{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:11:57Z","timestamp":1773306717676,"version":"3.50.1"},"reference-count":152,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 109-2320-B-400-026, 109-2326-B-400-003, 109-2923-B-400-001"],"award-info":[{"award-number":["MOST 109-2320-B-400-026, 109-2326-B-400-003, 109-2923-B-400-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["RSF 20-45-08002"],"award-info":[{"award-number":["RSF 20-45-08002"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["CS-109-PP-05"],"award-info":[{"award-number":["CS-109-PP-05"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Abdominal aortic aneurysm (AAA) and intracranial aneurysm (IA) are serious arterial diseases in the aorta and brain, respectively. AAA and IA are associated with old age in males and females, respectively, and if rupture occurs, they carry high morbidity and mortality. Aneurysmal subarachnoid hemorrhage (SAH) due to IA rupture has a high rate of complication and fatality. Despite these severe clinical outcomes, preventing or treating these devastating diseases remains an unmet medical need. Inflammation and oxidative stress are shared pathologies of these vascular diseases. Therefore, therapeutic strategies have focused on reducing inflammation and reactive oxygen species levels. Interestingly, in response to cellular stress, the inducible heme oxygenase-1 (HO-1) is highly upregulated and protects against tissue injury. HO-1 degrades the prooxidant heme and generates molecules with antioxidative and anti-inflammatory properties, resulting in decreased oxidative stress and inflammation. Therefore, increasing HO-1 activity is an attractive option for therapy. Several HO-1 inducers have been identified and tested in animal models for preventing or alleviating AAA, IA, and SAH. However, clinical trials have shown conflicting results. Further research and the development of highly selective HO-1 regulators may be needed to prevent the initiation and progression of AAA, IA, or SAH.<\/jats:p>","DOI":"10.3390\/antiox9111150","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T10:46:26Z","timestamp":1605782786000},"page":"1150","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Therapeutic Potential of Heme Oxygenase-1 in Aneurysmal Diseases"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0070-7906","authenticated-orcid":false,"given":"Wei-Cheng","family":"Jiang","sequence":"first","affiliation":[{"name":"Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan 35053, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Mei","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan 35053, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2011-2280","authenticated-orcid":false,"given":"Candra D.","family":"Hamdin","sequence":"additional","affiliation":[{"name":"Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan 35053, Taiwan"},{"name":"Molecular and Biomedical Sciences, Department of Life Sciences, National Central University, Zhongli District, Taoyuan City 32001, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3318-4681","authenticated-orcid":false,"given":"Alexander N.","family":"Orekhov","sequence":"additional","affiliation":[{"name":"Institute of Human Morphology, 3 Tsyurupa Street, 117418 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0978-6444","authenticated-orcid":false,"given":"Igor A.","family":"Sobenin","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Genetics, National Medical Research Center of Cardiology, 15A 3-rd Cherepkovskaya Street, 121552 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0007-4870","authenticated-orcid":false,"given":"Matthew D.","family":"Layne","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9097-3962","authenticated-orcid":false,"given":"Shaw-Fang","family":"Yet","sequence":"additional","affiliation":[{"name":"Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan 35053, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1161\/01.ATV.0000245819.32762.cb","article-title":"Abdominal aortic aneurysm: Pathogenesis and implications for management. Arterioscler","volume":"26","author":"Golledge","year":"2006","journal-title":"Thromb. Vasc. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.gheart.2013.12.009","article-title":"Estimation of Global and Regional Incidence and Prevalence of Abdominal Aortic Aneurysms 1990 to 2010","volume":"9","author":"Sampson","year":"2014","journal-title":"Glob. Hear."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.gheart.2013.12.010","article-title":"Global and Regional Burden of Aortic Dissection and Aneurysms: Mortality Trends in 21 World Regions, 1990 to 2010","volume":"9","author":"Sampson","year":"2014","journal-title":"Glob. Hear."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jvs.2010.05.090","article-title":"Analysis of risk factors for abdominal aortic aneurysm in a cohort of more than 3 million individuals","volume":"52","author":"Kent","year":"2010","journal-title":"J. Vasc. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Altobelli, E., Rapacchietta, L., Profeta, V.F., and Fagnano, R. (2018). Risk Factors for Abdominal Aortic Aneurysm in Population-Based Studies: A Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Heal., 15.","DOI":"10.20944\/preprints201810.0636.v1"},{"key":"ref_6","unstructured":"(2017). UN World Population Ageing 2017\u2014Highlights, United Nations, Department of Economic and Social Affairs, Population Division."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1002\/bjs.4342","article-title":"Persistent increase in the incidence of abdominal aortic aneurysm in Scotland, 1981\u20132000","volume":"90","author":"Best","year":"2003","journal-title":"BJS"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/brain\/123.2.205","article-title":"The detection and management of unruptured intracranial aneurysms","volume":"123","author":"Wardlaw","year":"2000","journal-title":"Brain"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1161\/01.STR.23.10.1416","article-title":"Impact of unruptured intracranial aneurysms on public health in the United States","volume":"23","author":"Wiebers","year":"1992","journal-title":"Stroke"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.7461\/jcen.2014.16.4.335","article-title":"A comparative review of the hemodynamics and pathogenesis of cerebral and abdominal aortic aneurysms: Lessons to learn from each other","volume":"16","author":"Tanweer","year":"2014","journal-title":"J. Cerebrovasc. Endovasc. Neurosurg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S1474-4422(11)70109-0","article-title":"Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: A systematic review and meta-analysis","volume":"10","author":"Vlak","year":"2011","journal-title":"Lancet Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000496701","article-title":"Association of Menopausal Age with Unruptured Intracranial Aneurysm Morphology","volume":"8","author":"Dharmadhikari","year":"2019","journal-title":"Interv. Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1056\/NEJMcp1605827","article-title":"Subarachnoid Hemorrhage","volume":"377","author":"Lawton","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1227\/01.neu.0000430290.93304.33","article-title":"The Epidemiology of Admissions of Nontraumatic Subarachnoid Hemorrhage in the United States","volume":"73","author":"Rincon","year":"2013","journal-title":"Neurosurgery"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1161\/01.STR.24.6.809","article-title":"Amount of blood on computed tomography as an independent predictor after aneurysm rupture","volume":"24","author":"Brouwers","year":"1993","journal-title":"Stroke"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/brain\/124.2.249","article-title":"Subarachnoid haemorrhage: Diagnosis, causes and management","volume":"124","author":"Rinkel","year":"2001","journal-title":"Brain"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart Disease and Stroke Statistics-2018 Update: A Report from the American Heart Association","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circulation"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1212\/WNL.50.5.1413","article-title":"The burden, trends, and demographics of mortality from subarachnoid hemorrhage","volume":"50","author":"Johnston","year":"1998","journal-title":"Neurology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1212\/01.WNL.0000035748.91128.C2","article-title":"Global and domain-specific cognitive impairment and outcome after subarachnoid hemorrhage","volume":"59","author":"Mayer","year":"2002","journal-title":"Neurology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s12028-020-00943-1","article-title":"Long-Term Outcome and Economic Burden of Aneurysmal Subarachnoid Hemorrhage: Are we Only Seeing the Tip of the Iceberg?","volume":"33","author":"English","year":"2020","journal-title":"Neurocrit. Care"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1212\/WNL.0b013e3181e04297","article-title":"Optimal screening strategy for familial intracranial aneurysms: A cost-effectiveness analysis","volume":"74","author":"Bor","year":"2010","journal-title":"Neurology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.3171\/2009.2.FOCUS0921","article-title":"Unruptured intracranial aneurysms and the assessment of rupture risk based on anatomical and morphological factors: Sifting through the sands of data","volume":"26","author":"Lall","year":"2009","journal-title":"Neurosurg. Focus"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.jvs.2009.07.002","article-title":"The care of patients with an abdominal aortic aneurysm: The Society for Vascular Surgery practice guidelines","volume":"50","author":"Chaikof","year":"2009","journal-title":"J. Vasc. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.jvs.2008.01.041","article-title":"Growth predictors and prognosis of small abdominal aortic aneurysms","volume":"47","author":"Tangelder","year":"2008","journal-title":"J. Vasc. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(05)66459-8","article-title":"Abdominal aortic aneurysm","volume":"365","author":"Sakalihasan","year":"2005","journal-title":"Lancet"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1053\/j.semvascsurg.2016.07.003","article-title":"Overview of aortic aneurysm management in the endovascular era","volume":"29","author":"Calero","year":"2016","journal-title":"Semin. Vasc. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0140-6736(03)13860-3","article-title":"Unruptured intracranial aneurysms: Natural history, clinical outcome, and risks of surgical and endovascular treatment","volume":"362","author":"Wiebers","year":"2003","journal-title":"Lancet"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s00062-009-8032-1","article-title":"Endovascular Treatment of Intracranial Aneurysms: Long-Term Stability, Risk Factors for Recurrences, Retreatment and Follow-Up","volume":"19","author":"Ries","year":"2009","journal-title":"Clin. Neuroradiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1161\/STR.0b013e3182587839","article-title":"Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage","volume":"43","author":"Connolly","year":"2012","journal-title":"Stroke"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.jvs.2006.01.005","article-title":"Invited commentary: Abdominal aortic aneurysm regression by medical treatment: Possibility or pipe dream?","volume":"43","author":"Baxter","year":"2006","journal-title":"J. Vasc. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1517\/14728222.10.4.547","article-title":"Pharmacological targets in the treatment of abdominal aortic aneurysms","volume":"10","author":"Bergoeing","year":"2006","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1161\/STROKEAHA.113.002390","article-title":"Review of Cerebral Aneurysm Formation, Growth, and Rupture","volume":"44","author":"Chalouhi","year":"2013","journal-title":"Stroke"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1096\/fasebj.2.10.3290025","article-title":"Heme oxygenase: Function, multiplicity, regulatory mechanisms, and clinical applications","volume":"2","author":"Maines","year":"1988","journal-title":"FASEB J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev.pharmtox.37.1.517","article-title":"The Heme Oxygenase System: A Regulator of Second Messenger Gases","volume":"37","author":"Maines","year":"1997","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Durante, W. (2020). Targeting Heme Oxygenase-1 in the Arterial Response to Injury and Disease. Antioxidants, 9.","DOI":"10.3390\/antiox9090829"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Hinds, J.T.D., Creeden, J.F., Gordon, D.M., Spegele, A.C., Britton, S.L., Koch, L.G., and Stec, D.E. (2020). Rats Genetically Selected for High Aerobic Exercise Capacity Have Elevated Plasma Bilirubin by Upregulation of Hepatic Biliverdin Reductase-A (BVRA) and Suppression of UGT1A1. Antioxidants, 9.","DOI":"10.3390\/antiox9090889"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1152\/physrev.00011.2005","article-title":"Heme Oxygenase-1\/Carbon Monoxide: From Basic Science to Therapeutic Applications","volume":"86","author":"Ryter","year":"2006","journal-title":"Physiol. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1172\/JCI4165","article-title":"Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency","volume":"103","author":"Yachie","year":"1999","journal-title":"J. Clin. Investig."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1152\/physrev.00003.2016","article-title":"Heme Oxygenases in Cardiovascular Health and Disease","volume":"96","author":"Ayer","year":"2016","journal-title":"Physiol. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.3389\/fimmu.2020.01467","article-title":"Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases","volume":"11","author":"Funes","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/0741-5214(85)90135-1","article-title":"Inflammatory abdominal aortic aneurysms: A thirty-year review","volume":"2","author":"Pennell","year":"1985","journal-title":"J. Vasc. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.vph.2010.03.004","article-title":"Hemodynamic Influences on abdominal aortic aneurysm disease: Application of biomechanics to aneurysm pathophysiology","volume":"53","author":"Dua","year":"2010","journal-title":"Vasc. Pharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1161\/CIRCULATIONAHA.108.817619","article-title":"Risk Factors for Abdominal Aortic Aneurysms","volume":"119","author":"Forsdahl","year":"2009","journal-title":"Circulation"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e001926","DOI":"10.1161\/JAHA.115.001926","article-title":"The Oxford Vascular Study Population-Based Study of Incidence of Acute Abdominal Aortic Aneurysms with Projected Impact of Screening Strategy","volume":"4","author":"Howard","year":"2015","journal-title":"J. Am. Hear. Assoc."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/HCO.0000000000000216","article-title":"Abdominal aortic aneurysm","volume":"30","author":"Davis","year":"2015","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1161\/ATVBAHA.110.206573","article-title":"Atherosclerosis and Abdominal Aortic Aneurysm","volume":"30","author":"Golledge","year":"2010","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"12984","DOI":"10.18632\/oncotarget.3848","article-title":"Differential gene expression in human abdominal aortic aneurysm and aortic occlusive disease","volume":"6","author":"Biros","year":"2015","journal-title":"Oncotarget"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1161\/CIRCULATIONAHA.115.016537","article-title":"Circulating Biomarkers and Abdominal Aortic Aneurysm Incidence","volume":"132","author":"Folsom","year":"2015","journal-title":"Circulation"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1161\/CIRCRESAHA.116.308765","article-title":"Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci","volume":"120","author":"Jones","year":"2017","journal-title":"Circ. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1161\/CIRCULATIONAHA.120.047544","article-title":"Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program","volume":"142","author":"Klarin","year":"2020","journal-title":"Circulation"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/152660280200900401","article-title":"Heme oxygenase-1 genotype is a vascular anti-inflammatory factor following balloon angioplasty","volume":"9","author":"Schillinger","year":"2002","journal-title":"J. Endovasc. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0049-3848(02)00100-7","article-title":"Heme oxygenase-1 gene promoter polymorphism is associated with abdominal aortic aneurysm","volume":"106","author":"Schillinger","year":"2002","journal-title":"Thromb. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/sj.ejhg.5201851","article-title":"Marfan syndrome: Clinical diagnosis and management","volume":"15","author":"Dean","year":"2007","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1399-0004.1998.tb03714.x","article-title":"Life expectancy in British Marfan syndrome populations","volume":"54","author":"Gray","year":"2008","journal-title":"Clin. Genet."},{"key":"ref_55","first-page":"337","article-title":"Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene","volume":"352","author":"Dietz","year":"1991","journal-title":"Nat. Cell Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/ng1392","article-title":"Heterozygous TGFBR2 mutations in Marfan syndrome","volume":"36","author":"Mizuguchi","year":"2004","journal-title":"Nat. Genet."},{"key":"ref_57","first-page":"1047","article-title":"FBN1,TGFBR1, and the Marfan-craniosynostosis\/mental retardation disorders revisited","volume":"140","author":"Sullivan","year":"2006","journal-title":"Am. J. Med. Genet. Part A"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1002\/humu.20354","article-title":"TGFBR1andTGFBR2mutations in patients with features of Marfan syndrome and Loeys-Dietz syndrome","volume":"27","author":"Singh","year":"2006","journal-title":"Hum. Mutat."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1161\/CIRCRESAHA.118.312439","article-title":"Pharmacologic Management of Aneurysms","volume":"124","author":"Lindeman","year":"2019","journal-title":"Circ. Res."},{"key":"ref_60","first-page":"150","article-title":"Heme oxygenase-1 in inflammation and cardiovascular disease","volume":"1","author":"Wu","year":"2011","journal-title":"Am. J. Cardiovasc. Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1161\/01.ATV.0000042082.38014.EA","article-title":"Flow Loading Induces Macrophage Antioxidative Gene Expression in Experimental Aneurysms","volume":"22","author":"Nakahashi","year":"2002","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Azuma, J., Wong, R.J., Morisawa, T., Hsu, M., Maegdefessel, L., Zhao, H., Kalish, F., Kayama, Y., Wallenstein, M.B., and Deng, A.C. (2016). Heme Oxygenase-1 Expression Affects Murine Abdominal Aortic Aneurysm Progression. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0149288"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"67760","DOI":"10.18632\/oncotarget.11917","article-title":"Heme oxygenase-1 deficiency exacerbates angiotensin II-induced aortic aneurysm in mice","volume":"7","author":"Ho","year":"2016","journal-title":"Oncotarget"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-49362-z","article-title":"Omega-3 fatty acids decrease oxidative stress and inflammation in macrophages from patients with small abdominal aortic aneurysm","volume":"9","author":"Meital","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jaad.2005.10.004","article-title":"Tetracyclines: Nonantibiotic properties and their clinical implications","volume":"54","author":"Sapadin","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/01.ATV.0000058404.92759.32","article-title":"Differential Effects of Doxycycline, a Broad-Spectrum Matrix Metalloproteinase Inhibitor, on Angiotensin II\u2013Induced Atherosclerosis and Abdominal Aortic Aneurysms","volume":"23","author":"Manning","year":"2003","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejphar.2017.05.041","article-title":"Inhibitory effects of doxycycline on the onset and progression of abdominal aortic aneurysm and its related mechanisms","volume":"811","author":"Yu","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1067\/mva.2001.117891","article-title":"Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: A randomized, double-blind, placebo-controlled pilot study","volume":"34","author":"Mosorin","year":"2001","journal-title":"J. Vasc. Surg."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1067\/mva.2002.125018","article-title":"Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: Report of a prospective (Phase II) multicenter study","volume":"36","author":"Baxter","year":"2002","journal-title":"J. Vasc. Surg."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1161\/CIRCULATIONAHA.108.806505","article-title":"Clinical Trial of Doxycycline for Matrix Metalloproteinase-9 Inhibition in Patients With an Abdominal Aneurysm","volume":"119","author":"Lindeman","year":"2009","journal-title":"Circulation"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"7560","DOI":"10.1002\/jcp.27517","article-title":"Licochalcone A attenuates abdominal aortic aneurysm induced by angiotensin II via regulating the miR-181b\/SIRT1\/HO-1 signaling","volume":"234","author":"Hou","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1161\/01.CIR.0000142610.10530.25","article-title":"Probucol Protects Against Smooth Muscle Cell Proliferation by Upregulating Heme Oxygenase-1","volume":"110","author":"Deng","year":"2004","journal-title":"Circulation"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/bph.14857","article-title":"Mechanisms underlying the inhibitory effects of probucol on elastase-induced abdominal aortic aneurysm in mice","volume":"177","author":"Chen","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ejvs.2012.04.020","article-title":"Simvastatin Decreases Free Radicals Formation in the Human Abdominal Aortic Aneurysm Wall via NF-\u03baB","volume":"44","author":"Goraca","year":"2012","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/01.sla.0000150258.36236.e0","article-title":"Treatment with Simvastatin Suppresses the Development of Experimental Abdominal Aortic Aneurysms in Normal and Hypercholesterolemic Mice","volume":"241","author":"Steinmetz","year":"2005","journal-title":"Ann. Surg."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejvs.2005.12.024","article-title":"Statins are Associated with a Reduced Infrarenal Abdominal Aortic Aneurysm Growth","volume":"32","author":"Schouten","year":"2006","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_77","first-page":"19","article-title":"The Abdominal Aortic Aneurysm and Intraluminal Thrombus: Current Concepts of Development and Treatment","volume":"2","author":"Nowak","year":"2015","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e008657","DOI":"10.1161\/JAHA.118.008657","article-title":"Statins Reduce Abdominal Aortic Aneurysm Growth, Rupture, and Perioperative Mortality: A Systematic Review and Meta-Analysis","volume":"7","author":"Salata","year":"2018","journal-title":"J. Am. Hear. Assoc."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2028936","DOI":"10.1155\/2018\/2028936","article-title":"Simvastatin Treatment Upregulates HO-1 in Patients with Abdominal Aortic Aneurysm but Independently of Nrf2","volume":"2018","author":"Kopacz","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1161\/01.STR.30.7.1396","article-title":"Structural fragility and inflammatory response of ruptured cerebral aneurysms. A comparative study between ruptured and unruptured cerebral aneurysms","volume":"30","author":"Kataoka","year":"1999","journal-title":"Stroke"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: An evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-019-1568-3","article-title":"Nrf-2 signaling inhibits intracranial aneurysm formation and progression by modulating vascular smooth muscle cell phenotype and function","volume":"16","author":"Shi","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"ref_83","first-page":"1077","article-title":"Treatment with dimethyl fumarate reduces the formation and rupture of intracranial aneurysms: Role of Nrf2 activation","volume":"40","author":"Pascale","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_84","first-page":"71","article-title":"Erythropoietin Attenuates Pulmonary Vascular Remodeling in Experimental Pulmonary Arterial Hypertension through Interplay between Endothelial Progenitor Cells and Heme Oxygenase","volume":"3","author":"Bartelds","year":"2015","journal-title":"Front. Pediatr."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.neuroscience.2011.02.051","article-title":"Erythropoietin increases circulating endothelial progenitor cells and reduces the formation and progression of cerebral aneurysm in rats","volume":"181","author":"Xu","year":"2011","journal-title":"Neuroscience"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.vph.2015.07.005","article-title":"Dipeptidyl peptidase-4 inhibition by gemigliptin prevents abnormal vascular remodeling via NF-E2-related factor 2 activation","volume":"73","author":"Choi","year":"2015","journal-title":"Vasc. Pharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1538\/expanim.18-0089","article-title":"Linagliptin protects rat carotid artery from balloon injury and activates the NRF2 antioxidant pathway","volume":"68","author":"Si","year":"2019","journal-title":"Exp. Anim."},{"key":"ref_88","first-page":"6","article-title":"Dipeptidyl Peptidase-4 Inhibitor Anagliptin Prevents Intracranial Aneurysm Growth by Suppressing Macrophage Infiltration and Activation","volume":"6","author":"Ikedo","year":"2017","journal-title":"J. Am. Hear. Assoc."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"928","DOI":"10.12659\/MSM.915005","article-title":"Atorvastatin Protects Against Cerebral Aneurysmal Degenerative Pathology by Promoting Endothelial Progenitor Cells (EPC) Mobilization and Attenuating Vascular Deterioration in a Rat Model","volume":"25","author":"Wei","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1161\/STROKEAHA.107.503086","article-title":"Simvastatin Suppresses the Progression of Experimentally Induced Cerebral Aneurysms in Rats","volume":"39","author":"Aoki","year":"2008","journal-title":"Stroke"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1227\/01.NEU.0000336764.92606.1D","article-title":"Pitavastatin Suppresses Formation and Progression of Cerebral Aneurysms Through Inhibition of the Nuclear Factor \u03baB Pathway","volume":"64","author":"Aoki","year":"2009","journal-title":"Neurosurgery"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.brainres.2010.01.044","article-title":"Effect of olmesartan and pravastatin on experimental cerebral aneurysms in rats","volume":"1322","author":"Kimura","year":"2010","journal-title":"Brain Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1161\/STROKEAHA.110.608034","article-title":"Statins Promote the Growth of Experimentally Induced Cerebral Aneurysms in Estrogen-Deficient Rats","volume":"42","author":"Tada","year":"2011","journal-title":"Stroke"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"638","DOI":"10.3171\/2011.10.JNS11153","article-title":"Do statins reduce the risk of aneurysm development: A case-control study","volume":"116","author":"Marbacher","year":"2012","journal-title":"J. Neurosurg."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3174\/ajnr.A5955","article-title":"Endothelialization following Flow Diversion for Intracranial Aneurysms: A Systematic Review","volume":"40","author":"Ravindran","year":"2019","journal-title":"Am. J. Neuroradiol."},{"key":"ref_96","first-page":"688","article-title":"Scanning electron microscopic findings in a basilar tip aneurysm embolized with Guglielmi detachable coils","volume":"18","author":"Horowitz","year":"1997","journal-title":"Am. J. Neuroradiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1161\/01.STR.26.11.2075","article-title":"Effect of Guglielmi Detachable Coils on Experimental Carotid Artery Aneurysms in Primates","volume":"26","author":"Tenjin","year":"1995","journal-title":"Stroke"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.3174\/ajnr.A4175","article-title":"Mechanisms of Healing in Coiled Intracranial Aneurysms: A Review of the Literature","volume":"36","author":"Brinjikji","year":"2015","journal-title":"Am. J. Neuroradiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1161\/01.RES.0000137877.89448.78","article-title":"Endothelial Progenitor Cells","volume":"95","author":"Urbich","year":"2004","journal-title":"Circ. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/j.1538-7836.2009.03478.x","article-title":"After vascular injury, heme oxygenase-1\/carbon monoxide enhances re-endothelialization via promoting mobilization of circulating endothelial progenitor cells","volume":"7","author":"Lin","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1161\/ATVBAHA.109.184713","article-title":"Heme Oxygenase-1 Increases Endothelial Progenitor Cells","volume":"29","author":"Wu","year":"2009","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3389\/fendo.2019.00823","article-title":"Sitagliptin stimulates endothelial progenitor cells to induce endothelialization in aneurysm necks through the SDF-1\/CXCR4\/NRF2 signaling pathway","volume":"10","author":"Yu","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.5966\/sctm.2015-0264","article-title":"Erythropoietin Stimulates Endothelial Progenitor Cells to Induce Endothelialization in an Aneurysm Neck After Coil Embolization by Modulating Vascular Endothelial Growth Factor","volume":"5","author":"Liu","year":"2016","journal-title":"STEM CELLS Transl. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.3171\/2015.3.JNS142841","article-title":"Rosuvastatin for enhancement of aneurysm neck endothelialization after coil embolization: Promotion of endothelial progenitor cells in a rodent model","volume":"124","author":"Liu","year":"2016","journal-title":"J. Neurosurg."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1136\/neurintsurg-2016-012265","article-title":"Statins are not associated with short-term improved aneurysm healing in a rabbit model of unruptured aneurysms","volume":"9","author":"Brinjikji","year":"2016","journal-title":"J. NeuroInterv. Surg."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.3174\/ajnr.A4422","article-title":"Could Statin Use Be Associated with Reduced Recurrence Rates following Coiling in Ruptured Intracranial Aneurysms?","volume":"36","author":"Brinjikji","year":"2015","journal-title":"Am. J. Neuroradiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3174\/ajnr.A5078","article-title":"Lack of Association between Statin Use and Angiographic and Clinical Outcomes after Pipeline Embolization for Intracranial Aneurysms","volume":"38","author":"Brinjikji","year":"2017","journal-title":"Am. J. Neuroradiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e525","DOI":"10.1016\/j.wneu.2018.08.119","article-title":"Statin Therapy and Diabetes Do Not Affect Aneurysm Occlusion or Clinical Outcomes After Pipeline Embolization Device Treatment: A Preliminary Study","volume":"120","author":"Salem","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1161\/STROKEAHA.115.008778","article-title":"Contribution of Convexal Subarachnoid Hemorrhage to Disease Progression in Cerebral Amyloid Angiopathy","volume":"46","author":"Beitzke","year":"2015","journal-title":"Stroke"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"e2160","DOI":"10.1038\/cddis.2016.63","article-title":"Paravascular pathways contribute to vasculitis and neuroinflammation after subarachnoid hemorrhage independently of glymphatic control","volume":"7","author":"Luo","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0304-3940(93)90326-G","article-title":"Neurotoxicity of hemoglobin in cortical cell culture","volume":"153","author":"Regan","year":"1993","journal-title":"Neurosci. Lett."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1471-4159.2010.06826.x","article-title":"Accelerated hemolysis and neurotoxicity in neuron-glia-blood clot co-cultures","volume":"114","author":"Jaremko","year":"2010","journal-title":"J. Neurochem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1634\/stemcells.2005-0521","article-title":"In Vitro Differentiation of Human Placenta-Derived Multipotent Cells into Hepatocyte-Like Cells","volume":"24","author":"Chien","year":"2006","journal-title":"STEM CELLS"},{"key":"ref_114","first-page":"823","article-title":"Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology","volume":"5","author":"Greenhalgh","year":"2012","journal-title":"Dis. Model. Mech."},{"key":"ref_115","first-page":"801418","article-title":"Curcumin Pretreatment Induces Nrf2 and an Antioxidant Response and Prevents Hemin-Induced Toxicity in Primary Cultures of Cerebellar Granule Neurons of Rats","volume":"2013","year":"2013","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0006-8993(95)01511-6","article-title":"Heme-oxygenase-1 induction in glia throughout rat brain following experimental subarachnoid hemorrhage","volume":"713","author":"Matz","year":"1996","journal-title":"Brain Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1172\/JCI78443","article-title":"Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1","volume":"125","author":"Schallner","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Kaiser, S., Frase, S., Selzner, L., Lieberum, J.-L., Wollborn, J., Niesen, W.-D., Foit, N.A., Heiland, D.H., and Schallner, N. (2019). Neuroprotection after Hemorrhagic Stroke Depends on Cerebral Heme Oxygenase-1. Antioxidants, 8.","DOI":"10.3390\/antiox8100496"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/jnr.22577","article-title":"Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage","volume":"89","author":"Chen","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Wang, Z., Ji, C., Wu, L., Qiu, J., Li, Q., Shao, Z., and Chen, G. (2014). Tert-Butylhydroquinone Alleviates Early Brain Injury and Cognitive Dysfunction after Experimental Subarachnoid Hemorrhage: Role of Keap1\/Nrf2\/ARE Pathway. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0097685"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"915","DOI":"10.3171\/2014.11.JNS132348","article-title":"Dimethylfumarate alleviates early brain injury and secondary cognitive deficits after experimental subarachnoid hemorrhage via activation of Keap1-Nrf2-ARE system","volume":"123","author":"Liu","year":"2015","journal-title":"J. Neurosurg."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/02688690500305456","article-title":"Polymorphism of the heme oxygenase-1 gene and cerebral aneurysms","volume":"19","author":"Morgan","year":"2005","journal-title":"Br. J. Neurosurg."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1161\/STROKEAHA.114.006635","article-title":"Recombinant milk fat globule-EGF factor-8 reduces oxidative stress via integrin \u03b23\/nuclear factor erythroid 2-related factor 2\/heme oxygenase pathway in subarachnoid hemorrhage rats","volume":"45","author":"Liu","year":"2014","journal-title":"Stroke"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1479-5876-12-50","article-title":"Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2\/HO-1 signaling","volume":"12","author":"Hong","year":"2014","journal-title":"J. Transl. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bcp.2009.08.002","article-title":"Beneficial actions of oleanolic acid in an experimental model of multiple sclerosis: A potential therapeutic role","volume":"79","author":"Nieto","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejphar.2018.09.018","article-title":"Role of Oleanolic acid in maintaining BBB integrity by targeting p38MAPK\/VEGF\/Src signaling pathway in rat model of subarachnoid hemorrhage","volume":"839","author":"Han","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"11883","DOI":"10.1038\/s41598-017-12160-6","article-title":"Nrf2\/HO-1 mediates the neuroprotective effect of mangiferin on early brain injury after subarachnoid hemorrhage by attenuating mitochondria-related apoptosis and neuroinflammation","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.jnutbio.2012.09.003","article-title":"Anti-inflammatory effects of mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1","volume":"24","author":"Gong","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainres.2015.11.035","article-title":"The role of rhynchophylline in alleviating early brain injury following subarachnoid hemorrhage in rats","volume":"1631","author":"Zhang","year":"2016","journal-title":"Brain Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1111\/bph.13492","article-title":"Antioxidant effects of resveratrol in the cardiovascular system","volume":"174","author":"Xia","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1007\/s11064-011-0561-8","article-title":"Resveratrol Pretreatment Attenuates Cerebral Ischemic Injury by Upregulating Expression of Transcription Factor Nrf2 and HO-1 in Rats","volume":"36","author":"Ren","year":"2011","journal-title":"Neurochem. Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jss.2014.01.062","article-title":"Resveratrol prevents neuronal apoptosis in an early brain injury model","volume":"189","author":"Zhou","year":"2014","journal-title":"J. Surg. Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.4103\/1673-5374.257529","article-title":"Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting oxidative stress and endoplasmic reticulum stress","volume":"14","author":"Wang","year":"2019","journal-title":"Neural Regen. Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1379\/CSC-51R.1","article-title":"Paeoniflorin, a novel heat shock protein\u2013inducing compound","volume":"9","author":"Yan","year":"2004","journal-title":"Cell Stress Chaperon"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s11011-020-00571-w","article-title":"Paeoniflorin attenuates early brain injury through reducing oxidative stress and neuronal apoptosis after subarachnoid hemorrhage in rats","volume":"35","author":"Wang","year":"2020","journal-title":"Metab. Brain Dis."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1111\/bph.14465","article-title":"Haem oxygenase-1 up-regulation by rosiglitazone via ROS-dependent Nrf2-antioxidant response elements axis or PPAR\u03b3 attenuates LPS-mediated lung inflammation","volume":"175","author":"Cho","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s12028-014-0010-z","article-title":"Rosiglitazone Attenuates Cerebral Vasospasm and Provides Neuroprotection in an Experimental Rat Model of Subarachnoid Hemorrhage","volume":"21","author":"Lin","year":"2014","journal-title":"Neurocritic. Care"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.brainres.2015.07.025","article-title":"Rosiglitazone attenuates early brain injury after experimental subarachnoid hemorrhage in rats","volume":"1624","author":"Gu","year":"2015","journal-title":"Brain Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"6218239","DOI":"10.1155\/2019\/6218239","article-title":"Neuroprotective Role of the Nrf2 Pathway in Subarachnoid Haemorrhage and Its Therapeutic Potential","volume":"2019","author":"Zolnourian","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3171\/2009.3.JNS081332","article-title":"Acute systemic erythropoietin therapy to reduce delayed ischemic deficits following aneurysmal subarachnoid hemorrhage: A Phase II randomized, double-blind, placebo-controlled trial","volume":"111","author":"Tseng","year":"2009","journal-title":"J. Neurosurg."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Helbok, R., Shaker, E., Beer, R., Chemelli, A., Sojer, M., Sohm, F., Broessner, G., Lackner, P., Beck, M., and Zangerle, A. (2012). High dose Erythropoietin increases Brain Tissue Oxygen Tension in Severe Vasospasm after Subarachnoid Hemorrhage. BMC Neurol., 12.","DOI":"10.1186\/1471-2377-12-32"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s00701-007-1284-z","article-title":"Erythropoietin in patients with aneurysmal subarachnoid haemorrhage: A double blind randomised clinical trial","volume":"149","author":"Springborg","year":"2007","journal-title":"Acta Neurochir."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/neurosurgery\/57.2.420a","article-title":"Simvastatin Reduces Vasospasm after Aneurysmal Subarachnoid Hemorrhage: Results of a Pilot Randomized Clinical Trial","volume":"57","author":"Lynch","year":"2005","journal-title":"Neurosurgery"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S1474-4422(14)70084-5","article-title":"Simvastatin in aneurysmal subarachnoid haemorrhage (STASH): A multicentre randomised phase 3 trial","volume":"13","author":"Kirkpatrick","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1161\/01.STR.0000176743.67564.5d","article-title":"Effects of Acute Treatment With Pravastatin on Cerebral Vasospasm, Autoregulation, and Delayed Ischemic Deficits After Aneurysmal Subarachnoid Hemorrhage","volume":"36","author":"Tseng","year":"2005","journal-title":"Stroke"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1097\/CCM.0b013e31822f05e7","article-title":"Atorvastatin decreases computed tomography and S100-assessed brain ischemia after subarachnoid aneurysmal hemorrhage","volume":"40","author":"Nouet","year":"2012","journal-title":"Crit. Care Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.04.022","article-title":"Statin Use and Risk of Cerebral Aneurysm Rupture: A Hospital-based Case\u2013control Study in Japan","volume":"23","author":"Yoshimura","year":"2014","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ijcard.2016.07.234","article-title":"GT-repeat length polymorphism in heme oxygenase-1 promoter determines the effect of cilostazol on vascular smooth muscle cells","volume":"222","author":"Chen","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jns.2013.10.027","article-title":"Effect of cilostazol in patients with aneurysmal subarachnoid hemorrhage: A systematic review and meta-analysis","volume":"336","author":"Niu","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.06.027","article-title":"Efficacy of Cilostazol in Prevention of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: A Meta-Analysis","volume":"27","author":"Saber","year":"2018","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1007\/s00415-019-09198-z","article-title":"Effectiveness and feasibility of cilostazol in patients with aneurysmal subarachnoid hemorrhage: A systematic review and meta-analysis","volume":"267","author":"Shan","year":"2019","journal-title":"J. Neurol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/ana.25361","article-title":"Cilostazol decreases duration of spreading depolarization and spreading ischemia after aneurysmal subarachnoid hemorrhage","volume":"84","author":"Sugimoto","year":"2018","journal-title":"Ann. Neurol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/9\/11\/1150\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:34:32Z","timestamp":1760178872000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/9\/11\/1150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,19]]},"references-count":152,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["antiox9111150"],"URL":"https:\/\/doi.org\/10.3390\/antiox9111150","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,19]]}}}