journal-title":"Circ. Res."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1253\/circj.67.253","article-title":"Protective effects of hydrogen peroxide against ischemia\/reperfusion injury in perfused rat hearts","volume":"67","author":"Yaguchi","year":"2003","journal-title":"Circ. J."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/01.RES.80.5.743","article-title":"Oxygen radicals can induce preconditioning in rabbit hearts","volume":"80","author":"Tritto","year":"1997","journal-title":"Circ. Res."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1113\/jphysiol.2003.034231","article-title":"Ischaemic preconditioning inhibits opening of mitochondrial permeability transition pores in the reperfused rat heart","volume":"549","author":"Javadov","year":"2003","journal-title":"J. Physiol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0008-6363(02)00455-8","article-title":"Inhibiting mitochondrial permeability transition pore opening: A new paradigm for myocardial preconditioning?","volume":"55","author":"Hausenloy","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cardiores.2003.11.003","article-title":"Preconditioning delays Ca2+-induced mitochondrial permeability transition","volume":"61","author":"Argaud","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s10517-016-3410-6","article-title":"Involvement of Protein Kinase C-\u03b4 in the Realization of Cardioprotective Effect of Ischemic Postconditioning","volume":"161","author":"Lishmanov","year":"2016","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"H284","DOI":"10.1152\/ajpheart.00034.2002","article-title":"Mechanisms by which opening the mitochondrial ATP- sensitive K+ channel protects the ischemic heart","volume":"283","author":"Kowaltowski","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"H1048","DOI":"10.1152\/ajpheart.00847.2002","article-title":"Targeting nucleotide-requiring enzymes: Implications for diazoxide-induced cardioprotection","volume":"284","author":"Dzeja","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.yjmcc.2011.07.015","article-title":"Intracellular Energetic Units regulate metabolism in cardiac cells","volume":"52","author":"Saks","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.yjmcc.2011.07.027","article-title":"Studies of the role of tubulin beta II isotype in regulation of mitochondrial respiration in intracellular energetic units in cardiac cells","volume":"52","author":"Grichine","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"7757","DOI":"10.1016\/S0021-9258(17)39672-2","article-title":"Creatine kinase of rat heart mitochondria: The demonstration of functional coupling to oxidative phosphorylation in an inner membrane-matrix preparation","volume":"260","author":"Saks","year":"1985","journal-title":"J. Biol. Chem."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"6937","DOI":"10.1074\/jbc.275.10.6937","article-title":"Direct evidence for the control of mitochondrial respiration by mitochondrial creatine kinase in oxidative muscle cells in situ","volume":"275","author":"Kay","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0005-2728(93)90166-D","article-title":"Retarded diffusion of ADP in cardiomyocytes: Possible role of mitochondrial outer membrane and creatine kinase in cellular regulation of oxidative phosphorylation","volume":"1144","author":"Saks","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.bbamcr.2010.09.006","article-title":"Bioenergetics of the failing heart","volume":"1813","author":"Garnier","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0022-2828(89)90839-0","article-title":"Quantitative evaluation of relationship between cardiac energy metabolism and post-ischemic recovery of contractile function","volume":"21","author":"Saks","year":"1989","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_194","first-page":"30","article-title":"Phosphocreatine pathway for intracellular energy transport: Facilitation of restricted diffusion of ADP in cardiomyocytes and alterations in cardiomyopathy","volume":"261","author":"Saks","year":"1991","journal-title":"Am. J. Physiol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/S0006-291X(89)80030-0","article-title":"Alterations in the creatine kinase system in the cardiomyopathic hamsters","volume":"165","author":"Khuchua","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000046878","article-title":"Mitochondrial creatine kinase in contact sites: Interaction with porin and adenine nucleotide translocase, role in permeability transition and sensitivity to oxidative damage","volume":"10","author":"Dolder","year":"2001","journal-title":"Biol Signals Recept."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"19914","DOI":"10.1074\/jbc.270.34.19914","article-title":"Muscle creatine kinase deficient mice: Alteration in myofibrillar function","volume":"270","author":"Kuznetsov","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"19921","DOI":"10.1074\/jbc.270.34.19921","article-title":"Muscle creatine kinase deficient mice: Cardiac and skeletal muscle tissue-specificity of adaptation of the mitochondrial function","volume":"270","author":"Veksler","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"17760","DOI":"10.1074\/jbc.M208705200","article-title":"Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentation","volume":"278","author":"Dolder","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1042\/BST20170504","article-title":"The creatine kinase system as a therapeutic target for myocardial ischaemia-reperfusion injury","volume":"46","author":"Cao","year":"2018","journal-title":"Biochem. Soc. Trans."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/8\/10\/454\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:27:53Z","timestamp":1760189273000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/8\/10\/454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,6]]},"references-count":200,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10]]}},"alternative-id":["antiox8100454"],"URL":"https:\/\/doi.org\/10.3390\/antiox8100454","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,6]]}}}