{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:43:38Z","timestamp":1784097818577,"version":"3.55.0"},"reference-count":75,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Background: The role of herbal products in the prevention of cardiovascular disease requires supporting evidence. This open pilot study assessed the effect of 2-month supplementation of a combination of olive leaf and fruit extracts (Tensiofytol\u00ae, Tilman SA, Baillonville, Belgium) in the clinical management of hypertension and metabolic syndrome (MetS). Methods: A total of 663 (pre)-hypertensive patients were enrolled by general practitioners and supplemented for two months with Tensiofytol\u00ae, two capsules per day (100 mg\/d of oleuropein and 20 mg\/d of hydroxytyrosol). Systolic and diastolic blood pressures (SBP\/DBP) were measured before and after treatment. Markers of MetS, high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), fasting blood glucose (FG) and waist circumference (WC), were also examined. Results: Significant reductions (p &lt; 0.0001) in SBP\/DBP (13 \u00b1 10\/7.1 \u00b1 6.6 mmHg) were observed and similarly in pre-diabetic and diabetic patients. Improvements in SBP\/DPB were independent of age and gender but greater for elevated baseline SBP\/DBP. Tensiofytol\u00ae supplementation also significantly improved markers of MetS, with a decrease of TG (11%), WC (1.4%) and FG (4.8%) and an increase of HDL-C (5.3%). Minor side effects were reported in 3.2% patients. Conclusions: This real-life, observational, non-controlled, non-randomized pilot study shows that supplementation of a combination of olive leaf and fruit extracts may be used efficiently and safely in reducing hypertension and MetS markers.<\/jats:p>","DOI":"10.3390\/antiox9090872","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T10:24:09Z","timestamp":1600165449000},"page":"872","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Supplementation Effect of a Combination of Olive (Olea europea L.) Leaf and Fruit Extracts in the Clinical Management of Hypertension and Metabolic Syndrome"],"prefix":"10.3390","volume":"9","author":[{"given":"Michel P.","family":"Hermans","sequence":"first","affiliation":[{"name":"Service d\u2019Endocrinologie et de Nutrition and P\u00f4le Endocrinologie, Diab\u00e8te et Nutrition (EDIN), Institut de Recherche exp\u00e9rimentale et clinique, UCLouvain, 1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lempereur","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, Centre Hospitalier Bois de l\u2019Abbaye, 4100 Seraing, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Salembier","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, CHU UCL Namur - site Sainte-Elisabeth, 5000 Namur, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Maes","sequence":"additional","affiliation":[{"name":"Biostatistics and Medico-economic Information Department, University Hospital of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelin","family":"Albert","sequence":"additional","affiliation":[{"name":"Biostatistics and Medico-economic Information Department, University Hospital of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Jansen","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmacognosie, Centre Interdisciplinaire de Recherche sur le M\u00e9dicament (CIRM), Universit\u00e9 de Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00ebl","family":"Pincemail","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, CREDEC and Platform Nutrition Antioxydante et Sant\u00e9, CHU and University of Li\u00e8ge, Sart Tilman, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1161\/01.CIR.0000111245.75752.C6","article-title":"American Heart Association; National Heart, Lung, and Blood Institute. 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