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Their interaction has been recently reported to be relevant during physical and psychological trauma. However, literature reports on H2S in physical trauma and OT in psychological trauma are abundant, whereas available information regarding H2S in psychological trauma and OT in physical trauma is much more limited. This review summarizes recent direct and indirect evidence of the interaction of the two systems and their convergence in downstream nitric oxide-dependent signaling pathways during various types of trauma, in an effort to better understand biological correlates of psychosomatic interdependencies.<\/jats:p>","DOI":"10.3390\/antiox9080748","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T08:28:35Z","timestamp":1597393715000},"page":"748","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Interaction of the Endogenous Hydrogen Sulfide and Oxytocin Systems in Fluid Regulation and the Cardiovascular System"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3655-6433","authenticated-orcid":false,"given":"Nicole","family":"Denoix","sequence":"first","affiliation":[{"name":"Clinic for Psychosomatic Medicine and Psychotherapy, Ulm University Medical Center, 89081 Ulm, Germany"},{"name":"Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University Medical Center, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7879-7695","authenticated-orcid":false,"given":"Oscar","family":"McCook","sequence":"additional","affiliation":[{"name":"Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University Medical Center, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Ecker","sequence":"additional","affiliation":[{"name":"Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University Medical Center, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Science, York University, Toronto, ON M3J 1P3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Waller","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy, Nuremberg General Hospital, Paracelsus Medical University, 90419 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Radermacher","sequence":"additional","affiliation":[{"name":"Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University Medical Center, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5519-9171","authenticated-orcid":false,"given":"Tamara","family":"Merz","sequence":"additional","affiliation":[{"name":"Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University Medical Center, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wang, C.-J., Chen, Y.-C., Chien, T.-H., Chang, H.-Y., Chen, Y.-H., Chien, C.-Y., and Huang, T.-S. (2018). Impact of comorbidities on the prognoses of trauma patients: Analysis of a hospital-based trauma registry database. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0194749"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/TA.0b013e3181d8941d","article-title":"The relationship between mortality and preexisting cardiac disease in 5971 trauma patients","volume":"69","author":"Ferraris","year":"2010","journal-title":"J Trauma Acute Care Surg."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Aux\u00e9m\u00e9ry, Y. (2018). Post-traumatic psychiatric disorders: PTSD is not the only diagnosis. Presse. Med., 47.","DOI":"10.1016\/j.lpm.2017.12.006"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.yhbeh.2014.11.008","article-title":"Effects of hydrogen sulfide (H2S) on water intake and vasopressin and oxytocin secretion induced by fluid deprivation","volume":"67","author":"Coletti","year":"2015","journal-title":"Horm. Behav."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.psyneuen.2010.01.009","article-title":"Marital behavior, oxytocin, vasopressin, and wound healing","volume":"35","author":"Gouin","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.psyneuen.2013.06.019","article-title":"The role of oxytocin in social bonding, stress regulation and mental health: An update on the moderating effects of context and interindividual differences","volume":"38","author":"Olff","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/CIRCRESAHA.114.300505","article-title":"Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease","volume":"114","author":"Polhemus","year":"2014","journal-title":"Circ. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: A whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40635-020-0296-4","article-title":"Emerging pharmacological tools to control hydrogen sulfide signaling in critical illness","volume":"8","author":"Marutani","year":"2020","journal-title":"Intensive Care Med. Exp."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"900","DOI":"10.3109\/09513590.2010.551563","article-title":"Hydrogen sulfide inhibits the spontaneous and oxytocin-induced contractility of human pregnant myometrium","volume":"27","author":"Hu","year":"2011","journal-title":"Gynecol. Endocrinol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1530\/REP-16-0549","article-title":"Endogenous hydrogen sulfide contributes to uterine quiescence during pregnancy","volume":"153","author":"You","year":"2017","journal-title":"Reproduction"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Akahoshi, N., Handa, H., Takemoto, R., Kamata, S., Yoshida, M., Onaka, T., and Ishii, I. (2019). Preeclampsia-Like Features and Partial Lactation Failure in Mice Lacking Cystathionine \u03b3-Lyase-An Animal Model of Cystathioninuria. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143507"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1152\/physiol.00040.2014","article-title":"Gaseous modulators in the control of the hypothalamic neurohypophyseal system","volume":"30","author":"Ruginsk","year":"2015","journal-title":"Physiology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1113\/expphysiol.2004.027714","article-title":"Stress-induced pressor and corticosterone responses in oxytocindeficient mice","volume":"89","author":"Bernatova","year":"2004","journal-title":"Exp. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Ellmers, L.J., Templeton, E.M., Pilbrow, A.P., Frampton, C., Ishii, I., Moore, P.K., Bhatia, M., Richards, A.M., and Cameron, V.A. (2020). Hydrogen Sulfide Treatment Improves Post-Infarct Remodeling and Long-Term Cardiac Function in CSE Knockout and Wild-Type Mice. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124284"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/SHK.0000000000000746","article-title":"The role of cystathionine-\u03b3-lyase in blunt chest trauma in cigarette smoke exposed mice","volume":"47","author":"Hartmann","year":"2017","journal-title":"Shock"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: Hypertension in mice with deletion of cystathionine gamma-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1111\/bph.12613","article-title":"Body temperature and cardiac changes induced by peripherally administered oxytocin, vasopressin and the non-peptide oxytocin receptor agonist WAY 267,464: A biotelemetry study in rats","volume":"171","author":"Hicks","year":"2014","journal-title":"Br. J. Pharm."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s40635-018-0207-0","article-title":"Interaction of the hydrogen sulfide system with the oxytocin system in the injured mouse heart","volume":"6","author":"Merz","year":"2018","journal-title":"Intensive Care Med. Exp."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0034-5687(97)00086-8","article-title":"Oxygen-sensing neurons in the caudal hypothalamus and their role in cardiorespiratory control","volume":"110","author":"Horn","year":"1997","journal-title":"Respir. Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jacbts.2020.03.007","article-title":"Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure","volume":"5","author":"Dyavanapalli","year":"2020","journal-title":"JACC Basic. Transl. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1093\/cvr\/cvx084","article-title":"Chronic activation of hypothalamic oxytocin neurons improves cardiac function during left ventricular hypertrophy-induced heart failure","volume":"113","author":"Garrott","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Khademullah, C.S., and Ferguson, A.V. (2013). Depolarizing actions of hydrogen sulfide on hypothalamic paraventricular nucleus neurons. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0064495"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e12686","DOI":"10.1111\/jne.12686","article-title":"Nitric oxide acutely modulates hypothalamic and neurohypophyseal carbon monoxide and hydrogen sulphide production to control vasopressin, oxytocin and atrial natriuretic peptide release in rats","volume":"31","author":"Coletti","year":"2019","journal-title":"J. Neuroendocr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3389\/fneur.2020.00649","article-title":"Cerebral immunohistochemical characterization of the H2S and the Oxytocin systems in a porcine model of acute subdural hematoma","volume":"11","author":"Denoix","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/bja\/aeg033","article-title":"Of mice and men (and rats): Implications of species and stimulus differences for the interpretation of studies of nitric oxide in sepsis","volume":"90","author":"Reade","year":"2003","journal-title":"Br. J. Anaesth."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"104536","DOI":"10.1016\/j.phrs.2019.104536","article-title":"Effects of sodium thiosulfate (Na2S2O3) during resuscitation from hemorrhagic shock in swine with preexisting atherosclerosis","volume":"151","author":"Datzmann","year":"2020","journal-title":"Pharm. Res."},{"key":"ref_28","first-page":"233","article-title":"Galanin affects vasopressin and oxytocin release from the hypothalamo-neurohypophysial system in haemorrahaged rats","volume":"54","author":"Ciosek","year":"2003","journal-title":"J. Physiol. Pharm."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/SHK.0000000000000599","article-title":"Association of Kidney Tissue Barrier Disrupture and Renal Dysfunction in Resuscitated Murine Septic Shock","volume":"46","author":"Stenzel","year":"2016","journal-title":"Shock"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1124\/jpet.107.133538","article-title":"Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human mammary artery","volume":"324","author":"Webb","year":"2008","journal-title":"J. Pharm. Exp."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3389\/fneur.2018.00779","article-title":"Vascular Protection of Hydrogen Sulfide on Cerebral Ischemia\/Reperfusion Injury in Rats","volume":"9","author":"Wen","year":"2009","journal-title":"Front. Neurol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/jnen\/nlz023","article-title":"Peri-Infarct Upregulation of the Oxytocin Receptor in Vascular Dementia","volume":"78","author":"McKay","year":"2019","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_33","first-page":"51","article-title":"A cardioprotective insight of the cystathionine \u03b3-lyase\/hydrogen sulfide pathway","volume":"7","author":"Huang","year":"2015","journal-title":"Int. J. Cardiol. Heart Vasc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.1111\/bph.12900","article-title":"Emerging role of hydrogen sulfide in hypertension and related cardiovascular diseases","volume":"172","author":"Meng","year":"2014","journal-title":"Br. J. Pharm."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/j.cellsig.2013.07.010","article-title":"Dysregulation of cystathionine \u03b3-lyase (CSE)\/hydrogen sulfide pathway contributes to ox-LDL induced inflammation in macrophage","volume":"25","author":"Wang","year":"2013","journal-title":"Cell Signal."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1582-4934.2009.00645.x","article-title":"Hydrogen sulfide and the vasculature: A novel vasculoprotective entity and regulator of nitric oxide bioavailability?","volume":"13","author":"Whiteman","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.phrs.2014.06.006","article-title":"Statins upregulate cystathionine \u03b3-lyase transcription and H2S generation via activating Akt signaling in macrophage","volume":"87","author":"Xu","year":"2014","journal-title":"Pharm. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cca.2014.07.012","article-title":"Hydrogen sulfide as a potent cardiovascular protective agent","volume":"437","author":"Yu","year":"2014","journal-title":"Clin. Chim. Acta"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.apsb.2015.06.004","article-title":"Hydrogen sulfide prodrugs-a review","volume":"5","author":"Zheng","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40635-017-0131-8","article-title":"Cardiovascular disease and resuscitated septic shock lead to the downregulation of the H2Sproducing enzyme cystathionine-\u03b3- lyase in the porcine coronary artery","volume":"5","author":"Merz","year":"2017","journal-title":"Intensive Care Med. Exp."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40635-016-0089-y","article-title":"Left ventricular function during porcine resuscitated septic shock with pre-existing atherosclerosis","volume":"4","author":"Nussbaum","year":"2016","journal-title":"Intensive Care Med. Exp."},{"key":"ref_42","first-page":"1","article-title":"Cystathionine Gamma-lyase is expressed in human atherosclerotic plaque microvessels and is involved in micro-angiogenesis","volume":"6","author":"Mencke","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neuroscience.2007.12.008","article-title":"Hydrogen sulphide in the hypothalamus causes an ATP-sensitive K channel-dependent decrease in blood pressure in freely moving rats","volume":"152","author":"Dawe","year":"2008","journal-title":"Neuroscience"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"729","DOI":"10.33549\/physiolres.932092","article-title":"The cardiovascular effects of central hydrogen sulfide are related to K(ATP) channels activation","volume":"60","author":"Liu","year":"2011","journal-title":"Physiol. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1146\/annurev-pharmtox-010510-100505","article-title":"Hydrogen Sulfide and Cell Signaling","volume":"51","author":"Li","year":"2011","journal-title":"Annu. Rev. Pharm. Toxicol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3389\/fendo.2020.00299","article-title":"The Role of Glucocorticoid Receptor and Oxytocin Receptor in the Septic Heart in a Clinically Relevant, Resuscitated Porcine Model With Underlying Atherosclerosis","volume":"11","author":"Merz","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/bjd.17824","article-title":"Oxytocin alleviates cellular senescence through oxytocin receptor-mediated extracellular signal-regulated kinase\/Nrf2 signalling","volume":"181","author":"Cho","year":"2019","journal-title":"Br. J. Derm."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"203","DOI":"10.7555\/JBR.28.20140037","article-title":"GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats","volume":"29","author":"Meng","year":"2015","journal-title":"J. Biomed. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1124\/jpet.116.235119","article-title":"Cardioprotection by H2S donors: Nitric oxide-dependent and -independent mechanisms","volume":"358","author":"Chatzianastasiou","year":"2016","journal-title":"J. Pharm. Exp."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.phrs.2016.06.028","article-title":"Pharmacological postconditioning against myocardial infarction with a slow-releasing hydrogen sulfide donor, GYY4137","volume":"111","author":"Karwi","year":"2016","journal-title":"Pharm. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.yjmcc.2015.07.028","article-title":"GYY4137 attenuates remodeling, preserves cardiac function and modulates the natriuretic peptide response to ischemia","volume":"87","author":"Lilyanna","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1038\/s41598-017-03941-0","article-title":"A Long-Term and Slow-Releasing Hydrogen Sulfide Donor Protects against Myocardial Ischemia\/Reperfusion Injury","volume":"7","author":"Sun","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"R165","DOI":"10.1186\/cc9257","article-title":"Effects of hydrogen sulfide on hemodynamics, inflammatory response and oxidative stress during resuscitated hemorrhagic shock in rats","volume":"14","author":"Ganster","year":"2010","journal-title":"Crit. Care"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/SHK.0000000000001210","article-title":"The Mitochondria-Targeted H2Sdonor AP39 in a Murine Model of Combined Hemorrhagic Shock and Blunt Chest Trauma","volume":"52","author":"Wepler","year":"2018","journal-title":"Shock"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.niox.2014.05.014","article-title":"Hydrogen sulfide and nitric oxide interactions in inflammation","volume":"41","author":"Fox","year":"2014","journal-title":"Nitric Oxide"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3389\/fnins.2019.00454","article-title":"Therapeutic Potential of Oxytocin in Atherosclerotic Cardiovascular Disease: Mechanisms and Signaling Pathways","volume":"13","author":"Wang","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1097\/CCM.0b013e31824e6b30","article-title":"Effects of intravenous sulfide during resuscitated porcine hemorrhagic shock","volume":"40","author":"Bracht","year":"2012","journal-title":"Crit. Care Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/SHK.0b013e3181d0ee3d","article-title":"Hydrogen sulfide does not increase resuscitability in a porcine model of prolonged cardiac arrest","volume":"34","author":"Derwall","year":"2010","journal-title":"Shock"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/SHK.0b013e3181e86f49","article-title":"Intravenous hydrogen sulfide does not induce hypothermia or improve survival from hemorrhagic shock in pigs","volume":"35","author":"Drabek","year":"2011","journal-title":"Shock"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"59ps54","DOI":"10.1126\/scitranslmed.3000721","article-title":"Gaseotransmitters: New frontiers for translational science","volume":"2","author":"Szabo","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1590\/1414-431X20133309","article-title":"The role of oxytocin in cardiovascular regulation","volume":"47","author":"Gutkowska","year":"2014","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"11704","DOI":"10.1073\/pnas.94.21.11704","article-title":"Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart","volume":"94","author":"Gutkowska","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"14558","DOI":"10.1073\/pnas.95.24.14558","article-title":"Rat heart: A site of oxytocin production and action","volume":"95","author":"Jankowski","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1073\/pnas.110137497","article-title":"Oxytocin and its receptors are synthesized in the rat vasculature","volume":"97","author":"Jankowski","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"E183","DOI":"10.1152\/ajpendo.00346.2016","article-title":"Regulation of the macrophage oxytocin receptor in response to inflammation","volume":"312","author":"Szeto","year":"2017","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3389\/fpsyg.2018.00173","article-title":"Child Maltreatment Is Associated with a Reduction of the Oxytocin Receptor in Peripheral Blood Mononuclear Cells","volume":"9","author":"Krause","year":"2018","journal-title":"Front. Psychol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"102099","DOI":"10.1016\/j.ceca.2019.102099","article-title":"Oxytocin induces intracellular Ca2+ release in cardiac fibroblasts from neonatal rats","volume":"84","author":"Ali","year":"2019","journal-title":"Cell Calcium."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Jankowski, M., Broderick, T.L., and Gutkowska, J. (2016). Oxytocin and cardioprotection in diabetes and obesity. BMC Endocr. Disord., 16.","DOI":"10.1186\/s12902-016-0110-1"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.peptides.2012.08.001","article-title":"The role of nitric oxide, reactive oxygen species, and protein kinase C in oxytocin-induced cardioprotection in ischemic rat heart","volume":"37","author":"Faghihi","year":"2012","journal-title":"Peptides"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1365-2826.2011.02235.x","article-title":"Oxytocin revisited: Its role in cardiovascular regulation","volume":"24","author":"Gutkowska","year":"2012","journal-title":"J. Neuroendocr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1752-8062.2008.00030.x","article-title":"The human heart: A self-renewing organ","volume":"1","author":"Kajstura","year":"2008","journal-title":"Clin. Transl. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1161\/01.HYP.38.2.292","article-title":"Negative inotropic and chronotropic effects of oxytocin","volume":"38","author":"Yin","year":"2001","journal-title":"Hypertension"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1566-0702(02)00134-0","article-title":"Postnatal oxytocin treatment and postnatal stroking of rats reduce blood pressure in adulthood","volume":"99","author":"Holst","year":"2002","journal-title":"Auton. Neurosci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neulet.2008.05.091","article-title":"Postnatal oxytocin treatment of spontaneously hypertensive male rats decreases blood pressure and body weight in adulthood","volume":"440","author":"Petersson","year":"2008","journal-title":"Neurosci. Lett."},{"key":"ref_75","first-page":"3","article-title":"The role of nitric oxide in the hypothalamic control of LHRH and oxytocin release, sexual behavior and aging of the LHRH and oxytocin neurons","volume":"44","year":"2006","journal-title":"Folia. Histochem. Cytobiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jneuroim.2006.10.021","article-title":"Participation of iNOS-derived NO in hypothalamic activation and vasopressin release during polymicrobial sepsis","volume":"183","author":"Correa","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1046\/j.1440-1681.2000.03264.x","article-title":"Centrally produced nitric oxide and the regulation of body fluid and blood pressure homeostases","volume":"27","author":"Kadekaro","year":"2000","journal-title":"Clin. Exp. Pharm. Physiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1113\/expphysiol.2007.037911","article-title":"Central nitric oxide blocks vasopressin, oxytocin and atrial natriuretic peptide release and antidiuretic and natriuretic responses induced by central angiotensin II in conscious rats","volume":"92","author":"Reis","year":"2007","journal-title":"Exp. Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.regpep.2010.11.004","article-title":"Role of endogenous oxytocin in cardiac ischemic preconditioning","volume":"167","author":"Alizadeh","year":"2011","journal-title":"Regul. Pept."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00395-009-0076-5","article-title":"Anti-inflammatory effect of oxytocin in rat myocardial infarction","volume":"105","author":"Jankowski","year":"2010","journal-title":"Basic. Res. Cardiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jjcc.2012.08.021","article-title":"Role of central oxytocin in stress-induced cardioprotection in ischemic-reperfused heart model","volume":"61","author":"Moghimian","year":"2013","journal-title":"J. Cardiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4149\/gpb_2012_030","article-title":"Prolonged oxytocin treatment in rats affects intracellular signaling and induces myocardial protection against infarction","volume":"31","author":"Ondrejcakova","year":"2012","journal-title":"Gen. Physiol. Biophys."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1113\/jphysiol.2009.176461","article-title":"Downregulation of oxytocin and natriuretic peptides in diabetes: Possible implications in cardiomyopathy","volume":"587","author":"Gutkowska","year":"2009","journal-title":"J. Physiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1748-1716.2010.02134.x","article-title":"Downregulation of oxytocin receptors in right ventricle of rats with monocrotaline-induced pulmonary hypertension","volume":"200","author":"Broderick","year":"2010","journal-title":"Acta Physiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/FJC.0b013e3181c5e7d4","article-title":"Cardiovascular effects of oxytocin infusion in a porcine model of myocardial infarct","volume":"55","author":"Authier","year":"2010","journal-title":"J. Cardiovasc. Pharm."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1161\/CIRCULATIONAHA.113.002208","article-title":"Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis","volume":"127","author":"Mani","year":"2013","journal-title":"Circulation"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1161\/ATVBAHA.108.179333","article-title":"Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice","volume":"29","author":"Wang","year":"2009","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_88","first-page":"169","article-title":"Role of Oxytocin in deceleration of early atherosclerotic inflammatory processes in adult male rats","volume":"4","author":"Ahmed","year":"2011","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.psyneuen.2012.08.009","article-title":"Oxytocin administration attenuates atherosclerosis and inflammation in Watanabe Heritable Hyperlipidemic rabbits","volume":"38","author":"Szeto","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00134-012-2766-y","article-title":"Carbamylated erythropoietin-FC fusion protein and recombinant human erythropoietin during porcine kidney ischemia\/reperfusion injury","volume":"39","author":"Scheuerle","year":"2013","journal-title":"Intensive Care Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4244\/EIJV6I2A42","article-title":"Familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis: A model for preclinical studies","volume":"6","author":"Thim","year":"2010","journal-title":"Eurointervention"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1177\/1535370217732325","article-title":"Hydrogen sulfide ameliorated L-NAME-induced hypertensive heart disease by the Akt\/eNOS\/NO pathway","volume":"242","author":"Jin","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5527\/wjn.v8.i1.11","article-title":"Insulin receptors in the kidneys in health and disease","volume":"8","author":"Singh","year":"2019","journal-title":"World J. Nephrol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3389\/fendo.2015.00121","article-title":"Two Birds with One Stone: Possible Dual-Role of Oxytocin in the Treatment of Diabetes and Osteoporosis","volume":"6","author":"Elabd","year":"2015","journal-title":"Front. Endocrinol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1089\/ars.2017.7046","article-title":"Hydrogen Sulfide and Glucose Homeostasis: A Tale of Sweet and the Stink","volume":"28","author":"Untereiner","year":"2018","journal-title":"Antioxid Redox Signal."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1210\/en.2009-0624","article-title":"Oxytocin increases glucose uptake in neonatal rat cardiomyocytes","volume":"151","author":"Florian","year":"2010","journal-title":"Endocrinology"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Zhang, H., Huang, Y., Chen, S., Tang, C., Wang, G., Du, J., and Jin, H. (2020). Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? A review. J. Adv. Res.","DOI":"10.1016\/j.jare.2020.02.013"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1530\/JOE-13-0417","article-title":"Hypooxytocinaemia in obese Zucker rats relates to oxytocin degradation in liver and adipose tissue","volume":"220","author":"Gajdosechova","year":"2014","journal-title":"J. Endocrinol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40635-017-0140-7","article-title":"Impact of hyperglycemia on cystathionine-\u03b3-lyase expression during resuscitated murine septic shock","volume":"5","author":"Merz","year":"2017","journal-title":"Intensive Care Med. Exp."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0167-0115(91)90182-G","article-title":"Interactions between oxytocin, glucagon and glucose in normal and streptozotocin-induced diabetic rats","volume":"34","author":"Widmaier","year":"1991","journal-title":"Regul. Pept."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.genhosppsych.2015.10.002","article-title":"High prevalence of posttraumatic stress in patients with primary hypertension","volume":"38","author":"Balint","year":"2016","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0749-3797(98)00017-8","article-title":"Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study","volume":"14","author":"Felitti","year":"1998","journal-title":"Am. J. Prev. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/apha.12189","article-title":"A mechanistic look at the effects of adversity early in life on cardiovascular disease risk during adulthood","volume":"210","author":"Loria","year":"2014","journal-title":"Acta Physiol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/gps.1723","article-title":"Depression and the risk for cardiovascular diseases: Systematic review and meta analysis","volume":"22","author":"Marwijk","year":"2007","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"9256","DOI":"10.1073\/pnas.1604285113","article-title":"Distinct oxytocin effects on belief updating in response to desirable and undesirable feedback","volume":"113","author":"Ma","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"15118","DOI":"10.1073\/pnas.1113137108","article-title":"Oxytocin receptor gene (OXTR) is related to psychological resources","volume":"108","author":"Way","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/10253890500456287","article-title":"Enhanced involment of brain vasopressin V1 receptors in cardiovascular responses to stress in rats with myocardial infarction","volume":"8","author":"Dobruch","year":"2005","journal-title":"Stress"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.amjcard.2005.06.035","article-title":"Myocardial perfusion study of panic attacks in patients with coronary artery disease","volume":"96","author":"Fleet","year":"2005","journal-title":"Am. J. Cardiol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.psyneuen.2014.01.021","article-title":"Dose-dependent effects of chronic central infusion of oxytocin on anxiety, oxytocin receptor binding and stress-related parameters in mice","volume":"42","author":"Peters","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"ref_110","first-page":"123","article-title":"Oxytocin in the cardiovascular responses to stress","volume":"59","author":"Wsol","year":"2008","journal-title":"J. Physiol. Pharm."},{"key":"ref_111","first-page":"H1369","article-title":"Central oxytocin systems may mediate a cardiovascular response to acute stress in rats","volume":"256","author":"Callahan","year":"1989","journal-title":"Am. J. Physiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.biopsycho.2011.04.003","article-title":"Plasma oxytocin is related to lower cardiovascular and sympathetic reactivity to stress","volume":"87","author":"Grewen","year":"2011","journal-title":"Biol. Psychol."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Wigger, D.C., Gr\u00f6ger, N., Lesse, A., Krause, S., Merz, T., G\u00fcndel, H., Braun, K., McCook, O., Radermacher, P., and Bock, J. (2020). Maternal Separation Induces Long-Term Alterations in the Cardiac Oxytocin Receptor and Cystathionine \u03b3-Lyase Expression in Mice. Oxid. Med. Cell Longev., 4309605.","DOI":"10.1155\/2020\/4309605"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jpedsurg.2016.10.013","article-title":"Intestinal epithelial injury induced by maternal separation is protected by hydrogen sulfide","volume":"52","author":"Li","year":"2016","journal-title":"J. Pediatr. Surg."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.peptides.2004.10.005","article-title":"Oxytocin ameliorates oxidative colonic inflammation by a neutrophil-dependent mechanism","volume":"26","author":"Iseri","year":"2005","journal-title":"Peptides"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1124\/pr.117.014050","article-title":"International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors","volume":"69","author":"Szabo","year":"2017","journal-title":"Pharm. Rev."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Merz, T., Denoix, N., Wepler, M., G\u00e4\u00dfler, H., Messerer, D.A.C., Hartmann, C., Datzmann, T., Radermacher, P., and McCook, O. (2020). H2S in acute lung injury: A therapeutic dead end(?). Intensive Care Med. Exp., in press.","DOI":"10.1186\/s40635-020-00324-0"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"109597","DOI":"10.1016\/j.mehy.2020.109597","article-title":"Oxytocin may have a therapeutical potential against cardiovascular disease. Possible pharmaceutical and behavioral approaches","volume":"138","author":"Buemann","year":"2020","journal-title":"Med. 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