{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:48:02Z","timestamp":1773726482024,"version":"3.50.1"},"reference-count":46,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Network for Extreme Environments Research project (NEXER)","award":["Project ANT1756"],"award-info":[{"award-number":["Project ANT1756"]}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["FONDECYT 1180059"],"award-info":[{"award-number":["FONDECYT 1180059"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Vicerrector\u00eda de Investigaci\u00f3n, Innovaci\u00f3n y Postgrado Universidad Arturo Prat","award":["VRIIP0047-19, VRIIP0179-19"],"award-info":[{"award-number":["VRIIP0047-19, VRIIP0179-19"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Parastrephia quadrangularis (Pq), commonly called \u201cTola\u201d, is widely used in folk medicine in the Andes, including for altitude sickness. In this study, polyphenolic composition was determined, and hypotensive effects were measured; the ethnopharmacological use as hypotensive was related to the presence of phenolic compounds. For this purpose, male Sprague-Dawley rats (6 to 8 weeks of age, 160 to 190 g) were fed Pq extract (10 to 40 mg\/kg) for 10 days through gavage. Blood pressures and heart rate were significantly (p &lt; 0.01) reduced in normotensive rats receiving Pq extract (40 mg\/kg body weight). Pq extract induced a negative inotropic effect, and endothelium-dependent vasodilation mediated by nitric oxide (NO). Furthermore, preincubation with Pq extract significantly decreased the cytosolic calcium on vascular smooth muscle cells A7r5 in response to L-phenylephrine (PE). Seven metabolites were isolated from the Pq extract, but three flavonoids (10\u22124 M) showed similar vasodilation to the extract in intact rat aorta as follows: 5,3\u2032,4\u2032-trihydroxy-7-methoxyflavanone (2); 3,5,4\u2032-trihydroxy-7,8,3\u2032-trimethoxyflavone (6); and 5,4\u2032-dihydroxy-3,7,8,3\u2032-tetramethoxyflavone (7). The Pq extract and compounds 2 and 7 significantly (p &lt; 0.05) reduced the contraction to Bay K8644 (10 nM, an agonist of CaV1.2 channels). Administration of Pq decreased cardiac contractility and increased endothelium-dependent and -independent vasodilation.<\/jats:p>","DOI":"10.3390\/antiox8120591","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T03:55:51Z","timestamp":1574826951000},"page":"591","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Polyphenolic Composition and Hypotensive Effects of Parastrephia quadrangularis (Meyen) Cabrera in Rat"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5922-8892","authenticated-orcid":false,"given":"Fredi","family":"Cifuentes","sequence":"first","affiliation":[{"name":"Laboratorio de Fisiolog\u00eda Experimental (EPhyL), Instituto Antofagasta (IA), Universidad de Antofagasta, 1270300 Antofagasta, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7997-9295","authenticated-orcid":false,"given":"Javier","family":"Palacios","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioqu\u00edmica Aplicada, Facultad de Ciencias de la Salud, Universidad Arturo Prat, 1110939 Iquique, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7092-9382","authenticated-orcid":false,"given":"Chukwuemeka","family":"Nwokocha","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences (Physiology Section), Faculty of Medical Sciences, The University of the West Indies, Mona, Kingston 7, Jamaica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"B\u00f3rquez","sequence":"additional","affiliation":[{"name":"Laboratorio de Productos Naturales, Departamento de Qu\u00edmica, Universidad de Antofagasta, 1270300 Antofagasta, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4552-3123","authenticated-orcid":false,"given":"Mario","family":"Simirgiotis","sequence":"additional","affiliation":[{"name":"Instituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia 5090000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Norambuena","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases (ACCDiS), CEMC, Department of Biochemistry and Molecular Biology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago 8380492, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Chiong","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases (ACCDiS), CEMC, Department of Biochemistry and Molecular Biology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago 8380492, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3332-8582","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Paredes","sequence":"additional","affiliation":[{"name":"Laboratorio de Qu\u00edmica Biol\u00f3gica, Instituto Antofagasta (IA), Universidad de Antofagasta, 1270300 Antofagasta, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"ref_1","first-page":"7","article-title":"La tradici\u00f3n surandina del desierto: Etnobot\u00e1nica del \u00e1rea del Salar de Atacama (Provincia de El Loa, Regi\u00f3n de Antofagasta, Chile)","volume":"16","author":"Castro","year":"1998","journal-title":"Estud. 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