{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:03:05Z","timestamp":1781535785633,"version":"3.54.5"},"reference-count":73,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF) funded by the Ministry of Education","award":["2016R1A6A1A03012862"],"award-info":[{"award-number":["2016R1A6A1A03012862"]}]},{"name":"Cooperative R&amp;D between Industry, Academy, and Research Institute funded by Korea Ministry of SMEs and Startups in 2015","award":["grant number C0297060"],"award-info":[{"award-number":["grant number C0297060"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>This study evaluated the protective effects of Dendropanax morbifera leaf (DML) extracts in the liver due to excessive ethanol consumption. Our results showed that the ethanol extract had better antioxidant activity than the water extract, likely due to the higher levels of total flavonoid and phenolic compounds in the former. We found that the main phenolic acid was chlorogenic acid and the major flavonoid was rutin. Results from the animal model experiment showed concentration-dependent liver protection with the distilled water extract showing better liver protection than the ethanol extract. Gut microbiota dysbiosis induced by alcohol consumption was significantly shifted by DML extracts through increasing mainly Bacteroides and Allobaculum. Moreover, predicted metabolic activities of biosynthesis of beneficial monounsaturated fatty acids such as oleate and palmitoleate were enhanced. Our results suggest that these hepatoprotective effects are likely due to the increased activities of antioxidant enzymes and partially promoted by intestinal microbiota shifts.<\/jats:p>","DOI":"10.3390\/antiox9100911","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T08:33:03Z","timestamp":1600936383000},"page":"911","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Dendropanax morbifera Leaf Extracts Improved Alcohol Liver Injury in Association with Changes in the Gut Microbiota of Rats"],"prefix":"10.3390","volume":"9","author":[{"given":"Taekil","family":"Eom","sequence":"first","affiliation":[{"name":"Subtropical\/Tropical Organism Gene Bank, SARI, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3830-9092","authenticated-orcid":false,"given":"Gwangpyo","family":"Ko","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology, College of Agriculture &amp; Life Sciences, SARI, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeoung Cheol","family":"Kim","sequence":"additional","affiliation":[{"name":"Majors in Plant Resource and Environment, College of Agriculture &amp; Life Sciences, SARI, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7227-3345","authenticated-orcid":false,"given":"Ju-Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Majors in Plant Resource and Environment, College of Agriculture &amp; Life Sciences, SARI, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2373-2100","authenticated-orcid":false,"given":"Tatsuya","family":"Unno","sequence":"additional","affiliation":[{"name":"Subtropical\/Tropical Organism Gene Bank, SARI, Jeju National University, Jeju 63243, Korea"},{"name":"Faculty of Biotechnology, College of Agriculture &amp; Life Sciences, SARI, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sookoian, S., and Pirola, C.J. (2013). Systems biology elucidates common pathogenic mechanisms between nonalcoholic and alcoholic-fatty liver disease. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0058895"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ratna, A., and Mandrekar, P. (2017). Alcohol and cancer: Mechanisms and therapies. Biomolecules, 7.","DOI":"10.3390\/biom7030061"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1470-2045(09)70019-1","article-title":"Alcohol and genetic polymorphisms: Effect on risk of alcohol-related cancer","volume":"10","author":"Tehard","year":"2009","journal-title":"Lancet Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nrc2191","article-title":"Molecular mechanisms of alcohol-mediated carcinogenesis","volume":"7","author":"Seitz","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3748\/wjg.v22.i1.37","article-title":"Relationships among alcoholic liver disease, antioxidants, and antioxidant enzymes","volume":"22","author":"Han","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1017\/S0007114512005235","article-title":"Linking the gut microbiota to human health","volume":"109","author":"Alonso","year":"2013","journal-title":"Brit. J. Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.cell.2012.01.035","article-title":"The impact of the gut microbiota on human health: An integrative view","volume":"148","author":"Clemente","year":"2012","journal-title":"Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fimmu.2012.00033","article-title":"The commensal microbiota drives immune homeostasis","volume":"3","author":"Arrieta","year":"2012","journal-title":"Front. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/apt.13376","article-title":"Systematic review: Microbial dysbiosis and nonalcoholic fatty liver disease","volume":"42","author":"Wieland","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41575-018-0099-1","article-title":"Alcohol, liver disease and the gut microbiota","volume":"16","author":"Bajaj","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/apt.13164","article-title":"Alcohol and gut microbiota-the possible role of gut microbiota modulation in the treatment of alcoholic liver disease","volume":"41","author":"Vassallo","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41575-018-0011-z","article-title":"The gut-liver axis and the intersection with the microbiome","volume":"15","author":"Tripathi","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jep.2012.09.044","article-title":"Herbal medicines for the prevention of alcoholic liver disease: A review","volume":"144","author":"Ding","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1053\/j.gastro.2014.12.004","article-title":"Herbal products and the liver: A review of adverse effects and mechanisms","volume":"148","author":"Seeff","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_15","first-page":"2087","article-title":"Anti-inflammatory effects of Dendropanax morbifera in lipopolysaccharide-stimulated raw264.7 macrophages and in an animal model of atopic dermatitis","volume":"19","author":"Choo","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s13273-016-0047-5","article-title":"Dendropanax morbifera leveille extract ameliorates memory impairments and inflammatory responses in the hippocampus of streptozotocin-induced type 1 diabetic rats","volume":"12","author":"Jung","year":"2016","journal-title":"Mol. Cell. Toxicol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/j.foodchem.2013.05.021","article-title":"Evaluation of anti-oxidant and anti-cancer properties of Dendropanax morbifera leveille","volume":"141","author":"Hyun","year":"2013","journal-title":"Food Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1142\/S0192415X18500234","article-title":"Ethyl acetate fraction from Dendropanax morbifera leaves increases t cell growth by upregulating nf-at-mediated il-2 secretion","volume":"46","author":"Park","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Eom, T., Kim, K.C., and Kim, J.S. (2020). Dendropanax morbifera leaf polyphenolic compounds: Optimal extraction using the response surface method and their protective effects against alcohol-induced liver damage. Antioxidants, 9.","DOI":"10.3390\/antiox9020120"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.sjbs.2015.02.008","article-title":"Antioxidant, alpha-glucosidase inhibitory and anti-inflammatory effects of aerial parts extract from korean crowberry (Empetrum nigrum var. Japonicum)","volume":"23","author":"Hyun","year":"2016","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s10068-015-0193-x","article-title":"Hepatoprotective effects of aqueous extracts from leaves of Dendropanax morbifera leveille against alcohol-induced hepatotoxicity in rats and in vitro anti-oxidant effects","volume":"24","author":"Bae","year":"2015","journal-title":"Food Sci. Biotechnol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1016\/S0021-9258(18)63504-5","article-title":"Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)","volume":"244","author":"McCord","year":"1969","journal-title":"J. Biol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase invitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.phymed.2017.01.013","article-title":"Polydatin alleviates alcohol-induced acute liver injury in mice: Relevance of matrix metalloproteinases (mmps) and hepatic antioxidants","volume":"27","author":"Koneru","year":"2017","journal-title":"Phytomedicine"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1128\/AEM.01541-09","article-title":"Introducing mothur: Open-source, platform-independent, community-supported software for describing and comparing microbial communities","volume":"75","author":"Schloss","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The silva ribosomal RNA gene database project: Improved data processing and web-based tools","volume":"41","author":"Quast","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e2584","DOI":"10.7717\/peerj.2584","article-title":"Vsearch: A versatile open source tool for metagenomics","volume":"4","author":"Rognes","year":"2016","journal-title":"PeerJ"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"D169","DOI":"10.1093\/nar\/gkl889","article-title":"The ribosomal database project (RDP-II): Introducing myrdp space and quality controlled public data","volume":"35","author":"Cole","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e00073-17","DOI":"10.1128\/mSphereDirect.00073-17","article-title":"Opticlust, an improved method for assigning amplicon-based sequence data to operational taxonomic units","volume":"2","author":"Westcott","year":"2017","journal-title":"mSphere"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1461-0248.2004.00707.x","article-title":"A new statistical approach for assessing similarity of species composition with incidence and abundance data","volume":"8","author":"Chao","year":"2005","journal-title":"Ecol. Lett."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1145\/584091.584093","article-title":"A mathematical theory of communication","volume":"5","author":"Shannon","year":"2001","journal-title":"SIGMOBILE Mob. Comput. Commun. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Beals, E.W. (1984). Bray-curtis ordination: An effective strategy for analysis of multivariate ecological data. Advances in Ecological Research, Academic Press.","DOI":"10.1016\/S0065-2504(08)60168-3"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Douglas, G.M., Maffei, V.J., Zaneveld, J.R., Yurgel, S.N., Brown, J.R., Taylor, C.M., Huttenhower, C., and Langille, M.G.I. (2020). PICRUSt2 for prediction of metagenome functions. Nat. Biotechnol., 1\u20135.","DOI":"10.1038\/s41587-020-0548-6"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/2049-2618-2-15","article-title":"Unifying the analysis of high-throughput sequencing datasets: Characterizing rna-seq, 16S rRNA gene sequencing and selective growth experiments by compositional data analysis","volume":"2","author":"Fernandes","year":"2014","journal-title":"Microbiome"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1530-0277.2002.tb02573.x","article-title":"Binge ethanol exposure in adult rats causes necrotic cell death","volume":"26","author":"Obernier","year":"2002","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"G364","DOI":"10.1152\/ajpgi.00010.2018","article-title":"Emerging role of circadian clock disruption in alcohol-induced liver disease","volume":"315","author":"Bailey","year":"2018","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.cld.2016.02.004","article-title":"Pathogenesis of alcoholic liver disease","volume":"20","author":"Dunn","year":"2016","journal-title":"Clin. Liver Dis."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Wang, F., Li, Y., Zhang, Y.J., Zhou, Y., Li, S., and Li, H.B. (2016). Natural products for the prevention and treatment of hangover and alcohol use disorder. Molecules, 21.","DOI":"10.3390\/molecules21010064"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3390\/ijms11020595","article-title":"The creation and physiological relevance of divergent hydroxylation patterns in the flavonoid pathway","volume":"11","author":"Halbwirth","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.etap.2012.05.004","article-title":"Synthesis of phenolic acid conjugated chitooligosaccharides and evaluation of their antioxidant activity","volume":"34","author":"Eom","year":"2012","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Desideri, E., Ciccarone, F., and Ciriolo, M.R. (2019). Targeting glutathione metabolism: Partner in crime in anticancer therapy. Nutrients, 11.","DOI":"10.3390\/nu11081926"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/ptr.6621","article-title":"Natural products for the prevention and treatment of cholestasis: A review","volume":"34","author":"Ma","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Patel, K., and Patel, D.K. (2019). The beneficial role of rutin, a naturally occurring flavonoid in health promotion and disease prevention: A systematic review and update. Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases, Academic Press.","DOI":"10.1016\/B978-0-12-813820-5.00026-X"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"6464","DOI":"10.1021\/acs.jafc.0c01554","article-title":"Chlorogenic acids in cardiovascular disease: A review of dietary consumption, pharmacology, and pharmacokinetics","volume":"68","author":"Li","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"25808","DOI":"10.1073\/pnas.1912359116","article-title":"Alcohol shifts gut microbial networks and ameliorates a murine model of neuroinflammation in a sex-specific pattern","volume":"116","author":"Caslin","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12944-016-0392-3","article-title":"Flaxseed oil ameliorates alcoholic liver disease via anti-inflammation and modulating gut microbiota in mice","volume":"16","author":"Zhang","year":"2017","journal-title":"Lipids Health Dis."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Yu, L., Wang, L., Yi, H., and Wu, X. (2020). Beneficial effects of lrp6-crispr on prevention of alcohol-related liver injury surpassed fecal microbiota transplant in a rat model. Gut Microbes, 1\u201315.","DOI":"10.1080\/19490976.2020.1736457"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1089\/jmf.2018.4357","article-title":"Lactobacillus rhamnosus granules dose-dependently balance intestinal microbiome disorders and ameliorate chronic alcohol-induced liver injury","volume":"23","author":"Gu","year":"2020","journal-title":"J. Med. Food"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"G413","DOI":"10.1152\/ajpgi.00361.2016","article-title":"Gut-liver axis at the frontier of host-microbial interactions","volume":"312","author":"Brandl","year":"2017","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.indcrop.2015.05.002","article-title":"Anti-inflammatory activity and phenolic composition of Dendropanax morbifera leaf extracts","volume":"74","author":"Hyun","year":"2015","journal-title":"Ind. Crop. Prod."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.anaerobe.2004.06.004","article-title":"Allobaculum stercoricanis gen. Nov., sp. Nov., isolated from canine feces","volume":"10","author":"Greetham","year":"2004","journal-title":"Anaerobe"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1111\/acer.12428","article-title":"Tributyrin supplementation protects mice from acute ethanol-induced gut injury","volume":"38","author":"Cresci","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/jgh.13731","article-title":"Prophylactic tributyrin treatment mitigates chronic-binge ethanol-induced intestinal barrier and liver injury","volume":"32","author":"Cresci","year":"2017","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.jhep.2016.11.008","article-title":"Fecal microbiota manipulation prevents dysbiosis and alcohol-induced liver injury in mice","volume":"66","author":"Ferrere","year":"2017","journal-title":"J. Hepatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1099\/ijs.0.007674-0","article-title":"Butyricimonas synergistica gen. Nov., sp. Nov. and Butyricimonas virosa sp. Nov., butyric acid-producing bacteria in the family \u2018Porphyromonadaceae\u2019 isolated from rat faeces","volume":"59","author":"Sakamoto","year":"2009","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1099\/ijs.0.052126-0","article-title":"Coprobacter fastidiosus gen. nov., sp. nov., a novel member of the family Porphyromonadaceae isolated from infant faeces","volume":"63","author":"Shkoporov","year":"2013","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1099\/ijs.0.032508-0","article-title":"Macellibacteroides fermentans gen. nov., sp. nov., a member of the family Porphyromonadaceae isolated from an upflow anaerobic filter treating abattoir wastewaters","volume":"62","author":"Jabari","year":"2012","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_59","first-page":"4733","article-title":"Probiotic and glutamine treatments attenuate alcoholic liver disease in a rat model","volume":"18","author":"Huang","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"G168","DOI":"10.1152\/ajpgi.00190.2011","article-title":"Linkage of gut microbiome with cognition in hepatic encephalopathy","volume":"302","author":"Bajaj","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/glycob\/cwp039","article-title":"The cmp-legionaminic acid pathway in campylobacter: Biosynthesis involving novel gdp-linked precursors","volume":"19","author":"Schoenhofen","year":"2009","journal-title":"Glycobiology"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Rodrigues, D.R., Briggs, W., Duff, A., Chasser, K., Murugesan, R., Pender, C., Ramirez, S., Valenzuela, L., and Bielke, L. (2020). Cecal microbiome composition and metabolic function in probiotic treated broilers. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0225921"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Reina, A., Urdiales, J.L., and S\u00e1nchez-Jim\u00e9nez, F. (2018). What we know and what we need to know about aromatic and cationic biogenic amines in the gastrointestinal tract. Foods, 7.","DOI":"10.3390\/foods7090145"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1053\/gast.2002.33613","article-title":"Alcohol and mitochondria: A dysfunctional relationship","volume":"122","author":"Hoek","year":"2002","journal-title":"Gastroenterology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"831","DOI":"10.2174\/138161211795428957","article-title":"Oleic acid in olive oil: From a metabolic framework toward a clinical perspective","volume":"17","author":"Bermudez","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.cmet.2015.09.028","article-title":"Microbiota-dependent hepatic lipogenesis mediated by stearoyl coa desaturase 1 (scd1) promotes metabolic syndrome in tlr5-deficient mice","volume":"22","author":"Singh","year":"2015","journal-title":"Cell Metab."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"10035","DOI":"10.1016\/S0021-9258(18)99181-7","article-title":"Transcriptional regulation of the glucokinase gene by biotin in starved rats","volume":"266","author":"Chauhan","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_68","first-page":"27065","article-title":"Chronic ethanol consumption inhibits glucokinase transcriptional activity by Atf3 and triggers metabolic syndrome in vivo","volume":"289","author":"Kim","year":"2014","journal-title":"J. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/ibd\/izaa007","article-title":"Fucose ameliorate intestinal inflammation through modulating the crosstalk between bile acids and gut microbiota in a chronic colitis murine model","volume":"26","author":"Ke","year":"2020","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"27923","DOI":"10.1038\/srep27923","article-title":"Ecophysiological consequences of alcoholism on human gut microbiota: Implications for ethanol-related pathogenesis of colon cancer","volume":"6","author":"Tsuruya","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.toxlet.2018.01.021","article-title":"Gut microbiota modulates alcohol withdrawal-induced anxiety in mice","volume":"287","author":"Xiao","year":"2018","journal-title":"Toxicol. Lett."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Millman, J., Okamoto, S., Kimura, A., Uema, T., Higa, M., Yonamine, M., Namba, T., Ogata, E., Yamazaki, S., and Shimabukuro, M. (2019). Metabolically and immunologically beneficial impact of extra virgin olive and flaxseed oils on composition of gut microbiota in mice. Eur. J. Nutr.","DOI":"10.1007\/s00394-019-02088-0"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/gerona\/glx197","article-title":"Impact of age-related mitochondrial dysfunction and exercise on intestinal microbiota composition","volume":"73","author":"Houghton","year":"2018","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/9\/10\/911\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:13:10Z","timestamp":1760177590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/9\/10\/911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,24]]},"references-count":73,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10]]}},"alternative-id":["antiox9100911"],"URL":"https:\/\/doi.org\/10.3390\/antiox9100911","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,24]]}}}