{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T16:10:15Z","timestamp":1771949415951,"version":"3.50.1"},"reference-count":27,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T00:00:00Z","timestamp":1591401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017R1C1B2007195"],"award-info":[{"award-number":["NRF-2017R1C1B2007195"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2019R1I1A2A01061731"],"award-info":[{"award-number":["NRF-2019R1I1A2A01061731"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The difference between metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) phenotypes might be partly attributable to genetic traits modulating body fat distribution and other obesity-related metabolic traits, specifically with regard to LEPR rs8179183 in Korean women with obesity. A total of 177 females with obesity participated in the study and were grouped by genotype (GC or GG) and metabolic health status (MHO and MUO). Between the MHO and MUO groups, significant differences were found in waist circumference, waist-to-hip ratio, lipid profiles, glucose-related markers, biomarkers of liver health, adiponectin, oxidative stress markers, whole fat area (WFA), and subcutaneous fat area (SFA) at the level of the L1 vertebra, and WFA and visceral fat area (VFA) at the level of the L4 vertebra. Lipid profiles, glucose-related markers, adipokines, oxidative stress markers, and WFA and VFA at the L4 level were significantly different between the GC and GG genotypes. Notably, the individuals with the MUO phenotype and the GG genotype had the least favorable values of glucose-related markers, lipid profiles, adipokines, oxidative stress markers, and regional fat distribution. These observations suggest that the development of obesity-related metabolic traits is highly associated not only with the rs8179183 genotype but also with metabolic status in Korean females with obesity.<\/jats:p>","DOI":"10.3390\/antiox9060497","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T04:19:39Z","timestamp":1591676379000},"page":"497","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Risk Associated with the LEPR rs8179183 GG Genotype in a Female Korean Population with Obesity"],"prefix":"10.3390","volume":"9","author":[{"given":"Kyunghye","family":"Jang","sequence":"first","affiliation":[{"name":"National Leading Research Laboratory of Clinical Nutrigenetics\/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul 03722, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0437-1434","authenticated-orcid":false,"given":"Gurum","family":"Shin","sequence":"additional","affiliation":[{"name":"National Leading Research Laboratory of Clinical Nutrigenetics\/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul 03722, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2075-0426","authenticated-orcid":false,"given":"Hye Jin","family":"Yoo","sequence":"additional","affiliation":[{"name":"National Leading Research Laboratory of Clinical Nutrigenetics\/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul 03722, Korea"},{"name":"Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul 03722, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"National Leading Research Laboratory of Clinical Nutrigenetics\/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul 03722, Korea"},{"name":"Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul 03722, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4261-9333","authenticated-orcid":false,"given":"Minjoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, College of Life Science and Nano Technology, Hannam University, Daejeon 34054, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.metabol.2018.11.009","article-title":"Metabolically healthy versus metabolically unhealthy obesity","volume":"92","author":"Iacobini","year":"2019","journal-title":"Metabolism"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.2337\/db15-1671","article-title":"Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension, and heart disease","volume":"65","author":"Yaghootkar","year":"2019","journal-title":"Diabetes"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.2337\/db14-0318","article-title":"Genetic evidence for a normal-weight \u201cmetabolically obese\u201d phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes","volume":"63","author":"Yaghootkar","year":"2014","journal-title":"Diabetes"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.2337\/db14-0319","article-title":"Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity","volume":"63","author":"Scott","year":"2014","journal-title":"Diabetes"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/sj.ijo.0800809","article-title":"Linkages and associations between the leptin receptor (LEPR) gene and human body composition in the Qu\u00e9bec Family Study","volume":"23","author":"Chagnon","year":"1999","journal-title":"Int. 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