{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:21:43Z","timestamp":1788916903854,"version":"build-2803163510"},"reference-count":74,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL70562"],"award-info":[{"award-number":["HL70562"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD097498"],"award-info":[{"award-number":["HD097498"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD102451"],"award-info":[{"award-number":["HD102451"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Opening of large conductance calcium-activated and voltage-dependent potassium (BKCa) channels hyperpolarizes plasma membranes of smooth muscle (SM) to cause vasodilation, underling a key mechanism for mediating uterine artery (UA) dilation in pregnancy. Hydrogen sulfide (H2S) has been recently identified as a new UA vasodilator, yet the mechanism underlying H2S-induced UA dilation is unknown. Here, we tested whether H2S activated BKCa channels in human UA smooth muscle cells (hUASMC) to mediate UA relaxation. Multiple BKCa subunits were found in human UA in vitro and hUASMC in vitro, and high \u03b21 and \u03b31 proteins were localized in SM cells in human UA. Baseline outward currents, recorded by whole-cell and single-channel patch clamps, were significantly inhibited by specific BKCa blockers iberiotoxin (IBTX) or tetraethylammonium, showing specific BKCa activity in hUASMC. H2S dose (NaHS, 1\u20131000 \u00b5M)-dependently potentiated BKCa currents and open probability. Co-incubation with a Ca2+ blocker nifedipine (5 \u00b5M) or a chelator (ethylene glycol-bis (\u03b2-aminoethyl ether)-N,N,N\u2032,N\u2032-tetraacetic acid (EGTA), 5 mM) did not alter H2S-potentiated BKCa currents and open probability. NaHS also dose-dependently relaxed phenylephrine pre-constricted freshly prepared human UA rings, which was inhibited by IBTX. Thus, H2S stimulated human UA relaxation at least partially via activating SM BKCa channels independent of extracellular Ca2+.<\/jats:p>","DOI":"10.3390\/antiox9111127","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T08:44:02Z","timestamp":1605257042000},"page":"1127","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Hydrogen Sulfide Relaxes Human Uterine Artery via Activating Smooth Muscle BKCa Channels"],"prefix":"10.3390","volume":"9","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, University of California, Irvine, CA 92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4241-8814","authenticated-orcid":false,"given":"Jin","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, University of California, Irvine, CA 92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-hua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, University of California, Irvine, CA 92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of California, Irvine, CA 92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-bao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, University of California, Irvine, CA 92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"key":"ref_1","first-page":"52","article-title":"Uterine blood flow during pregnnacy","volume":"8","author":"Greiss","year":"1972","journal-title":"MCV Q."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0146-0005(00)80047-6","article-title":"Hemodynamic changes in pregnancy","volume":"24","author":"Thornburg","year":"2000","journal-title":"Semin. Perinatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1152\/physiol.00033.2008","article-title":"Maternal uterine vascular remodeling during pregnancy","volume":"24","author":"Osol","year":"2009","journal-title":"Physiology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S1357-4310(95)90793-9","article-title":"Intrauterine programming of adult disease","volume":"1","author":"Barker","year":"1995","journal-title":"Mol. Med. Today"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1126\/science.1251816","article-title":"Preterm labor: One syndrome, many causes","volume":"345","author":"Romero","year":"2014","journal-title":"Science"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/S0002-9378(11)91726-8","article-title":"Mechanisms of relaxation induced by prostaglandins in isolated canine uterine arteries","volume":"167","author":"Kimura","year":"1992","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_7","first-page":"H1730","article-title":"Endothelial vasodilator production by uterine and systemic arteries. II. Pregnancy effects on NO synthase expression","volume":"272","author":"Magness","year":"1997","journal-title":"Am. J. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"H1642","DOI":"10.1152\/ajpheart.00227.2010","article-title":"Augmented EDHF signaling in rat uteroplacental vasculature during late pregnancy","volume":"299","author":"Gokina","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/0002-9378(85)90275-3","article-title":"Hemodynamic effects of indomethacin in chronically instrumented pregnant sheep","volume":"151","author":"Naden","year":"1985","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1172\/JCI119022","article-title":"Nitric oxide contributes to estrogen-induced vasodilation of the ovine uterine circulation","volume":"98","author":"Rosenfeld","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1093\/biolre\/ioz027","article-title":"Ovine uterine artery hydrogen sulfide biosynthesis in vivo: Effects of ovarian cycle and pregnancy","volume":"100","author":"Lechuga","year":"2019","journal-title":"Biol. Reprod."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1095\/biolreprod.116.143834","article-title":"Augmented H2S production via cystathionine-beta-synthase upregulation plays a role in pregnancy-associated uterine vasodilation","volume":"96","author":"Sheibani","year":"2017","journal-title":"Biol. Reprod."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Bai, J., Qi, Q.R., Li, Y., Day, R., Makhoul, J., Magness, R.R., and Chen, D.B. (2020). Estrogen receptors and estrogen-induced uterine vasodilation in pregnancy. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124349"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"16146","DOI":"10.3390\/molecules191016146","article-title":"Hydrogen sulfide and polysulfides as biological mediators","volume":"19","author":"Kimura","year":"2014","journal-title":"Molecules"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: Hypertension in mice with deletion of cystathionine gamma-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"21972","DOI":"10.1073\/pnas.0908047106","article-title":"Hydrogen sulfide is an endogenous stimulator of angiogenesis","volume":"106","author":"Papapetropoulos","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1210\/jc.2017-00437","article-title":"Pregnancy Augments VEGF-Stimulated In Vitro Angiogenesis and Vasodilator (NO and H2S) Production in Human Uterine Artery Endothelial Cells","volume":"102","author":"Zhang","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1124\/mol.105.017467","article-title":"Direct Stimulation of KATP Channels by Exogenous and Endogenous Hydrogen Sulfide in Vascular Smooth Muscle Cells","volume":"68","author":"Tang","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"596.e6","DOI":"10.1016\/j.ajog.2010.07.038","article-title":"Role of KATP and L-type Ca2+ channel activities in regulation of ovine uterine vascular contractility: Effect of pregnancy and chronic hypoxia","volume":"203","author":"Xiao","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"H1446","DOI":"10.1152\/ajpheart.00506.2012","article-title":"Hydrogen sulfide dilates rat mesenteric arteries by activating endothelial large-conductance Ca2+-activated K+ channels and smooth muscle Ca2+ sparks","volume":"304","author":"Osmond","year":"2013","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1146\/annurev-physiol-022516-034038","article-title":"Regulation of BK Channels by Beta and Gamma Subunits","volume":"81","author":"Lingle","year":"2019","journal-title":"Annu. Rev. Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/bs.irn.2016.03.017","article-title":"BK Channels in the Vascular System","volume":"128","author":"Koide","year":"2016","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1126\/science.1373909","article-title":"Regulation of arterial tone by activation of calcium-dependent potassium channels","volume":"256","author":"Brayden","year":"1992","journal-title":"Science"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7917","DOI":"10.1073\/pnas.1205435109","article-title":"BK potassium channel modulation by leucine-rich repeat-containing proteins","volume":"109","author":"Yan","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nature09162","article-title":"LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium","volume":"466","author":"Yan","year":"2010","journal-title":"Nature"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1161\/HYPERTENSIONAHA.117.09059","article-title":"Pregnancy reprograms large-conductance Ca2+-activated K+ channel in uterine arteries: Roles of ten-eleven translocation methylcytosine dioxygenase 1-mediated active demethylation","volume":"69","author":"Hu","year":"2017","journal-title":"Hypertension"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"H422","DOI":"10.1152\/ajpheart.2001.281.1.H422","article-title":"Ca2+-activated K+ channels modulate basal and E2beta-induced rises in uterine blood flow in ovine pregnancy","volume":"281","author":"Rosenfeld","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"H1878","DOI":"10.1152\/ajpheart.01185.2008","article-title":"Pregnancy modifies the large conductance Ca2+-activated K+ channel and cGMP-dependent signaling pathway in uterine vascular smooth muscle","volume":"296","author":"Rosenfeld","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jsgi.2005.04.009","article-title":"Large-conductance Ca2+-dependent K+ channels regulate basal uteroplacental blood flow in ovine pregnancy","volume":"12","author":"Rosenfeld","year":"2005","journal-title":"J. Soc. Gynecol. Investig."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1113\/JP274524","article-title":"The large-conductance voltage- and Ca2+-activated K+ channel and its gamma1-subunit modulate mouse uterine artery function during pregnancy","volume":"596","author":"Lorca","year":"2018","journal-title":"J. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1210\/en.2015-1086","article-title":"Estrogen replacement therapy in ovariectomized nonpregnant ewes stimulates uterine artery hydrogen sulfide biosynthesis by selectively up-regulating cystathionine beta-synthase expression","volume":"156","author":"Lechuga","year":"2015","journal-title":"Endocrinology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1124\/jpet.117.241679","article-title":"XE991 and linopirdine are state-dependent inhibitors for Kv7\/KCNQ channels that favor activated single subunits","volume":"362","author":"Greene","year":"2017","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1172\/JCI79727","article-title":"M-current preservation contributes to anticonvulsant effects of valproic acid","volume":"125","author":"Kay","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/293471a0","article-title":"Single channel recordings of Ca2+-activated K+ currents in rat muscle cell culture","volume":"293","author":"Pallotta","year":"1981","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"H474","DOI":"10.1152\/ajpheart.00013.2002","article-title":"H(2)S-induced vasorelaxation and underlying cellular and molecular mechanisms","volume":"283","author":"Zhao","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1161\/HYPERTENSIONAHA.117.09864","article-title":"MicroRNA-210 targets ten-eleven translocation methylcytosine dioxygenase 1 and suppresses pregnancy-mediated adaptation of large conductance Ca2+-activated K+ channel expression and function in ovine uterine arteries","volume":"70","author":"Hu","year":"2017","journal-title":"Hypertension"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"C799","DOI":"10.1152\/ajpcell.1995.268.4.C799","article-title":"Physiological roles and properties of potassium channels in arterial smooth muscle","volume":"268","author":"Nelson","year":"1995","journal-title":"Am. J. Physiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: A whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.drudis.2012.04.002","article-title":"Function and regulation of large conductance Ca2+-activated K+ channel in vascular smooth muscle cells","volume":"17","author":"Hu","year":"2012","journal-title":"Drug Discov. Today"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nrn1992","article-title":"High-conductance potassium channels of the SLO family","volume":"7","author":"Salkoff","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"8222","DOI":"10.1074\/jbc.272.13.8222","article-title":"The chemical modification of KCa channels by carbon monoxide in vascular smooth muscle cells","volume":"272","author":"Wang","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1085\/jgp.117.3.253","article-title":"Oxidative regulation of large conductance calcium-activated potassium channels","volume":"117","author":"Tang","year":"2001","journal-title":"J. Gen. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4942","DOI":"10.1523\/JNEUROSCI.17-13-04942.1997","article-title":"Redox modulation of hslo Ca2+-activated K+ channels","volume":"17","author":"DiChiara","year":"1997","journal-title":"J. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"27045","DOI":"10.1074\/jbc.M203087200","article-title":"Interacting effects of N-terminal variation and strex exon splicing on slo potassium channel regulation by calcium, phosphorylation, and oxidation","volume":"277","author":"Erxleben","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0304-3940(00)01121-6","article-title":"Redox modulation of large conductance calcium-activated potassium channels in CA1 pyramidal neurons from adult rat hippocampus","volume":"286","author":"Gong","year":"2000","journal-title":"Neurosci. Lett."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1089\/ars.2009.2894","article-title":"Molecular mechanism for H2S-induced activation of K(ATP) channels","volume":"12","author":"Jiang","year":"2010","journal-title":"Antioxid Redox Signal."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"H2088","DOI":"10.1152\/ajpheart.01290.2010","article-title":"Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channels","volume":"300","author":"Liang","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mvr.2016.11.001","article-title":"Vasodilator activity of hydrogen sulfide (H2S) in human mesenteric arteries","volume":"109","author":"Materazzi","year":"2017","journal-title":"Microvasc Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mvr.2013.09.002","article-title":"Hydrogen sulphide vasodilates human pulmonary arteries: A possible role in pulmonary hypertension?","volume":"90","author":"Ariyaratnam","year":"2013","journal-title":"Microvasc Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.bbabio.2009.03.019","article-title":"Is hydrogen sulfide a circulating \u201cgasotransmitter\u201d in vertebrate blood?","volume":"1787","author":"Olson","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3109\/10408448409029321","article-title":"A critical review of the literature on hydrogen sulfide toxicity","volume":"13","author":"Beauchamp","year":"1984","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1146\/annurev.pa.32.040192.000545","article-title":"Toxicology of hydrogen sulfide","volume":"32","author":"Reiffenstein","year":"1992","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"R297","DOI":"10.1152\/ajpregu.00045.2011","article-title":"The therapeutic potential of hydrogen sulfide: Separating hype from hope","volume":"301","author":"Olson","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1161\/HYPERTENSIONAHA.111.179952","article-title":"Pregnancy upregulates large-conductance Ca2+-activated K+ channel activity and attenuates myogenic tone in uterine arteries","volume":"58","author":"Hu","year":"2011","journal-title":"Hypertension"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00424-013-1359-0","article-title":"MaxiK channel and cell signalling","volume":"466","author":"Toro","year":"2014","journal-title":"Pflugers Arch."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"14066","DOI":"10.1073\/pnas.94.25.14066","article-title":"Large conductance voltage- and calcium-dependent K+ channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus","volume":"94","author":"Meera","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0014-5793(96)83884-1","article-title":"A calcium switch for the functional coupling between alpha (hslo) and beta subunits (Kv,cabeta) of maxi K channels","volume":"385","author":"Meera","year":"1996","journal-title":"FEBS Lett."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1113\/jphysiol.1984.sp015501","article-title":"Three types of calcium-dependent channel in rat lacrimal glands","volume":"357","author":"Marty","year":"1984","journal-title":"J. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/glia.10064","article-title":"BK channels in human glioma cells have enhanced calcium sensitivity","volume":"38","author":"Ransom","year":"2002","journal-title":"Glia"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00232-005-0830-z","article-title":"BKCa channels activating at resting potential without calcium in LNCaP prostate cancer cells","volume":"208","author":"Gessner","year":"2005","journal-title":"J. Membr. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1007\/s00424-018-2151-y","article-title":"Calcium- and voltage-gated BK channels in vascular smooth muscle","volume":"470","author":"Dopico","year":"2018","journal-title":"Pflugers Arch."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1177\/1933719108319160","article-title":"Large conductance Ca2+-activated K+ channel channels contribute to vascular function in nonpregnant human uterine arteries","volume":"15","author":"Rosenfeld","year":"2008","journal-title":"Reprod. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1139\/y97-111","article-title":"Potassium channel diversity in vascular smooth muscle cells","volume":"75","author":"Michelakis","year":"1997","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"H1417","DOI":"10.1152\/ajpheart.01174.2004","article-title":"Estrogen regulates {beta}1-subunit expression in Ca2+-activated K+ channel in arteries from reproductive tissues","volume":"289","author":"Nagar","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0165-6147(00)01775-2","article-title":"Protein kinases: Tuners of the BKCa channel in smooth muscle","volume":"22","author":"Schubert","year":"2001","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.molcel.2017.05.028","article-title":"Intracellular Ca2+ sensing: Its role in calcium homeostasis and signaling","volume":"66","author":"Bagur","year":"2017","journal-title":"Mol. Cell"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"C1769","DOI":"10.1152\/ajpcell.2001.281.6.C1769","article-title":"Micromolar Ca2+ from sparks activates Ca2+-sensitive K+ channels in rat cerebral artery smooth muscle","volume":"281","author":"Perez","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_69","first-page":"H1694","article-title":"Pregnancy-induced alterations of neurogenic constriction and dilation of human uterine artery","volume":"268","author":"Nelson","year":"1995","journal-title":"Am. J. Physiol."},{"key":"ref_70","first-page":"1277","article-title":"Functional role of charybdotoxin-sensitive K+ channels in the resting state of cerebral, coronary and mesenteric arteries of the dog","volume":"267","author":"Asano","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00424-009-0737-0","article-title":"Hydrogen sulfide increases calcium-activated potassium (BK) channel activity of rat pituitary tumor cells","volume":"459","author":"Sitdikova","year":"2010","journal-title":"Pflugers Arch."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1161\/HYPERTENSIONAHA.118.12484","article-title":"Pregnancy increases Ca2+ sparks\/spontaneous transient outward currents and reduces uterine arterial myogenic tone","volume":"73","author":"Hu","year":"2019","journal-title":"Hypertension"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"ra72","DOI":"10.1126\/scisignal.2000464","article-title":"H2S signals through protein S-sulfhydration","volume":"2","author":"Mustafa","year":"2009","journal-title":"Sci. Signal."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1161\/CIRCRESAHA.111.240242","article-title":"Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels","volume":"109","author":"Mustafa","year":"2011","journal-title":"Circ. Res."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/9\/11\/1127\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:33:06Z","timestamp":1760178786000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/9\/11\/1127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,13]]},"references-count":74,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["antiox9111127"],"URL":"https:\/\/doi.org\/10.3390\/antiox9111127","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,13]]}}}